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Joe Rogan Experience #2195 - Andrew Huberman

Andrew Huberman, PhD, is a neuroscientist and tenured professor at Stanford University’s School of Medicine. Andrew is also the host of the Huberman Lab podcast, which aims to help viewers and listeners improve their health with science and science-based tools. New episodes air every Monday on YouTube and all podcast platforms. www.hubermanlab.com

Joe RoganhostAndrew Hubermanguest
Aug 27, 20243h 7mWatch on YouTube ↗

EVERY SPOKEN WORD

  1. 0:0015:00

    (drumbeats) Joe Rogan podcast,…

    1. NA

      (drumbeats) Joe Rogan podcast, check it out. The Joe Rogan Experience. Train by day, Joe Rogan podcast by night. All day. (rock music plays)

    2. JR

      All right, we're good. Mr. Huberman, how are you, sir? Good to see you. (laughs)

    3. AH

      Good to see you. Good to see you.

    4. JR

      So, what were you just saying about dog breeds that... Like, we were talking about Carl, like the little bulldog breeds have more mastiff than wolf?

    5. AH

      Yeah, so-

    6. JR

      So, mastiff is a different thing?

    7. AH

      Well, so-

    8. JR

      Don't they all come from wolves?

    9. AH

      Yeah, they all originate from wolves, but then dog selection has been twofold. Mainly for phenotype, like morphology, the shape we call it, and then temperament, right? So, there's this chart I... Uh, might be a little hard to find online, um, about the dosing of wolf versus mastiff genetics, essentially. And there's a bunch of other things woven into dog genetics. First of all, cool point, dogs are among, I don't know if they are the most, maybe whales are the most, but they are among the greatest variation in body size within a given species. You think of Chihuahua and Great Dane-

    10. JR

      Right, right.

    11. AH

      ... and it looks like it's dosing of the genes controlling IGF-1.

    12. JR

      Oh.

    13. AH

      Which makes sense.

    14. JR

      Right.

    15. AH

      A growth hormone.

    16. JR

      Yeah.

    17. AH

      But kinda wild, right? Like, you-

    18. JR

      Yeah.

    19. AH

      ... we got some big humans and some smaller humans, but not-

    20. JR

      Not like dogs.

    21. AH

      Not like dogs, and then-

    22. JR

      Chihuahuas-

    23. AH

      Yeah.

    24. JR

      ... and then what are those enormous, uh, shepherd dogs? Those, um, what are those ones, those insane dogs they use to fight off wolves? What the fuck are those things called? Those gigantic hairy things? You know what I'm talking about? Uh... We've talked about them before.

    25. AH

      The-

    26. JR

      They're terrifying-looking dogs. Yeah, the-

    27. AH

      Yeah, I mean, just the-

    28. JR

      What's it called? It's that but it doesn't show on camera.

    29. AH

      Oh, my goodness.

    30. JR

      Oh, yeah, those things.

  2. 15:0030:00

    Like skunk spray. …

    1. AH

      olfaction, which is that there's a particular compound that when introduced to a swimming pool people can detect a difference in the smell of the water at a dilution that is outrageously s- uh, outrageously small.

    2. JR

      Like skunk spray.

    3. AH

      Like skunk spray. Um, forgive me, because I'm not remembering the name of the chemical, but he said you can essentially add a drop of this to a, a swimming pool and then people can smell the difference between the water.

    4. JR

      Mm.

    5. AH

      And so what, his argument is not that humans are walking around sensing all these smells consciously as well as a bloodhound or as well as a bear, but that we have a tremendous capacity for olfaction that, you know, that the chocolate tracking ex- experiment exemplifies, but it requires some removal of our most dominant sense, vision-

    6. JR

      Mm.

    7. AH

      ... and hearing, our second most dominant sense, and in that case, tactile d- um, uh, orientation as well. And so the idea is that, you know, we have an amazing olfactory apparatus. In fact, he, he makes the argument, and there's evidence for the fact that as soon as people meet and, y- they've done these beautiful experiments, people meet, they shake hands, and you know what the next thing they do? They tend to, uh, within about a minute, they wipe the scent of the other person on their face typically. I guess I wasn't paying attention. I was-

    8. JR

      And they don't realize it?

    9. AH

      People don't realize this. And he's done-

    10. JR

      They just do it-

    11. AH

      Yeah.

    12. JR

      ... subconsciously?

    13. AH

      Yeah.

    14. NA

      Mercaptan, I think is, uh-

    15. JR

      Mercaptans, th- also known as thiol, how do you say that? Thiols?

    16. AH

      Uh, where is it? I'm guessing thiols.

    17. JR

      Sulfur-containing organic compounds with a strong unpleasant owner. They are colorless, yellows, liquids, it can be flammable. Mercaptans are found in nature and in living organisms as a waste product of, of metabolism and in oil and gas. They are also present in certain foods such as some nuts and cheese and in decaying organic matter in marshes.

    18. AH

      Right. So we're probably sensitive to the odors that, that matter.

    19. JR

      That can kill us.

    20. AH

      That can kill us. He also has this idea that I think, uh, uh, is starting to take hold in real data, that we are constantly sensing our own o- odor plumes. That we are, you know, that we, we smell ourselves a lot of times per day.

    21. JR

      Mm-hmm.

    22. AH

      That's actually very normal behavior.

    23. JR

      Right.

    24. AH

      You know, there are all sorts of ways people do that that nobody talks about. But pe-

    25. JR

      Yeah, you like check a sniff.

    26. AH

      People check their sniff.

    27. JR

      Yeah.

    28. AH

      And it's a, it's an indication of hormone status, immune status. When you have babies or puppies like, you know, you're looking at like, oh, is it good poop or a bad poop, you know? You're also peing at people, some people will smell the poop. I'm, I'm not a, a proponent of that. But we're constantly sensing the scent and taste of, for instance, our partner's saliva, right? Uh, uh, actually, an ex-girlfriend of mine wrote to me recently, uh, I don't know what this question represented, but she said, um, "Do you think that when you become unattracted to somebody, the, um, the taste of their mouth, um, becomes bad to you or the other way around?"

    29. JR

      When you become unattracted to them?

    30. AH

      Unattracted. I guess she might've been dating somebody and like maybe they'd fallen out of favor and she was kind of no- not attracted and she was sort of noting that, um-

  3. 30:0045:00

    Yeah, but it's not…

    1. AH

      yes, no, or maybe.

    2. JR

      Yeah, but it's not reliable. Like, I, I just be, to, to be completely honest, I've been bullshitted before. But it... I think I'm better at it than most, and I think maybe that's 'cause I've had more conversations with people than most people have. But, uh, it's not 100%. Sometimes people are full of shit and you don't... You're not sure, or you have your defenses down.

    3. AH

      I mean, I've been badly, badly manipulated before.

    4. JR

      Yeah.

    5. AH

      Yeah.

    6. JR

      It happens.

    7. AH

      Yeah, yeah. (laughs) It happens.

    8. JR

      Yeah, especially if you like someone. You know, that's part of the problem. You don't want them to be full of shit.

    9. AH

      Yeah.

    10. JR

      You know?

    11. AH

      And some of the best manipulators, certainly in my experience, are people that have really...... figured out the combination lock of the things that-

    12. JR

      Mm-hmm.

    13. AH

      ... like that I have felt deprived of and they come in and-

    14. JR

      Sure.

    15. AH

      And those tend to be unique things, right, that you can't get uh- anywhere.

    16. JR

      Mm-hmm.

    17. AH

      You know, and boy, uh, somebody said that, uh, to me recently, like there are certain categories of humans that I just, I can't be seduced by. I'm not talking about just sexual seduction, right?

    18. JR

      Right. Right. Right.

    19. AH

      But, you know, um, you know, I'm saying that y- I just can't be seduced by.

    20. JR

      Mm-hmm.

    21. AH

      Um, and then there are... Some people are just, are able to get past that force field.

    22. JR

      Right.

    23. AH

      And so m- I consider myself pretty good at threat sensing, except in that domain.

    24. JR

      Right.

    25. AH

      Where like my threat sensing is like the equivalent of a, of a stuffed animal.

    26. JR

      My friend Tony always says that erotic and psychotic are so close to each other that, you know, like, the, it crosses over back and forth.

    27. AH

      Mm-hmm.

    28. JR

      And I think there's something to that too, that some of the craziest people are also some of the sexiest people for some weird reason. Like you, you wanna be with them even though you know they're dangerous. Like, they're crazy. Like, there's some weird thing going on there. Almost like you want wild kids 'cause wild kids could survive better.

    29. AH

      Oh, that's an interesting one.

    30. JR

      You know what I'm saying?

  4. 45:001:00:00

    Hmm. …

    1. AH

      So, couple of more things about olfaction. And by the way, I love this stuff. This is so wild, 'cause it's the most primitive part of our brain and nervous system. We were chemical sensors before we were light sensors.

    2. JR

      Hmm.

    3. AH

      Right? We were sensing chemical environments. "Is this a, a safe chemical environment?"

    4. JR

      Right.

    5. AH

      And we evolved from that.

    6. JR

      Right.

    7. AH

      We know that, for instance, memories that are associated with smell, like the... People will say, "The smell of my grandmother's kitchen," or, "Somebody's hands, my grandfather's hands," that, those memories stick with us longer than anything, because the olfactory bulb has a direct line to a couple of structures in the brain. We ha- so we have an olfactory bulb, which is the main thing for smell. Then there's something called the accessory olfactory bulb. It sort of divides into primitive smells that are like, ugh, aversive, get away quick. Those tend to go through a really fast line, through the olf- accessory olfactory bulb, takes us straight to the amygdala, to the piriform cortex that says, "Move your body and face in, away from that." Like, I didn't sit there and (sniffs) -

    8. JR

      Right, right, right.

    9. AH

      ... on those smelling salts. It's like, boom, get away.

    10. JR

      Right.

    11. AH

      It's, it's like a reflex.

    12. JR

      Yeah.

    13. AH

      It's like in fish, there's this thing called the Mauthner neuron, where you touch on one side of the body. What does the fish do? Goes the opposite direction.

    14. JR

      Mm-hmm.

    15. AH

      Big, huge neuron. Hardwired circuit.

    16. JR

      Well, they have those lateral lines that detects-

    17. AH

      Exactly.

    18. JR

      ... scen- sounds and things and vibrations in the water.

    19. AH

      They're sensing, electrosensing at a distance.

    20. JR

      Mm-hmm.

    21. AH

      And it... These Mauthner neurons are incredible. You touch, boom. The fish heads the opposite direction. Doesn't go like, "Oh, are you another friendly fish? You want a mate?"

    22. JR

      Right.

    23. AH

      They go, "I'm out of here. Oh," and then they check you out.

    24. JR

      Right.

    25. AH

      Right? And is... So it's a reflex for safety. The olfactory system has these two pathways, the olfactory bulb for kind of like, "Oh, is this Black Rifle coffee?" You know? And then there's the smelling salt one that goes to the olf- uh, the accessory olfactory bulb straight to the amygdala, which is associated with threat detection and other things, straight to the piriform cortex, and then to a motor circuit. Boom. Turn the head the other way, get out, exhale. Don't inhale more.

    26. JR

      Mm.

    27. AH

      Aversive. Okay? So, the thing about smell is that, you know, it's got these very hardwired components. Okay? And they're set up for either appetitive, like, "Hmm, let me explore more, sniff in more," versus avers- a- as opposed to aversive behaviors, like, "Get, get me the hell away."

    28. JR

      Mm.

    29. AH

      And the- these brain areas are among the more ancient brain areas. Now when I say ancient, people nowadays start picking apart at like, "Well, it's not just limbic and cortex. The cortex is part of limbic." That's all true. But if you look at our brains and you look at the brains of a, like a turtle or even a snake, all the stuff we're talking about right here are all... They're not exactly the same, but they're all present. When you get to humans, what you really add is a lot of cerebral cortex for the th- thinking and association stuff. Like, you know, "I've been here before, so I'm a little bit less, you know, uh, like s- looking around as much as I did last time." Like, things that, you know, not... Context-dependent learning.

    30. JR

      Hmm.

  5. 1:00:001:09:11

    It's like total economy…

    1. JR

      in his technique. There's no wasted movement. So when an opportunity presents itself, everything is so fast because the technique is so streamlined. But like look at how he hits the pads. And when you watch how he hits the pads, and Mayweather is a great example of that as well. Did I send it to you? Uh-huh. No? It didn't go through? No. I totally sent it. Hold on. It says I sent it. Is it on Instagram? No. I, yeah, it's on Instagram. Okay. I sent it to you though, uh, on a text message. I think it hit... Really? Yeah. I sent it twice. I got it. I got it. You got it? Okay. Um, Ilia Topuria, like I said, um, one of the, some of the best hands in the sport, current UFC featherweight champion and knocked out Volkanovski who was maybe the greatest of all time. Watch him hit the punches. Look at this. See how he's moving his head when the guy throws punches, just slipping just slightly?

    2. AH

      It's like total economy of movement.

    3. JR

      And the speed, man. Oh. The fucking speed of that. Look at the hand. Look at the hand speed.Fucking incredible. I mean, if you know how difficult that is to do-

    4. AH

      Yeah.

    5. JR

      ... and do it that fast. Give me that ha- sound again. Let me hear this. (punching sounds) (grunting) I mean, these are like five, six punches a second.

    6. AH

      Yeah. It almost-

    7. JR

      I mean-

    8. AH

      ... sounds li- it almost looks like it's sped up by-

    9. JR

      Right.

    10. AH

      ... one, one and a half times, 1.75.

    11. JR

      But it's not. (punching sounds)

    12. AH

      Yeah.

    13. JR

      And just phenomenal technique. (punching sounds) But see how those pu- it's like they're, they're not even talking.

    14. AH

      Oh.

    15. JR

      So when he's s- throwing the mitts at his head to get him to duck, there are no- there's no communication. He just sees that hand coming towards him and he's ducking. He sees this hand coming towards him and he's ducking. It's all, like, slight slips away. And it's slight motions, which is all you need to get away from a punch, right?

    16. AH

      Mm-hmm.

    17. JR

      You just ... You don't wanna move too far or you're wasting a lot of energy and you can't counterattack. Y- One of the best things about Floyd and one of the most brilliant things about him, he's one of the most elusive fighters of all time, but he didn't move around. He stood right in front of you and you couldn't fucking hit him. That's true mastery of space and true mastery of technique. I mean, he was ... He's ... In my opinion, he's the best boxer that's ever lived.

    18. AH

      Yeah. I mean, I'm, I'm not qualified to, to, to rank people, but I, I watched when he was making that ascent towards ... It ended up being 50 and 0.

    19. JR

      He just fought last weekend.

    20. AH

      Did he?

    21. JR

      This weekend. Yeah. He fought a, um ... He fought a match against John Gotti's grandson, which is crazy.

    22. AH

      That's scary for a lot of reasons.

    23. JR

      Yeah, for a lot of reasons. Right? But this is the second time they fought. The first time they fought, it ended in a brawl. Like, a, like a bunch of people jumped in the ring. It was crazy because they stopped the fight because they were talking too much shit to each other and holding onto each other too much. So the referee stopped the fight for whatever reason. I don't know. And then this fight was even crazy too because the referee was ... The first referee was terrible. And the, the referee called Floyd ... Said Floyd Mayweather hit him behind the head. A- absolutely incorrect call. Floyd threw a right hand and it caught him on the side of the head, and the referee claimed that it was behind the head. So Floyd fired the referee in the middle of the bout. They s- He stops the bout. He's like, "Get the fuck outta here. Get out of here."

    24. AH

      'Cause he's the promoter also.

    25. JR

      Well, I guess.

    26. AH

      Yeah.

    27. JR

      I mean, also it's Floyd Mayweather. Like, what's the referee gonna do? "Fuck you"?

    28. AH

      (laughs)

    29. JR

      You know, "I'm gonna stop the fight"? Like, h- he, uh ... Also they're in Mexico City, like, you could get killed. Like, "Just get out of the ring, buddy." So Floyd throws this punch and he's 100% correct. The punch landed the side of the head, it's a right hook, it's a perfect punch. And the, the referee was saying, "Watch the back of the head." He's like, "What the fuck are you talking about? That wasn't the back of the head." And so he kicks the guy out. And they bring in a different referee, who finishes the fight. It was, it was insanity.

    30. AH

      And Floyd won.

Episode duration: 3:07:30

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