Dr Rangan ChatterjeeYou’re NOT Just Getting Old! — These Daily Habits Are Destroying Your Body After 40 | Vonda Wright
EVERY SPOKEN WORD
105 min read · 21,080 words- 0:00 – 2:24
The hidden drivers of “aging faster”: myths, resignation, and self-neglect
- RCDr. Rangan Chatterjee
When you look around across society, what are some of the common things people are doing that are perhaps resulting in them neglecting their bodies-
- VWDr. Vonda Wright
Mm
- RCDr. Rangan Chatterjee
... and therefore increasing the speed at which they age?
- VWDr. Vonda Wright
I think there are a couple factors that may be surprising, and then several that are obviously not. But I think the first reason people begin to decline, without even realizing it, is this bias or this myth we believe that aging is an inevitable decline, and that there's something abnormal about it. But I say quite frequently that aging alone is the most natural thing we do from the minute of our conception to the moment of our death, and it's how we handle the passage of time that matters. But if you believe that there's absolutely nothing you can do about the future, then you're gonna resign yourself to the first time you feel an ache or a pain, or the first time you come up against a no, as, "Well, that's just getting old, I guess I'll just accept it." And what I find people doing is giving things up one at a time until they don't recognize it. I'll give you some examples. So believing the myth that it's inevitable is, I think, a primary motivator. The second motivator I see is that sometimes people don't believe they're worth the effort. Maybe everybody else is worth the effort, particularly for women, like, the, the neglect, the self-neglect comes because we're not neglecting others, we're investing all of our energy externally and not redirecting anything internally. And so those being primary drivers I see in the stepwise allowing decline.
- RCDr. Rangan Chatterjee
Hmm. It's interesting, this idea about mindset or beliefs.
- VWDr. Vonda Wright
Mm.
- RCDr. Rangan Chatterjee
You know, if we believe, if we get the message from the world around us that getting older means frailty-
- VWDr. Vonda Wright
Mm-hmm
- RCDr. Rangan Chatterjee
... means weakness-
- VWDr. Vonda Wright
Mm-hmm
- RCDr. Rangan Chatterjee
... means you have to give up the things that you don't wanna give up necessarily-
- VWDr. Vonda Wright
Mm-hmm
- RCDr. Rangan Chatterjee
... then of course your behaviors are going to follow-
- VWDr. Vonda Wright
That's right
- RCDr. Rangan Chatterjee
... your beliefs.
- VWDr. Vonda Wright
Mm-hmm.
- RCDr. Rangan Chatterjee
And there's so many things about your new book, Unbreakable, that I really, really enjoy.
- VWDr. Vonda Wright
Yeah.
- 2:24 – 5:13
What “normal aging” is really measuring (and why sedentary data misleads us)
- RCDr. Rangan Chatterjee
I think it's beautifully written. And in the introduction you actually say, "I contend that although we certainly undergo some life stage changes-
- VWDr. Vonda Wright
Mm-hmm
- RCDr. Rangan Chatterjee
... what we call normal aging is actually normal aging for stressed out, undernourished people who are not intentionally building muscle, not attending to their hormonal health, and not prioritizing mobility."
- VWDr. Vonda Wright
Exactly. And what I mean by that is if you go back to the medical literature, there was a study, and there are many studies like this. Uh, there was a study called the Health ABC in the United States funded by our National Institutes of Health, that took a cohort of 70-year-olds and just watched them age over a decade. These were people straight out of the population. Well, what do we know about people in the world and in the United States in particular, is that more than 70% of them do not invest any energy any day in mobility or health habits. So if we're watching a population of people to see how they age, and they're truly just a random sample of the population, then you are sampling sedentary people who make very little effort to age in a different way. So I, I state that so clearly is because I contend, and why we formed the research group at the University of Pittsburgh called PRIMA, the Performance and Research Initiative for Masters Athletes, is because I wanted to see what we were capable of if we took the variable of sedentary living out of the way.
- RCDr. Rangan Chatterjee
Mm-hmm.
- VWDr. Vonda Wright
So we began studying active people, not professional masters age athletes, but people over 40 who were consistently active. Many of them were podium-type, uh, age group athletes-
- RCDr. Rangan Chatterjee
Mm
- VWDr. Vonda Wright
... meaning, you know, winning the 50-year-old, uh, podium. So they were invested, but not pros, and what we found was very different than we find in the population. We found over 15 years we can retain muscle mass and bone density and brain function. Um, and so when I say that we don't really truly know the state of healthy, active ageing, it's based on facts, not fiction.
- RCDr. Rangan Chatterjee
Yeah. So in terms of what people can do then as they get older, we're gonna get into all the detail-
- VWDr. Vonda Wright
Yeah
- RCDr. Rangan Chatterjee
... but top line-
- VWDr. Vonda Wright
Mm-hmm
- RCDr. Rangan Chatterjee
... right at the top for people-
- VWDr. Vonda Wright
Mm-hmm
- RCDr. Rangan Chatterjee
... what are some of the things that you want people to consider doing as they get older?
- VWDr. Vonda Wright
Mm-hmm. Yep.
- RCDr. Rangan Chatterjee
As I say, we'll get into all the detail-
- VWDr. Vonda Wright
Yeah
- RCDr. Rangan Chatterjee
... but just top line, what are some of those things you want people to be focusing on as they get older?
- 5:13 – 6:23
The top-line blueprint: mindset, resilience, and your “five-person” circle
- VWDr. Vonda Wright
Number one, mindset mobilization. We have to quit worshiping our youth. Number two, we have to work hard at building mental resilience. Aging is not for sissies. It can get hard, so we have to build the mental resistance to stay in the process. Number three, we need to build physical resilience, and part of this book is all about that. How do we know where we are physically, and then use the science-backed ways to build physical resilience? Um, and then I firmly believe and encourage people to form groups of at least five to travel this road with you-
- RCDr. Rangan Chatterjee
Mm-hmm
- VWDr. Vonda Wright
... towards an aging process that is vibrant, because, you know, experts in, in social theory and, and relationships will say that we are the product of the five people we spend the most time with.
- RCDr. Rangan Chatterjee
Mm.
- VWDr. Vonda Wright
And if those five people are naysayers of health and aging, if they are naysaying in your ear, "What are you doing out there trying to get healthier?"It's gonna hold you back. So as a broad outline-
- RCDr. Rangan Chatterjee
Mm
- VWDr. Vonda Wright
... those would be the things I identify.
- 6:23 – 9:30
Why this women-focused book matters to men (and to families)
- RCDr. Rangan Chatterjee
Yeah. I love those. This book is primarily focused on women.
- VWDr. Vonda Wright
Mm.
- RCDr. Rangan Chatterjee
I'm a man-
- VWDr. Vonda Wright
Yes
- RCDr. Rangan Chatterjee
... in my 40s.
- VWDr. Vonda Wright
Yes.
- RCDr. Rangan Chatterjee
What is it you would like me to take from reading this book?
- VWDr. Vonda Wright
You know what? This book is specifically, uh, through the vision and voice of women, but many of the principles are directly applicable, especially the mindset principles, to men. But listen, all men are from women. S- y- all men were at one point in a woman's womb, right? So you, you must have a mother figure. Many men are partnered with women. You have sisters. You are in working relationships with women. The more understanding men have of the differences between what happens as a man ages and a woman ages, there will be a greater understanding and ability to work together, and, and even probably save a lot of midlife marriages because of an understanding that women go through a completely tumultuous time that is of not their choosing.
- RCDr. Rangan Chatterjee
Yeah.
- VWDr. Vonda Wright
It's just biology.
- RCDr. Rangan Chatterjee
Yeah, I love that. I mean, I, I, I believe that to be the case. I believe books like this can actually save many marriages.
- VWDr. Vonda Wright
Exactly.
- RCDr. Rangan Chatterjee
And I think it is very relevant to men.
- VWDr. Vonda Wright
Yes.
- RCDr. Rangan Chatterjee
Even though, you know, the strap line is A Woman's Guide to Ageing With Power.
- VWDr. Vonda Wright
[laughs]
- RCDr. Rangan Chatterjee
I really enjoyed reading it.
- VWDr. Vonda Wright
Mm-hmm.
- RCDr. Rangan Chatterjee
And of course, I'm married.
- VWDr. Vonda Wright
Yes, you are.
- RCDr. Rangan Chatterjee
Okay? Um, I, I help look after my elderly mum, so some of these things that you talk about-
- VWDr. Vonda Wright
Mm-hmm
- RCDr. Rangan Chatterjee
... I have seen what happens if people don't pay attention. I have a daughter.
- VWDr. Vonda Wright
Yes.
- RCDr. Rangan Chatterjee
And I've heard you talk about the importance of bone health and how we get to our peak bone density maybe at 25 or 30.
- VWDr. Vonda Wright
Yes.
- RCDr. Rangan Chatterjee
And so this book has already made me think about, well, what is my daughter doing right now at 12 years of age-
- VWDr. Vonda Wright
Mm-hmm
- RCDr. Rangan Chatterjee
... that's gonna ensure she's putting force and pressure through her bones to make sure she has the maximum bone capacity that she can have. So yeah, yes, it's for women. It's also just as relevant to men.
- VWDr. Vonda Wright
I love that you say that because, you know, particularly in reference to your daughter, is it's my intention, I have, I have two daughters and, and f- four daughters-in-law. It is my intention that they never suffer, because your... that, so that your 12-year-old and my 17-year-old and my 31-year-old will know what's going to happen, build solid bases of muscle and bone and, and brain health in their youth, know what's going to happen as estrogen walks out the door, and know where to have the resources. Because what's happened to certainly baby-booming women, certainly Generation X women, which we do not want to happen to the oldest millennial women who are 43, 44, is the hitting the wall phenomenon, not being yourself, cataclysmic changes. So for your 12-year-old and my 17-year-old, my vision and motivating factor is that they will never feel this.
- 9:30 – 17:46
Why women and men age differently: the hormone timeline and the estrogen cliff
- RCDr. Rangan Chatterjee
Let's take a big-picture view, right? You mentioned the differences between women and men. Of course, there are many differences.
- VWDr. Vonda Wright
Completely.
- RCDr. Rangan Chatterjee
But I saw you speak a couple of days ago in London.
- VWDr. Vonda Wright
Mm.
- RCDr. Rangan Chatterjee
And you put up some very provocative images.
- VWDr. Vonda Wright
Mm.
- RCDr. Rangan Chatterjee
They... Very, very thought-provoking. And one of them that I'm gonna make sure we pop up on screen-
- VWDr. Vonda Wright
Yes
- RCDr. Rangan Chatterjee
... on the YouTube version of this-
- VWDr. Vonda Wright
Mm
- RCDr. Rangan Chatterjee
... conversation, is how men and women's hormones change-
- VWDr. Vonda Wright
Yes
- RCDr. Rangan Chatterjee
... through their life.
- VWDr. Vonda Wright
Mm-hmm.
- RCDr. Rangan Chatterjee
And the thing that I really took from this image was this idea that men have a gradual decline in testosterone over a number of decades.
- VWDr. Vonda Wright
Yes.
- RCDr. Rangan Chatterjee
Whereas women have this sharp, precipitous decline-
- VWDr. Vonda Wright
Mm-hmm
- RCDr. Rangan Chatterjee
... in estrogen during perimenopause.
- VWDr. Vonda Wright
That's right.
- RCDr. Rangan Chatterjee
Could you speak to that-
- VWDr. Vonda Wright
Mm-hmm
- RCDr. Rangan Chatterjee
... and speak to these more broad differences and why so many women go through what you went through, I think, at 47-
- VWDr. Vonda Wright
Yes
- RCDr. Rangan Chatterjee
... which you can perhaps explain at some point.
- VWDr. Vonda Wright
Yes, I will.
- RCDr. Rangan Chatterjee
But just take us through what those differences are and how they manifest for us in terms of the quality of our lives.
- VWDr. Vonda Wright
So let's start back at the first big bump in the road for everyone who lives, which is adolescence, right? We come into our hormones. We all expect that to be an awkward stage.
- RCDr. Rangan Chatterjee
Mm-hmm.
- VWDr. Vonda Wright
We describe it as that. We describe it as, uh, all these body changes. It's something that we readily accept.
- 17:46 – 22:12
Estrogen is a whole-body hormone: brain, heart, bone, muscle—and pain
- VWDr. Vonda Wright
Yes. There is a normal, natural aging process, and in the book I talk about what I call the time bombs of aging. They're actually the hallmarks of aging. We know aging happens at a cellular level, but women have stacked on top the loss of estrogen. Let... Do you mind if I give you a couple organ examples?
- RCDr. Rangan Chatterjee
Oh, take your time.
- VWDr. Vonda Wright
In the brain, for instance, the work of Lisa Mosconi has shown that the brain is covered, literally covered, with estrogen receptors. The work of Robbie Brinton-A brain scientist has shown that without estrogen sitting in those receptors, the brain literally starves and changes its chemistry. That's why it manifests as brain fog. We can't find our keys. We can't remember why we walked into a room. For me and many other women, I forgot nouns. Imagine this, I tell this story all the time, and I wanna tell everybody my brain is back. It's as good as it ever was because of the estrogen that I take now. But when I, bef- in my critical decade, before I became an expert on this, I would walk into the operating room, and I would know exactly what I was gonna do, and I was gonna know exactly how to do it, but I forgot the name of the piece of equipment that picks things up. And I would say to my scrub tech, "I need the thing..." For those of you listening, I'm, I'm doing a pincing motion. "I need the thing that does this thing." I needed a Nansen, which is a, which is a forcep.
- RCDr. Rangan Chatterjee
Mm-hmm.
- VWDr. Vonda Wright
I could-- I knew exactly what I was doing, but I lost my nouns, and I frankly thought that I was getting dementia. So I start googling early signs of dementia. Think how frightening that is for a brain person.
- RCDr. Rangan Chatterjee
That is, yeah.
- VWDr. Vonda Wright
Yeah. My... I'm a brain person. My brain's the best part of me. There's that. Many women experience that. Um, and I don't think it ends there. These mechanisms are not clearly worked out, but there must be a reason that 70% of all people with Alzheimer's are women. It can't just be coincidence. I think we're gonna work out the mechanisms to find that although multifactorial, it has to do with estrogen sharply declining. So that's the brain. The heart has an increase of 30% to 40% of microvascular disease.
- RCDr. Rangan Chatterjee
Mm-hmm.
- VWDr. Vonda Wright
When men's hearts have, have, uh, disease, it's in the big, major vessels. For women, it's in the much smaller vessels, so it goes undetected a lot of times. But we know that estrogen plays a critical role in heart health. If we get to musculoskeletal health, which is obviously where I live, there's a natural rate of decline of bone for men and women of about f- 1% a year in their bone density. During perimenopause, that precipitously increases to 2% to 3% a year so that over five to seven years, 10 years, you can lose 20% of your bone density. So if you've never built enough bone as a child, and now you're gonna lose 20% of it predictably, that's why 70% of all hip fractures are in women. Muscle is the same way. We will lose 8% to 10% of our muscle, um, mass in the decades surrounding perimenopause. The list goes on-
- RCDr. Rangan Chatterjee
Mm-hmm
- VWDr. Vonda Wright
... and on and on. And so when I say men and women age differently, the most direct contributing factor, lifestyles being equal, has to be, at least in part, due to our estrogen.
- RCDr. Rangan Chatterjee
Yeah, it's interesting. Simply calling estrogen a sex hormone is so limiting-
- VWDr. Vonda Wright
Oh
- RCDr. Rangan Chatterjee
... isn't it? These labels we put on these things.
- VWDr. Vonda Wright
Yes.
- RCDr. Rangan Chatterjee
And I feel medicine's done this in many different places.
- VWDr. Vonda Wright
Mm-hmm.
- RCDr. Rangan Chatterjee
Actually, there's been unintended consequences, right? So by viewing estrogen purely as a sex hormone, we therefore don't think about the effects of estrogen-
- VWDr. Vonda Wright
Yes
- RCDr. Rangan Chatterjee
... on the brain-
- VWDr. Vonda Wright
Mm-hmm
- RCDr. Rangan Chatterjee
... or the heart-
- VWDr. Vonda Wright
Mm-hmm
- RCDr. Rangan Chatterjee
... or the bone. And you could sort of make the same case, like, with exercise, right, or physical activity, how for many years in society it was about weight.
- VWDr. Vonda Wright
Yeah.
- RCDr. Rangan Chatterjee
Physical activity is what you need to do to maintain a healthy weight.
- VWDr. Vonda Wright
Mm.
- RCDr. Rangan Chatterjee
And I would say, I think, over the last five or 10 years, realizing that your muscles aren't just dumb muscle sitting there.
- VWDr. Vonda Wright
[laughs]
- RCDr. Rangan Chatterjee
They're also important for your hormones-
- 22:12 – 29:35
Bone health rebranded: bone as master communicator (and why fractures are so deadly)
- RCDr. Rangan Chatterjee
... and all kinds of communication molecules around the body. And then yesterday, I was watching this beautiful 30-minute video on your YouTube channel about-
- VWDr. Vonda Wright
Oh
- RCDr. Rangan Chatterjee
... bone.
- VWDr. Vonda Wright
Yes.
- RCDr. Rangan Chatterjee
And I was thinking the same thing with bone, right?
- VWDr. Vonda Wright
Yes.
- RCDr. Rangan Chatterjee
Like, muscle has had a PR job over the last five years, where we now understand that muscle is important for so much more than our physicality.
- VWDr. Vonda Wright
Yes.
- RCDr. Rangan Chatterjee
And I feel with that video [laughs] and in this book, you're almost giving this kind of new marketing to bone, saying, "Hey, bone isn't just your structure."
- VWDr. Vonda Wright
That's right. [laughs]
- RCDr. Rangan Chatterjee
Bone does so many other things.
- VWDr. Vonda Wright
Absolutely, and I'm so glad you're giving time to this on this podcast because it is now a, a vision and mission of mine to help people understand a- and care about their bones. I mean, it's Fashion Week in around the world right now, and that's about the only time we think about bones is, oh, gorgeous cheekbones.
- RCDr. Rangan Chatterjee
[laughs]
- VWDr. Vonda Wright
Look at our wrist structure, or when we fracture, obviously. Bones are seemingly silent until they break, and then they're screaming 'cause that's excruciating. But the reality is bones have so many functions in the body. From structure, sure, they're structural. Otherwise, you know, think about it. I love to say this out loud, that without bones, muscle that we're all in love with is just this heaping pile of metabolic tissue like a chicken breast on the counter. It does nothing but lay there. But with bone, you have structure. It gives you human form. It gives you locomotion, but it is a master communicator. Bone produces a multitude of hormones, one of which, uh, I talked about on that video you're referencing, called osteocalcin.
- RCDr. Rangan Chatterjee
Yeah.
- VWDr. Vonda Wright
Yeah. Osteocalcin is released by the bone. It goes to your brain. It causes your brain to secrete bone-derived neurotrophic factor, which builds better neurons. So bone is helping you build a better brain, yes. It goes to your muscles and helps with glucose absorption. It goes to your pancreas for insulin, uh, release and resistance. In men, it goes to the testicles and helps you produce testosterone. There are gut, uh, bone-brain axes. There are bone-gut axes that are only being worked out. AndNot only do they talk to the rest of the body, but they are intimately talking to muscle and fat.
- RCDr. Rangan Chatterjee
Mm.
- VWDr. Vonda Wright
Because the musculoskeletal system, fat, tendon, ligament, bone, muscle, muscle stem cells, are all from the same stem cell originally, the mesenchymal stem cell. They're all cousins. Why wouldn't they talk to each other and do so in a way that coordinates the whole body? And so not only is it a master c- a structural master communicator, it is the storehouse of all the minerals we need for our body to function, the calcium, the phosphorus, a lot of collagen. Bone is made out of collagen. When your body needs it to live, it will take it from the storehouse. It's not abnormal to resorb bone. What's abnormal is a disconnect between reabsorption and rebuilding s- because we use the products we store in our bone. It is also, believe it or not, the incubator of all of our blood cells. All of your blood cells are made in your pelvis, and when you're young, in your long bones. So if we were gonna do a stem cell therapy on you, we would get your stem cells from your pelvis.
- RCDr. Rangan Chatterjee
Mm-hmm.
- VWDr. Vonda Wright
Isn't that fascinating-
- RCDr. Rangan Chatterjee
Yeah
- VWDr. Vonda Wright
... that bones are doing all these things? And listen, if I were designing a human being, why wouldn't I make bone the master communicator? Because we have bone from the top of our skull to the bottom of our pinky toe. It's a highway for communication. But you're right, we never think about it unless we're thinking about fracture. And it's funny, people say bones are silent. Bones are not silent, but we just can't hear them-
- RCDr. Rangan Chatterjee
Yeah
- VWDr. Vonda Wright
... until they break. And I'm gonna tell you from being in the trauma bay many years, it's excruciating, and I never want someone to have to deal with it. But we think about it, especially bone health with aging, because as we lose our bone density and break big bones like the femur or, you know, the top of the femur is the hip, um, especially in women, men break their bones, too. M- uh, uh, let's just talk about this. Two million men in the United States have osteoporosis. It's not just a disease of women, but more prevalent in women. 70% of all hip fractures, which is the biggest bone in the body, happen in women. The instant, literally the instant, snap your fingers, the instant you break that bone, you have a 30% chance of dying in the next year. I mean, that's grave. Isn't that? That is a grave statistic, that if we could think about our 12-year-old and our 17-year-old daughters that we have, to get their bones so strong at peak mass that they never reach that point.
- RCDr. Rangan Chatterjee
Yeah.
- VWDr. Vonda Wright
So 30% of the time, Aunt Miriam, who's a story I told to the FDA in the United States recently as we're trying to change the thoughts about estrogen, 30% of the time she's gonna die, and if you live, 50% of the time you will not return to the home that you came from because you don't have the functional strength or, or you can't get up from a chair anymore. So bone is... That kind of fracture is not only a personal pain, it's a family and social dilemma. What do we do with Mom, right? Do we hire a full-time caregiver? That's expensive. Do we have her move in? You know, in some cultures, and I'm Chinese, in my culture, that's what would happen.
- RCDr. Rangan Chatterjee
Mm-hmm.
- VWDr. Vonda Wright
I mean, my parents live with me, 'cause that's just what we do. But in many cultures, that's not what you do. You find a place for your parents to live. Well, if you find a place for your parents to live, that is prohibitively expensive many places, and so in the United States, you must use your life savings to pay for that at the rate of 5 to $15,000 a month until you're a pauper, and that's when the Medicaid-
- RCDr. Rangan Chatterjee
Yeah.
- VWDr. Vonda Wright
Who wants to be in that situation?
- 29:35 – 42:51
The “critical decade” (35–45): bone scans, early warning, and why young adults already have osteopenia
- RCDr. Rangan Chatterjee
This is huge. But how do you get a woman in their late 30s who is in what you call the critical decade-
- VWDr. Vonda Wright
Yes
- RCDr. Rangan Chatterjee
... which you can perhaps explain in a moment-
- VWDr. Vonda Wright
Yes
- RCDr. Rangan Chatterjee
... to actually care about this neck of femur fracture that they might get at 75?
- VWDr. Vonda Wright
Yeah.
- RCDr. Rangan Chatterjee
Because that seems like, "Oh, yeah, whatever," you know.
- VWDr. Vonda Wright
I'll deal with it then.
- RCDr. Rangan Chatterjee
I'm still active.
- VWDr. Vonda Wright
Mm-hmm.
- RCDr. Rangan Chatterjee
I can still pick the kids up, and I can still see my girlfriends at the weekend and-
- VWDr. Vonda Wright
Mm-hmm
- RCDr. Rangan Chatterjee
... you know. How do you get someone in their 30s or 40s to care about those bone density implications later on in life? It's difficult, isn't it?
- VWDr. Vonda Wright
It's so hard, because there's a temporal disconnect. There's this, there's this banking idea, I learned it from my bankers, that they experience called tem- temporal disconnect. On average, they cannot get the average person to save $10 for their s- fu- for their pension, right? It's the same in health.I cannot get people motivated in their youth for their old age. So for the women and men in the critical decade, which I call 35 to 45-
- RCDr. Rangan Chatterjee
I love that. Is, is it just for women though, or is it for men as well?
- VWDr. Vonda Wright
No, it's for men. It is time to get your proverbial health standards in check, because if you build a lifestyle where you're eating a non-inflammatory, high-protein diet so that you're able to build, or if you're eating at all, many women decide not to eat enough.
- RCDr. Rangan Chatterjee
Mm.
- VWDr. Vonda Wright
We can talk about that. If you've got your food down, and it doesn't mean you can't live and have an occasional... I, you know what, I had a piece of chocolate before I walked in here. I'm not talking about austerity. The standards of nutrition, a muscle-building practice, a cardiovascular building practice, it's a lifestyle to you. It is not a burden-
- RCDr. Rangan Chatterjee
Mm
- VWDr. Vonda Wright
... if that's just the way you live.
- RCDr. Rangan Chatterjee
My family and I have been wearing VIVOBAREFOOT shoes for over 12 years, and there is no way that I would go back to wearing cushioned shoes. The human foot is a masterpiece, but modern footwear has disconnected us from our natural movement, and barefoot shoes are a tool to restore that primal link. VIVOBAREFOOT strips away the unnecessary. No thick foam, no elevated heels, just thin, flexible protection that lets your feet move in the way that nature intended. When your feet can feel the ground, your body naturally moves better. Now, VIVO offer a fantastic range of shoes, office shoes, athletic shoes, but also amazing winter boots like the Tracker Forest, my current favorite, which is super comfortable, warm, and also has amazing grip. I can't recommend them enough. And if you want to give them a try, please do use VIVO's online sizing tools to ensure that you find your own perfect fit. To get 20% off your first order and enjoy a 100-day money-back guarantee, visit vivobarefoot.com/livemore, click on the link in the description box below, or scan the QR code on screen. I've been wearing a WHOOP band for about a year now, and it has had a transformative impact on my health and wellbeing. I've gained so many different insights, how different types of exercise or life stress affect my recovery, how different evening routines affect my sleep, and overall, it's helped me understand my own body much better. WHOOP is the only wearable that turns your health and fitness data into personalized guidance. And I'm pleased to announce that the all-new WHOOP band is now here, 7% smaller and with 14-plus days of battery life. The all-new WHOOP includes so many exciting new features, including hormonal insights and on-demand ECG readings. But I think, for me, my own personal favorite is Health Span, and seeing this regularly helps motivate me and keep me on track with my habits. Now, I've been a medical doctor for over 20 years. I think it's really important to use the WHOOP data as a tool to help guide you, not as something to dictate your life. Honestly, I don't think health wearables are necessarily for everyone, but for some people, like me, they can be absolutely game-changing. If you join WHOOP right now, they are giving my audience the all-new WHOOP 5.0 device, plus they are giving you the first month completely free. And if you're still not sold yet, there's also a 30-day money-back guarantee, so you can try it out for free. Go to join.whoop.com/livemore.
- VWDr. Vonda Wright
The critical decade is the time to get that in order before you lose your hormones, right? For women, once you hit your mid-40s, now you're adding that burden that we already discussed.
- RCDr. Rangan Chatterjee
Yeah. It's almost as if we can kind of get away with things until our mid-30s, right?
- VWDr. Vonda Wright
That's right.
- RCDr. Rangan Chatterjee
So yeah, there are health-promoting things to do, but even if you don't do them-
- VWDr. Vonda Wright
You'll skim by
- RCDr. Rangan Chatterjee
... you still seem to get by-
- VWDr. Vonda Wright
Mm-hmm
- RCDr. Rangan Chatterjee
... or a lot of us do in our 20s and early 30s.
- VWDr. Vonda Wright
Yeah.
- 42:51 – 46:27
Family-based movement: teaching kids to load bones through play (and reclaiming what adults abandon)
- RCDr. Rangan Chatterjee
And as you say, of course, you know, the kids today are digital natives.
- VWDr. Vonda Wright
Yes.
- RCDr. Rangan Chatterjee
And it's something my wife and I are constantly talking about with our kids. I mean, my daughter's 12, and she got into netball about three years ago.
- VWDr. Vonda Wright
Mm-hmm.
- RCDr. Rangan Chatterjee
And so she probably plays five times a week.
- VWDr. Vonda Wright
Mm.
- RCDr. Rangan Chatterjee
And I'm delighted because she enjoys playing, her friends are there-
- VWDr. Vonda Wright
Mm-hmm
- RCDr. Rangan Chatterjee
... so there's this big social component.
- VWDr. Vonda Wright
Mm-hmm.
- RCDr. Rangan Chatterjee
And I'm thinking, actually, you know what, if I think about netball through the lens of bone health-
- VWDr. Vonda Wright
Mm-hmm
- RCDr. Rangan Chatterjee
... there's a lot of impact-
- VWDr. Vonda Wright
Nice
- RCDr. Rangan Chatterjee
... a lot of jumping-
- VWDr. Vonda Wright
Yes
- RCDr. Rangan Chatterjee
... a lot of speed. Um, I'm thinking, this is good.
- VWDr. Vonda Wright
Multidirectional jumping, perfect.
- RCDr. Rangan Chatterjee
Yeah, and I'm thinking, this is good, right?
- VWDr. Vonda Wright
Mm-hmm.
- RCDr. Rangan Chatterjee
Because there's a social component for her.
- VWDr. Vonda Wright
Mm-hmm.
- RCDr. Rangan Chatterjee
And as a side effect, she's getting all of this great movement in.
- VWDr. Vonda Wright
Yes.
- RCDr. Rangan Chatterjee
I think the difficulty for me would be is, well, if she wasn't into netball, actually, and I know a lot of, uh, parents face this, if their children don't enjoy a particular sport-
- VWDr. Vonda Wright
Yeah
- RCDr. Rangan Chatterjee
... they could hear a podcast like this-
- VWDr. Vonda Wright
Mm-hmm
- RCDr. Rangan Chatterjee
... and think, "Well, hold on a minute. What are my kids actually doing-
- VWDr. Vonda Wright
Mm-hmm
- 46:27 – 1:07:13
Pregnancy and breastfeeding: how bone can be depleted—and how to rebuild
- RCDr. Rangan Chatterjee
Going back to this idea that women and men age differently-
- VWDr. Vonda Wright
Yes
- RCDr. Rangan Chatterjee
... I'm really interested as to what happens when a woman gets pregnant.
- VWDr. Vonda Wright
Oh.
- RCDr. Rangan Chatterjee
Because I know that can have an impact-
- VWDr. Vonda Wright
Completely, yes, uh-huh
- RCDr. Rangan Chatterjee
... on bone health, and breastfeeding can as well.
- VWDr. Vonda Wright
Yes, mm-hmm.
- RCDr. Rangan Chatterjee
So can you just talk us through that?
- VWDr. Vonda Wright
Yes.
- RCDr. Rangan Chatterjee
Because again, I think it's empowering to realize the impact of those things-
- VWDr. Vonda Wright
Yes
- RCDr. Rangan Chatterjee
... and therefore what we can do on the other end.
- VWDr. Vonda Wright
Completely love that you brought that up, because if we talk about that bone is a lifespan pursuit, we just talked about the young women, then when women enter their fertility years, when they're choosing to have children, or if you don't, bones are still of concern to you, but during pregnancy, we are building a baby from ourselves. The baby's not eating itself. The baby is eating the mother, either through the nutrients coming in, or if there's not enough, from her muscle, from her bone. Takes about 500 milligrams of calcium a day to build a baby. Where are we getting that? We're either absorbing it from the gut and then passing it to the baby, or we're resorbing the mother's bone.
- RCDr. Rangan Chatterjee
Um, and just for people who don't know what resorb means?
- VWDr. Vonda Wright
Yes. It means that there's a, the way bone works, just as a bone building primer, how bones work, our bones are constantly doing something called remodeling, meaning taking a little bit away, building a little bit up. It's two different cell types. The osteoclast, with a C, is taking bone away, and then you use all the minerals that you've harvested. And then the osteoblast, B, blast, is building bone.
- RCDr. Rangan Chatterjee
Mm.
- VWDr. Vonda Wright
And in normal circumstances, with enough hormones, that is a, a pretty equal process. Homeostasis, balance.
- RCDr. Rangan Chatterjee
Mm-hmm.
- VWDr. Vonda Wright
Those are all synonyms. If your body requires more than you're able to build or replace, you will get in bone deficit. That can happen during pregnancy if we're not getting enough nutrition. The mother's body will prioritize the baby and resorb what it needs, regardless of what happens to the mother, such that-
- RCDr. Rangan Chatterjee
Mm
- VWDr. Vonda Wright
... there is a, a phenomenon called the osteoporosis of pregnancy. It's a documented medical phenomenon. Because women can lose a significant amount of bone density. Now, here's the good thing.Our bodies know this is gonna happen, and we are, we are designed to rebuild that bone, uh, post-pregnancy, but only if we eat enough. Mothers get busy. Sometimes they don't have time to take a shower, let alone eat, right? Pile on top of that breastfeeding. Now, I always like to have the caveat based on responses I've got that I am all for breastfeeding for women who choose to do it. I breastfed my youngest child for a year. I think it was that important. Where are we get... Again, it's the same argument. Where are we getting the nutrients from? It takes 500 milligrams of calcium a day to make enough milk for a baby. We're gonna take that from our bones. So every time your baby latches on, in addition to drinking water, we have to be thinking about replacing-
- RCDr. Rangan Chatterjee
Mm
- VWDr. Vonda Wright
... our calcium, our magnesium, our phosphorus, so that we don't end up in deficit. Because now with women, uh, millennial women delaying childbirth into their early 30s, mid-30s, um, we're entering the critical decade, right? So we have less time to build bone back, and then what if we're having children more rapidly at an older age, and so we may never have time to build back? I just want people, women to be aware, right? Because you can correct that. But if you never correct that, and then we've already talked about what happens in perimenopause, losing 15 to 20% of your bone density, do you see how this can add up across a lifespan such that it is not un- it is even more common for women truly in their menopause years, I, at, at this conference we were at-
- RCDr. Rangan Chatterjee
Mm-hmm
- VWDr. Vonda Wright
... I had many women come up to me afterwards and say, "You know what? I thought I was doing everything right." They're doing all the lifestyle things.
- RCDr. Rangan Chatterjee
Mm.
- VWDr. Vonda Wright
But they go and get this DEXA scan or this REMS scan, and they're osteopenic or osteoporotic, and they're so disappointed-
- RCDr. Rangan Chatterjee
Mm
- VWDr. Vonda Wright
... because they thought they were doing everything right now. Well, they may be, but maybe they didn't build enough bone in their youth.
- 1:07:13 – 1:16:02
Movement as the universal medicine: cellular aging, stem cells, and the F.A.C.E. framework
- VWDr. Vonda Wright
So if we have, if we have hypertension, high blood pressure, there's a pill for that. If we have diabetes, metabolic disorder, there are a variety of pills for that. If there is heart disease, a pill for that. But there is one pill, one activity, one set of skills that treats everything, and that is movement, baseline. In fact, it is so critical in so many diseases that, um, a pro- I wish I had made this up. I didn't, but there's a professor out of, uh, Columbia University in Missouri in the United States that coined the word sedentary death syndrome. It is the 33 chronic diseases that we die from, including heart disease, that are directly impacted by the amount of movement we do. So how does that work? So, um, let's just take skeletal muscle contraction, mo- movement. Skeletal muscle contraction produces a, a, a cytokine, a hormone called irisin that is directly related to glucose metabolism, uh, insulin resistance. I've already talked about the way the bone talks to the brain and the muscle and the pancreas.
- RCDr. Rangan Chatterjee
Mm-hmm.
- VWDr. Vonda Wright
So any time we're moving our body, it's not just locomoting us, it's changing us chemically on the inside. When I recommend people sprint at the end of their cardio workout, literally get your heart rate way up, that will change the number of mitochondria, which are the powerhouse units in our cells. It will help stimulate the r- uh, the division of something called satellite muscle stem cells, which are called satellite cells. Mobility in the form of exercise causes the transcription and changing of body molecules of more than 9,800 molecules every time you go out for a run. It's signaling your DNA to express the genes that you need to stay healthy. Um, it, it's just fascinating that, that one modality, mobility, can change us at a cellular level. It can change us at a tissue level. Um, here's an experiment we did in the labs with my partners that I had at University of Pittsburgh. Mobility is actually the fountain of youth for our stem cells. So what the experiment was this. We took little old lady mice. A little old lady mouse is two years old. She's old.
- RCDr. Rangan Chatterjee
[laughs]
- VWDr. Vonda Wright
She's just sitting back in her cage waiting for her next meal. So we sampled her muscle, and we took out a few of her little muscle stem cells, and what did we find? We found that her muscle stem cells in sedentary living were dying. Dying cells, it's an active process.
- RCDr. Rangan Chatterjee
Mm-hmm.
- VWDr. Vonda Wright
You turn on something called programmed cell death. They were dying. They had lost their round plumpness. Healthy cells are round like a grape. They were more like a, a, a, a branch.
- RCDr. Rangan Chatterjee
Mm-hmm.
- VWDr. Vonda Wright
They were spindly, and they were no longer reproducing or producing growth factors. That's what these little old stem cells were doing. Then we took these girls, and I spent a lot of money buying mouse treadmills. It's unbelievable how much mouse treadmills cost. But I bought some, and we put these girls on the mouse treadmills, and they were just like the rest of us. They didn't wanna run, but we encouraged them to do so.
- RCDr. Rangan Chatterjee
Mm.
- VWDr. Vonda Wright
Twice a day for two weeks, we ran these girls on treadmills, and then we resampled their stem cells. The spindly dying stem cells were now plump like grapes again.
- RCDr. Rangan Chatterjee
Wow.
- VWDr. Vonda Wright
They were producing growth factors. They had turned off programmed cell death. So the simple act of mobility changed our stem cell function and rejuvenated it. It was a signal to these mou- mice bodies, these murine model, that we're not dead. We're living and ex-
- RCDr. Rangan Chatterjee
Yeah.
- VWDr. Vonda Wright
So down to the cellular level, so... And that's what I'm trying to r- to explain to people in the book and give them... I mean, I think my readers are smart. They need to know why-
- RCDr. Rangan Chatterjee
Yeah
- VWDr. Vonda Wright
... not just go do this program. We can change our mitochondria. We can change the expression of our genes. We can change the amount of inflammation in our body-
- RCDr. Rangan Chatterjee
Yeah
- VWDr. Vonda Wright
... by regulating glucose metabolism and insulin sensitivity, a- and really have profound changes of the hallmarks of aging by simple activities that become how we live, not just programs.
- RCDr. Rangan Chatterjee
Yeah. I, I love the bit sort of halfway through the book where you move on to the next section, where you've covered exercise in detail, and there's this beautiful chart where you, you've got listed all the time bombs of aging.
- VWDr. Vonda Wright
Uh-huh.
- RCDr. Rangan Chatterjee
DNA change and damage-
- VWDr. Vonda Wright
Yeah
- RCDr. Rangan Chatterjee
... mitochondrial dysfunction, senescence, fuel gauge malfunction, and stem cell exhaustion.
- VWDr. Vonda Wright
Yes.
- RCDr. Rangan Chatterjee
And then you cross-reference that-
- VWDr. Vonda Wright
Mm-hmm
- RCDr. Rangan Chatterjee
... with different kinds of exercise.
- VWDr. Vonda Wright
Yes.
- RCDr. Rangan Chatterjee
And basically, you follow that chart. You go, wait a minute. If you do this hybrid training program-
- 1:16:02 – 1:42:10
A real-world weekly training template: Zone 2, sprint intervals, and heavy lifting for strength/power
- RCDr. Rangan Chatterjee
do check out my book, Make Change That Lasts: Nine Simple Ways to Break Free from the Habits That are Holding You Back. It's in all the usual places as a paperback, e-book, and as an audiobook, which I'm narrating. Now, back to the video. So I guess my question to you is, at this stage in your life, are you able to share with us what a typical week of training or movement looks like for you?
- VWDr. Vonda Wright
Sure, sure.
- RCDr. Rangan Chatterjee
And I appreciate that may not feel achievable for someone who's about to start, but I wonder if we could start off with what-
- VWDr. Vonda Wright
Yeah
- RCDr. Rangan Chatterjee
... you do.
- VWDr. Vonda Wright
Yeah.
- RCDr. Rangan Chatterjee
And then we can perhaps wind back to someone who's never done any of this before and where they can start.
- VWDr. Vonda Wright
Absolutely, yes. Um, and n- number one, I want people to give themselves grace because sometimes when people say what I'm about to say, they're like, "Ugh, I could never." It's not about that. Start where you are.
- RCDr. Rangan Chatterjee
Mm.
- VWDr. Vonda Wright
And I'll give you the example. I'm on a book tour right now. I am really busy in different time zones, so I'm not doing everything that I would normally love to do, and I'm gonna give myself grace, it's the period of life, and not judge myself for it. But ideally, this is what I do. Um, I have a flexibility and mobility practice, meaning I am trying to stretch out my tendon, ligaments, and muscles nearly every day. This is where... I don't do Pilates or yoga, but if you do, this is where that comes in to be marvelous. I do s- a dynamic warmup every day, which gets every joint, every set of tendons and ligaments around my major joints moving, right? So daily flexibility and mobility.
- RCDr. Rangan Chatterjee
10 minutes?
- VWDr. Vonda Wright
You know what, it's just a series, and it's outlined in the book, the dynamic warm-up. It's just a series of 10 things that if I do the inchworm motion, it warms up my ankles, my knees, my hips. If I do, um, hamstring extensions, it gets my hips and my knees.
- RCDr. Rangan Chatterjee
First thing in the morning? Is that when you tend to do it?
- VWDr. Vonda Wright
No, I do it before I work out.
- RCDr. Rangan Chatterjee
Before you work out.
- VWDr. Vonda Wright
To work. I d- I put it all together.
- RCDr. Rangan Chatterjee
Yeah, that's interesting. And, and the only reason I ask is because I do mobility every day-
- VWDr. Vonda Wright
Yeah
- RCDr. Rangan Chatterjee
... but it's part of my morning routine.
- VWDr. Vonda Wright
Oh, that's great.
- RCDr. Rangan Chatterjee
So I'll get up.
- VWDr. Vonda Wright
Yeah.
- RCDr. Rangan Chatterjee
I'll-- at the moment, I'm really into meditation, so I'll meditate, and then it's in my living room, which has got a carpet on the floor, so it's straight afterwards. I'll probably spend five, 10 minutes just doing a whole variety-
- VWDr. Vonda Wright
Yes
- RCDr. Rangan Chatterjee
... of mobility exercises.
- VWDr. Vonda Wright
Mm-hmm.
- RCDr. Rangan Chatterjee
I almost feel like it's waking up all of my joints-
- VWDr. Vonda Wright
Mm-hmm
- RCDr. Rangan Chatterjee
... for the day ahead.
- VWDr. Vonda Wright
Yeah.
- 1:42:10 – 1:48:18
VO2 max and the frailty line: predicting independence decades in advance
- RCDr. Rangan Chatterjee
And I wanted to talk about VO2 max.
- VWDr. Vonda Wright
Okay.
- RCDr. Rangan Chatterjee
Right? Because, again, one of my other favorite chapters is this almost self-assessment chapter-
- VWDr. Vonda Wright
Yes
- RCDr. Rangan Chatterjee
... where I know we mentioned DEXA scans before and what people can do, but you go through the kind of self-assessment process that people can do on themselves, even if they don't want to see a doctor-
- VWDr. Vonda Wright
Yeah
- RCDr. Rangan Chatterjee
... or pay any money for anything-
- VWDr. Vonda Wright
Mm-hmm
- RCDr. Rangan Chatterjee
... which I think is, is really, really awesome. But in terms of really trying to get this idea through to people that what you do in your 20s and your 30s and your 40s impacts your 70s, your 80s, and your 90s, I love the way you've described VO2 max and the frailty line.
- VWDr. Vonda Wright
Yes.
- RCDr. Rangan Chatterjee
Okay, so could you just outline-
- VWDr. Vonda Wright
Mm-hmm
- RCDr. Rangan Chatterjee
... what is VO2 max?
- VWDr. Vonda Wright
Mm-hmm.
- RCDr. Rangan Chatterjee
What is the frailty line?
- VWDr. Vonda Wright
Yeah.
- RCDr. Rangan Chatterjee
And therefore, what are the implications for us in our lives?
- VWDr. Vonda Wright
VO2 max is the best measurement of your overall fitness. It's cardiovascular fitness. It actually measures oxygen diffusion, which means passage from your, from the blood in your heart to your lungs. It's, and therefore measures how fit you are. The, the higher your VO2 max, the more fit you are. And now endurance athletes, like, uh, Tour de France athletes, they're just genetically specimens. I mean, and their VO2 max is just outrageous, like 95.Most people, for their fitness level to be great, it's considered in the 50s to 60s of, of this measurement. Um, what happens is with time and disuse, our VO2 max will decline 10% a decade. And so you may think, "Okay, great, I'm not trying to be a endurance athlete. Why does that matter?" Because there is a line which you have cited, the fragility line, where you are too frail, you have so little fitness, you cannot take care of yourself. Meaning, once you have so little fitness, you cannot get up from a chair by yourself, you gotta live with somebody or you gotta move into a home. So our goal is to never pass the fragility line. So if we're gonna lose 10% of our VO2 max if we don't reinvest in it-
- RCDr. Rangan Chatterjee
Yeah
- VWDr. Vonda Wright
... now we can build VO- But let's say you're not gonna make the effort. You will lose 10% per decade. So if you start out with a low VO2 max in midlife, say 30, 25, take 10% away per decade, at some point in your life you are likely to pass the fragility line and not be able to get up from a chair and not be able to take care of yourself. For men and women, the line is 15 to 18. So we, you know, great is 50. If we pass 15 to 18, we're not getting up from a chair and living independently. We can work on that by a different type of exercising protocol called the Norwegian protocol, which is going as fast as you can in an aerobic activity for four minutes, and then recovering, but only for four minutes. And by using the Norwegian protocol one time a week, you can build your VO2 max.
- RCDr. Rangan Chatterjee
Mm.
- VWDr. Vonda Wright
So it's not that all hope is lost if you find yourself in midlife with poor fitness. But again, it's like bone, you're starting behind the eight ball.
- RCDr. Rangan Chatterjee
Yeah. I guess the central message there is, is that although it's not inevitable that we're going to become frail as we get older, it is inevitable that there are gonna be some changes in your body.
- VWDr. Vonda Wright
Absolutely.
- RCDr. Rangan Chatterjee
And that's the normal process of aging.
- VWDr. Vonda Wright
Normal.
- RCDr. Rangan Chatterjee
And of course, there's many things we can do to improve things. We can stay active.
- VWDr. Vonda Wright
Mm-hmm.
- RCDr. Rangan Chatterjee
We can do it in, you know, this kind of hybrid-type training-
- VWDr. Vonda Wright
Yep
- 1:48:18 – 1:55:28
Hormone replacement and informed choice: the WHI fallout and risk framing
- RCDr. Rangan Chatterjee
There's perfection, and there's also make progress from where you are. Let's now talk about hormones.
- VWDr. Vonda Wright
Okay.
- RCDr. Rangan Chatterjee
Right? Because right at the start, Vonda, you mentioned how there's a precipitous drop in estrogen for women in perimenopause. In your book, you also make the case that to you, estrogen is the elixir of longevity.
- VWDr. Vonda Wright
Yes.
- RCDr. Rangan Chatterjee
Does it necessarily follow, then, that all women need to replace their estrogen?
- VWDr. Vonda Wright
Here's how I position this. I believe that every woman is a sentient being with agency to make her decision, but I insist that that decision be made based on facts and not fear. And here's what I mean. Prior to the 2002 Women's Health Initiative study, which was a study done by the National Institutes of Health in the United States, more than 40% of women in the US, I don't know the, the, uh, European numbers, but, uh, 40% were optimizing their estrogen by replacing it because of the known effects it has on bone and muscle and heart and brain.After the Women's Health Initiative was published with the data that has been now strongly refuted as a travesty, the current number is between 2 and 4%, not because estrogen is bad for you, but because of the fear that was released from that study that made a blanket statement, which turns out to be nuanced and not true, that you will have a high incidence of breast cancer. You can't put that genie back in the bottle. Generations of women still today come into my office, and when I start talking about it, they just automatically say, "I can't do that. It causes cancer," to which I have to walk back, "Well, here are the data. You are free to make your own decision." S- so if we go to that data, do you mind if I name the one piece of data?
- RCDr. Rangan Chatterjee
Please.
- VWDr. Vonda Wright
So out of that-
- RCDr. Rangan Chatterjee
Hey, take your time. This is really important.
- VWDr. Vonda Wright
It's critical.
- RCDr. Rangan Chatterjee
And I know people listening are gonna wanna know your perspective on this.
- VWDr. Vonda Wright
Yeah, so the Women's Health Initiative was designed, and it's-- and a lot of good work has come out of it, but not this piece of work, not this particular question. W- was-- the question initially was heart disease as it relates to, uh, giving hormones. Now, at that time, because of when it was, the hormone they used was conjugated equine estrogen, which is a synthetic form, or which is a form that comes from pregnant horse urine. Um, now what we're talking about when I advise people to, um, consider estrogen replacement, we al- we also have the options of transdermal using patches, so it's not only these pills made out of horse's urine. But in the, in the WHI, they were asking the question, does a estrogen replacement increase cardiovascular disease? So they recruited older women. The women in this study were in their 60s, uh, on average. Here is the data that they found. They stopped the study early, called a press conference. Dr. Russeau, the head of the study, uh, called a press conference, from reading about that time and talking to people who were actually there, without consulting the study group of other doctors, and announced that the study was being stopped because estrogen caused breast cancer. Here are the data. In the women who did not take estrogen, the incidence of new breast cancer diagnosis was 3 out of 1,000. 3 out of 1,000. For the women in the study group who were given estrogen and sometimes synthetic progestins if they had a uterus, the incidence was 3.8 per thousand. So the difference between control group and, and study group was 0.8 women per thousand. Less than one woman per thousand was subsequently diagnosed with breast cancer. Now, listen, I am not making light, because one is one. One woman is one woman. I was a cancer nurse. I get it. I was taking care of, in my youth, women struggling with this. But for one woman in 1,000, estrogen was taken away from generations of women, just blanketly taken away, and in the same study, there was no increase in cancer deaths.
- RCDr. Rangan Chatterjee
Mm-hmm.
- VWDr. Vonda Wright
So instead of making this blanket statement, which has now affected women for generations, from which we have a high incidence of frailty in women and suffering, for what? So I think every woman gets to make her decision. If 0.8 is enough for you to not wanna be on it, that's your decision. But I personally, and the women I w- I take care of, I value my brain too much to let it starve to death. I value my heart too much to allow myself to develop 30 to 40% more microvascular disease. I don't wanna lose any more bone than I've had to lose.
- RCDr. Rangan Chatterjee
Mm-hmm.
- VWDr. Vonda Wright
And I feel like myself again.
- RCDr. Rangan Chatterjee
Mm-hmm.
- VWDr. Vonda Wright
Because my brain is back. I am stronger than I've ever been, and it is all the things I'm doing-
- RCDr. Rangan Chatterjee
Yeah
- VWDr. Vonda Wright
... but it's also because I've given my body back what it's always had, which is estradiol, which is the, the compound our ovaries make; progesterone, because I have a uterus; and once we're settled out on that, I often discuss testosterone use with women. Because the reality is women make more testosterone than we make estrogen. It's a hormone, not a male hormone.
- RCDr. Rangan Chatterjee
Mm-hmm.
- VWDr. Vonda Wright
And so I think every woman has the right to make those decisions.
- RCDr. Rangan Chatterjee
Yeah. Thank you for sharing that.
- VWDr. Vonda Wright
Mm-hmm.
- RCDr. Rangan Chatterjee
It's really interesting for me to hear your own experience and, of course, that of many of the patients you've seen over the years.
- VWDr. Vonda Wright
Yes.
- RCDr. Rangan Chatterjee
And yes, the fallout of the WHI study has had huge implications-
- VWDr. Vonda Wright
Yes
- RCDr. Rangan Chatterjee
... across society, and particularly for women, for, for a number of years now. Going back to the start of this conversation, when you were explaining that estrogen declines, so every woman is gonna have a decline in estrogen-
- VWDr. Vonda Wright
It's inevitable
- 1:55:28 – 2:02:30
Why symptoms vary across cultures: stress load, pain normalization, and community support
- RCDr. Rangan Chatterjee
So help me understand this from your perspective, that on the face of it, that would imply that all women would benefit from estrogen supplementation.
- VWDr. Vonda Wright
Mm-hmm.
- RCDr. Rangan Chatterjee
At the same time-I think if we look around the world, we see clearly that there are certain communities around the world where women don't seem to report the same number of symptoms-
- VWDr. Vonda Wright
Hmm
- RCDr. Rangan Chatterjee
... through menopause.
- VWDr. Vonda Wright
Mm-hmm.
- RCDr. Rangan Chatterjee
And that there are women in their 70s and 80s who seem to be thriving-
- VWDr. Vonda Wright
Mm-hmm
- RCDr. Rangan Chatterjee
... having not replaced their estrogen. And again, this, I- I've seen so many women have their lives transformed-
- VWDr. Vonda Wright
Mm-hmm
- RCDr. Rangan Chatterjee
... once they start taking hormones.
- VWDr. Vonda Wright
Yeah.
- RCDr. Rangan Chatterjee
But I find that interesting to go, what is it?
- VWDr. Vonda Wright
It's a struggle. What is that, right?
- RCDr. Rangan Chatterjee
What is going on?
- VWDr. Vonda Wright
Mm-hmm.
- RCDr. Rangan Chatterjee
Because also, you mentioned before about how women, if you're breastfeeding and you're not careful about, uh, replacing those nutrients, you could be losing a lot of your bone structure. And as you were describing that, Vonda, I was thinking about the modern world, and in particular, the modern Western world, where actually now women are having to do so much. Now, you know, there used to be a time in many cultures, and even in Western culture, where women would be supported during pregnancy and in the early years, right? While they were breastfeeding, the family would support them and go, "Actually, this is a time where we need to really take care of the mother and the baby, make sure the mother has time to rest, that we're also..." Do you know what I mean? And that, that-
- VWDr. Vonda Wright
I do. I've read about it in books, but I've never seen it in my life.
- RCDr. Rangan Chatterjee
E- exactly.
- VWDr. Vonda Wright
[laughs]
- RCDr. Rangan Chatterjee
And it does... And of course, it's very hard now in these, in the modern world where people are often not living near their parents-
- VWDr. Vonda Wright
Yes
- RCDr. Rangan Chatterjee
... or their family.
- VWDr. Vonda Wright
Mm-hmm.
- RCDr. Rangan Chatterjee
Often two parents in a two-parent family-
- VWDr. Vonda Wright
Yeah
- RCDr. Rangan Chatterjee
... are working.
- VWDr. Vonda Wright
Yes.
- RCDr. Rangan Chatterjee
There's a pressure, particularly in the United States, for women to get back to work really, really quickly. So I wonder, and I, I have this question in my head all the time, what is going on? Is it that in those other cultures, yes, we think they're doing well, but had they been given estrogen, they would be doing even better? Or is there something about the stress load in our modern Western world which is exacerbating these issues?
- VWDr. Vonda Wright
Interesting.
- 2:02:30 – 2:05:57
Closing mindset: a personal vision statement and the core message of self-worth
- RCDr. Rangan Chatterjee
... and take control of their health. One that we've not really gone into, which is, as, when you arrived today, I sort of shared was one of my favorite things in the book, is there's a chapter on mindset and a chapter on resilience.
- VWDr. Vonda Wright
Yes.
- RCDr. Rangan Chatterjee
And just to sort of bring this conversation to a close, in the mindset section, you talk about a vision statement and why you think it's really important for every woman who goes on this journey to have their own vision statement. What's your vision statement?
- VWDr. Vonda Wright
You know, I have a vision for, um, being able to do what I wanna do when I wanna do it at all times. It doesn't matter if I'm my age now or if I'm 97, I want to have that independence. Because if I'm that independent, then I'm gonna have the fullness of life that I've worked for my whole life. I'm gonna have the fullness of relationship in an equally, um, giving relationship. I won't be just a taking. You know, my children, hopefully I'll be giving back as much to them as, as they're giving to me in my old age, right? And so I just want that independence. And to have that vision, it takes active pursuit now. It's just not gonna happen.
- RCDr. Rangan Chatterjee
Mm-hmm.
- VWDr. Vonda Wright
Um, and all the visions that, and this is what I teach people, have to be based on your values. Who are you? What do you wanna be? What do you really value in life? And from that you can build your vision, because otherwise, if you don't have that, these are just six-week programs. These are just more things to do without the end purpose.
- RCDr. Rangan Chatterjee
Yeah. The book is called Unbreakable: A Woman’s Guide to Ageing With Power. And right at the end of this conversation, which I have thoroughly enjoyed-
- VWDr. Vonda Wright
Aw, thank you
- RCDr. Rangan Chatterjee
... for that woman who has been listening-
- VWDr. Vonda Wright
Mm
- RCDr. Rangan Chatterjee
... who your words have sparked a little bit of interest.
- VWDr. Vonda Wright
Mm-hmm.
- RCDr. Rangan Chatterjee
They have started to see themselves differently.
- VWDr. Vonda Wright
Mm-hmm.
- RCDr. Rangan Chatterjee
They've started to go, "Well, wait a minute. Yeah, Vonda's right, actually. I have neglected myself. I have put everyone else first. I've not looked after my bone health. I've not looked after my physical health. I've never done anything for me, but now I see, Vonda, why it's so important."
- VWDr. Vonda Wright
Mm-hmm.
- RCDr. Rangan Chatterjee
For that woman who hasn't done much before but wants to get started-
- VWDr. Vonda Wright
Mm-hmm
- RCDr. Rangan Chatterjee
... what are your final words to her?
- VWDr. Vonda Wright
What I want you to know about this whole process and this book, before anything else, is that you are worth the daily investment in your health. You have worth. That means that you can focus on yourself. You can prioritize these things ahead of everyone else you love and serve, because you are worth it. You were created and made and have value. Until you believe that, you will continue to neglect yourself.
- RCDr. Rangan Chatterjee
Vonda, thank you so much for coming on the show.
- VWDr. Vonda Wright
My pleasure.
- RCDr. Rangan Chatterjee
If you enjoyed that conversation, then I think you are really going to enjoy this one.
- VWDr. Vonda Wright
When we talk to women about what they think is a normal calorie intake, especially active women, they're like, "Oh, well, I eat 15 to 1,800 calories a day." That is not enough
Episode duration: 2:05:58
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