9 HRT and Menopause Podcasts

Curated by Ahaan Ugale · Last reviewed Apr 29, 2026

In late 2025 the FDA removed the boxed warning from low-dose vaginal estrogen products, narrowing a decades-old caution that had been applied broadly across menopausal hormone therapies — and reopening a public conversation that, for two decades, told women hormone therapy was too risky to consider. These nine long-form interviews bring in the OB-GYNs, neuroscientists, and orthopedic surgeons actually doing the research: Dr. Mary Claire Haver and Dr. Sara Gottfried on the endocrinology of perimenopause, Dr. Lisa Mosconi on what menopause does to the brain, Dr. Rachel Rubin on the genitourinary syndrome of menopause and the boxed-warning history, and Dr. Vonda Wright on bone, muscle, and joint changes after estrogen loss. For the broader hub on women's health — covering PCOS, fertility, mental health, and the musculoskeletal syndrome — see /channels/topic/womens-health. None of these episodes prescribes a single 'right answer' on hormone therapy: they explain the mechanisms, the trade-offs, and the updated evidence so you can have a more informed conversation with your own clinician.

The anchor of the page. OB-GYN Dr. Mary Claire Haver with Andrew Huberman on perimenopause as a 'zone of chaos,' the endocrinology of declining estrogen, and the discussion around HRT timing — covering brain, bone, cardiometabolic, and sleep effects across the transition.

Redefinition and physiology of perimenopause and menopauseNeuroendocrine chaos: brain, mood, sleep, and cognition changesHormone replacement therapy (HRT): estrogen, progesterone, testosteroneCardiometabolic, bone, and body composition changes across menopauseNutrition, gut health, and supplements (protein, fiber, creatine, collagen)

Start here for the most accessible version. Dr. Mary Claire Haver with Mel Robbins covers the same territory as the Huberman primer — estrogen's reach across the body, hormone therapy concepts, and lifestyle foundations — at a slower pace that's the better entry if the topic is new.

Massive knowledge and research gap in menopause care and medical trainingBiology of estrogen, egg loss, and the perimenopause-to-menopause transitionHow estrogen loss affects the brain, heart, bones, joints, gut, and genital/urinary systemMisconceptions and updated science on hormone replacement therapy (HRT) and cancer/heart risksWeight gain, belly fat, inflammation, and metabolic changes in midlife women

OB-GYN Dr. Sara Gottfried with Andrew Huberman on a lifespan strategy for female hormones — teens through menopause — covering how stress, gut microbiome, and the HPA-cortisol axis shape midlife symptoms, plus the discussion around oral contraceptives, IUDs, and HRT.

Life-stage hormone strategy for women (teens through menopause)Gut microbiome, constipation, and female-specific digestive issuesStress, trauma, HPA axis, cortisol patterns, and the PINE systemPCOS, androgens, insulin resistance, and long-term cardiometabolic riskOral contraceptives, IUDs, and hormone replacement therapy (HRT)

The pick when menopause symptoms are mostly above the neck. Neuroscientist Dr. Lisa Mosconi presents brain-imaging research showing menopause as a neuroendocrine transition that rewires the female brain — and discusses Alzheimer's risk, hormone therapy timing, and 'designer estrogen' approaches.

Menopause as a brain-centered neuroendocrine transitionBrain imaging evidence: energy loss, structural changes, and Alzheimer’s riskStages of menopause and symptom patterns (including brain fog)Hormone therapy, timing, and new ‘designer estrogen’ approachesLifestyle strategies: exercise, sleep, caffeine/alcohol, toxins, and diet

The most directly on-topic for the 2026 HRT conversation. Dr. Rachel Rubin walks through the genitourinary syndrome of menopause, her four-bucket framework for hormone care (systemic estrogen, progesterone, testosterone, vaginal hormones), and the history behind the FDA's boxed warning — including its recent removal for vaginal estrogen products.

Why women’s sexual health is under-taught and under-diagnosedDismissive advice and medical gaslighting around pain and libidoGSM/GSL: pH shifts, thinning tissue, microbiome changes, misdiagnosed “UTIs”Recurrent UTIs as a hormone-linked condition; prevention beyond antibioticsVaginal estrogen: safety, dosing, delivery options (cream/tablet/ring), cost
6Hormone & Fertility Experts: We've Been Lied To About Women's Health! If This Happens, Call A Doctor

Hormone & Fertility Experts: We've Been Lied To About Women's Health! If This Happens, Call A Doctor

The Diary of a CEO3h 34mOct 16, 2025

Guests: Dr Natalie Crawford, Dr Vonda Wright, Dr Stacy Sims, Dr Mary Claire Haver

Four specialists — fertility, sports medicine, orthopedics, and menopause — on the systemic underfunding of women's health research. Useful for situating the menopause conversation inside the broader hormonal lifespan: cycle physiology, PCOS, endometriosis, and the perimenopause-to-menopause transition.

Systemic underfunding and bias in women's health research and educationMenstrual cycle as a core health marker and hormonal basicsPCOS, insulin resistance, and metabolic health across the lifespanEndometriosis: underdiagnosis, mismanagement, and fertility consequencesContraception choices, long‑term implications, and cycle awareness

OB-GYN Dr. Jen Gunter with Mel Robbins on the difference between FDA-approved menopausal hormone therapy and unregulated compounded 'bioidentical' pellet products — and how clinicians weigh the documented risks and benefits around breast cancer, heart disease, osteoporosis, and dementia.

Menopause as a normal physiological transition (“puberty in reverse”)Common symptoms, variability of experience, and major myths about menopauseEvidence-based menopausal hormone therapy vs. compounded “bioidentical” hormones and pelletsNon-hormonal foundations: exercise, nutrition, and lifestyle for midlife healthReal risks and benefits of hormone therapy (breast cancer, heart disease, osteoporosis, dementia)

The shortest reference on the page. Andrew Huberman's 'Essentials' summary of how testosterone and estrogen work across the lifespan and the behaviors that shape them — with a dedicated section on menopause and hormone therapy.

Biology and life‑cycle dynamics of testosterone and estrogenRole of competition, dopamine, and parenting in hormone shiftsImpact of sleep, breathing patterns, and sleep apnea on sex hormonesLight exposure, circadian rhythms, dopamine, and hormone regulationEffects of heat, cold, and different exercise modalities on testosterone

Orthopedic surgeon Dr. Vonda Wright on the musculoskeletal side of estrogen loss — the bone, muscle, and joint changes that arrive with the menopausal transition — plus exercise, mobility, and bone-health strategies to extend healthspan rather than treating decline as inevitable.

Myths and mindset about aging and health spanMuscle, mobility, and the impact of sedentary livingJoint health, weight, and osteoarthritis preventionExercise prescriptions: strength, VO2 max, sprints, and balanceBody composition, fat loss, and the role of sugar

How we picked these

We searched every transcript in our catalog of 6,000+ podcast episodes for substantive discussion of HRT and menopause, then ranked by relevance — not popularity, recency, or paid placement. Summaries and topic tags are AI-generated from the full transcripts.

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