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Why lifestyle, not genes, drives 70% of how you age

What happens when you skip vitamin D, magnesium, and omega-3: she ties sedentary years to lost VO2 max and creatine to faster aging in older adults.

Dr Rhonda PatrickguestSteven Bartletthost
Jul 28, 20252h 58mWatch on YouTube ↗

Episode Details

EPISODE INFO

Released
July 28, 2025
Duration
2h 58m
Channel
The Diary of a CEO
Watch on YouTube
▶ Open ↗

EPISODE DESCRIPTION

Anti-aging expert Dr Rhonda Patrick reveals how magnesium, HIIT workouts, creatine, and vitamin D can prevent disease, slow aging, and boost brain power - starting today. Dr. Rhonda Patrick is a PhD biomedical scientist, expert in aging, nutrition, and metabolism, and founder of FoundMyFitness. She produces a monthly series of in-depth, science-focused podcasts exploring actionable strategies for enhancing longevity, cognitive performance, and physical health. She explains: ▫️Why cardiovascular fitness is the #1 predictor of lifespan ▫️The groundbreaking science behind rejuvenating your heart by 20 years ▫️How small daily habits can cut your risk of Alzheimer’s and cancer ▫️The hidden link between mitochondrial health, aging, and chronic disease ⏱ Timestamps: 00:00 Intro 02:04 My Mission to Improve People's Health 03:37 What Impact Will Rhonda's Research Have on People? 05:09 The Role of Genetics in Aging vs. Lifestyle 09:53 The Future of Aging, Longevity, and Gene Therapy 15:15 Death-Related Risks of Being Sedentary 22:17 How to Improve Your Cardiorespiratory Fitness 25:32 Best Workout Routine to Improve Cardio Health 30:01 Norwegian 4x4 Training Explained 32:28 How the Body Generates Energy and Exercise Intensity 38:14 Why We Can’t Drink Lactate and the Impact of Vigorous Training 41:09 Decline in Production of Lactate, Creatine, and Other Key Substances 42:20 How to Reduce Cognitive Decline 46:58 What Causes Dementia and Alzheimer’s 52:56 Do Multivitamins Improve Cognitive Performance? 01:00:13 70% of the U.S. Population Is Vitamin D Deficient 01:02:59 Vitamin D Deficiency and Increased Risk of Dementia 01:06:49 Views on the Ketogenic Diet 01:09:39 What Is Ketosis? 01:14:28 How the Keto Diet Affects Life Expectancy 01:19:30 Exogenous Ketones and Cognitive Repair 01:23:53 Recommended Superfoods 01:26:33 Omega-3: Effects on Mental Health, Depression, and Longevity 01:32:08 Is Omega-3 Supplementation the Same as a High Omega-3 Diet? 01:35:12 Ads 01:36:09 Creatine: Importance and Benefits 01:42:13 Effects of Creatine on Cognitive Function 01:45:21 How Long Does Creatine Take to Work? 01:50:54 Does Creatine Cause Hair Loss? 01:53:40 Rhonda’s Views on Fasting 01:55:26 What Is Autophagy? 01:59:51 Fasting Windows to Achieve Autophagy 02:01:46 Intermittent Fasting: Do’s and Don’ts 02:03:03 Effects of Fasting on Sleep 02:05:33 How Soon After Training Should You Take Protein? 02:07:14 Ads 02:11:13 Benefits of Red Light Therapy 02:12:20 Infrared vs. Traditional Saunas 02:19:26 Sauna Benefits: Reducing Stress and Improving Mood 02:22:53 Ads 02:22:56 What Are Microplastics and Are They Harmful? 02:28:33 The Role of Fiber in Eliminating Microplastics 02:31:13 What Is BPA? 02:32:28 Are There Risks to Living Near a Golf Course? 02:34:38 The Importance of Magnesium 02:40:16 Can a Drop in Magnesium Intake Cause Cancer? 02:43:02 What Is Choline? Follow Dr Rhonda: Instagram - https://bit.ly/3TYAEUD X - https://bit.ly/3IFvCu1 Website - https://bit.ly/4o75U1F Weekly health newsletter - https://bit.ly/4kYsR4f You can subscribe to Rhonda’s monthly series on YouTube, Spotify, and Apple Podcasts: YouTube: https://bit.ly/4l1FZW9 Spotify: https://bit.ly/45l77Lc You can download Rhonda's free protocol guides, here: The Cognitive Enhancement Blueprint - https://bit.ly/44QYF6t The Omega-3 Supplementation Guide- https://bit.ly/44Pi1sE How to Train According to the Experts - https://bit.ly/4mbtzMm Research Document: https://stevenbartlett.com/wp-content/uploads/2025/07/DOAC-Dr-Rhonda-Patrick-Independent-Research-further-reading.pdf The Diary Of A CEO: ⬜️Join DOAC circle here - https://doaccircle.com/ ⬜️Buy The Diary Of A CEO book here - https://smarturl.it/DOACbook ⬜️The 1% Diary is back - limited time only: https://bit.ly/3YFbJbt ⬜️The Diary Of A CEO Conversation Cards (Second Edition): https://g2ul0.app.link/f31dsUttKKb ⬜️Get email updates - https://bit.ly/diary-of-a-ceo-yt ⬜️Follow Steven - https://g2ul0.app.link/gnGqL4IsKKb Sponsors: Bon Charge - http://boncharge.com/diary?rfsn=8189247.228c0cb with code DIARY for 25% off Intuit - https://shorturl.at/jEbgm KetoneIQ - Visit https://ketone.com/STEVEN for 30% off your subscription order

SPEAKERS

  • Dr Rhonda Patrick

    guest
  • Steven Bartlett

    host

EPISODE SUMMARY

In this episode of The Diary of a CEO, featuring Dr Rhonda Patrick and Steven Bartlett, Why lifestyle, not genes, drives 70% of how you age explores lifestyle, Not Genes: Simple Habits That Radically Slow Your Aging Dr. Rhonda Patrick explains that around 70% of how we age is driven by lifestyle, not genetics, and outlines practical strategies to extend both lifespan and healthspan. She highlights the profound effects of exercise, especially vigorous cardio and saunas, on brain and heart aging, showing they can reverse structural aging markers by decades.

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