Dr. Natalie Crawford on Huberman Lab: Why AMH drops early

Tracking ovulation and testing AMH early flags fertility reserve loss; meiosis errors, luteal defects, and inflammation compound age effects on fertility.

Dr. Natalie CrawfordguestAndrew Hubermanhost

Apr 13, 20262h 36mWatch on YouTube ↗

EPISODE INFO

Released: April 13, 2026
Duration: 2h 36m
Channel: Huberman Lab
Watch on YouTube: ▶ Open ↗

EPISODE DESCRIPTION

Dr. Natalie Crawford, MD, is a double board-certified OB-GYN and reproductive endocrinologist. We discuss how to improve hormone health at any age and the importance of fertility markers not just for pregnancy, but as a powerful window into overall health, vitality and longevity. We discuss hormone replacement therapy, egg freezing, IVF, and what biomarkers like AMH really indicate. Plus, how anti-inflammatory diets and specific supplements can be beneficial and the impact of microplastics and certain fragrances on hormones. We also discuss lesser-known factors that deplete male and female fertility, vitality and health. This conversation highlights how better understanding of hormones and your reproductive markers can empower better informed choices at every stage of life. Show notes: https://go.hubermanlab.com/czMXcT4 Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman BetterHelp: https://betterhelp.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman Huberman Lab Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab X: https://x.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://www.hubermanlab.com Newsletter: https://www.hubermanlab.com/newsletter Dr. Natalie Crawford As a Woman podcast: https://www.nataliecrawfordmd.com/podcast Website: https://www.nataliecrawfordmd.com The Fertility Formula (book): https://amzn.to/4c79e8Z Fora Fertility clinical practice: https://www.forafertility.com Pinnacle: https://pinnacle-conference.com Courses: https://www.nataliecrawfordmd.com/courses Instagram: https://www.instagram.com/nataliecrawfordmd YouTube: https://www.youtube.com/c/NatalieCrawfordMD Facebook: https://www.facebook.com/nataliecrawfordmd X: https://twitter.com/ncrawfordmd TikTok: https://www.tiktok.com/@nataliecrawfordmd Pinterest: https://www.pinterest.com/nataliecrawfordmd LinkedIn: https://www.linkedin.com/in/natalie-crawford-md-8a56021a0 Timestamps 00:00:00 Natalie Crawford 00:02:26 Fertility as a Health Marker, Infertility 00:05:34 Perimenopause, Menopause, Hormone Replacement Theory 00:11:01 Sponsors: David & BetterHelp 00:13:35 Hormone Therapy, Extending Ovarian Lifespan 00:19:11 Plastics, Toxins & Fertility 00:22:02 Does Prior Pregnancy Make Conception Easier?, Secondary Infertility 00:29:02 Testing Sperm; Pregnancy Loss & Conceiving Again, Fertility Testing 00:38:17 Sponsor: AG1 00:39:40 Menstrual Cycle, Egg Number & Quality, AMH Test 00:48:17 Tool: AMH Test; Fertility Education & Patient Choices 00:53:13 Tool: Tracking Ovulation; Ovulation Disorders 00:55:11 AMH Test Cost; Genetic Testing & Patient Choice 01:01:13 Does Egg Freezing Cause Early Menopause?, In Vitro Fertilization (IVF) 01:05:29 Egg Freezing, IVF, Ethical Concerns; Embryo Banking 01:15:21 Sponsor: Eight Sleep 01:16:39 Egg Freezing, Cost & Patient Choices 01:21:22 Concieving After Hormonal Birth Control, IUD or Depo-Provera 01:27:17 Pregnancy Termination & Concieving Again 01:29:28 Support Egg Quality, Tools: Ovulation & Avoiding NSAIDs; 5 Lifestyle Non-Negotiables 01:34:03 Sleep, Melatonin; Cold Plunge 01:38:41 Curcumin, NAD/NR, CoQ10, Supplements for Prenatal Care & Sperm Health 01:42:05 Sponsor: Function 01:43:16 Fertility Research into Supplements & Lifestyle Factors 01:48:21 Inflammation, Red Light 01:53:12 Cannabis & Detriments to Egg & Sperm Health 01:58:57 Nicotine, Smoking, Egg Health & Sperm Count; Healthy Lifestyle Practices 02:02:21 GLP-1s, PCOS, Endometriosis; Human Growth Hormone 02:10:58 Platelet-Rich Plasma; Paternal Age & Sperm Quality; Biotin 02:17:27 Endocrine Disruptors, Fragrances, Receipts, Tool: Fragrance-Free 02:22:48 Patient Education & Empowerment; Inflammation, Celiac Disease 02:25:40 Anti-Inflammatory Diet, Protein, Fiber, Red Meat 02:33:25 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter #hubermanlab #health #hormonehealth #fertility Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

SPEAKERS

Dr. Natalie Crawford
guest
Double board-certified physician specializing in obstetrics and gynecology, fertility, and reproductive health.
Andrew Huberman
host
Professor of neurobiology and ophthalmology at Stanford School of Medicine and host of the Huberman Lab podcast.

EPISODE SUMMARY

In this episode of Huberman Lab, featuring Dr. Natalie Crawford and Andrew Huberman, Dr. Natalie Crawford on Huberman Lab: Why AMH drops early explores science-based fertility and hormone strategies: testing, lifestyle, and key myths Fertility is framed as a broad health marker tied to metabolic health, chronic inflammation, and long-term risks like cardiovascular disease and earlier mortality, rather than only the ability to get pregnant.

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