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How Your Immune System Works & How to Improve It | Dr. Max Krummel

My guest is Dr. Matthew (Max) Krummel, PhD, professor at UCSF and one of the world’s leading immunologists. We discuss how your immune system works and how sleep, emotions, and even memories shape immune function. We also explore thymus function, its role in autoimmunity, and its potential role in combating cancer. And we discuss how the type and timing of immunization can impact health. This episode provides an actionable framework for understanding how your immune system works, which ought to benefit people of all ages and health statuses. Show notes: https://go.hubermanlab.com/zKNruC3 Pre-order Protocols: https://protocolsbook.com Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman Joovv: https://joovv.com/huberman Follow Huberman Lab Website: https://www.hubermanlab.com Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab X: https://x.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Timestamps 00:00:00 Max Krummel 00:02:18 Immune System, Immunotherapy 00:08:36 Illness, Childhood & Immune System 00:13:02 Aging & Immunity, DNA Mutations 00:18:36 Sponsors: Joovv & Eight Sleep 00:21:14 Self vs Non-Self Recognition, Aging, Cancer; Immune Surveillance 00:30:11 Cancer, Immune System, Age & Measuring Change 00:35:57 Thymus, T Cells; Aging & Cancer 00:42:13 Reproduction, Aging & Immune System; Basic Research 00:47:28 Sleep & Illness Susceptibility 00:52:55 Sponsor: AG1 00:54:08 Umbilical Cord Banking; Organoids, CAR T Cells, Thymus 01:02:57 Scientific Curiosity, Failures, & Discovery 01:13:14 Spatial Biology & Immune Cells; Memory & Immune State; Stress, Meditation 01:25:00 Sponsor: Function 01:26:37 Mindset; Tissue Engineering, Peptides, Systems Biology 01:34:25 Immunizations in Childhood and Beyond 01:39:37 Pharmaceutical Companies, Public Distrust 01:49:22 Disease Risk, Immunity; Autism, Flu, 01:58:56 Biological Resilience, Cancer; Computational Research 02:08:02 Autoimmune Conditions, Asthma, IBD 02:13:34 Autoimmunity & Genetic Diversity Benefits 02:17:11 Science Communication, Max's Substack 02:24:07 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter #hubermanlab #hubermanlabpodcast Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

Dr. Max KrummelguestAndrew Hubermanhost
Aug 3, 20262h 27mWatch on YouTube ↗

Episode Details

EPISODE INFO

Released
August 3, 2026
Duration
2h 27m
Channel
Huberman Lab
Watch on YouTube
▶ Open ↗

EPISODE DESCRIPTION

My guest is Dr. Matthew (Max) Krummel, PhD, professor at UCSF and one of the world’s leading immunologists. We discuss how your immune system works and how sleep, emotions, and even memories shape immune function. We also explore thymus function, its role in autoimmunity, and its potential role in combating cancer. And we discuss how the type and timing of immunization can impact health. This episode provides an actionable framework for understanding how your immune system works, which ought to benefit people of all ages and health statuses. Show notes: https://go.hubermanlab.com/zKNruC3 Pre-order Protocols: https://protocolsbook.com Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman Joovv: https://joovv.com/huberman Follow Huberman Lab Website: https://www.hubermanlab.com Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab X: https://x.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Timestamps 00:00:00 Max Krummel 00:02:18 Immune System, Immunotherapy 00:08:36 Illness, Childhood & Immune System 00:13:02 Aging & Immunity, DNA Mutations 00:18:36 Sponsors: Joovv & Eight Sleep 00:21:14 Self vs Non-Self Recognition, Aging, Cancer; Immune Surveillance 00:30:11 Cancer, Immune System, Age & Measuring Change 00:35:57 Thymus, T Cells; Aging & Cancer 00:42:13 Reproduction, Aging & Immune System; Basic Research 00:47:28 Sleep & Illness Susceptibility 00:52:55 Sponsor: AG1 00:54:08 Umbilical Cord Banking; Organoids, CAR T Cells, Thymus 01:02:57 Scientific Curiosity, Failures, & Discovery 01:13:14 Spatial Biology & Immune Cells; Memory & Immune State; Stress, Meditation 01:25:00 Sponsor: Function 01:26:37 Mindset; Tissue Engineering, Peptides, Systems Biology 01:34:25 Immunizations in Childhood and Beyond 01:39:37 Pharmaceutical Companies, Public Distrust 01:49:22 Disease Risk, Immunity; Autism, Flu, 01:58:56 Biological Resilience, Cancer; Computational Research 02:08:02 Autoimmune Conditions, Asthma, IBD 02:13:34 Autoimmunity & Genetic Diversity Benefits 02:17:11 Science Communication, Max's Substack 02:24:07 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter #hubermanlab #hubermanlabpodcast Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

SPEAKERS

  • Dr. Max Krummel

    guest

    Professor and leading expert in immunology and cancer biology at the University of California, San Francisco.

  • Andrew Huberman

    host

    Professor of neurobiology and ophthalmology at Stanford School of Medicine and host of the Huberman Lab Podcast.

EPISODE SUMMARY

In this episode of Huberman Lab, featuring Dr. Max Krummel and Andrew Huberman, How Your Immune System Works & How to Improve It | Dr. Max Krummel explores immune system as tunable sensor network shaped by aging and mind The immune system is presented as a dynamic, tunable sensory network that constantly measures the body—not just to fight pathogens, but to regulate tissue maintenance, microbiome balance, and organ function.

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