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GLP-1s Are a Bigger Business Than AI

In this episode of Invest Like The Best, Patrick O'Shaughnessy sits down with Zach Reitano, co-founder and CEO of Ro, for his first long-form podcast in nine years.

Zach ReitanoguestPatrick O'Shaughnessyhost
Nov 11, 20261h 24mWatch on YouTube

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At a glance

WHAT IT’S REALLY ABOUT

A patient-led healthcare revolution: removing middlemen, scaling access, extending healthspan

  1. Zach Reitano says US healthcare’s root problem is that the patient is usually not the customer, because payment flows are controlled by insurers, PBMs, employers, and government, which drives opacity and misaligned incentives.
  2. He argues healthcare should be judged by value delivered per dollar rather than the share of GDP alone, noting US strengths in acute care but major failures around chronic disease and high administrative burden.
  3. He describes GLP-1s as a transformative drug class that is upstream of major chronic conditions and is also “rewiring” healthcare by pulling demand toward direct-to-consumer access, transparent pricing, and fewer middlemen.
  4. He explains Ro’s business as a vertically integrated, software-driven care distribution platform spanning cardiometabolic health (including GLP-1s), sexual health, dermatology, and fertility, with rapid growth and significant organizational streamlining after a 2022 reset.
  5. He outlines a future “patient revolution” powered by biology coming online, AI turning specialist work into promptable workflows, and new treatments that can meaningfully extend healthy life—while arguing society should prioritize outcomes over preserving legacy jobs or processes.

IDEAS WORTH REMEMBERING

5 ideas

The central flaw is that the patient is not the customer.

He argues that whoever controls the flow of money at the point of purchase becomes the true “customer,” and that in most healthcare interactions it isn’t the patient. He links this to opaque pricing, misaligned incentives, and low trust.

Healthcare feels best where patients pay directly and can “vote with their feet.”

He points to LASIK, cosmetic surgery, and other cash-pay settings where costs fall and quality and convenience rise. His claim is that consumer choice plus transparent prices forces providers to compete in ways that are largely absent in insurance-driven care.

GLP-1s are catalyzing disintermediation and price transparency in parts of healthcare.

He describes GLP-1s as a “foil” that exposed the list-to-net pricing gap, and says going direct-to-consumer removed PBMs and largely removed insurers for cash-pay use. He claims this can lower prices while drug makers can still earn more through higher volume.

The system’s biggest gap is chronic disease and rising unit costs, not acute care capability.

He says US healthcare is strong at acute care (e.g., strokes, heart attacks), while worsening outcomes and spending are driven more by chronic disease (“slow clock”) plus other mortality drivers (“fast clock” like overdoses and car accidents). He frames the issue as value-for-dollar and unit costs rather than total spend alone.

Employer-based coverage creates a time-horizon mismatch that pushes the system away from patient priorities.

He argues employers care about employees “in plural” over shorter horizons, while individuals care about themselves and family over a lifetime—creating structurally suboptimal outcomes. GLP-1 adoption and cash-pay behavior, in his view, are already challenging employer-driven coverage decisions.

WORDS WORTH SAVING

5 quotes

If I had to say, like, what is the problem with our healthcare system, it is that the patient is not the customer.

— Zach Reitano

To me, at the limit, you should be spending every single dollar towards the health of your society.

— Zach Reitano

PBMs to me are like, they are like the appendix of the healthcare system.

— Zach Reitano

We should not and we cannot prioritize jobs over lives.

— Zach Reitano

We had grown nine percent in 2021. We had hundreds of millions of dollars in the bank, and we were burning but, uh, we, we were what I would call, like, a zombie company, which is like you're not growing fast enough to get out of it, but you're not burning where you're gonna die.

— Zach Reitano

Read the available transcript
Patient as customer vs payer as customerPrice opacity and list-to-net drug pricingPBMs and middlemen removalAcute care strengths vs chronic disease burdenEmployer incentives and time-horizon mismatchRo’s vertically integrated telehealth modelGLP-1 future adoption and societal impact

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SPEAKERS

  • Zach Reitano

    guest

    Founder/CEO of Ro, a direct-to-consumer telehealth company focused on making healthcare more patient-centric (including GLP-1 access).

  • Patrick O'Shaughnessy

    host

    Host of Invest Like The Best and interviewer focused on business and investing conversations.

High quality AI-generated summary created from speaker-labeled transcript.

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