Joe Rogan Experience #1246 - Pot Debate - Alex Berenson & Dr. Michael Hart

THC is psychoactive and linked to paranoia, cognitive changes, and potential psychosis in some users, while CBD is non-intoxicating and better supported for seizures, anxiety, and possibly PTSD and TBI; lumping them together distorts both risk and benefit profiles.

Both guests agree that using potent THC before roughly age 25—when the frontal lobe is still developing—raises concern for triggering or worsening psychotic disorders, with observational data linking early heavy use to schizophrenia-like outcomes in susceptible individuals.

Hart cites emerging genetic markers (e.g., MAPK14, AKT1, CADM2) that may predispose a minority of users (collectively ~15–20%) to adverse neurocognitive or psychotic reactions, underscoring that what is benign for one person can be destabilizing or disastrous for another.

There is solid evidence for CBD in childhood epilepsy and reasonable support for THC in chemotherapy nausea and appetite stimulation; other touted uses—PTSD, chronic pain, cancer, Alzheimer’s, TBI—rest on mixed or early-stage data, case reports, and clinician experience rather than robust randomized trials.

Berenson argues, based on forensic psychiatry cases and limited studies, that cannabis-triggered or -worsened psychosis can amplify paranoid delusions and contribute to rare but severe violence, especially when combined with stimulants—though Hart counters that broad population-level links to crime remain weak.