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Joe Rogan Experience #1513 - Andrew Huberman

Andrew Huberman is a neuroscientist and tenured professor in the Department of Neurobiology at the Stanford University School of Medicine. He has made numerous important contributions to the fields of brain development, brain plasticity, and neural regeneration and repair.

Joe RoganhostAndrew Hubermanguest
Jul 23, 20202h 44mWatch on YouTube ↗

EVERY SPOKEN WORD

  1. 0:0015:00

    Andrew, how are you?…

    1. JR

      Andrew, how are you? What's happening, man?

    2. AH

      Doing great.

    3. JR

      Nice to meet you.

    4. AH

      Nice to meet you too.

    5. JR

      R- really excited to talk to you about this. Um, just sort of f- for an introduction, tell people what you do.

    6. AH

      So I'm a neuroscientist, uh, meaning I'm a professor of neurobiology and ophthalmology, Stanford School of Medicine. So I run a laboratory. I teach a little bit. I teach neuroanatomy to medical students. But mainly, my lab does research, so I've got students and post-docs, and we're trying to figure out the answers to two problems. The first problem is how to regenerate the damaged nervous system, in particular, the connections between the eye and the brain, to restore vision to the blind, so that's a big mission of ours, and to prevent vision loss in people that are losing their vision. And the other thing that we're doing is we're focusing a lot on stress and other states of mind. So I'm obsessed with the idea that all our states of mind come from the brain and the body, and we're trying to figure out what happens in the brain and body when we're stressed and how to control it, what happens in the brain and body when we are creative and how to control it, and essentially, for all states of mind. But rather than try and tackle the really high level stuff like flow and states of awe, we're really focused on these states of stress and things like focus and the ability to think clearly and do certain things athletically or cognitively because, first of all, there's a lot of suffering. There are a lot of people out there that are suffering from an inability to control their states of mind. And also, there's great potential for people who aren't suffering to be able to create and perform and do better things once we can understand how those states come about.

    7. JR

      That's an interesting way of putting it, suffering 'cause they can't control their states of mind. Um, that- that is the case, but that's not, like, a politically correct way of, uh, describing it.

    8. AH

      I guess I never thought about that.

    9. JR

      Would that be accurate?

    10. AH

      Well, I think that it's fair to say that all our states of mind and body, and I say mind and body 'cause the nervous system, which is the brain, the spinal cord, and all that stuff, it connects to our body-

    11. JR

      Mm-hmm.

    12. AH

      ... and our bo- body connects to our brains, so we can't really separate those. But states of mind, which include the stuff in our skull and the body, those essentially dictate our whole life experience, right? So whether or not we're feeling calm when we wanna be calm, whether or not we're feeling stressed when we'd rather be calm, whether or not we are feeling focused when we need to do work, or whether or not we're feeling creative when we wanna be creative, all of that stems from the nervous system. The other organs are, of the body are involved, but the nervous system, the brain and those connections is really what it's about. So if you see somebody who's in a state of depression, or you see somebody who's in a state of flow and creativity, you can be pretty sure that that's reflecting the activity of neurons in the brain.

    13. JR

      D- it's, um, the- the idea that the body and the brain are inseparable, um, most people who are physically active accept that and- and appreciate that and- and they know that this is probably true. But there's a lot of people that kind of wanna deny that and concentrate only on the brain. And particularly, like, there's psychiatrists that will prescribe medication before they'll prescribe exercise. And this is, uh, it's- it's a controversial subject. That's what I meant by saying, like, that you're, you are unable to control aspects of- of- of your brain, or aspects of th- the way you're viewing things or the way you feel about things. But...

    14. AH

      Yeah, so I think, um, if we take a step back and we just kinda think about what the brain and nervous system does, and again, nervous system includes all of it, we can say the brain is special, right? This brain, there is something fundamentally important about the brain part because if somebody who, let's say, has a limb amputated, it doesn't fundamentally change who they are. It can change what they can do, but their, and there will be aspects of their personality and temperament that might shift, but who they are hasn't changed. Whereas if someone has a brain lesion or their brain is degenerating, that person is fundamentally different. So there is something special about the real estate in our skulls. But that said, the job of the brain is really to combine our experience of what's going on in our body with what's going on in our mind and to react and behave to things in an adaptive way. So, um, if I may, there's just sort of, like, if we take a step back and just think, there are basically five things that the nervous system's responsible for doing. First is sensation. Sensation is nonnegotiable. It's happening all the time. Sound waves are coming in. Your feet are in contact with your shoes or the floor. That's all happening, and you can't control it because we have sensors, things in our eye, our tongue, our nose, our skin, our ears, that take physical events in the universe, photons of light, sound waves, touch res-, you know, physical pressure on the skin, and it transforms that into one language, and the language is the language of electricity, of neurons. Now, perception is the next thing that the brain does, and perception is all about which sensations we are conscious of. So if I say, you know, the contact of your hands with the table, now you're conscious of it, that's just your perceptual window. It's like a spotlight, vtt, it just goes straight to your hands. So there's sensation, perception, and then there are these things we call emotions, which are brain/body states. They tend to make us either wanna get up and move or stay still. They tend to make us think, "This is a good p- place for me to be at mentally and physically," or, "I wanna shift this." And then there are thoughts, which we could discuss in detail if you want, which kind of arise spontaneously. They're kinda running in the background all the time like pop-up windows on a badly filtered internet connection. But we can also deliberately have a thought. Like, I can say, "That pad of paper to my right is yellow." I can decide that. In the same way, I can do the fifth thing, which is an action. So you've got sensations, perceptions, feelings/emotions, thoughts, and actions, and all five of those include the brain and the body. But how much brain and how much body-

    15. JR

      Mm-hmm.

    16. AH

      ... is shifted by a kind of underlying, let's just think of it as a tide, like the level of the tide, and that's the autonomic nervous system. So if I'm suddenly stressed for whatever reason, my perceptual window is gonna shift. My eyes are literally gonna change their focus. My world will become more like portrait mode. I'll see you and everything else will become blurry. When I'm calm, I actually have panoramic vision. I can see everything around me. So I better... So...... my state, my internal state of alertness or sleepiness impacts all this. And in sleep, which is kinda the opposite extreme of stress, I'm not in relation to anything outside me. I'm not perceiving anything. I'm sensing things, it's non-negotiable. I'm not having real thoughts, but the thoughts are kind of disoriented in space and time. And behavior is done. You're lying down. You're sometimes paralyzed in sleep. So when I say states, it's really about this dynamic shift between what we're perceiving and how we're perceiving it. And we could go really in depth in this or not, but states of mind are fundamentally, I think, the m- to me anyway, are the most important aspect of trying to understand how the brain works. Because ultimately, if you wanna understand mental illness and mental health, if you want us to understand high performance, which is something my lab is really interested in, if you wanna understand any of that, you have to understand how these states of mind and body relate. Because the autonomic nervous system, which is strongly impacting these states, is in the body. It in- it is, the basis of it is connections between the brain and body.

    17. JR

      So you're analyzing people in stress states, and are you doing cognitive function tests on these people in stress states versus people in calm, placid states? Like, how are you, how are, how are you doing? Are you doing, like, similar tests or like-

    18. AH

      Yeah, so there are two states that ... Like, we can take that whole, um, tangle of mess that I just, you know, uh, threw out on the table and, and simplify it and say, look, there are two states that I think if we could really crack, we could really understand the underlying neural mechanisms, and we could understand how people could get themselves into these two states, we would greatly improve human health and human performance, cognitively and physically.

    19. JR

      Okay.

    20. AH

      And those two states are the, the state of sleep, so not just the importance of sleep, I know you had Matt on here, so, uh, you know, great sleep researcher. Not just that sleep is important, but how to get better at sleeping, how to access sleep. So if you ... A lot of people struggle with that. And the other state is clear, calm, focused. Those two states for my lab right now are the target states. W- you know, there's so many states, but if we can figure out how those work and how to put, allow people to put themselves into those states, I think w- it's my belief that we'll do humankind a great service.

    21. JR

      Okay, so when you say sleep, the state of sleep, like, what techniques are you talking about to achieve the state of sleep or, or do a, a better job of, of sleeping?

    22. AH

      Yeah, so when people come into my laboratory, we essentially start pressure testing them from the moment they walk in the door. So we have a laboratory, we do some animal work, we work on mice, and we study states like fear and courage, and, um, we're interested in what leads to c- uh, winning in certain forms of competition between animals and these kinds of things, aggression, those kind of very primal states. We also have a human lab. So people come into the laboratory. We have an equivalent lab, essentially, to our mouse lab. People put on VR goggles. We wire them into a lot of gear that allows us to measure things like heart rate, breathing. We're measuring pupil size, eye tracking, and in some people, because they are neurosurgery patients, we have access to the brain. We drop electrodes down into the brain-

    23. JR

      Whoa.

    24. AH

      ... record from the human amygdala.

    25. JR

      So you have a hole in their head?

    26. AH

      They have a hole in their skull.

    27. JR

      Ooh.

    28. AH

      The neurosurgeons actually, uh, which I am not, uh, tell us that, you know, it's no big deal, right, that, that, um, you know, that basically they look at the skull as kind of a, a poorly evolved device. They, they always tell me, you know, "You're much better off with a titanium plate there anyway. It's much stronger." So they don't have a problem putting a little hole in the skull. These are surg- these are patients that have other issues, right? So th-

    29. JR

      They, they're saying you're, you're better off with a titanium plate than skull bone?

    30. AH

      Well, if you're concerned about concussion or anything-

  2. 15:0030:00

    Oh, I hate that…

    1. AH

      the really annoying kinda-

    2. JR

      Oh, I hate that shit.

    3. AH

      Yeah.

    4. JR

      That's a lot near where you live.

    5. AH

      Yeah. Yeah. (laughs)

    6. JR

      That's a San Francisco tech thing.

    7. AH

      I- is it?

    8. JR

      Yeah. It's like, what they're doing is letting you know that they're one of the tribe, okay, and, uh, we're all in this together-

    9. AH

      Okay. (laughs)

    10. JR

      ... and I think like you do, and you can trust me 'cause I'm unoriginal.

    11. AH

      Well, it might reflect a subtle brain damage. Um-

    12. JR

      You think?

    13. AH

      I think the data show that it's a distortion of the, of the regular map.

    14. JR

      I think it's the same thing as a Southern accent.

    15. AH

      Hmm.

    16. JR

      I think you're just fitting in with your environment 'cause I know people that have adopted that shit once they've gotten into the tech world. I'm like, "Hey, fuckface, you didn't used to talk like that."

    17. AH

      Or the people that go to, to, you know, England and start speaking with a British accent.

    18. JR

      Oh, like Madonna.

    19. AH

      Oh, did she do that?

    20. JR

      Yes, she did.

    21. AH

      I don't follow pop culture carefully enough.

    22. JR

      Yes, she did.

    23. AH

      Mm-hmm.

    24. JR

      Yeah, I'm moving to Texas. I'm gonna start saying y'all two weeks in. I'm giving myself two weeks.

    25. AH

      Interesting.

    26. JR

      I'm gonna try out y'all.

    27. AH

      Interesting. Well, some of this stuff is learned...

    28. JR

      (laughs)

    29. AH

      Are you moving?

    30. JR

      Yes, yes.

  3. 30:0045:00

    Mm-hmm. …

    1. AH

      do a cognitive task, which is a duration-path-outcome task. And then we put them into these states of pseudo sleep, and then we evaluate their ability to perform in these tasks again, and we, what we found is interesting. What we found is that they're, first of all, these sleep-like states can be very restorative. I imagine that, um, uh, you mentioned the float tank earlier-

    2. JR

      Mm-hmm.

    3. AH

      ... like maybe float tanks, and we can talk about why the float tank would put you into a s- pseudo sleep-like state. Certain substances put us into sleep-like states. Naps and just letting the mind drift can put us into sleep-like states, and those sleep-like states do two things that are very powerful. One is they reset our ability to do these very taxing, demanding duration-path-outcome kinda brain functions. As well, they allow people to access sleep more easily. You know, so we want people to be able to get into deep sleep because nothing is a, as restorative as deep sleep because in deep sleep, and in the states that I'm talking about, these rela- deeply relaxed states, duration-path-outcome analyses are impossible.And I think being able to toggle back and forth between these states is really where high performance emerges. So, for the very stressed human being who's suffering from generalized anxiety, we study those types of patients. But, in addition, for people who are doing well in life but are high performers, so we do some work with elite military, with some athletes. We've had David Goggins out to the lab. Um, we'll talk about it.

    4. JR

      You can't use him.

    5. AH

      You can't use him.

    6. JR

      Just, just to break-

    7. AH

      So he's a, he's an extreme outlier, right?

    8. JR

      It's too... He's too far on the outside.

    9. AH

      So, what's remarkable about him is he has figured out how to tap into dura-... He can force himself into duration path outcome.

    10. JR

      Mm-hmm.

    11. AH

      Now, I don't know his state while he's running, if he's relaxed, if he's aggro the whole time. I don't know. But he is a bit of a mutant in the sense that... But he's created, in his words-

    12. JR

      Yes.

    13. AH

      ... he's crea-

    14. JR

      He's turned himself into that mutant.

    15. AH

      He's figured it out.

    16. JR

      Yeah.

    17. AH

      He's figured it out. He was not born that way.

    18. JR

      No.

    19. AH

      We know that. And-

    20. JR

      Well, that's the most special thing about him, really, is that... And also, that he's willing to share that he was, at one point in time, a large, fat, lazy guy, you know, and then he became this savage that you see.

    21. AH

      Yeah.

    22. JR

      He d- he forced his mind into that particular state.

    23. AH

      Well, and the states that will allow people to go there often are fear states, anxiety states, things that are extremely high pressure because the, the adult brain especially doesn't wanna change. You know, we're basically born, we get wired up by our experience, we get wired up by what we're exposed to. Brain plasticity is very passive for the first 25 years of life. You know, I, um... If you're a child, y- the things you hear and see and do are shaping you, right?

    24. JR

      Mm-hmm.

    25. AH

      Kids come home saying things they've never even heard before. It's amazing.

    26. JR

      Right.

    27. AH

      There's... And as an adult, you have to crack into that neural circuitry and reshape it. And-

    28. JR

      Yeah, but why is that? What, what is it about adults? Because I have my own theory, and this is, uh, just a, a martial arts-based theory. Young kids learn so fast. They learn so fast. But I always feel like it's 'cause they don't have jobs. They don't have a family to take care of. They don't have a girlfriend who's on their back. They don't have bills and the IRS breathing down their neck. They don't have anything, so they can just think about it and their mind... Like, if, if they have a hard drive, right, and they're, they have a one-terabyte hard drive, they got, like, 100 gigs full. They have all this space. You could fill that space up with technique and movement and, and it becomes their whole life 'cause it's thrilling, and it's exciting to learn, and their body heals quicker so they can, they can force themselves into situations. With adults, it's extremely difficult to find the bandwidth, to find the amount of time to really completely focus on something because you have so many distractions.

    29. AH

      Yeah. Well, the-

    30. JR

      Does that make sense, that...

  4. 45:001:00:00

    He is every bit…

    1. JR

    2. AH

      He is every bit as intense as that public persona.

    3. JR

      Yeah.

    4. AH

      He, when, when he came out to the lab, it was kind of interesting 'cause we had just built this great white shark experience, and I'd gone down to Mexico. We had dealt with these sharks, and my friend, Michael Muller, he's got this whole thing where we could leave the cages, and we did all this, and it was, it was fun and crazy and probably a little stupid, frankly. But we bring it back, we build this VR stimulus, and he and a couple other team guys came in and, you know, so I'm explaining what we're doing, and we show the shark thing on the screen, and, and he goes, "I don't like sharks." And I'm thinking-

    5. JR

      (laughs)

    6. AH

      ... "Okay, well..." So we'll give him something else. And then we go through the whole thing, and I'm explaining how we wire people in, and we record from the brain, and I said, "All right, so, um, who would like to try the sharks?" David. "I'll go." Like, just he, he just-

    7. JR

      (laughs)

    8. AH

      ... wanted to be first. And I realized, I was like, "Okay." And he wasn't showboating. That's just the way he is.

    9. JR

      Yeah.

    10. AH

      It's just if there's something that creates that sense of agitation, that's a signal for him to go forward.

    11. JR

      Do you know what he does in the summers?

    12. AH

      I don't.

    13. JR

      He goes to Montana to fight forest fires.

    14. AH

      Does he really?

    15. JR

      Yeah, he doesn't even make any money.

    16. AH

      Amazing.

    17. JR

      He just goes there. He's rich, and he gets fucking dropped off in Montana in the woods, camps out there, and fights forest fires with a bunch of other savages, and he does it to keep his brain hard.

    18. AH

      That's fantastic.

    19. JR

      That's, he's the real deal. (laughs)

    20. AH

      He is the real deal.

    21. JR

      Can you imagine? You got millions of dollars in the bank, and you're like, "I'm gonna go fight forest fires all summer-

    22. AH

      Yeah.

    23. JR

      ... just to stay hard." (laughs)

    24. AH

      (laughs) Yeah. Maybe I woulda done that when I was-

    25. JR

      (laughs)

    26. AH

      ... a teenager to impress girls, but I don't, I don't think-

    27. JR

      Bro, he's 40.

    28. AH

      He's doing it for him.

    29. JR

      He doesn't give a fuck.

    30. AH

      Well, that's the thing is I think-

  5. 1:00:001:12:34

    Mm-hmm. …

    1. AH

      what's going on in the body-

    2. JR

      Mm-hmm.

    3. AH

      ... it's the command center, except what signals it receives back from the body. And so if the visualization is intense, the brain isn't completely convinced, but it's pretty convinced that you're actually experiencing that thing and rehearsing it. It's a little bit of your own internally driven virtual reality-

    4. JR

      Mm.

    5. AH

      ... is what you're doing.

    6. JR

      Right.

    7. AH

      And so you're cre- and so I think mental training is powerful, but there's no replacement for repetition.

    8. JR

      So, what about y- obviously, physical training has its limitations in your, your body's ability to keep doing the movements. You're gonna get tired-

    9. AH

      Sure.

    10. JR

      ... and, and you're gonna break down. Would it be more beneficial to get more rest or would it be more beneficial to get rest but also spend a significant amount of time visualizing?

    11. AH

      We haven't looked at visualization specifically. The one thing that is very close to visualization which is very powerful based on neuroimaging studies, so legitimate science I should m- say, is hypnosis.

    12. JR

      Mm.

    13. AH

      Hypnosis is real- a really unique state, and this is of mind and body. The-

    14. JR

      Have you been hypnotized?

    15. AH

      Many times.

    16. JR

      Oh.

    17. AH

      Yeah. And I'm very interested in hypnosis because of the work with Spiegel and the incredible, you know, success that he's had with pain management, smoking cessation, these kinds of things. Hypnosis is a state of deep relaxation not unlike sleep, but also deep focus. So it's very unlike any other state of mind. You're either usually asleep or you're focused, or somewhere in between, kinda drifting back and forth in between. But hypnosis is a deliberate...... narrowing of context, so the person or the audio script is bringing you into a state of mind that's centered around particular types of events, but you're in deep rest. And the idea is that you're taking that plasticity process of focus and urgency and then rest, and you're combining them into a single session. And so hypnosis and deep hypnotic states are the, are the place where neuroplasticity can be accelerated.

    18. JR

      Mm. So when you say hypnosis, what kind of sessions are you talking about and how often? Like, say if you're an athlete, like let's, let's say maybe you're a basketball player and you wanna get better at basketball. You train as much as you possibly can, but there's limitations to that. You sleep as much as you possibly can. How often would you recommend someone doing some sort of a hypnosis session to try to improve their skills?

    19. AH

      Probably one, well, it depends on how intense their training is. For some of the people I'm doing work with in, in athletics and in the military community, uh, you might, they have extremely demanding lives, right?

    20. JR

      Mm-hmm.

    21. AH

      And certainly for the military folks, it's, you know, high risk, high consequence, you know, even when they're in tr- non-de- non-deployment. So under those conditions, maybe every day, 30.

    22. JR

      Hypnosis every day?

    23. AH

      Yeah, 30 to 45 minutes.

    24. JR

      Wow.

    25. AH

      As a replacement for some other standard form of nap or meditation. I mean, not necessarily lumped on top of that.

    26. JR

      So the standard eight-hour sleep, and then on top of that some sort of meditation for like 30 minutes? Like, what would-

    27. AH

      Yeah. There's a, um, a process of doing this. We have a script, uh, that we use in our lab, I'd be happy to send it to you, that takes you into these deep, uh, medi- sort of relaxation states. They're sort of meditative. Some people can self-hypnose by induce- you know, some people call them intentions, but I don't like that 'cause it sounds a little bit too much like a uncomfortable set of yoga classes I've taken-

    28. JR

      (laughs)

    29. AH

      ... where they start with the whole-

    30. JR

      Yeah.

Episode duration: 2:44:45

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