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Lewis HowesLewis Howes

REVERSE AGING: What To Eat & When To Eat For LONGEVITY | Dr. Mark Hyman & Lewis Howes

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Dr. Mark HymanguestLewis Howeshost
Jan 16, 20231h 37mWatch on YouTube

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Transcript

  1. 0:00 – 2:22

    Can We Live Healthy to 120 or 150?

    1. MH

      So one of the key things I talk about in the book is mindset-

    2. LH

      Mm

    3. MH

      ... you know, is how our minds really play a role in our longevity, and if we don't get that straight, we're screwed. Like, we, when people kill themselves by their thoughts. [upbeat music]

    4. LH

      I think you gotta have a dream.

    5. LH

      The school of greatness.

    6. LH

      Really? [laughs]

    7. MH

      Yeah.

    8. LH

      Please welcome Lewis Howes.

    9. LH

      Uh, you've got a book, Young Forever: The Secrets to Living Your Longest Healthiest Life. I'm curious, you've been studying this for a while now. You've gone all over the world and studied this with people who've lived the longest. You've been, you know, a doctor for many, many years. You've researched this stuff for a long time. Do you think it's possible to live in our 90s, in our 100s, fit, mentally sharp, healthy at that age still?

    10. MH

      1,000%.

    11. LH

      Really?

    12. MH

      I mean, here's my plan. I wanna be 120, maybe 150. We'll see how it goes.

    13. LH

      Wow.

    14. MH

      I wanna go for a hike in the mountains. I wanna swim in a cool lake with my love. I wanna go back to the cabin, make a beautiful dinner, have a glass of wine, make love, and just drift off into the neverland.

    15. LH

      At 150?

    16. MH

      [laughs] Yeah. Why not?

    17. LH

      120, 150.

    18. MH

      Actually, yes, 'cause, you know, what we see as aging, this country, is really abnormal aging. Decrepitude, decline, frailty, disease, disability, loss of cognitive function, faculties, and those are abnormal things that happen, and they don't have to happen. You know, I was in Sardinia and I met this guy, Pietro, who was 95 years old, and he had literally just stopped being a shepherd, where he was hiking up and down the mountains five miles a day, herding his sheep for, I don't know, 80 years probably. [laughs] And he was, like, straight up fit, strong, bellowing voice, super strong handshake, eyes clear. I'm like, man, you know, it's possible to be very vibrant if we know how to take care of ourselves. And what we've done in our culture is activate all of our disease systems and degradation and dysfunction. But we now know that we have an innate healing system, and we can activate our healing system. When I was in medical school, I studied a book called The Pathologic Basis of Disease.

    19. LH

      Mm-hmm.

    20. MH

      We never had a book called The Scientific Basis of Wellness. [laughs] Right? We never even took that class. But now we understand that the body has its ino- innate mechanisms for repair and healing, rejuvenation, renewal, that can be activated at any point in life.

  2. 2:22 – 6:11

    A Sick Society: Chronic Disease and Longevity Science

    1. LH

      Okay. So what are the disease systems that most of us are turning on throughout the world?

    2. MH

      Well, so, so listen. We, we have, uh, an extraordinarily sick society. You know, America was 4% of the population of the world now, and, uh, it's 16% of the cases and deaths for COVID. Why?

    3. LH

      So four... America is 4% of the population-

    4. MH

      In the world

    5. LH

      ... of the world.

    6. MH

      But we were 16% of the cases and deaths, four times what it should've been, and probably considering we have a great healthcare system, it should've been half of that, right?

    7. LH

      Why, why is that, you think?

    8. MH

      Yeah. Well, well it's not a question. It's an, it is a clear answer. It's because we are a very sick population. So we were pre-inflamed. We were overweight as a society. 93.2% of us are metabolically unhealthy, meaning we have high blood pressure, high cholesterol, high blood sugar, have had a heart attack or stroke, or are overweight.

    9. LH

      Mm-hmm.

    10. MH

      [laughs] That means 6.8% of us are healthy. So when COVID hits that population, who is obese and pre-inflamed, who is chronically ill, which is also a disease of inflammation, who is elderly, which is also a disease of inflammation, the COVID takes over and just kinda wipes these people out.

    11. LH

      Mm.

    12. MH

      And, and so we, we are suffering from diseases of, uh, heart disease, cancer, diabetes, dementia, all the things we see as people get older, and these are all entirely preventable. They just, they're relatively new. I mean, if you look back in the 150 years ago in all the hospital records in Mass General or the hospitals in Boston, diabetes was almost non-existent-

    13. LH

      What?

    14. MH

      ... as a admitting diagnosis. So if there was a case of a heart attack, the entire, you know, medical school, the residents, the doctors, would all come around to see this rare case. It's like if somebody had, like, schistosomiasis today in a hospital-

    15. LH

      Really?

    16. MH

      ... they'd come in and everyone, "What is this disease?" You know? Yeah, for sure. It was so unusual. So, uh, we now have a, a society where six in 10 of us have chronic disease, where four in 10 have more than one, where if you're over 65, you know, 80% have, have a chronic disease, and, and probably even more when you look at things a little more subtly about dysfunction that happens. So what we see as aging today is something that, uh, it gives us an impression that it's bad to get older because-

    17. LH

      Yeah

    18. MH

      ... you're gonna become disabled, decrepit, dysfunctional, frail. But th- that's a model that is now being challenged by-

    19. LH

      Wow

    20. MH

      ... researchers in longevity and who are proposing that we may be able to even create something called longevity escape velocity, meaning we can escape death by advancing science that will keep us living longer and longer each year we're alive.

    21. LH

      Really?

    22. MH

      Now, I'm not sure I'm, I'm into that [laughs] 'cause I don't know if I wanna live to be 1,000, but I do think that it, it is pushing the boundaries of what we thought is possible. And we know in animal models we've been able to extend life by a third, right? So if we, if we do certain interventions, we can take animals and make them live a third longer, which means for humans you'd live to be 120.

    23. LH

      Mm.

    24. MH

      So we've had women, uh, who've lived to be very old, like Madame Calment, who lived to be 122 years old, who was a French woman who was documented legitimately to be [laughs] 122 years old.

    25. LH

      That's incredible.

    26. MH

      It's incredible, and she was a, a wine-drinking, smoking chocoholic. [laughs] But I wouldn't follow her longevity plan. [laughs]

    27. LH

      She had other things going for her to go against that, yeah.

    28. MH

      Yeah, for sure. And so, so that was an anomaly, but there are, um, cases of, of very vital, healthy people, and I travel to the blue zones around the world where people live to be well over 100. I had, I had, I, I had... [laughs] saw this couple that had a combined age of 210.

    29. LH

      Oh my gosh.

    30. MH

      [laughs]

  3. 6:11 – 9:24

    Ultra-Processed Food, Sugar, and Insulin Resistance

    1. LH

      What are the, what would you say are the three to five main causes of our society that causes us to get overweight and get sick-

    2. MH

      Yeah

    3. LH

      ... easily?

    4. MH

      I mean, hands down, it's the food. You know-

    5. LH

      Mm

    6. MH

      ... we are eating a diet, a toxic diet that is unlike anything we've eaten in human history. It's 60% of our calories are ultra-processed food, which means they're made from, uh, basically food-like substances that are from soy, corn, and wheat, and other additives and ingredients and fillers and colors and dyes and thickeners that are highly toxic to our systems. Uh, and they're inordinately high in sugar and starch. We've talked about this, but we eat about a pound a day of sugar and starch per person, per day in America, flour, sugar, and that's average. So [laughs] some people-

    7. LH

      Right

    8. MH

      ... having a lot more, and it's just physiologically not something we evolved with. We used to eat 22 teaspoons a year as hunter gatherers if we were lucky to find a beehive or a berry patch. Now, we have that every day on average, and kids have, like 34, which is like 2 and 1/2 soda, like large sodas a day.

    9. LH

      Right.

    10. MH

      So that, that's what's driving a lot of this, and that drives this phenomenon called insulin resistance, which is at the heart of the aging process, and that insulin resistance causes-

    11. LH

      Mm

    12. MH

      ... inflammation and all the age-related diseases. So-

    13. LH

      What is insulin, for those who don't know what that is?

    14. MH

      So insulin is, you know, what your pancreas makes in order to drop your blood sugar and keep your blood sugar balanced. So we, we all know Type 1 diabetics need to take insulin shots, but Type 2 diabetics ... I mean, by the way, there's, I think, been a 400% increase in Type 2 diabetes in kids [laughs] in the last 30 years, which is frightening to me. But they used to call it adult onset diabetes and they had to change the name because little kids were getting it.

    15. LH

      Wow.

    16. MH

      You know, 15-year-olds are now getting liver transplants because of fatty liver from drinking too much soda. I mean, it- it is really scary stuff.

    17. LH

      Wow.

    18. MH

      So, so insulin is important to keep your blood sugar in balance, but if you eat too much starch and sugar, your body pumps out more and more insulin. And then just like the boy who cried wolf, your cells don't pay attention anymore. You get resistant to the effects of insulin, and then you need more insulin, and that, you know, causes the deposition of belly fat.

    19. LH

      Mm-hmm.

    20. MH

      And belly fat is this dangerous fat around your organs that is not just holding up your pants, but it's pr- it's a whole organ itself. It's producing hormones and inflammatory molecules and neurotransmitters that are regulating your appetite. So it makes you really sick-

    21. LH

      Mm

    22. MH

      ... and it's the central driver of all these age-related diseases. So that's a huge factor. There are other factors like toxins, our sedentary lifestyle, chronic stress, our sleep disruption. These are all things that are activating our disease systems, not our healing systems. So-

    23. LH

      But the food is the main thing

    24. MH

      ... food is the, for sure, the main thing. Because, you know, think about it, you eat pounds of this stuff every day, and it's not just calories, it's information. So the molecules in the food make a difference. So in, in Ikaria, for example, one of the blue zones in Greece, they, they eat tons of wild food, wild greens. They have summer greens-

    25. LH

      Mm

    26. MH

      ... winter greens, wild mushrooms. Every day they have wild sage tea because it's just free and cheap, right? They're poor over there [laughs]

    27. LH

      Right, right,

    28. MH

      So they all go out in the backyard and they pull up sa- [laughs] And it's like, turns out, I looked it up and it's full of catechins, which are these compounds in green tea that make green tea such a longevity compound, an antioxidant compound-

    29. LH

      Mm

    30. MH

      ... an anti-inflammatory compound.

  4. 9:24 – 17:24

    Foods for Longevity: Phytochemicals, Fats, and Protein vs. Fasting

    1. LH

      What would you say the, the five main in- ingredients or foods to support longevity, whether it be like a, you know-

    2. MH

      Well, this is great. It's a great question, right? So, so what should we be eating, right?

    3. LH

      Mm-hmm.

    4. MH

      We shouldn't be eating ultra-processed food. Process- uh, we shouldn't be eating too much starch and sugar. We shouldn't be eating refined oils. We shouldn't be eating additives and chemicals. We eat about five pounds of additives per person a year. We shouldn't be eating pesticides, herbicides, all that crap. So that's just a given. But what should we be eating? Well, start out with the most important things for longevity, which are these phytochemicals in plant foods. So the majority of your diet by volume should be colorful fruits and vegetables-

    5. LH

      Mm-hmm

    6. MH

      ... and weird stuff if you can. You know, eat dandelion greens, eat seaweed, eat all this weird stuff because that's where all the medicine is.

    7. LH

      Mm-hmm.

    8. MH

      So the more colorful it is, the more heirloom it is, the more regenerative it is, the more organic it is, the more wild it is, the better it is. So if you had a wild strawberry, it's about the size of a, you know, a peanut, but it tastes like an explosion of flavor-

    9. LH

      Mm-hmm

    10. MH

      ... if you ever ate a summer wild strawberry.

    11. LH

      Sure, sure.

    12. MH

      But you can go to the supermarket and buy these giant strawberries that look great, but then you put it in your mouth, it's like, "Mm, I think it's a strawberry." It's so sh-

    13. LH

      [laughs]

    14. MH

      You know, it's like-

    15. LH

      More like an apple.

    16. MH

      Yeah, like an apple, you know. [laughs]

    17. LH

      [laughs]

    18. MH

      But it's, it's not very tasty because-

    19. LH

      Sure

    20. MH

      ... the, the phytochemicals aren't there.

    21. LH

      Ah.

    22. MH

      So we know that, uh, you want to include a rich array of these phytochemicals, and the special ones for longevity are things like fisetin that's in strawberries. From pomegranate, you can produce urolithin A, which improves your mitochondrial function. So you can have green tea, which is epigallocatechin gallate compounds, which I talked about the sage. You can have, uh, um, resveratrol, which is in red grapes, green skins.

    23. LH

      Mm-hmm.

    24. MH

      There's a lot, there's a lot of plant compounds that you can start to include. Curcumin, which is a powerful anti-inflammatory. So you can, you can have a wonderful time having a delicious diet.

    25. LH

      Yeah.

    26. MH

      And then, and then, um, mushrooms. They're not really a vegetable. I mean, they're its own category, and mushrooms have an incredible array of, uh, of compounds, these polysaccharides that, turn out, are immune modulating, anti-cancer, adaptogenic. And so we need to be including a lot more good mushrooms.

    27. LH

      Okay.

    28. MH

      And you can take mushrooms as supplements, but you can also eat a lot more of the good mushrooms. Uh, also garlic and onions are really important-

    29. LH

      Mm

    30. MH

      ... for sulfur and the broccoli family specifically because they up-regulate glutathione, which is important for detox. Um, so you really wanna have a wide array of these-

  5. 17:24 – 20:02

    Hyman's Transformation and the Tarahumara

    1. MH

      I just changed my diet. It's... And I did a little bit of band resistance training.

    2. LH

      Some resistance training, yeah.

    3. MH

      I was always doing yoga, running, biking.

    4. LH

      Mm-hmm.

    5. MH

      I thought that's enough, but then I started doing a little bit resistance training. I started doing this strategy of, you know, this time-restricted eating, and then, and then adding a bunch of protein after my workouts-

    6. LH

      Mm-hmm

    7. MH

      ... and it just, and it worked.

    8. LH

      Now, what is, what's this-

    9. MH

      You wanna, you wanna see?

    10. LH

      Let's see it. Yeah, yeah, I do wanna see.

    11. MH

      Wanna see? Okay, I'll show you.

    12. LH

      You'll have to send it to me, well, I don't have the video today, yeah.

    13. MH

      I'll, I'll send it to you. It's like, it's pretty, it's pretty wild, like I can't even quite believe it, you know?

    14. LH

      Now, will the same strategy be at 60, in your 60s, as in your 80s?

    15. MH

      Yeah, I think, you know, the po- the possibility of staying young longer is, is amazing. The, the research has shown that, that if you take even 60 years old, they can perform at the level of 30-year-olds if they're trained right.

    16. LH

      Wow.

    17. MH

      So we don't have to lose that much function. And there's an amazing, uh, study on the Tarahumara Indians. The Tarahumara Indians live in Mexico-

    18. LH

      Mm-hmm

    19. MH

      ... and they were really very, um... Here's, here's the picture of them.

    20. LH

      Oh, my gosh.

    21. MH

      [laughs]

    22. LH

      That's crazy.

    23. MH

      Yeah. [laughs] So- The Tarahumara Indians, uh-

    24. LH

      Ah, yeah, we'll put it up on the screen for you to see

    25. MH

      ... had this belief that if you were older, you were a better runner. These were runners. They would run 100 miles a day, right? They would just do these ultra-marathons before there was anything like that. They would run from village to village, mountain to mountain.

    26. LH

      Crazy.

    27. MH

      And so they went down from Harvard, and they tested these people, and this is the power of mindset, right? And the beliefs and what that does. And so they believed that as you got older, you got better.

    28. LH

      Ah, cool.

    29. MH

      So the 20-year-olds are good, the 40-year-olds are better, and the 60-year-olds were better by every objective metric. Their pulmonary function test, their VO2 max, their, all their performance metrics that were objective, not just how fast they could run, but all the objective measures of fitness were better-

    30. LH

      Mm

  6. 20:02 – 29:06

    The Hallmarks of Aging and Biological Age

    1. MH

      Yeah. And I, I think, I think the, the other, the other thing is to understand how to eat for your microbiome.

    2. LH

      Mm-hmm.

    3. MH

      Because we didn't, we didn't get into this yet, but there's a phenomena called the hallmarks of aging, which are these underlying things that go wrong as we age, and these are phenomena that seem to underlie all disease. So the idea is if you, if you treat these things, or if you correct these problems, called the hallmarks of aging, that it will dramatically extend life.

    4. LH

      Mm.

    5. MH

      So if we, if we cured all the cancer and heart disease from the planet, how many years extra do you think we'd live?

    6. LH

      Phew. Um, probably an extra 10? I don't know.

    7. MH

      Mm. Three to five.

    8. LH

      Three to five, okay.

    9. MH

      Maybe push it seven.

    10. LH

      Okay.

    11. MH

      If you address the hallmarks, we go to 120 or 150. So-

    12. LH

      So if we eliminate diseases-

    13. MH

      The number one and two killers in the world, we got rid of them, it's only gonna give us a few extra years of life.

    14. LH

      Really?

    15. MH

      Yeah.

    16. LH

      Wow. What are the other hallmarks then?

    17. MH

      Well, the, so the o- other hallmarks are really, well, driven around, uh, well, a- around these 10, I call, 10 things. One of them is the microbiome, and we'll get back to how to take care of your microbiome. But I'll just sort of list the hallmarks, and then we can come back to how to eat for your microbiome.

    18. LH

      Okay. [laughs]

    19. MH

      Um, but the, the first, the first thing is, that happens is you get damage to your DNA. So there's, every day there's little insults, toxins, the diet we're eating, whatever it is, stress, causing little death by a thousand cuts. But thank God you have a repair system. You know, you have a DNA repair system that goes out on a mission and starts to fix all the damages. Now, over time, you, you, you may have 99.9% fixing, but then there's that 1.1% that keeps getting worse over time. So that's one thing. Second is we get damage to our telomeres, which are these little, these little things at the end of our chromosomes that keep them safe and intact, and they shorten as we get older. And if they're too short, the cells stop replicating-

    20. LH

      Mm

    21. MH

      ... and you die. Uh, then there's epigenetic changes, and epi- epigenetics are really important because it helps us distinguish between our chronological age and our biological age. So how, our chronological age is how long we're alive.

    22. LH

      Mm-hmm.

    23. MH

      I was born in 1959. I can't do anything about that. [laughs] I just can't. I'm 60, uh, 3 on the calendar, and I can't do anything about that. But my biological age-

    24. LH

      Yeah

    25. MH

      ... is how old I am on the inside.

    26. LH

      So how do we reverse the biolog- uh, the biological age while we continue to age chronologically?

    27. MH

      That's the plan. So I did, I did my biological age, and I, at, at 62, and I was 43.

    28. LH

      Wow.

    29. MH

      So biologically, I'm 43. I'm going for 25. But I'm chronologically 62.

    30. LH

      That's crazy.

  7. 29:06 – 32:44

    Eating for Your Microbiome and Eating with Joy

    1. MH

      And the, the microbiome is really important, and it's not on the classic list of hallmarks of aging. I added it. But when you look at the literature, it's really clear that as we age, our microbiome degrades. We get what we call dysbiosis, imbalances in our gut bacteria, and those gut bacteria become toxic and inflammatory. So part of the diet you have to have is to take care of your inner garden. Mm-hmm. You need pre and probiotic foods and polyphenols. So prebiotic foods are things like, you know, asparagus, artichokes, Jerusalem artichokes, jicama, uh, plantains. These are foods that feed the good bacteria, right? And then there's probiotic foods. Sauerkraut, kimchi, miso, tempeh. These ancient foods that have been around forever that are fermented foods, that are prebiotic foods. I grew up on pickles, I'm Jewish. I didn't even know that was a probiotic food [laughs] until recently. Yeah. [laughs] And then, and then there's polyphenols, and this is an incredible discovery, that there are certain compounds in plants that your gut bacteria love. So you're not only eating for yourself, you're eating for the trillions of microbes- Mm-hmm ... that almost outnumber your cells in your gut. Right. And those microbes, when they're bad, cause inflammation and disease and diabetes and cancer and everything else. But when they're good, they regulate inflammation, they help you stay healthy. It's super important to feed them right. So you have to learn how to tend your inner garden. Mm-hmm. And there's a couple of ones that are really important, like green tea, pomegranate, cranberry. Um, and pomegranate's an interesting one. I talk about this in the book. Most people have pretty crappy microbiomes, uh, pun intended. [laughs] And the, the truth is that you, you've lost a lot of important species that you need to work with your diet to make good stuff. So- If you eat pomegranate, it has a compound in it that gets converted by good gut bacteria to something called urolithin A. Now, urolithin A-

    2. LH

      Mm

    3. MH

      ... you might not have heard about, but you will. It's really amazing, and there's m- millions of dollars of research on this compound that is derived from pomegranate being metabolized by your gut bacteria and producing this compound. But you could also make it and give it externally. And, and in, in studies they found that without exercise, it increases fitness level through VO2 max, increases muscle strength, and increases, uh, mitochondrial-

    4. LH

      Wow

    5. MH

      ... uh, cleanup or, uh, mitochondrial autophagy.

    6. LH

      Without exercise.

    7. MH

      Without exercise. And also increases, uh, mitochondrial renewal and re- and biogenesis to make new mitochondria. So basically you're taking... think about it, you're taking this, like, pomegranate, your gut's metabolizing it and you create this magical longevity-

    8. LH

      Hm

    9. MH

      ... compound. And that's just one example.

    10. LH

      Wow.

    11. MH

      Right? So we need to feed our gut bacteria with lots of these colorful vegetables.

    12. LH

      That's beautiful.

    13. MH

      Yeah.

    14. LH

      Wow, okay. So eat for your microbiome is something you said to come back to. Is that what we're talking about here?

    15. MH

      We just did.

    16. LH

      And then what would be the fifth thing to add to this?

    17. MH

      I think, I think, you know, the, uh-

    18. LH

      Five main things, foods for longevity.

    19. MH

      Yeah, I think, you know, um, I probably would say it would be, uh, eating with joy. You know, because-

    20. LH

      No, I love that

    21. MH

      ... I think, I think people get so screwed up about food and get so obsessive and so, uh, rigid about it that, you know, part of the key is celebration-

    22. LH

      Mm

    23. MH

      ... enjoyment, you know. It's my birthday soon, I'm having a crew over or we're having a friends Thanksgiving. You know, it's gonna be yummy and delicious, we're probably gonna overeat.

    24. LH

      [laughs]

    25. MH

      There's definitely gonna be some pecan pie.

    26. LH

      Oh, man.

    27. MH

      You know? [laughs]

    28. LH

      Sounds incredible.

    29. MH

      So that's okay. So I think we shouldn't be too rigid, but I think the key of community and eating with joy and eating with pleasure and savoring your food and it, it's really, really important.

    30. LH

      Mm-hmm.

  8. 32:44 – 40:20

    Lessons from the Blue Zones: Wild Food, Community and Purpose

    1. LH

      What was the things that you saw when you went to these Blue Zones that they did that maybe you weren't even thinking they would do? Like, what were the surprising things they did?

    2. MH

      Well-

    3. LH

      Or the unsurprising things they did.

    4. MH

      Yeah, I mean, well, well, the few things I saw that were kind of, kind of striking to me that made sense, but one was that in, in, in Ikaria, which was one of the Greek Blue Zones, they eat so much wild food. So they had wild greens, summer greens, winter greens. They had wild mushrooms, they had wild sage tea, they had wild fish. They had so much wild food in their diet.

    5. LH

      Hm.

    6. MH

      And it, and we know that wild foods are much more nutrient-dense. Why? Because they're stressed, and stressed plants make more protective compounds. Those protective compounds are called phytochemicals. They give the color and the richness and the flavor.

    7. LH

      Mm-hmm.

    8. MH

      And what people don't understand is the more flavorful a food is naturally, the more phytochemicals it has.

    9. LH

      Interesting.

    10. MH

      You know, if you go to your garden at the end of August and pick a cherry tomato that's ripened in the hot sun that explodes in your mouth, like, the most incredible flavor. But if you go to a store-bought tomato and you cut it, it's like cardboard, tasteless. What's the difference? It's the phytochemicals. So flavor always follows the phytochemical richness of a food. So, so not the stuff you put on it or sauces or salt or fat or sugar to make it taste better, which food industry does.

    11. LH

      Wow.

    12. MH

      But just the natural flavor.

    13. LH

      Interesting.

    14. MH

      So, so you know, the more flavorful a food is, the better it is.

    15. LH

      Hm.

    16. MH

      So, uh, it's, it... wild- they eat a lot of wild food, and it's so flavorful. Uh, the other thing was, uh, interesting was that shepherds, um, you know, had this culture of, of going and knowing exactly which plants to feed their animals at which time of year-

    17. LH

      Hm

    18. MH

      ... to graze them. So would shepherd them, they'd eat all these wild plants, but they know if they, this was, this herb was coming in at this time of year, they'd go eat this herb. And if this plant was coming in this time of year, they'd go eat that thing. I'm like, "Why are you doing this?" He says, "We know be- because the meat and the milk tastes better when we"-

    19. LH

      Wow.

    20. MH

      "When we..." Yeah. And so it, it kind of... you know, they were not doing it 'cause it, it was better for them or 'cause it was for longevity or because-

    21. LH

      Tastes better

    22. MH

      ... right, the cheese... yeah, tastes better. So i- it turns out that we know now that phytochemicals are not just in plants, and phyto means plant, right? They're not just in plants, they're also in animals.

    23. LH

      Hm.

    24. MH

      So the work of Fred Provenza and Stephen DeBette from Duke have clearly shown that when animals are eating a wide array of wild plants or a wide array of, you know, you know, planted grasses and flowers and different things, they will seek out medicine in the food. So they will literally go and eat major, like, you know, calorie crops, let's say, but then they'll go and sample from, like, 100 different plants to get their medicines.

    25. LH

      Hm.

    26. MH

      And so these, these wild animals, these wild plants are being eaten, and the phytochemicals are accumulating in the meat and the milk of these animals. So studies have shown, for example, that you can have as high levels of the catechins in green tea in goat milk that's from goats eating certain wild plants.

    27. LH

      Really?

    28. MH

      Yeah. So it's mind- mind-blowing, and there may be ways that even these get transmuted. So eating regeneratively raised meat. I went to a restaurant here in LA, uh, last night called Matu where they have regeneratively raised meat.

    29. LH

      Was it amazing?

    30. MH

      It was amazing. Now, it wasn't as, like, fatty and, like, kind of like marble-like corn-fed meat-

  9. 40:20 – 47:47

    Mind, Stress, Meaning, and Loneliness

    1. LH

      Why, why... Can you live long and still-

    2. MH

      Hustle? [laughs]

    3. LH

      ... hustle or just want more, want to build something greater in your life?

    4. MH

      I think you can. I think, I think it's really about, you know, what happens on the inside because-

    5. LH

      Yeah

    6. MH

      ... you know, one of the biggest, uh, things that regulates your epigenome is your mind. So your, your biggest pharmacy in your body is between your ears.

    7. LH

      Mm.

    8. MH

      It's the most powerful pharmacy in the world.

    9. LH

      Wow.

    10. MH

      And you can activate it for good or bad. So when we are having thoughts that are, um, you know, uh, uh, stressful thoughts, when we're in toxic relationships, when we're worried or anxious, when we aren't in, you know, harmony with ourselves, it activates all these really nasty pathways that drive inflammation and harm your mitochondria and dest- I mean, your microbiome is listening in on your thoughts.

    11. LH

      Wow.

    12. MH

      It's eavesdropping. So those bugs don't like it when you are not happy.

    13. LH

      Really?

    14. MH

      Yeah. [laughs]

    15. LH

      What, what is the process of that from an idea, a thought into the mitochondria? How does that transfer into a healthy, uh, information into a physical manifestation versus unhealthy information, data in a thought into physical-

    16. MH

      Well, well-

    17. LH

      ... unhealth?

    18. MH

      So what, what's the biochemistry of it? Well, well, for example, um, if you're stressed, you're producing cortisol and adrenaline and all these other hormones and proteins that then will trigger a whole cascade of downstream effects that activate, uh, transcription factors, that, that transcription factors-

    19. LH

      Mm

    20. MH

      ... that turn on genes, that cause inflammation and all these other problems. So you're basically, you know, creating inflammatory thoughts are creating inflammation in your body, literally. And-

    21. LH

      Isn't that crazy?

    22. MH

      And you have-

    23. LH

      That's-

    24. MH

      ... receptors on your s- like immune cells, for example, for neurotransmitters. So if, if you're stressed, your immune system is eavesdropping on your thoughts.

    25. LH

      Wow.

    26. MH

      That's why if you're stressed, you are more likely to have an infection or get sick or have other bad health consequences.

    27. LH

      Why do you think it is that our body is built this way that a thought can either make us feel and physically transform into joy and health-

    28. MH

      Mm

    29. LH

      ... or feel sick and then become sick? Why do you think our body-

    30. MH

      Why, from an evolutionary point of view? How do we-

  10. 47:47 – 57:49

    What Functional Medicine Is, Gut Health, and a Patient Case

    1. LH

      If you enjoyed that interview, then I know you'll love what we have coming up right now. Let's go back to functional medicine.

    2. MH

      Yeah, yeah.

    3. LH

      What does that actually mean?

    4. MH

      So functional medicine is, is-

    5. LH

      Compared to regular medicine.

    6. MH

      Yeah, yeah. Well, you know, my, uh... I don't know if people listening really have a great understanding of-

    7. LH

      Sure

    8. MH

      ... like, what's happening right now in science.

    9. LH

      Uh-huh.

    10. MH

      But it's profound, that the shift that's happening in our understanding of the body is, it's like Columbus going, "Hey, the earth isn't flat."

    11. LH

      Wow.

    12. MH

      And, uh-

    13. LH

      Right now, the last few years.

    14. MH

      Right. It's just, like the last decade or two-

    15. LH

      Okay

    16. MH

      ... with our understanding of the human genome, of systems biology, of the body as a biological network-

    17. LH

      Mm-hmm

    18. MH

      ... as a system. It's like an ecosystem where everything's connected, working together. And so the way we organize medicine is according to these organs. You know, you've got your cardiovascular system, your neurologic system, your GI system, your, you know... And so you go to all these specialists.

    19. LH

      Right.

    20. MH

      Right? Everyb- And, and, and everybody treats your, their part of your body. If you have a migraine, we're actually learning that it might be related to gut flora, but-

    21. LH

      Wow

    22. MH

      ... or if you have heart att- if, I mean, now we know that your, you might be getting cancer 'cause of your gut bacteria. Well, no oncologist is asking you what's going on in your gut microbiome. [laughs]

    23. LH

      Right.

    24. MH

      And so now we know, for example, like the microbiome is a great example of this disruption that's happening in healthcare. You know, the microbiome- Which is your gut flora. It's really, it's like, uh, 10 times as many cells as your own cells. It's 100 times as much DNA as your own DNA.

    25. LH

      Huh.

    26. MH

      So I, we're kind of lazy. We have about as much DNA as an earthworm.

    27. LH

      Okay. [laughs]

    28. MH

      But we borrow the DNA of the bicromes, the microbes in our gut, to do things for us. And we, we, we borrow things from plants to do things from us, like s- like-

    29. LH

      Hmm

    30. MH

      ... for example, glucosinolates. And so the, the microbiome is this huge thing that's got two to three million genes. We only have 20,000 genes, and it regulates-

  11. 57:49 – 1:07:50

    Practical Reset Programs, Fasting Tips, and Why He Became a Doctor

    1. LH

      So if someone is listening, and they're on some type of a medication, or they're just feeling, like, constantly sick-

    2. MH

      Mm-hmm, mm-hmm

    3. LH

      ... you know, something's just constantly happening to them, what do you think is ... You know, 'cause there's so much information online that it's scary.

    4. MH

      So it's scary, right. Well, here's what I would say.

    5. LH

      You know, the letter D stuff, just, like-

    6. MH

      Yeah

    7. LH

      ... looking up anything-

    8. MH

      Yeah

    9. LH

      ... and Googling it, and seeing all the nasty photos of, and just being like, "Ugh."

    10. MH

      Yeah, right.

    11. LH

      What is an approach that someone should take if they have some challenge that's constantly happening in their health? Should they first analyze the food they're intaking-

    12. MH

      Mm-hmm

    13. LH

      ... and do, like, an analysis? Do you have, like, a process?

    14. MH

      Absolutely, abs ... This is a great question, Lewis. So, you know, what I am is a doctor, and what I do is see patients in my office. That's my main job.

    15. LH

      Yeah.

    16. MH

      Yes, I've written a dozen books. Yes, I do a lot of stuff, but that's my main job.

    17. LH

      Yeah.

    18. MH

      And, and so I've learned over 30 years of doing this how to create sustainable, practical programs to help people get from sick to well-

    19. LH

      Mm

    20. MH

      ... very quickly. And what I've done, because not everybody can come see me, and there aren't that many of us out there yet-

    21. LH

      You only have so many hours in the day [laughs]

    22. MH

      ... and there's so, not that many functional medicine ... So I've written books and programs-

    23. LH

      Yes

    24. MH

      ... to help people operationalize this in their own life.

    25. LH

      Yes.

    26. MH

      So Eat Fat, Get Thin, I mean, look, I'm, you know, you know, I could say, you know, "Do my program," but, like, I'm not, I don't really care what program you do.

    27. LH

      Right.

    28. MH

      As long as it's based on the basic principles, and there are a lot of my colleagues who are writing great books about this. It's all-

    29. LH

      Yes

    30. MH

      ... it's all the same information-

  12. 1:07:50 – 1:18:09

    Policy Changes to Fix the Food System

    1. LH

      I like it. I got three questions for you. One is if you had an unlimited amount of money that you could spend on one thing to, to cure one thing in the world, what would that be?

    2. MH

      One disease or one-

    3. LH

      One thing in the world that you think-

    4. MH

      Ah

    5. LH

      ... needs curing.

    6. MH

      Um.

    7. LH

      Or solving one issue.

    8. MH

      Oof, gosh, I mean, that's, so many things flooded into me-

    9. LH

      [laughs]

    10. MH

      ... when you said that. I mean, I think, um, you know, the thing that I think is driving so many of our economic and social ills is our food system. And, and if I had a magic wand-

    11. LH

      Mm-hmm

    12. MH

      ... I would put in a... And I, I'm working actually on a petition right now to, I've got 150,000 people on our Fat Summit, which is an online-

    13. LH

      Right

    14. MH

      ... summit on, and we're ex- interview over 30 experts on fat. And it's available. Anybody can go to fatsummit.com and get to see this.

    15. LH

      Yeah.

    16. MH

      And, and, you know, to kind of list what are the policies that would really radically change things, not just in America but around the world, if we became the, the, the beacon for this. Um-

    17. LH

      Mm-hmm

    18. MH

      ... and I met with the surgeon general a couple of days ago, and he asked me to come to Washington to help change and shape this policy. So the things that matter are, you know, ending food subsidy, e- ending s- agricultural subsidies for commodity products like corn-

    19. LH

      Yeah

    20. MH

      ... soy, and wheat that go into all our processed industrial food. Subsidizing fruits and vegetables and things that actually promote health.

    21. LH

      Yeah.

    22. MH

      Ending food marketing to kids, right? We, we, we-

    23. LH

      All the cereals and sugar and pop

    24. MH

      ... market junk food to kids. I think we're one of only 50 countries that, that, that, uh, uh, that we are, one, one of the only countries that doesn't do this. 50 countries control food marketing to kids.

    25. LH

      Really?

    26. MH

      Regulate. Yeah.

    27. LH

      They don't-

    28. MH

      Us and Syria, no, are the only ones I think. [laughs]

    29. LH

      Oh my gosh.

    30. MH

      I would, uh, end all use of antibiotics in animal feed except, except in animal husbandry except for treatment of disease.

  13. 1:18:09 – 1:26:59

    Diabetes, Food Causes of Disease, and Industry Influence

    1. LH

      So let's go back to diabetes for a second. Tell me again the stat on diabetes, how many people have it-

    2. MH

      Yeah

    3. LH

      ... or are pre-diabetic.

    4. MH

      Okay. Yes.

    5. LH

      And, and what, I'm undereducated on this, so how many different types of diabetes are there?

    6. MH

      Okay, good.

    7. LH

      And how is it caused?

    8. MH

      Okay. Okay. So type 1 diabetes is an autoimmune disease. Pancreas fails. It's called ju- we used to call it juvenile diabetes. Uh, and you need insulin. It's just, it's-

    9. LH

      You need it

    10. MH

      ... it's, you need insulin. But you-

    11. LH

      If you have type 1 diabetes, you need insulin.

    12. MH

      You need insulin, yeah.

    13. LH

      To do what?

    14. MH

      'Cause your pancreas dies. 'Cause your pancreas makes insulin and helps your blood sugar, uh, get balanced, keeps, that's the blood, it's sort of the gatekeeper that lets the, the glucose into your cells.

    15. LH

      Okay.

    16. MH

      So it's really important. Um, and-

    17. LH

      So how does that die? How, what happens-

    18. MH

      Can people die from that?

    19. LH

      I mean, how does the pancreas die?

    20. MH

      Oh, well, it's an autoimmune-

    21. LH

      How does it get to that point?

    22. MH

      It's an autoimmune, like an auto- like you get multiple sclerosis or rheumatoid arthritis.

    23. LH

      Gotcha.

    24. MH

      It's, it's basically your body attacks your pancreas. And, and-

    25. LH

      Is that from eating a lot of bad foods?

    26. MH

      Uh, well, there's been links to dairy, and actually as an, a driver of-

    27. LH

      Wow

    28. MH

      ... type 1, uh, diabetes. Gluten, 29% of people who have type 1 diabetes have celiac that are undiagnosed.

    29. LH

      Wow.

    30. MH

      So, uh, celiac is a big cause of autoimmune diseases-

  14. 1:26:59 – 1:37:30

    Dairy, Nut Milks, Food Diversity, and the 10-Day Reset

    1. LH

      I'm curious, you said something about nut milk, uh, and about dairy.

    2. MH

      Yeah.

    3. LH

      Dairy, has dairy been declining-

    4. MH

      Yeah, dairy-

    5. LH

      ... in the last five years?

    6. MH

      Yes, dairy consumption-

    7. LH

      Do you know the-

    8. MH

      ... has been declining dramatically.

    9. LH

      Do you know the percentages or the-

    10. MH

      Uh, it's, like, yeah, I think, you know, over the last few years, like, it's gone down about 25%. Borden, uh, which is a big milk producer, has been around since 18, I think, 87, has gone bankrupt.

    11. LH

      What?

    12. MH

      Yeah. The, a lot, and then a lot of these bu- milk producers. Now people are still eating cheese.

    13. LH

      Yeah.

    14. MH

      They're eating yogurt, they're eating these, but, but actual milk, uh, consumption has gone down, and the-

    15. LH

      Is that-

    16. MH

      ... nut milks have gone up.

    17. LH

      Why is that?

    18. MH

      I think-

    19. LH

      Is that because of education? Is that because of disease-

    20. MH

      I think, you know-

    21. LH

      ... that-

    22. MH

      [laughs] I think probably a lot of reasons.

    23. LH

      Okay.

    24. MH

      75% of the population is lactose intolerant.

    25. LH

      Yeah.

    26. MH

      So they don't feel good. Uh, you should-

    27. LH

      I used to drink m- so much milk every day as a kid.

    28. MH

      And how did you feel? Fine?

    29. LH

      I always had, like, a stuffy nose. [laughs]

    30. MH

      Right. Right.

Episode duration: 1:37:30

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