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The Mel Robbins Podcast

Why 80% of Autoimmune Diseases Happen to Women & Solutions From a Renowned MD

In this episode, you will learn why 80% of autoimmune diseases happen to women and the solutions to take back control of your health.

Mel RobbinshostDr. Sarah Szalguest

Feb 3, 20251h 23mWatch on YouTube

Summaries, chapters, transcripts, and FAQs on this page are made by uListen, not YouTube.

CHAPTERS

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Chapter summaries

Why this episode went viral: women, autoimmunity, and the promise of lifestyle medicine
Mel introduces the episode’s central question—why autoimmune diseases disproportionately affect women—and tees up a practical, low-cost roadmap to feel better. Dr. Sarah Szal frames the goal as restoring energy, regulation, and empowerment through lifestyle medicine rather than symptom-only care.
- •80% claim sparks demand for deeper explanation and solutions
- •What listeners can expect: more energy, safety/regulation, empowerment
- •Lifestyle medicine: addressing sleep, food, movement, stress, connection as first-line tools
- •Autoimmune rates rising; focus on what’s actionable and often free
What autoimmune disease actually is (and why it often goes undiagnosed)
Dr. Szal explains autoimmunity as a ‘mistaken identity’ problem where the immune system attacks normal tissue using autoantibodies. She also describes a continuum from health to early immune dysfunction to full disease—one reason people can struggle for years before diagnosis.
- •Immune system becomes imbalanced and attacks self-tissue
- •Autoantibodies are measurable markers of the ‘civil war’
- •Autoimmune disorder vs disease as a continuum with a large gray zone
- •Many patients face 7–14 years to diagnosis due to scattered symptoms
The huge (surprising) list: common conditions that are autoimmune or autoimmune-adjacent
Mel reacts to how many illnesses fall under autoimmunity, including psoriasis and type 1 diabetes. Dr. Szal distinguishes classic autoimmune diseases (100+) from broader autoimmune-related syndromes like endometriosis and some IBS/long COVID presentations.
- •Classic autoimmunity: RA, Hashimoto’s, Graves’, celiac, MS, psoriasis, type 1 diabetes
- •Psoriasis framed as immune attack on skin/scalp
- •Autoimmune-adjacent conditions: endometriosis, some IBS, chronic Lyme, long COVID
- •Why naming it matters: shifts focus to root causes, not just topical/symptom fixes
Why autoimmune rates are rising: autoantibodies tripling and what that implies
Dr. Szal highlights a major trend: anti-nuclear antibodies have nearly tripled over 25 years. She argues genetics can’t explain this jump, pointing instead to environmental and lifestyle changes such as food systems, stress, and trauma exposure.
- •Anti-nuclear antibodies (ANA) prevalence has nearly tripled in ~25 years
- •Signals environmental/lifestyle shifts rather than genetic change
- •Food, stress load, and trauma are positioned as major drivers
- •Sets up the ‘root causes’ framework to follow
The 3 root-cause requirements: genes + leaky gut + a trigger
The core model is introduced: genetic predisposition, intestinal permeability (‘leaky gut’), and a trigger that ignites symptoms. Triggers often include trauma/toxic stress, but can also be hormonal transitions like pregnancy or menopause.
- •Three requirements: genetics, leaky gut, and a trigger
- •Triggers: trauma/toxic stress; also pregnancy, postpartum, peri/menopause
- •Genes are informative but not modifiable (yet)
- •Leaky gut and triggers are the main leverage points for prevention/reversal
Leaky gut explained: lost boundaries, immune activation, and what worsens it
Dr. Szal explains leaky gut as breakdown of tight junctions in the intestinal lining, allowing particles to cross into the body and activate immune responses. She links this to the fact that most immune tissue sits near the gut, then names major disruptors like alcohol and chronic stress.
- •Leaky gut = impaired tight junctions; ‘loss of boundary’ metaphor
- •Foreign particles/foods can cross and provoke immune responses
- •70–80% of the immune system is located around the gut
- •Alcohol and excessive stress can directly worsen gut permeability; circadian disruption may contribute
Why women are hit harder: biology, culture, caregiving load, and medical bias
The conversation turns to why women experience autoimmune disease at much higher rates. Dr. Szal separates sex-based biology (chromosomes) from gendered social stressors and highlights research and treatment gaps that leave women undertreated or dismissed.
- •Women have ~4x higher autoimmune disease rates; Hashimoto’s even higher
- •Beyond biology: women experience more trauma, earlier trauma, higher PTSD rates
- •Hormonal transitions add additional immune stressors
- •Gender bias and research gaps: male-based studies, under-treatment (e.g., menopause care)
Gabor Maté clip unpacked: ‘nice’ coping styles, suppressed anger, and stress physiology
Mel plays a viral clip connecting autoimmune risk to patterns like over-functioning, prioritizing others, and fearing disappointment. Dr. Szal agrees it resonates because cultural norms can foster chronic stress and boundary collapse that carry real health costs.
- •Maté’s 4 traits: people-pleasing, duty/role identity, repressed anger, responsibility for others’ feelings
- •Chronic stress undermines immune function and can fuel autoimmunity
- •Framing shifts blame away from ‘personal failure’ toward cultural programming
- •Reinforces the need for boundaries and stress reduction as health interventions
Childhood trauma, ACE scores, and the PINE Network (psychology–immune–neuro–endocrine)
Dr. Szal introduces ACEs and their links to dozens of chronic illnesses, including autoimmune disease. She explains trauma’s long-term imprint via dysregulation of the PINE Network, shaping immune, endocrine (cortisol), and nervous system responses well into adulthood.
- •ACE questionnaire origins (CDC/Kaiser) and strong chronic disease correlations
- •Higher ACE scores increase midlife risk across ~45 diseases, including autoimmunity
- •PINE Network: psychology, immune, neurological, endocrine systems as an integrated stress-response unit
- •Trauma can persist ‘in the body’ even when cognitively processed
Recognizing autoimmune symptoms and why they’re confused with menopause or ‘nonspecific’ issues
Dr. Szal lists common cross-cutting symptoms such as fatigue, inflammation, joint pain, gut issues, mood changes, rashes, and neuropathy. Mel connects symptom overlap with perimenopause, and Dr. Szal notes the 40–55 window is a frequent spike period.
- •Common symptoms: fatigue, swelling/inflammation, aches, joint pain
- •System-specific signs: thyroid symptoms, neuropathy, GI issues, skin changes, vision changes
- •Autoimmune symptoms often ‘nonspecific,’ contributing to delayed diagnosis
- •Perimenopause/menopause (40–55) is a major flare/spike period with multi-system changes
Immediate action plan: testing, elimination diet, and tracking triggers
Dr. Szal gives a simple three-part starting protocol: test key markers, do an elimination diet, and identify/track triggers (especially trauma and stress). She offers concrete lab categories—immune markers, inflammation, metabolic and hormone measures—and a no-test fallback using diet changes.
- •Three steps: get tested, do an elimination diet, track/hunt triggers
- •Suggested labs: CBC/differential, hs-CRP, ESR, NLR; glucose/insulin; hormones; vitamin D
- •Elimination diet targets gluten, dairy, sugar, alcohol for ~3 weeks to gauge response
- •Lifestyle changes can complement meds and may support dose reduction under supervision
Diet as the biggest lever: ‘bringing the outside world inside’ + locus of control and hope
Mel illustrates how daily choices compound into inflammation or healing, emphasizing what’s within personal control even when life stressors remain. Dr. Szal reinforces that small, consistent lifestyle shifts can improve regulation, reduce symptoms, and rebuild confidence and momentum.
- •Diet framed as a boundary decision: what you let into the body
- •‘Locus of control’: small daily choices add up to major physiology shifts
- •Personal story: ANA positivity and feeling worse than the effort of change
- •Encouragement: symptom improvements (brain fog, joints, energy) reinforce adherence
Regulating the nervous system: breathwork ‘rule of fives’ and embodied trauma healing
Dr. Szal calls breath the most underutilized health tool and teaches slow abdominal breathing (about 5.5 seconds in/out) to signal safety to the body. They discuss why talk therapy alone may not resolve trauma, and why somatic/embodied practices (yoga, meditation, nature, etc.) matter for immune regulation.
- •Shallow chest breathing can reinforce threat signals; deep slow breathing supports safety
- •Rule of fives: ~5.5 seconds in/out for minutes (even 3 breaths helps)
- •Trauma resolution starts with creating safety and regulation in the body
- •Embodiment and somatic tools complement cognitive processing and standard care
Specific conditions spotlight: Hashimoto’s and POTS (and how to test for them)
Mel asks about trending diagnoses, and Dr. Szal explains Hashimoto’s as autoimmune attack on the thyroid, its symptoms, and confirmatory labs. They also cover POTS, its connection to autonomic dysfunction and long COVID, and simple in-office testing plus lifestyle supports.
- •Hashimoto’s: thyroid autoantibodies; fatigue, weight gain, constipation, hair/eyebrow thinning; confirm via thyroid labs + antibodies
- •Hypothyroidism vs Hashimoto’s: Hashimoto’s is the most common cause
- •POTS: orthostatic intolerance with pulse/BP changes when standing; often autoimmune or post-viral (long COVID)
- •POTS supports: electrolytes/salt, addressing insulin resistance, lifestyle-first then meds if needed
Take back control: one priority action and closing message on living regulated
Dr. Szal’s final emphasis is trauma assessment and resolution as a cornerstone for healing and prevention. The episode ends with a broader message: living in a regulated, safe internal state is easier than chronic dysregulation—and practical tools can help listeners reclaim agency in their health.
- •Single most important action: assess and resolve trauma
- •Start with safety practices (breath, meditation, yoga) especially for early-life trauma
- •Regulation sends ‘safety’ cues to immune, nervous, and endocrine systems
- •Closing encouragement: empowerment, actionable steps, and sharing resources with others

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