#02 – Rhonda Patrick, Ph.D.: paradox of IGF-1, ketogenic diets and genetics, benefits of sauna, NAD+

ℹ️ EPISODE INFO

Released

December 17, 2019

Duration

1h 49m

Channel

Peter Attia MD

Watch on YouTube

▶ Open ↗

📝 EPISODE DESCRIPTION

Original release date: 7/2/2018 Rhonda Patrick, Ph.D. and I go on a Nerd Safari into the jungle of health, nutrition, fitness, performance, and longevity. We visit IGF-1 and whether there’s a tradeoff between having high or low levels. We discuss the PPARs (receptor proteins) and genetic polymorphisms. Does Rhonda think there’s any benefit in a NAD+ booster for health and longevity? Can saunas lower the risk of heart disease, dementia, and all-cause mortality? We dig into those questions…and a lot more. We discuss: -What Rhonda believes differently today than she did a few years ago; -The paradox of GH/IGF-1 in performance and longevity; -The role of PPAR in fat metabolism and ketogenic diets; -The possible genetic explanations for why some patients don’t respond well to a ketogenic diet; -The health benefits of heat and cold exposure; -NAD+; and -More. Show notes page: https://peterattiamd.com/rhondapatrick/ About: The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 10 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more. Peter is the founder of Attia Medical, PC, a medical practice with offices in San Diego and New York City, focusing on the applied science of longevity. The practice applies nutritional biochemistry, exercise physiology, sleep physiology, techniques to increase distress tolerance, lipidology, pharmacology, and four-system endocrinology to increase lifespan (delaying the onset of chronic disease), while simultaneously improving healthspan (quality of life). Learn more: https://peterattiamd.com/ Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on: Facebook: http://bit.ly/PeterAttiaMDFB Twitter: http://bit.ly/PeterAttiaMDTW Instagram: http://bit.ly/PeterAttiaMDIG Subscribe to The Drive: Apple Podcast: http://bit.ly/TheDriveApplePodcasts Overcast: http://bit.ly/TheDriveOvercast Spotify: http://bit.ly/TheDriveSpotify Google Play: http://bit.ly/TheDriveGooglePlay

🎤 SPEAKERS

• Peter Attia

  host

  Physician and host of The Peter Attia Drive, focused on longevity, metabolism, and health.

• Rhonda Patrick

  guest

  Ph.D. biomedical scientist and creator of FoundMyFitness, focused on nutrition, genetics, and aging biology.

🧾 EPISODE SUMMARY

In this episode of Peter Attia MD, featuring Peter Attia and Rhonda Patrick, #02 – Rhonda Patrick, Ph.D.: paradox of IGF-1, ketogenic diets and genetics, benefits of sauna, NAD+ explores rhonda Patrick and Peter Attia revisit IGF-1, ketosis, sauna, fasting Both speakers have moved away from the idea that chronically low IGF-1 and constant caloric restriction are the best route to healthspan, favoring cycling between low and high IGF-1 through fasting, refeeding and exercise.

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