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Dr Rangan ChatterjeeDr Rangan Chatterjee

You May Never Eat Sugar Again! – How To Reverse Diabetes & Prevent Early Death | Dr. David Unwin

This episode is brought to you by: Ketone IQ: Save 30% OFF your subscription order PLUS get a free gift with your second shipment https://ketone.com/livemore. Bon Charge: Save 20% off all Bon Charge products with code LIVEMORE https://boncharge.com/livemore The Way app: Get 30 FREE sessions and begin your journey towards peace, calm and wellbeing. https://thewayapp.com/livemore If you have ever struggled with your weight, low energy, pre-diabetes or even type 2 diabetes, this is a conversation that could change your life. Dr David Unwin is an NHS GP who not only put his own type 2 diabetes into drug free remission, he has also helped over 150 patients do the same in a standard UK general practice – with ordinary people, on ordinary budgets, using food and lifestyle. It’s estimated that around 7/8ths of the adult population are metabolically unhealthy, which means that only a tiny minority of us are truly metabolically well. And this is a serious issue because poor metabolic health is one of the root cause drivers of insulin resistance, type 2 diabetes, cardiovascular disease, strokes, Alzheimer’s and many forms of cancer. In fact, this is one of the main reasons why I co-founded Do Health https://drchatterjee.com/do-health/ - a personalised health companion, powered by your individual biology and lifestyle - as a way of helping people improve their metabolic health early, well before they get sick in the future. In this week’s episode, we cover: ● The early signs of poor metabolic health, and why symptoms like fatigue, belly fat and brain fog are often overlooked. ● Why many issues we see as ‘normal ageing’ are actually signs of insulin resistance. ● How David himself reversed his own type 2 diabetes and, at the same time, improved his mood, energy and cognition. ● How reducing starchy carbohydrates if you have metabolic dys-regulation can dramatically improve blood sugar control ● Why so many of us struggle with bread, pasta, and ultra processed foods – and how food addiction may be silently driving our behaviour. ● The two women who helped David rethink everything he thought he knew about food, hope and healing ● And why it’s never too late to work on your metabolic health and why doing so can change every aspect of your life. One of the things I love most about David is his passion. He really is someone who genuinely wants to improve the health and lives of his patients and our hope is this conversation empowers you to make small changes that will improve your blood sugar, weight, energy, and ultimately, your future. #feelbetterlivemore Connect with Dr Unwin: Website https://www.dietdoctor.com/authors/dr-david-unwin Twitter https://twitter.com/lowcarbGP Dr Unwin resources: Teaspoon sugar infographics https://phcuk.org/sugar/ #feelbetterlivemore #feelbetterlivemorepodcast ------- Order MAKE CHANGE THAT LASTS. US & Canada version https://amzn.to/3RyO3SL, UK version https://amzn.to/3Kt5rUK ----- Follow Dr Chatterjee at: Website: https://drchatterjee.com/ Facebook: https://www.facebook.com/drchatterjee Twitter: https://twitter.com/drchatterjeeuk Instagram: https://www.instagram.com/drchatterjee/ Newsletter: https://drchatterjee.com/subscription DISCLAIMER: The content in the podcast and on this webpage is not intended to constitute or be a substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay in seeking it because of something you have heard on the podcast or on my website.

Dr. Rangan Chatterjeehost
Jan 14, 20262h 15mWatch on YouTube ↗

EVERY SPOKEN WORD

  1. 0:005:24

    Early warning signs of insulin resistance (before prediabetes and diabetes)

    1. RC

      David, welcome to the podcast.

    2. DU

      Rangan, thank you.

    3. RC

      I have been so looking forward to this for a number of years. In fact, I can't believe we're only doing it now-

    4. DU

      [laughs]

    5. RC

      ... because I think we share quite a similar philosophy-

    6. DU

      We do. We do

    7. RC

      ... about health and maybe life in general.

    8. DU

      Yeah.

    9. RC

      To start, I wanted to talk about the continuum of health. You're someone who has helped over 150 people in your practice put their type 2 diabetes into remission, which is amazing, and we're gonna-

    10. DU

      Yeah

    11. RC

      ... talk about how you've done that. But at the same time, I don't think there's an awareness out there that type 2 diabetes is the end process. Things have been going wrong with your-

    12. DU

      Yeah

    13. RC

      ... metabolic health for a number of years.

    14. DU

      Yeah.

    15. RC

      So what would you say are some of the signs that we can look for in ourselves that might indicate our metabolic health is a little bit off, and maybe we're on the road to getting type 2 diabetes?

    16. DU

      That's a fabulous question. You're right, it starts years before, uh, you actually have type 2 diabetes. And the things I would say, or the things I noticed in myself actually, because I have type 2 diabetes, so I know a bit about this. The first thing is I used to find myself tired, particularly after meals. So I remember after lunch, even in the practice, I'd have to have a little nap on my own doctor's couch. Isn't that terrible? And I was only 55. I... And I thought that was aging. So the first thing is tiredness, particularly after meals, and also the... I was always ready to lie down in the evening. I was always thinking I'd put my feet up instead of doing anything. That's one thing. Um, another one is, is your belly size, and I, I think loads of us have noticed that. That you, you... We, we, we call that just middle-age spread, but I think that is... That's a euphemism really, because if your belly is more than half your height, you may have a problem. So all you have to do actually is get a piece of string as long as you are tall, cut it in half, and will it reach round the biggest bit of your belly? And in my case, it wouldn't have done. So belly size is another early, uh, thing that people might notice. What else might they notice?

    17. RC

      Cognition.

    18. DU

      That certainly happened to me. Yeah. They call it brain fog, don't they?

    19. RC

      Mm.

    20. DU

      Again, I thought this was normal ageing, so I was 55, which s- I'm now 67, so it's kind of crazy. I just noticed that the younger partners in the practice seemed to have s- intellectually more horsepower, and that was another thing for me, sort of fogginess. Um, but then another odd thing, I remember a thing at Christmas. I got sleepier and sleepier through Christmas and, and slightly depressed. And again, all of that turned out to be reversible, and all of it turned out to be those early signs that I was becoming insulin resistant.

    21. RC

      Yeah.

    22. DU

      And my insulin wasn't working properly. I mean, and then you have the, the various biochemical tests that doctors might do. So, uh, any sign of fatty liver, but maybe we'll come onto that. A third of everybody in the world now has fatty liver.

    23. RC

      Mm-hmm.

    24. DU

      So I had that as well.

    25. RC

      Wow.

    26. DU

      Um, and then in blood tests, uh, a high triglyceride, uh, is a thing that people may have and not know why, why they've got that. So that's on the lipid, fasting lipid panel-

    27. RC

      Yeah

    28. DU

      ... if you do a triglyceride, and it might be high. One final thing with me, I became fretty. So I would sort of chew on stuff for days and sort of circular thinking. It was funny 'cause when I improved my diet, all of those things went away, and my confidence increased. So that's my personal experience, actually.

    29. RC

      Yeah. It's really interesting. You're talking about what on the surface seems to be quite a variety of different symptoms.

    30. DU

      Yeah.

  2. 5:247:33

    David Unwin’s personal turnaround: from unwell GP to medication-free vitality

    1. DU

      I'm changed, really changed. So yeah, I'm 67 now, and I run regularly, which would've been impossible when I was a younger man. It didn't occur to me it was a, a thing I c- I could do. So I can, I can out-sprint my grandchildren.

    2. RC

      [laughs]

    3. DU

      And I'm 67. I've got eight amazing grandchildren. They think it's hilarious seeing an old guy run. They say that I win because they, they laugh so much-

    4. RC

      [laughs]

    5. DU

      ... 'cause they think it's so funny to see an old guy s- actually sprinting.

    6. RC

      [laughs]

    7. DU

      But I can, uh, and all of these things have changed, and I'm not on any medication. Oh, I didn't tell you. I had high, significantly high blood pressure.And do you know, I didn't want to be a patient. Isn't that stupid of me? So I put my head in the sand. I knew it was high. It wasn't that bad. It was like one sixty over ninety-four, ninety-five. I never went to a doctor, but, uh, now my blood pressure's ab-about one twenty over seventy.

    8. RC

      Wow!

    9. DU

      So that's another-- yet another thing, high blood pressure that I sorted out, and all of these things, no medication. And I'm so lucky. So very, very lucky.

    10. RC

      There's so much I want to cover with you today, David. So let's perhaps start off with your personal story.

    11. DU

      Yeah.

    12. RC

      Yes, you've helped, I think hundred and fifty-three patients now put their type 2 diabetes into remission. I wanna hear how exactly you've done that because I think that's gonna be very helpful for everyone listening-

    13. DU

      Yeah, I hope so

    14. RC

      ...as to what they might be able to do in their own lives.

    15. DU

      Yes. Yeah.

    16. RC

      But why don't we start off with you? Because you were the patient.

    17. DU

      Yes.

    18. RC

      You were skeptical of any kind of approach that could perhaps work, and I believe that there were two, what you call two very intelligent women-

    19. DU

      [laughs]

    20. RC

      ...who helped you see things differently.

    21. DU

      Yeah. They were two formidable women, I would say. Formidable. Uh, so yeah, what a shock. The-- Little bit more background before we come to that.

    22. RC

      Sure.

  3. 7:3312:58

    The clinical ‘wake-up call’: a patient who achieved drug-free remission

    1. DU

      So I was unhappy in practice. So I, I was the senior partner of a large practice, ten thousand patients, and I'd-- I wasn't... I was dissatisfied somehow in my mid-fifties with what I'd achieved. You know, we all become-- You-- When you-- Do you remember when you're young, you know, why'd you become a doctor? And it's all like you're all excited by the difference you're gonna make, aren't you?

    2. RC

      Yeah.

    3. DU

      And you can't wait to, you know, get into practice. And I, in my mid-fifties, I was disappointed because it didn't really feel that great because actually the health of the population that I cared for had got worse, not better.

    4. RC

      Mm.

    5. DU

      S-- I, I mean, an example, we're talking about type 2 diabetes. So when I first joined the practice, which was in nineteen eighty-six, so I've been there since nineteen eighty-six, we had just fifty-seven people with type 2 diabetes. Fast-forward, we've now got six hundred.

    6. RC

      Wow!

    7. DU

      So that's a tenfold increase, and it's the same population. But along-- So that-- There's an epidemic for you, an epidemic of type 2 diabetes.

    8. RC

      Mm.

    9. DU

      But I'd also seen an epidemic of obesity. Really just astonishing. So back-- we're going back now to twenty twelve, and I, I'm aware of all these epidemics of poor-- lots of chronic h-ill health. And so h-how, how was I doing? The answer was poorly.

    10. RC

      Mm-hmm.

    11. DU

      So... And I had a sort of feeling. It felt depressing, all the prescribing. Don't know how you felt about that. But I was... You know, you, you add one drug, and then people deteriorate, and you add another drug, and it feels sort of wrong somewhere. Also, they didn't look well. So nobody came in like they were amazingly well, and that's how we come to the first very formidable woman because, um, part of the payment in general practice was to be sure that your patients are taking metformin for their type 2 diabetes. Metformin, I mean, it, it's the baseline treatment for type 2 diabetes. And I had a lady, we knew she wasn't cashing in her prescriptions for months. She was somebody I'd known for years. And so I, I wrote to her to say, "Please, can we, can we have a chat? Because I'm a bit worried about your, your type 2 diabetes." Nothing prepared me, uh, for that woman marching in, um, because she'd, she'd actually got her diabetes into drug free remission, so she wasn't taking any medication. She was a woman who'd had diabetes for a decade. And when we did the blood test, her blood sugars were normal. So I didn't know that could even be done after years of medication.

    12. RC

      And this was in twenty twelve?

    13. DU

      This was-

    14. RC

      Wow!

    15. DU

      ...twenty twelve, towards the end of twenty twelve, and she marched in. But the point was she was angry with me, and she felt I had let her down. And she said-- she explained, really. She said, "I never told you, but the metformin you'd been giving me, uh, gave me diarrhea. But that was a bit embarrassing to mention, so I didn't. I carried on trying to take it. Um, and if only you had told me that it wasn't just sugar I should be avoiding, but the starchy carbohydrates that break down into sugar, I could have had better health years ago, 'cause I had to find out about bread and rice and potatoes-

    16. RC

      Mm

    17. DU

      ...as sugar all by myself. And you're my doctor, but you never mentioned that once, and I, I wonder why you didn't. Surely, Doctor, I mean, this is schoolboy physiology. You know, bread, you should know, uh, from O-level biology that bread is starch, and starch is sugar molecules holding hands. So, you know, I'm even wondering whether you're medically qualified. How could you not have mentioned this in ten years?"

    18. RC

      How, how did you feel when she was starting to attack you like this?

    19. DU

      [laughs] Well, you know, as you get older as a doctor, you fear complaints.

    20. RC

      Mm.

    21. DU

      You really do, because they can run on for years. So I was scared, mainly because she was right. It was a completely justified complaint, and I felt I had let her down. So we, we had to say, "Okay, I agree. I've got stuff to learn."Uh, you know, maybe I have. Perhaps I can do better. Will you help me to do better? And that was-- that helped deflect her anger, but I'm grateful to her because she pointed me... It turned out she was one of forty thousand people-

    22. RC

      Hmm

    23. DU

      ... on a website, all teaching themselves how to improve diabetic control, but being ridiculed by healthcare professionals. They were being ridiculed. So that was the beginning of my mind cracked wide open, 'cause here was proof, right in front of me, that there was a different way. And it's funny, uh, when you look back in life, it's really odd how things can come and change you.

    24. RC

      Yeah.

  4. 12:5824:21

    Hope, behaviour change, and the shift from ‘doctor as prescriber’ to ‘doctor as learner’

    1. DU

      Lot of pivotal moments. And there was another one. The other formidable woman is my wife, Jen. She's a, a clinical health psychologist, and her, her expertise is, um, behavior change and the use of hope in chronic disease.

    2. RC

      Wow.

    3. DU

      So that's really relevant.

    4. RC

      Mm-hmm.

    5. DU

      And, uh, she read a book, which was Beat the Diet Trap by Dr. Briffa. Perhaps you remember Dr. Briffa.

    6. RC

      John Briffa, I do.

    7. DU

      John Briffa. And he was talking about, uh, diet, insulin resistance in this book, and she kept reading it out to me, "David, you have to listen to this. You've got to." And I was a bit resistant to that as well, 'cause I was too tired. You know, why is she going on at me like this? But she-

    8. RC

      It's a vicious-

    9. DU

      Yeah

    10. RC

      ... it's a vicious cycle, isn't it?

    11. DU

      It is.

    12. RC

      You're, you're feeling frustrated at work.

    13. DU

      Yes.

    14. RC

      You know deep in your heart that you're not helping as many patients as you thought you were gonna help-

    15. DU

      Yes

    16. RC

      ... when you were at medical school. There's this sort of evidence coming in front of you that there is a better way to do it, but you're, you're probably too knackered to act on it.

    17. DU

      I was.

    18. RC

      Plus, you've been doing it that way for 30 years.

    19. DU

      Yes. Well, my expertise lay in using medication, um, and I was really tired. I was really tired, and I was actually thinking of retiring anyway. I was thinking of going probably when I was 55, and many GPs do go when they're 55 now. So I'm, I'm now, I think I'm the oldest practicing GP maybe in a 100-mile radius. They've all gone because they get fed up and tired. I was really tired. I wasn't actually well.

    20. RC

      Yeah. It's kind of interesting hearing that and putting it in the context of what you do today. You're very, very active on social media.

    21. DU

      Yeah.

    22. RC

      You are constantly on X-

    23. DU

      Yeah

    24. RC

      ... sharing helpful information, showing you what you're able to do with your patients, publishing data. You're being-- you know, you're traveling to different places.

    25. DU

      I do.

    26. RC

      You're starting charities to help people improve their lives.

    27. DU

      Yeah, yeah.

    28. RC

      You're talking at international conferences. So, you know, h- what does that feel like? If you reflect back and we compare the David Unwin of today with the David Unwin of just 13 years ago-

    29. DU

      Yeah

    30. RC

      ... right? Con- can- contrast that for me.

  5. 24:2128:45

    What to say to a newly diagnosed type 2 diabetes patient (and why consent matters)

    1. RC

      But let's start off with people who do have type 2 diabetes.

    2. DU

      Yeah.

    3. RC

      Which is, you know, do you know the latest stats in the UK? I mean, how common is this now?

    4. DU

      It's somewhere-- I'd say somewhere between five to ten percent of the population, something like that. But we don't know because I'm finding people all the time who don't even know they have diabetes.

    5. RC

      Yeah. So they're not showing up on the research.

    6. DU

      No.

    7. RC

      Right.

    8. DU

      But it's going up, that's for sure. It, it's going up. So yeah, let's start with what-- Do you want to start with, say, a person that's just been diagnosed or-

    9. RC

      Yeah, let's-- In fact, maybe the best way for the audience is to just imagine, you know, what would you say to a patient, right?

    10. DU

      Perfect.

    11. RC

      Who-- A patient who's just been diagnosed-

    12. DU

      Yes

    13. RC

      ... with type two diabetes. What do you say to them?

    14. DU

      Yeah, I can think of a good example. So yeah, I had a, a guy who, who has given his permission, called Dan. He was thirty-nine years old. And, uh, we did a, the hemoglobin A1C, which is the average sugariness of his blood. And if you have the result which is above forty-eight, then that means you've got type two diabetes. So he came into me, and his result was ninety-six, which is sky high. That's really, really high. So what I'm saying to Dan is, "Okay, we've done this blood test, which is the average sugariness of your blood, and it's really, really high. It looks as if your insulin is not working properly. So your insulin is there to get rid of blood sugar, and you're not doing that properly." Um, so the, the point for Dan, uh, right that day is, we've got al-- you and I have alternatives today. I'd, I'd love to suggest a lifestyle change that could have you with much better health and change all sorts. Or it's lifelong medication. Which would you prefer? And the important thing, I think, is to give the patient the choice so that it becomes a collaborative approach.

    15. RC

      Mm-hmm.

    16. DU

      And, um, so Dan, uh, was interested in, in avoiding lifelong medication because he thought, "Well, I'm only thirty-nine, so I'd quite like not to be on, on drugs." And then we're talking about, okay, so if your problem is a high blood sugar, what are you eating that puts your blood sugar up? It's as simple as that. What are you eating? Because a high blood sugar for most people is what they've eaten in the few hours before. So we have to acknowledge that stress can put up blood sugar-

    17. RC

      Yeah

    18. DU

      ... and, um-

    19. RC

      Sleep deprivation

    20. DU

      ... illnesses.

    21. RC

      Yeah.

    22. DU

      All various things. But really, in clinical practice, ninety-five percent of the people you see with a high blood sugar have eaten something that put it up. And I broke the rules for Dan. I actually gave him a continuous glucose monitor to say, "Well, why don't you find out?"

    23. RC

      Hmm.

    24. DU

      You need to know what you're eating that puts up your blood sugar. This is years ago. I did this five years ago. You need to know what puts up your blood sugar and eat something else. And he discovered it in-- for him, it was bread and breakfast cereals were really spiking his blood glucose. And then I'm, I'm teaching people about a nutrient-dense diet. So I want you to get your nutrients of the macros and the, and the, and the micros, you know. Uh-

    25. RC

      Well, for people who don't know what macros and micros mean-

    26. DU

      So the macros, you've got, you've got three macros. So that is carbohydrate, which is a problem for me, uh, somebody with type two diabetes, because carbohydrates, uh, digest down into sugar. You've got fats, and then you've got protein. So I was-- I'd be talking about increasing the protein in Dan's diet, avoiding the carbohydrates and whatever you think healthy fats. But for me, that would be butter.

    27. RC

      Mm-hmm.

    28. DU

      And he'd be having, um, dairy, full fat, um, yogurt, that kind of thing, and loads of green veg. Then the micros are vitamins. So for that patient, it's, do you know what's putting your blood sugar up, yes or no? If you do know, then could you eat differently? Could you base your meal on maybe protein and add in loads of green veg? If you were gonna have, I don't know, steak and chips, do you have to have the chips? Could you not have lots of green veg?

  6. 28:4529:50

    ‘Teaspoons of sugar’ equivalents: making carbs visible (rice, potatoes, bananas)

    1. DU

      And that's what, uh, that's what Dan did. The idea of trying to work out what is putting your blood sugar up. And that brings me just a little segue into the teaspoon of sugar equivalents.

    2. RC

      Please.

    3. DU

      That-- So I had to find a way to help people like Dan understand the consequences in terms of blood sugar for what-

    4. RC

      Mm-hmm

    5. DU

      ... what they ate. And so, uh, I looked at the glycemic index and the glycemic load of foods because I had a hunch. I thought maybe if I could tell you in terms of teaspoons of sugar, this could help you understand what foods to avoid. For instance, so a hundred and fifty grams of boiled rice is equivalent approximately to ten teaspoons of sugar. So if you have a curry and you have a small bowl of rice, well, you've just added ten teaspoons of sugar to your sugar load. Could you have your curry, well, I don't know, with frozen green beans or something else?

  7. 29:5046:08

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    1. RC

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    2. DU

      So this turned out, this teaspoon of sugar idea that I had, was valid. So I went to the experts on glycemic load, one, a famous one, Dr. Jeffrey Leavey, and we published a paper together-

    3. RC

      Mm

    4. DU

      ... looking at many commonly eaten foods and doing a teaspoon of sugar equivalent. So a big baked potato is about nine teaspoons of sugar. Uh, a portion of chips is eight or nine. A banana is five or six teaspoons of sugar.

    5. RC

      Can I just pause you there, David?

    6. DU

      Yes.

    7. RC

      Because I think there's a couple of things to tease out here. So first of all, many people believe rice, potatoes-

    8. DU

      Yeah

    9. RC

      ... bananas, for example, are healthy foods.

    10. DU

      Yes.

    11. RC

      Now, of course, what is healthy depends on the context.

    12. DU

      It does, yeah

    13. RC

      Right? So and, and also, of course, sh- table sugar itself, you know, is not particularly good for your teeth, right?

    14. DU

      Yes. Yeah

    15. RC

      If consumed in excess.

    16. DU

      Fair point. Yeah.

    17. RC

      Um, whereas maybe white rice, you could argue it... Well, I guess what I'm trying to get to, you're talking about, I think, the impact of that food on your blood sugar levels.

    18. DU

      Exactly so. Or because if you have type 2 diabetes, your insulin isn't working properly, you're insulin resistant, so that you can't deal with extra glucose, the sugar we're talking about.

    19. RC

      Okay. So if you were metabolically healthy-

    20. DU

      Yeah

    21. RC

      ... so, you know, not only do you not have type 2 diabetes, but you have no insulin resistance-

    22. DU

      Yes

    23. RC

      ... which is getting rarer and rarer these days.

    24. DU

      Yeah.

    25. RC

      Do you think that these kind of foods are also problematic in that category of people, or is it more in the ones as they get closer and closer to type 2 diabetes?

    26. DU

      Great point. I think if, if we took children and fed them perhaps like our great-grandparents were-

    27. RC

      Yeah

    28. DU

      ... fed from a child, they would be metabolically healthy, as they used to be.

    29. RC

      Yeah.

    30. DU

      As they used to be. And for them, uh, bread was all right-

  8. 46:0851:18

    What to eat on low carb: protein-forward meals, adaptation, and keto basics

    1. RC

      Now, when you-

    2. DU

      The majority of what I've done was not with CGMs. That's come recently. So you're right. Sorry, I interrupted.

    3. RC

      No, no, it's fine. But when you say, you know, cut back on bread-

    4. DU

      Yes

    5. RC

      ... and, uh, pasta and potatoes and rice-

    6. DU

      They always wonder, "What shall I eat?"

    7. RC

      Yeah.

    8. DU

      Oh my God.

    9. RC

      So there will be listeners now going, "Well-

    10. DU

      Well, what's left?

    11. RC

      "Well, I'm gonna be hungry all the time, aren't I?"

    12. DU

      Yeah.

    13. RC

      So what have you found in your experience?

    14. DU

      Right. So I think one of the main things is more protein. A lot of older people don't have enough protein because you're trying, as you get older, to maintain muscle mass, so it makes sense to eat more protein. So I'm basing meals on fish, on chicken, on eggs, on red meat, and then you're adding loads of green veg and some butter if you want, or some olive oil or full-fat mayonnaise, that kind of thing. And there are loads and loads of recipe books, apps, everything online. So I-- my family, so I've been low carb, my wife, my eight grandchildren, my three children, our entire extended family are low carb, and we do Christmas and birthdays by, uh, learning how to cook low carb. You can actually, you can use almond flour instead of wheat flour, so that doesn't have as much carbohydrate in, hardly any. But you begin with having lots more protein, reducing the carbohydrate, 'cause how much you reduce the carbohydrate by varies depending on how sug- sugary you are. Not everybody has to cut it out altogether. Some just reduce it. Some people are having, when they actually admit to how many chocolate bars, how many, uh, sugary drinks they have, how many crisps, snacks through the day, they're having a lot of carbohydrate. So I just would encourage people to have less carbohydrate, and then how do you feel? How's it going?

    15. RC

      Is there a transitional period where people, of course, are used to having the rice and the pasta-

    16. DU

      Yes

    17. RC

      ... and the potatoes, right? So when you start to cut back on that, what do they complain of? Is it-

    18. DU

      Yeah

    19. RC

      ... "I don't know why I don't feel full, Dr. Unwin. I feel like I need something more." You know, what, what are some of the common issues-

    20. DU

      Yeah

    21. RC

      ... that come up?

    22. DU

      Right. Well, actually, most people who go low carb would say they feel a lot less hungry. Most of my patients tell you they're surprised not to be hungry.What some people, um, get is what is called keto flu, that's a bit of a strong word, where they don't feel as good for a few days, and that is because it takes up to a week for the enzyme balance in your liver to change. Your body has to think, "Oh, so this-

    23. RC

      Mm

    24. DU

      ... I'm gonna start burning fat." I think a point I'd like to make now is, is this idea we are a dual fuel-

    25. RC

      Yeah

    26. DU

      ... engine. So we are, gosh, so clever, our design. We can burn sugar or we can burn fat. But what happens is, so if you, if you have a high carbohydrate diet, then your levels of insulin are high, and insulin prevents you from being able to burn your own fat. This is the basis-

    27. RC

      Yeah

    28. DU

      ... of the keto diet. So the keto diet is people who are very low carb, under 50 grams of carbs a day. And because they're very low carb, their levels of insulin are very low, and then suddenly they're able to burn fat. And they, fat is turned into ketones as the fuel, that's why it's called a keto diet. And the keto diet is a type of low-carb diet which is becoming incredibly popular across the world. Um, and that shows very well this transition from relying upon carbohydrates to burn, which is what I did until I was 55 years old, to a greater emphasis on burning fat, which now I am actually, um, I've been on the keto diet for about eight years, and I burn fat.

    29. RC

      Now, some people listening will have heard negative stories about the keto diets.

    30. DU

      Yes.

  9. 51:1854:59

    Evolution, ‘perpetual autumn,’ and why modern eating drives insulin overload

    1. RC

      Do we know, or do you know, how many of our ancestors ate in a way that would be consistent with a ketogenic diet?

    2. DU

      Well, I do actually. Um, the, just a little aside. So years, years ago I was giving a, a speech in, uh, in Tel Aviv. And the dinner afterwards, I happened to sit next to, uh, Dr. Miki Ben-Dor, who is a worldwide expert on what cavemen ate. And he spent his life scraping the tartar off caveman's teeth, and also looking at the is- the bone isotopes.

    3. RC

      Mm.

    4. DU

      So we do know what they ate. And his conclusion, and he's published this, is that, uh, our ancestors were, uh, eating about 70% meat, and the isotope scans were about the same as a wolf. So our ancestors were, ate like wolves in terms of the amount of meat in the diet, and they were surprisingly healthy on that.

    5. RC

      'Cause that's the thing that what people will say, they go, "Okay, well, maybe our ancestors ate that way because they had to."

    6. DU

      Yeah.

    7. RC

      "But do we know what that did to their coronary arteries?"

    8. DU

      No.

    9. RC

      "Do we know what that did to their longevity?" That's, that's the pushback that sometimes comes.

    10. DU

      Yeah, it is. And so just to develop that a little bit, I asked him actually, I said, "Well, didn't they all die when they were about 30?" And, uh, the error in that is that the, if you do the arithmetical mean, it is about 35.

    11. RC

      Yeah, the average.

    12. DU

      The average. But the average is skewed very badly by infections killing children.

    13. RC

      Yeah.

    14. DU

      So if, as a cave, uh, as a caveman, you lived to be 12 to 15, you'd probably live to be 60 or even 70. If you once got over the childhood infections-

    15. RC

      Yeah

    16. DU

      ... they lived surprisingly long lives. Um, and just going back to the distribution of what they, what people ate or what the wolves ate. What, what wolves and people ate was more carbohydrate in the autumn if they could.

    17. RC

      Mm-hmm.

    18. DU

      Because they needed to put on fat. So insulin is, is fat fertilizer. So it makes you fatter, gives you a bigger tummy.

    19. RC

      Mm-hmm. Yeah.

    20. DU

      But that actually is adaptive because if you're going to get through the British winter, you've gotta get fat in the autumn. So you've gotta scoff those berries down. So wolves and humans were eating all the carbohydrate, all the berries they could in autumn to survive the winter. And I, I think we should now see we're, we're almost eating in a perpetual autumn now.

    21. RC

      Yeah.

    22. DU

      You can go to the supermarket and buy whatever you like, and have the bananas and the orange juice and the, uh, the waffles and everything. We're eating, uh, in a perpetual autumn for a winter that never comes.

    23. RC

      Yeah. Not only does the winter not come, certainly in this country, Christmas comes in the winter. So actually it's the opposite-

    24. DU

      Yes

    25. RC

      ... isn't it? Whereby we probably get rather gluttonous and overeat-

    26. DU

      Yes

    27. RC

      ... in that time where-

    28. DU

      In winter. We'd be fasting

    29. RC

      ... we'd be fasting. Exactly.

    30. DU

      Yeah. We, we would. And you know, I-It's always, isn't it? It's Father's Day, it's Mother's Day, it's Halloween, it's your holiday. It's, you know, we're eating so much more junk food, so much more sugar than we did when I was little.

  10. 54:591:15:43

    Real-world NHS data: remission rates, cost savings, and safety outcomes

    1. RC

      Mm-hmm. Can you talk about some of your data? Because I think your data, the way you've collected it, is so powerful because you're showing real world evidence-

    2. DU

      Yes

    3. RC

      ... in your NHS general practice-

    4. DU

      Yes

    5. RC

      ... that this, for some people at least, is working incredibly well.

    6. DU

      Yeah. Yeah, no, that's a good idea. Data is so powerful and, and you're talking about real world data. That's the difference as well. This is the Brit- sort of cash-strapped British health service with 10-minute appointments. So in our practice, um, if you, if you go low carb, so of, of all the people with diabetes, about 60% of them have, and it's increasing all the time, have gone low carb.

    7. RC

      In your practice?

    8. DU

      In our NHS practice. So we've... As I say, it's a big practice, 10,000 patients. But if you have diabetes in my practice, 60% is likely that you'll have gone low carb. The, the people that go low carb, we know that if they go low carb, 50% of them will achieve drug-free type 2 diabetes remission at three years. So it's not like in the first six months, they still have it three years later. And then you've got to ask, well, what happens, you know, are the other 50% dead? No, they're not. Uh, so we've got 50% improve to a point where they've, they've got drug-free remission. A further 48% have improved their blood sugar significantly.

    9. RC

      But haven't quite hit the threshold for remission.

    10. DU

      Yes, that's right. Or maybe they're on less medication.

    11. RC

      Yeah.

    12. DU

      So they're actually-

    13. RC

      So it's still great.

    14. DU

      It's amazing.

    15. RC

      Yeah.

    16. DU

      Yeah, yeah. Because the average improvements are 21 millimoles per mole in hemoglobin A1C, which to the doctors out there, that's, that's better than metformin would achieve. So even the ones that don't get remission, they're still getting a significant improvements-

    17. RC

      Mm

    18. DU

      ... in, in blood sugar, and only at the end of, uh, three years, only 2% have worse diabetes than when they began. Whereas if you did nothing, of course, diabetes would tend to deteriorate for everybody. So that's just-

    19. RC

      What, what, what do we get taught? It's a progressive, chronic-

    20. DU

      Yes

    21. RC

      ... irreversible-

    22. DU

      Yeah

    23. RC

      ... condition.

    24. DU

      So, so we've act-

    25. RC

      Which is just not true.

    26. DU

      Yeah, no. That, that's exactly... I just like you used to think, well, I'll add one drug and another, and I'm so proud of this data because it proves in the health service we can do-- we have a different way. And another statistic is that we will... There's nationally collected data-

    27. RC

      Mm

    28. DU

      ... on what my practice spends on type 2 diabetes. And compared to 20 local practices, all the 20 local practices, we've spent £370,000 less on drugs for diabetes since 2018. So we've saved money.

    29. RC

      Can-

    30. DU

      And there's more. There's more.

  11. 1:15:431:26:09

    Beyond low carb: Roy Taylor’s low-calorie approach, bariatric surgery, and the liver-fat model

    1. DU

      We should mention that, yes. There are-

    2. RC

      One of the ways, the way that you've used yourself and you-

    3. DU

      Yeah

    4. RC

      ... recommend to many of your patients is the low-carb approach, but it's not the only way, is it?

    5. DU

      No, not at all. And-

    6. RC

      I think it's an important point

    7. DU

      ... yeah, it's very, you know-- So, I mean, we must mention the work of, of Professor Roy Taylor-

    8. RC

      Roy Taylor, yeah

    9. DU

      ... who's a friend of mine, and he was a senior author on my last paper.

    10. RC

      And his work's great.

    11. DU

      He-- Yeah. So he, he's, he's doing, he's doing it a different way, which is, uh, just over eight hundred calories a day of the soups. Um, and the, the-- you can prescribe those. So he's, he's giving people a low-calorie diet, but actually it is low carb as well, of course. 'Cause it, you know, if it's low calorie, if it's low food, if you're only having eight hundred calories a diet, uh, uh, a day, that has to be low carb. But that's actually on prescription and, and what's interesting is bariatric surgery works really fast as well. Bariatric surgery can have people off insulin.

    12. RC

      But of course, there is a consequence to bariatric surgery, right?

    13. DU

      Well, there are.

    14. RC

      When you, when you're talking about risk rewards-

    15. DU

      You can't reverse it. Yeah

    16. RC

      ... or the pros and cons.

    17. DU

      Yeah. It's major surgery, and there's a mortality involved. So again, sharing with patients, which would you like to do? Um, so yeah, bariatric surgery can't be reversed. And it-- Bariatric surgery, for me, doesn't very well address what your problem actually is. And I think one thing you and I haven't talked about is we're both passionate about what-- why is this person suffering in this way?

    18. RC

      Yeah. Exactly.

    19. DU

      What's upstream? And, you know, what's upstream of diabetes is like, why did you eat like that?

    20. RC

      Yeah.

    21. DU

      And one of the reasons that you-- I ate a lot of junk food was I was kind of addicted to it. So, you know, I could have had bariatric surgery, but would that have cured me? Would it have taught me to eat better?

    22. RC

      Mm-hmm.

    23. DU

      I wouldn't have learned. So the drawback of bariatric surgery is it's, it's technically good, but have you learnt how to care for yourself? Have you learnt how to make it a long-term success? And we know that people who have bariatric surgery, after about two years, a significant number of them are gaining weight again by their, their blitzing Mars bars or so- that kind of thing, or some of them are drinking.

    24. RC

      Yeah.

    25. DU

      And that's because bariatric surgery did not deal with their actual problem.

    26. RC

      Yeah.

    27. DU

      It sort of put them in low-carb jail, and then they'd find a way around that.

    28. RC

      Yeah. I wanna talk about food addiction in just a moment-

    29. DU

      Yes

    30. RC

      ... 'cause I know you've got a lot of thoughts. I know your wife-

  12. 1:26:091:36:34

    Guidelines, curiosity, and why medicine struggles to adapt

    1. RC

      Well, some people will say, critics of this kind of approach-

    2. DU

      Yeah

    3. RC

      ... you, you know, I'm a fan of this approach. I-

    4. DU

      Yeah

    5. RC

      ... I used this approach on BBC One back in twenty fifteen-

    6. DU

      Yeah

    7. RC

      ... and helped a lady, I think still to this day, from what I can tell, was the first time that that had ever been done on television anywhere in the world-

    8. DU

      Yeah, it was. I watched it

    9. RC

      ... in thirty days.

    10. DU

      Yeah.

    11. RC

      Put type two diabetes into remission.

    12. DU

      I was cheering to that.

    13. RC

      Yeah.

    14. DU

      Yeah.

    15. RC

      And I mean, it's, it's a-

    16. DU

      You were my hero. I was like, "Wow. Yes."

    17. RC

      It's, it's-

    18. DU

      "Great"

    19. RC

      ... incredible. That was ten years ago, but I remember back then that was so controversial.

    20. DU

      It was.

    21. RC

      Um, that was twenty fifteen.

    22. DU

      Yeah.

    23. RC

      And I'm thinking... You know, I, [chuckles] I remember going back into my NHS practice after that aired, and I actually can still remember a conversation with one of my colleagues who watched the show and said, "You shouldn't have done that." I said, "Why not?" He said, "Well, I've just been to the diabetes conference in Cardiff-

    24. DU

      Mm

    25. RC

      ... and you shouldn't have put them on a low-carb diet. That's not the recommended diets." And I remember saying, "Yeah, but did you see what happened? Did you see the results?" "Doesn't matter," she said. You know, "That's not the recommended diet." And I, I remember thinking-

    26. DU

      Yeah

    27. RC

      ... oh, wow, this is kind of crazy. Like, this patient [chuckles] has had her health transformed. She's in remission.

    28. DU

      [chuckles]

    29. RC

      But such is the conditioning of our training that even a colleague of-- just couldn't see through it.

    30. DU

      Yeah.

  13. 1:36:341:52:54

    Ultra-processed food addiction: cravings, relapse cycles, and long-term maintenance

    1. RC

      What have you observed there?

    2. DU

      I think, so quite a lot of, uh, my female patients have told nobody that maybe they're addicted to bread or that they're secret eating or all sorts of things because they're ashamed or they-

    3. RC

      Mm

    4. DU

      ... you know, maybe they have a weight problem and, and that they suffer with stigma because of that. And so they, you know, they, they just think maybe they're weak-willed or something.

    5. RC

      Mm.

    6. DU

      And nobody's ever said to them, you know, "What if, if your problem was addiction?" You know, because so somebody with alcohol, well, then they're not an alcoholic to annoy me. They don't-- People with cigarettes don't smoke cigarettes to annoy me. It's an addiction problem that they can't regulate it.And therefore, moderation doesn't work very well with cigarettes and half a glass of whiskey. There's no doctor I know who would say half a glass of whiskey is okay, uh-

    7. RC

      If you're a, if you're a dead set.

    8. DU

      Yeah. And so I'd started thinking about women, uh, in terms of carb addiction. This is my wife's work 'cause she is a carb addict. I was married to one and didn't even realize.

    9. RC

      Mm.

    10. DU

      So I'd known her for so long. But then, um, just to finish on that, I actually just... I thought it was women, and then I started asking the blokes, and actually, some of them were carb addicts as well. So I, I don't know where that's going.

    11. RC

      But this topic of food addiction, again-

    12. DU

      Yeah

    13. RC

      ... has also been quite controversial-

    14. DU

      Yes, it is controversial

    15. RC

      ... because for many years-

    16. DU

      It's said not to exist.

    17. RC

      Yeah, they said it doesn't exist and you can't... Be-because of course, you don't need alcohol, you don't need a cigarette to exist. People used to say, well, and I think many people still do, that, well, you know, you need food, so you, you, you know, you can't be addicted to food.

    18. DU

      Yes.

    19. RC

      Or that was one of the lines of thinking-

    20. DU

      Yes. Yeah. That's-

    21. RC

      ... which I've always found a little bit problematic because if you look at the way people's behaviors are around foods, some people-

    22. DU

      Yes

    23. RC

      ... and you compare it, you're like, well, whether you wanna technically call it addiction or not-

    24. DU

      Yeah

    25. RC

      ... I think that looks like an addictive behavior for that individual.

    26. DU

      Right. Right. I have a few things to say on, a few things to say on that. So yes, we're told officially, uh, ultra-processed food addiction doesn't exist, so the... there are no clinical services for this problem. And what's interesting about this is, well, I've got clinics, I can refer you for, uh, nicotine, I can refer you for alcohol. But how about this? I can refer you for gambling addiction and there is no substance even.

    27. RC

      Mm.

    28. DU

      There are clinics, NHS, that is accepted gambling addiction and, and there is no substance even. And then if we come to, well, what is addiction? How would you diagnose addiction as a doctor? And you're diagnosing addiction when intelligent people do things they know harm their health and cannot stop. So somebody intelligent drinks when they know it will harm their health. They... nicotine when they've had a heart attack. But isn't it the same as intelligent people, and I know so many people do this, cannot stop eating bread or pasta or whatever it is? They get cravings. There's secret eating, and I've got permission from a patient to give you a specific case that illustrates this so well.

    29. RC

      Mm.

    30. DU

      And, um, I've seen this guy in the last week to check that we're, we're fine, and he wants me to tell this story. So this is a successful business person. He runs a business, and he has poorly controlled diabetes, and he's overweight. He has a really, a, a severe orthopedic problem, and he can't have the surgery on his orthopedic problem because his diabetes is so badly controlled. So he's been refused by the anesthetist for surgery.

  14. 1:52:542:03:29

    Family, budget, and environment: making low carb workable in real life

    1. RC

      Your children have also gone low carb-

    2. DU

      Yeah, yeah

    3. RC

      ... I believe, even though they don't have type 2 diabetes.

    4. DU

      Correct.

    5. RC

      So what was the motivation for them?

    6. DU

      That's ri- So we, we struggled in the family. So Jen and I did it first, and we annoyed the teenagers.

    7. RC

      [laughs]

    8. DU

      And, you know, 'cause they felt they had a right to the... So it was a r- it was a real struggle for the first few years. So we, we had to compromise, and I remember we used to have... First of all, we had carbohydrate corner.

    9. RC

      [laughs]

    10. DU

      So that was the, the, there it is. Okay, kids, that's your bit. And then we started thinking a bit, well, that's a bit disappointing because don't we love our children more than ourselves? And is that okay to just let them ruin themselves as I ruined myself? So that was... It was a worry anyway.

    11. RC

      Mm.

    12. DU

      And then we adapted it slightly, which is we did meals. So the protein was okay, the green veg was okay for everybody. If you wanted rice or oven chips, go and fix them yourself.

    13. RC

      Okay. [laughs]

    14. DU

      And they're dead lazy. Teenagers are dead lazy. And they, you know... So they made a fuss, and then they were just too... But we didn't, we didn't corner them.

    15. RC

      Mm.

    16. DU

      We, you know, we didn't corner them. We said, "Listen, we want to be fair. You know, we've, we, we used to get... You can get rice in little things that you put in the microwave." So we bought those for them. "Go and get it if you want it." And that was one approach that worked really well.

    17. RC

      Wow.

    18. DU

      Just like you fix it yourself if, if you want. But the other thing was Jen really went... She majored on delicious low-carb food. So she can make birthday cakes with almond flour.

    19. RC

      Wow.

    20. DU

      She can make pancakes using gram flour. So gram flour has got loads more protein. It's much better in many ways.

    21. RC

      Mm.

    22. DU

      It's a far superior flour to wheat flour. So she's making pancakes. She's making, uh, batter. So what's-

    23. RC

      So you're not depriving yourself.

    24. DU

      No.

    25. RC

      Right?

    26. DU

      So if you can have pancakes with fresh raspberries and double cream, well, that, isn't that okay? Or then I started doing a thing which is I was blending. I'd say, you know, "I'll make you some ice cream." So I would blend double cream with frozen raspberries at the table.

    27. RC

      Mm.

    28. DU

      And they'd kind of think that's fun.

    29. RC

      Mm.

    30. DU

      And it's like no pudding or that. So we were sneaky really. We learnt how, we learnt how to do really tasty low-carb cakes-

  15. 2:03:292:15:46

    Prevention and policy: taxing ultra-processed foods, planning laws, and better early testing

    1. RC

      I just wanna finish off, David, talking to you about prevention.

    2. DU

      Yes.

    3. RC

      We started off talking about people who were already sick.

    4. DU

      Yes.

    5. RC

      Maybe they were type 2 diabetic, or they were-

    6. DU

      Yeah

    7. RC

      ... pre-diabetic. They were just in that threshold just before.

    8. DU

      Yes.

    9. RC

      But this topic of prevention is really interesting to me. My sense is that the NHS doesn't really have prevention in its DNA.

    10. DU

      I agree.

    11. RC

      And I, I, I'm not saying that to be critical of any of them. The NHS-

    12. DU

      Mm

    13. RC

      ... has been wonderful at so many things over the years. But I don't think we really... I think it's very hard to do prevention well because I, I just think the whole model was developed around a different world, and maybe more acute problems that people came in with. So this idea of prevention is not really there. So my question to you is, if you could redesign the healthcare system to be more focused on prevention, what are some of the things you would do? What are some of the tests that you would like to offer people that they don't currently get?

    14. DU

      Fabulous. You're going to... Why not make me prime minister for a few weeks?

    15. RC

      [laughs] Let's do it.

    16. DU

      I think I'll do that-

    17. RC

      [laughs]

    18. DU

      ... because I think it's bigger than that. I, I think it's beyond medicine now. So with my new power, because you did say I could be prime minister for a minute then-

    19. RC

      [laughs]

    20. DU

      Um, the point you make is so good. The answer cannot be to drug everybody. The answer cannot be that we, what, we give the fat jabs to teenagers. Shall we do them all? Do we even know the long-term consequences?

    21. RC

      No.

    22. DU

      We haven't a clue. It's becoming ridiculous how many sick people there are, and prevention must be... I think the problem has been that we live in a political system, and each government has to get results within a few years.

    23. RC

      Yeah, exactly.

    24. DU

      And so prevention doesn't sound quite as sexy, and yet it's the only way.

    25. RC

      It's the only way to start.

    26. DU

      The health service is breaking. The health service, all my friends, they're breaking through the amount of chronic disease. It's getting worse and worse and worse. And so, um, for me, my big picture is just like cigarettes, why don't we tax ultra-processed food for the damage that it does? We know it affects all-cause mortality.

    27. RC

      Yeah.

    28. DU

      We know that. But what should we do with the money? And I think, should we not... This has been done in Brazil. There was a city in Brazil, and what they did, they taxed, this was Coca-Cola, which was the problem, ultra-processed food, and then they subsidized locally produced food in farmers markets.

    29. RC

      Right.

    30. DU

      So that you, you know, you think how is the food produced, uh, nearby? That deals with your air miles. It also helps local farmers, um, and shopkeepers or, you know, the local economy benefits rather than flying avocados from Brazil, you know. Subsidize locally produced foods, and then also you have to help people learn how to cook again.

Episode duration: 2:15:46

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