Skip to content
Tim FerrissTim Ferriss

The Random Show, Couch Edition! — Supplements, Breathing and Balance Training, and Much More!

Welcome to another wide-ranging “Random Show” episode that I recorded with my close friend Kevin Rose! We cover our recent Zen meditation retreat with Henry Shukman at Mountain Cloud Zen Center in Santa Fe, the fascinating science of vagus nerve stimulation, my recent back pain breakthrough, balance training tools, tendon-strengthening protocols from Swedish rock climber Emil Abrahamsson, the emerging research on photobiomodulation, urolithin A supplementation, blood flow restriction training, the Norwegian 4×4 protocol for cognitive longevity, podcast recommendations, vintage Japanese finds on Etsy, Kevin’s hummingbird feeder obsession, and much more. This episode is brought to you by: Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating: https://EightSleep.com/Tim Cresset family office services for CEOs, founders, and entrepreneurs: https://CressetCapital.com/Tim AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim [00:00] A meditative start. [02:08] Reflecting on our second Zen retreat in Santa Fe with Henry Shukman. [03:59] Ketone liver warnings and eggplant allergies: The perils of raiding Kevin's fridge. [07:59] "Just be still" — three simple words that miraculously shut down my OCD. [13:49] Is meditation secretly vagus nerve stimulation? [17:14] DIY vagus nerve stim for $25 vs. Kevin's $900 ear clip. [22:01] HeartMath and watching your HRV move in real time. [25:04] Marching toward 50: balance boards and the end of jiu-jitsu. [28:39] Tony Hawk snowboarding Hokkaido with screws in his hip. [30:15] Slacklining and why your nervous system needs sleep cycles. [32:36] Bertolotti's Syndrome: My six-year back pain gets a name. [34:34] The nerve block test: everything wrong, zero pain. [40:10] Abrahangs tendon protocol: 10 seconds on, 50 off. [42:27] The NUG: a pocket hangboard for travelers. [44:44] Craig Mod's Japanese toothbrush and Toaster's cameo. [46:58] Kevin's $92 vintage fire jacket: Blue Heritage Japan. [50:43] Podcast picks: The Power Broker and STEM Talk. [52:25] Alzheimer's: A plaque or mitochondrial problem? [53:46] 10 grams of ketones turns one-word answers into sentences. [54:58] Methylene blue on Amazon: 120 years of research, zero guardrails. [59:03] Bredesen Protocol, APOE genotyping, and a cognitive comeback. [01:02:06] Photobiomodulation: $30k laser to the forehead. [01:04:31] Urolithin A and the high price of mitochondrial upkeep. [01:11:38] Recipe for disaster pants: espresso + creatine + MCT oil. [01:14:29] Norwegian 4x4 training and lactate as a brain lever. [01:20:17] Blood flow restriction cuffs and schwantz ring koans. [01:26:21] Hummingbirds named Sunset and squirrel obstacle courses. [01:29:12] Parting thoughts. Tim Ferriss is one of Fast Company’s “Most Innovative Business People” and an early-stage tech investor/advisor in Uber, Facebook, Twitter, Shopify, Duolingo, Alibaba, and 50+ other companies. He is also the author of five #1 New York Times and Wall Street Journal bestsellers: The 4-Hour Workweek, The 4-Hour Body, The 4-Hour Chef, Tools of Titans and Tribe of Mentors. The Observer and other media have named him “the Oprah of audio” due to the influence of his podcast, The Tim Ferriss Show, which has exceeded one billion downloads and been selected for “Best of Apple Podcasts” three years running. Sign up for "5-Bullet Friday" (Tim's free weekly email newsletter): https://go.tim.blog/5-bullet-friday-yt/ Follow the Tim Ferriss Podcast: https://tim.blog/podcast/ Visit the Tim Ferriss Blog: https://tim.blog/ Follow Tim Ferriss on Twitter: https://twitter.com/tferriss/ Follow Tim Ferriss on Instagram: https://www.instagram.com/timferriss/ Like Tim Ferriss on Facebook: https://www.facebook.com/TimFerriss/

Tim FerrisshostKevin Rosehost
Mar 18, 20261h 30mWatch on YouTube ↗

EVERY SPOKEN WORD

  1. 0:00 – 2:08

    A meditative start.

    1. TF

      You wanna just move the base? You can. Just pick it up. [base clunks] [ding] You can also pick the whole thing up if you want to.

    2. KR

      That's the smallest-

    3. TF

      [laughs]

    4. KR

      ... smallest micro change I've ever seen in my life.

    5. TF

      [laughs] That was amazing.

    6. KR

      [laughs]

    7. TF

      Okay, ready?

    8. KR

      Oh, wait, wait, wait. So we're rolling?

    9. TF

      Yeah, we're rolling.

    10. KR

      Okay.

    11. TF

      Three, two, one. [base rings] [laughs]

    12. KR

      I feel like my-

    13. TF

      Feels actually really good. [laughs]

    14. KR

      I feel like my bowl is a little smaller than yours.

    15. TF

      [laughs] It's, it's, it's always been, it's always been the case.

    16. KR

      [laughs]

    17. TF

      [laughs]

    18. KR

      You wanna kick it off?

    19. TF

      Hello, friends and family, colleagues, uh-

    20. KR

      That was amazing

    21. TF

      ... very prominent ejaculation projection.

    22. KR

      Welcome to the Lorana Show.

    23. TF

      Welcome, folks, to another episode of the Lorana Show.

    24. KR

      Yes.

    25. TF

      Couch audition edition.

    26. KR

      That's right. ADU back of my place-

    27. TF

      Yeah

    28. KR

      ... edition.

    29. TF

      Why do we have these fancy bowls?

    30. KR

      So this is-

  2. 2:08 – 3:59

    Reflecting on our second Zen retreat in Santa Fe with Henry Shukman.

    1. KR

      Where should we start off, man?

    2. TF

      Well, so-

    3. KR

      We got tons

    4. TF

      ... we just came back from our retreat.

    5. KR

      We did. We did. You wanna describe the, the format?

    6. TF

      Yeah, so we've done a couple of these retreats. This is the second one, where it's just a small group of people that are interested in meditation and that wanna go a little bit deeper in the world of Zen. You know, you and I both have talked about The Way and Henry Shukman a ton, The Way being his app, and Henry's just a great leader, a great Zen master, and it was accompanied by Valerie, another Zen master, and-

    7. KR

      This was at Mountain Cloud

    8. TF

      ... at Mountain Cloud Zen Center in Santa Fe, New Mexico.

    9. KR

      In Santa Fe.

    10. TF

      So we flew out there, small group, got together, and it's kind of like if, if a, if a proper Zen retreat is, like, 5:30 cushion in the morning and then you're off at 7:00 PM, and it's hardcore, like no talking, shitty food, this was not that. [laughs] Like, this was, we had a good, good chef that was there, and we were allowed to ask questions in between sits. The sits were purposely kind of time-bound, to call it maximum of 25 minutes, and then a walking meditation, then another 25 minutes. That was, like, kind of the max.

    11. KR

      Yeah. Let me, let me interject, just so we don't get into hyper bougie territory-

    12. TF

      Yeah

    13. KR

      ... too fast. So the chef was not our chef. [laughs] He's actually, as I remember, this is a former, I think, James Beard Award winner-

    14. TF

      Yeah

    15. KR

      ... who decided to forgo the accolades and the attention.

    16. TF

      How is that less bougie than what I was gonna say?

    17. KR

      Well, you said we had a, like, a, a, a nice chef, and people might assume that we're, like, bringing in a chef. This is a chef who actually-

    18. TF

      He lives there locally

    19. KR

      ... lives ... I know. That's the point I'm making.

    20. TF

      Okay. [laughs]

    21. KR

      He lives at the Zen center and has chosen a life of simplicity working with local ingredients and so on.

    22. TF

      Yeah.

    23. KR

      And he is also normally there. It's not like we had our own dedicated-

    24. TF

      That's right

    25. KR

      ... chef.

    26. TF

      That's right. That's only in Tim's house. [laughs]

    27. KR

      That's only in my house. I

  3. 3:59 – 7:59

    Ketone liver warnings and eggplant allergies: The perils of raiding Kevin's fridge.

    1. KR

      eat, I eat venison jerky sticks most of the time.

    2. TF

      [laughs] And lentil-

    3. KR

      Lentils. Lentils out of a can.

    4. TF

      Still, it's good.

    5. KR

      And you chugged my freaking ketones about five minutes ago.

    6. TF

      Oh, yeah.

    7. KR

      Tim, Tim just goes to my fridge and he's like, "Okay, what do you have, too?" And you're like, "Okay, I-

    8. TF

      I wanna see what Kevin's up to. I wanna see the evidence.

    9. KR

      He's like, "Okay, we got a little semaglutide here. We got some Virpatha."

    10. TF

      Virpatha. What else you got?

    11. KR

      He's like, "Ooh, ketones," and he starts chugging my, my ketone esters. [laughs]

    12. TF

      Well, yeah, I unwrapped it, and I was like, "I probably should ask if I can drink this, but I'm guessing this has been in there for weeks."

    13. KR

      Dude, I don't ... That stuff that you drank is, like-

    14. TF

      Yeah

    15. KR

      ... so they make several ver- versions of that.

    16. TF

      Yeah.

    17. KR

      That's, like, the full on, I'm wanting ... Uh, F16 isn't even the latest fighter jet.

    18. TF

      Yes.

    19. KR

      Whatever the gen five fighter jet is, F22, ri-

    20. TF

      It's the highest intensity.

    21. KR

      Yeah.

    22. TF

      This is the Delta G brand Ketone Monoester, which is BHB, which is kind of what you want, bound with something called 1,3-butanediol, which I will say if you see that on the ingredient list of your supplement for exogenous ketones, treat it like a shot of tequila. You really wanna use it in moderation. There's mounting evidence that it's pretty unhealthy for your liver. So just use in moderation in terms of ketone supplementation. But, hey, right before a podcast-

    23. KR

      Yeah

    24. TF

      ... it's a great time for me to take, like, 15 grams. I will not do 30 because, and I talked to, she'll probably come up again, our mutual friend, Dr. Rhonda Patrick, about this. I don't think I'm talking out of school here. But when you take, when I take, and this is true for her as well, and I suspect other people, the full 30, like the entire shot, rather than decreasing anxiety, it actually, for me, spikes it, and I think that could be related to a very rapid rise and then trough-

    25. KR

      Right

    26. TF

      ... afterwards, but who knows? The point is keep it moderate.

    27. KR

      Y- you're the first person to tell me that it impacts liver function.

    28. TF

      Mm-hmm.

    29. KR

      And I have more often than not had elevated liver enzymes-

    30. TF

      Mm-hmm

  4. 7:59 – 13:49

    "Just be still" — three simple words that miraculously shut down my OCD.

    1. TF

      So the retreat, let's finish that off real quick.

    2. KR

      Yep.

    3. TF

      So we got together. What did you learn this time around? 'Cause we've done this twice. You've dabbled in the world of Zen.

    4. KR

      Mm-hmm.

    5. TF

      You've always said, uh, correct me if I'm wrong, but meditation's been a hard thing for you typically.

    6. KR

      Mm-hmm.

    7. TF

      W- where are you now with your practice?

    8. KR

      Well, what I would say is, you know, first thing, speaking as a very much still a novice on any level, I would say that meditation is kinda like sports or exercise. It's like, do you like exercise? Like, well, what kind of exercise, right? Meditation, there's so many different ways-

    9. TF

      Right

    10. KR

      ... to meditate or explore mindfulness. There's the Vipassana approach. There's transcendental meditation. There's Zen, which is very much its own thing, right? And you know more about that than I do. But what I do find helpful about the retreats is you can describe what is going on when you're sitting still with your eyes closed trying to focus on something, in the case of, say, the breath, or trying to just observe whatever comes up.

    11. TF

      Mm-hmm.

    12. KR

      And the feedback that you get from someone like Henry or Valerie where you can do a 25-minute sit and then take a short break, talk about it, and they can say, "Well, given that you experienced this, this, maybe you had restlessness. Maybe you had," in my case, "this sort of planning compulsion," right?

    13. TF

      Mm-hmm.

    14. KR

      So rather than memories or fantasies about who knows what, not necessarily [laughs] gonna run wild with that. But I default to plans, like things I need to do.

    15. TF

      Right.

    16. KR

      And it's like, okay, well, if that's coming up, then Henry might say, "Why don't you try in the next sit," which we're gonna do in 10 minutes or 5 minutes, "A, B, or C?" And then you do it and you provide feedback. And so you're able to really polish the stone moving forward. And similar, I suppose, to a lot of what we might call transcendental experiences, which sounds fancy, but it's really just perhaps not fixating on the self or interrogating what this thing is that we call the self-

    17. TF

      Mm-hmm

    18. KR

      ... which you can do through meditation.

    19. TF

      Mm-hmm.

    20. KR

      You can also do it with, or maybe you're forced to do it in some cases, with psychedelic experiences or other things, breathwork. When I was there at the retreat, you might remember this, I was getting very frustrated and I was like, "Where is all this frustration coming from?"

    21. TF

      Yeah.

    22. KR

      And while I was there, I was like, "I don't know how much I'm getting out of this right now."

    23. TF

      Mm-hmm.

    24. KR

      But when I got back to, quote-unquote, "real life" in Austin, I had like three to five days of this just kind of blissful, calm attention where I was able to get everything done that I needed to get done. There was no rushing.

    25. TF

      Mm.

    26. KR

      There was no looping and any kind of future tripping, and I was like, "Well, that's very interesting." And it also holds true for, say, breathwork, psychedelics. There are many different things that you could look at. And interestingly, maybe this is one way to think of it, I mean, in a sense, there are a lot of parallels between different methods for entering what people might consider a trance state, and I don't think meditation is exempt from that depending on what it is.

    27. TF

      Mm-hmm.

    28. KR

      But if it's a concentration practice-

    29. TF

      Mm-hmm

    30. KR

      ... it's like for sure you're using a mantra or you're using something you're repeating in the case of-

  5. 13:49 – 17:14

    Is meditation secretly vagus nerve stimulation?

    1. KR

      So I came out of the retreat thinking, you know what? Something along the lines of transcendental meditation, not necessarily with that branding, but using a koan.

    2. TF

      Mm-hmm.

    3. KR

      Using just be still-

    4. TF

      Mm-hmm

    5. KR

      ... as a concentration practice that I repeat really gives me a lot of payoff. If I just sit still for 10 to 20 minutes twice a day... Can I tell you my theory on this?

    6. TF

      No.

    7. KR

      So my, my, one of my theories, because I've been going super deep on bioelectric medicine and different ways-

    8. TF

      Yeah

    9. KR

      ... of using electricity in place of pills, basically, and medications, which I think is really the next frontier in a million different ways. People should check out Michael Levin at Tufts and some of the crazy stuff he's able to do. But related to meditation, I did this deep dive with someone named Kevin Tracey, who's very credible scientist, very widely cited, helped discover and explore a lot related to TNF alpha and all sorts of things.

    10. TF

      Hmm.

    11. KR

      And he is incredibly knowledgeable of vagus nerve stimulation. Not the bogus bullshit kind-

    12. TF

      Mm-hmm

    13. KR

      ... which is 99.9% of what you see on the internet.

    14. TF

      Yeah, yeah.

    15. KR

      But using, say, implants the size of an Omega-3 capsule in the neck, which is where the biggest nerves run. It's really like two transcontinental cables running down either side of the neck. Each one has about 100,000 fibers, and if you put an implant in that's giving continuous stimulation on and off, on and off, it's not 24/7, it's incredibly effective for things like rheumatoid arthritis.

    16. TF

      Hmm.

    17. KR

      And actually was FDA approved. It was on the cover of The New York Times-

    18. TF

      Holy shit

    19. KR

      ... the day that I interviewed him. And that raised the question, how? Why? What's going on? And it just so happens when you stimulate the vagus nerve, you activate something called the inflammatory reflex, and you can, in effect, prevent damaging cytokine storms, decrease systemic inflammation of all different types. That word inflammation is kind of a umbrella term for a thousand d- million different things. And I remember chatting with one of my friends who's a professor. He was using the Ten Percent Happier app by Dan Harris.

    20. TF

      Mm-hmm.

    21. KR

      And he was meditating twice a day, and then after like one or two weeks, he's like, all of his aches, which are debilitating, like he had a lot of musculoskeletal issues, they just went away. And one way people might try to explain that is like, "Well, you're becoming more present to your feelings."

    22. TF

      Right.

    23. KR

      "And maybe it was psychosomatic."

    24. TF

      Right.

    25. KR

      But I think it might actually be when you sit still and you inherently end up breathing rhythmically, because you can also stimulate your vagus nerve-

    26. TF

      Mm-hmm

    27. KR

      ... with, say, box breathing and other things.

    28. TF

      Mm-hmm.

    29. KR

      That you do that twice a day. If you were to use an implant or let's just say either ear-based or neck-based stimulation of the vagus nerve, guess how long it lasts? Roughly 12 hours. So you do it twice a day, you're getting full coverage.

    30. TF

      Oh, interesting.

  6. 17:14 – 22:01

    DIY vagus nerve stim for $25 vs. Kevin's $900 ear clip.

    1. KR

      from meditation.

    2. TF

      That's fascinating. So I bought one of the vagus nerve stimulators that hooks onto my ear.

    3. KR

      Mm-hmm.

    4. TF

      Have you seen that one? And you feel like this little tiny pulse of current that's happening.

    5. KR

      Yeah. People who are not watching this may have trouble envisioning this, but I'm actually in communication with a couple of scientists in Scandinavia. I don't wanna dox this guy 'cause I don't think he's public with it yet, but there are two ways currently, non-invasively, to s- to stimulate the vagus nerve-

    6. TF

      Mm-hmm

    7. KR

      ... that are commonly known. One is the neck, where you really like press some type of device. There are a number of them out there, mostly used for migraines or cluster headaches. It's pretty unpleasant. Like, you stimulate the neck and it activates the superficial muscles-

    8. TF

      Oh, yeah

    9. KR

      ... in your face, and it pulls your face down. And I used one of those for probably four to six weeks. Didn't see any systemic benefits. A friend of mine doubled his HRV using one of those devices.

    10. TF

      Hmm.

    11. KR

      Like from, he, he had some, I'm not gonna call it PTSD, but he had some overactive sympathetic drive.

    12. TF

      Mm-hmm.

    13. KR

      The vagus nerve stimulation is associated with the rest and digest parasympathetic

    14. TF

      Mm-hmm

    15. KR

      Okay, which is also why right now I stimulate before bed, five minutes twice a day

    16. TF

      Right [laughs]

    17. KR

      For, [laughs] for the ear-

    18. TF

      Jesus Christ

    19. KR

      For the-

    20. TF

      No, I mean, I ... Talking about the device [laughs]

    21. KR

      For, for the ear, there's something called the cymba concha, think I'm pronouncing that correctly.

    22. TF

      Yeah

    23. KR

      If you ... And people can see, most of the research has been-

    24. TF

      This, this little bit right here?

    25. KR

      Most ... Right here.

    26. TF

      Okay

    27. KR

      And you can look this up online. You kinda want the, the, the portion of the cymba concha that is closer to your sideburns, let's say.

    28. TF

      Okay

    29. KR

      And then you need another piece that is grounding and/or completing the circuit, and that's gotta be touching your skin. The contact point is incredibly important.

    30. TF

      Are there any of these that you like that are consumer available? 'Cause a lot of the stuff, like you, you mentioned-

  7. 22:01 – 25:04

    HeartMath and watching your HRV move in real time.

    1. TF

      Yeah.

    2. KR

      All right. What are we looking at?

    3. TF

      So this ... Have you ever heard of HeartMath?

    4. KR

      I have heard of HeartMath

    5. TF

      Okay.

    6. KR

      Yeah.

    7. TF

      I went to a little mini retreat where they were doing, like, a bunch of different modalities in terms of different therapies and things to, like, just really b- let you be the best version of yourself. And one of the things that they did was they gave you a HeartMath device, and they had a whole class on it.

    8. KR

      Mm

    9. TF

      And I was like, "Yeah, I heard of that thing before. I never tried it." And so I hooked it up to my ear, and it measures your HRV. But what, what blew my mind was that the app, once you launch it, it's like, "Follow this box breathing, and we're gonna watch ... You get to watch your HRV in real time."

    10. KR

      Yeah

    11. TF

      And dude, it ... When I followed it just as, as it was telling me what to do, the HRV just, like, shot up.

    12. KR

      Yeah

    13. TF

      And then I would try and trick it, and I'd be like ... I'd follow it, but I'd think of something really stressful, and my HRV would go down. So there ... I'm telling you, this is the coolest device I have owned in a while, and you lock into this coherence mode as you do this breathing. And it's, it's pretty awesome. It's 250 bucks. I'm not an investor or anything, but heartmath.com

    14. KR

      Heartmath.com. Yeah

    15. TF

      And a 60-day money back guarantee, and-

    16. KR

      [laughs]

    17. TF

      Well, I, I wanna say that because I, I hate recommending stuff

    18. KR

      Affiliate code Kevin 40%. [laughs]

    19. TF

      [laughs] Exactly. Tim, Tim, uh, 20% off. Uh, I, I hate recommending stuff when s-

    20. KR

      Yeah

    21. TF

      ... people spend their money and ... but I will say this was the one, one thing that I was really-

    22. KR

      I've heard good things about HeartMath

    23. TF

      Yeah

    24. KR

      I don't know who's involved. I did ... Maybe you didn't know this. For a period of time, uh, maybe it was about three months, I did training for this specifically bef- I think it was before any retail options were available with a doctor named Leah Lagos, who has a book about this, and we actually in real time would do a video call and identify what type of breathing specifically would have, in real time, the biggest impact on HRV

    25. TF

      Oh, that's cool

    26. KR

      And there is something to this. There's definitely something to this. I can't speak to HeartMath, but I've, I've heard of it before. So don't worry about the device for stimulation, the point being try meditating twice a day for 10 to 20 minutes.

    27. TF

      Yeah

    28. KR

      And if you're like, "Ugh, meditating. God, I'm allergic to that word 'cause it gets used so much," try breathing, right? Use HeartMath or something else. There's not a whole lot you need to worry about. Andy Weil has some very good breathing exercises

    29. TF

      Yeah, 4-7-8. Yeah, so I have box breathing and 4-7-8 on my app Oak. It's still in the App Store And it's 100% free

    30. KR

      Yeah

  8. 25:04 – 28:39

    Marching toward 50: balance boards and the end of jiu-jitsu.

    1. KR

      I don't know what else you got.

    2. TF

      I've got crazy things. I mean, I just had my birthday a few weeks ago, which is crazy 'cause I'm marching towards 50 really quick.

    3. KR

      [laughs] I know.

    4. TF

      And so are you.

    5. KR

      Getting, getting, getting dragged through-

    6. TF

      I know

    7. KR

      ... the doorway with your fingernails leaving-

    8. TF

      It, it's really scary

    9. KR

      ... lines on the linoleum. [laughs]

    10. TF

      Well, what's crazy is, dude, okay, so when I first [laughs] when Tim and I first started hanging out, like, whatever, 15 years ago, 17 years ago, he-

    11. KR

      Maybe like 20. I don't even know how long it's been.

    12. TF

      Close to, close to 20 years ago. Close to 20 years ago. You know, he's like, let me like... Every time you walk into Tim's house, he, like, tackles you with some kind of new jiu-jitsu move to take you down.

    13. KR

      [laughs]

    14. TF

      In, like, the last three years, he's been carrying a ball for his lower back where he's like, "I can't move."

    15. KR

      [laughs] Yeah.

    16. TF

      And it's like old man Tim has appeared [laughs] and, like, that old Tim that would tackle you with a jiu-jitsu move is gone.

    17. KR

      Yeah. And the gentle art, not so gentle-

    18. TF

      Yeah [laughs]

    19. KR

      ... turns out. Yeah.

    20. TF

      But I know one of the things that I wanna really focus on for this next decade is balance, right? Balance obviously is, is such a key thing, and it's the number-one way that people in their, as they get older, in their 60s, 70s and beyond, are actually permanently injured, is by falling and breaking a hip-

    21. KR

      Yeah

    22. TF

      ... and things like that. So two things to show off.

    23. KR

      Like incredible increase in risk, like all-cause mortality if you're older and you break a hip.

    24. TF

      Yes. Uh, uh, turns out breaking hips are not good. So check this out. This one right here I've had for a while.

    25. KR

      Don't fall on your ringing ball.

    26. TF

      So [laughs] I don't... Hopefully. Can you imagine?

    27. KR

      That's [laughs]

    28. TF

      Smash my face on the ringing ball.

    29. KR

      [laughs]

    30. TF

      So I'm gonna show you how this works.

  9. 28:39 – 30:15

    Tony Hawk snowboarding Hokkaido with screws in his hip.

    1. TF

      So, dude, I, when I was just in Japan last week-

    2. KR

      Oof. All right, there we go. That's enough. [laughs]

    3. TF

      When, when I was just in Japan last week, I was out there and I was, I was at this event. Whoops. I was at this friend's birthday party that Tony Hawk's also friends with.

    4. KR

      Yeah.

    5. TF

      So I was hanging with Tony, and he's like... La- Last time I saw Tony, I was like, "Dude, how you doing?" Because he had-

    6. KR

      Tony Hawk, one of the most legendary skateboarders of all time-

    7. TF

      [laughs]

    8. KR

      ... for people that don't know.

    9. TF

      People definitely know who Tony Hawk is, but yeah. You might. [laughs]

    10. KR

      I mean, a lot of people definitely don't.

    11. TF

      A lot of people-

    12. KR

      Yeah

    13. TF

      ... know who Tony Hawk is.

    14. KR

      So, so Tony-

    15. TF

      For the youngsters

    16. KR

      ... last time I saw him, he had a cane.

    17. TF

      Ugh.

    18. KR

      And I was like, this was probably, like, eight months ago or whatever, and I was like, "Dude, how you doing?" And he's like, "I just got a couple screws put into my hip."

    19. TF

      Oof.

    20. KR

      And, you know, he had this injury, and I was like, "Holy shit, man." I'm like, in my head I'm like, "Oh, the fucking legend," you know? Pushing himself in his 50s to do... Like, he's still doing, like, you know, whatever, 720s on the half pipe in, in his mid-50s, like fucking crazy. And I saw him up in, up in Hokkaido, and we're going snowboarding. He's like, "Yeah, I'm going boarding today." [laughs] He has no cane, no nothing. And I'm like, "Do you have pain?"

    21. TF

      Yeah.

    22. KR

      Like, "Do you have pain? Like, do you feel pain? Like, what, what are you doing in your mid-50s, like, doing vert snowboarding?" Like, you know what I mean?

    23. TF

      Yeah, yeah, yeah.

    24. KR

      And he's just like, "Yeah." He's like, "My, my wife jokes that I should have a shirt that says, like, 'Always in pain'" or something like that. [laughs]

    25. TF

      [laughs]

    26. KR

      And I was just like, that is a le- Some people are built like that, though.

    27. TF

      Yeah.

    28. KR

      Well-

    29. TF

      Have you ever seen his shins?

    30. KR

      I'm sure they're just like, he looks like a Thai kickboxer.

  10. 30:15 – 32:36

    Slacklining and why your nervous system needs sleep cycles.

    1. TF

      You, and your birthday, when I was at your birthday in New York probably about, I don't know, maybe seven, 10 years ago-

    2. KR

      Yeah

    3. TF

      ... you had a slackline in your backyard.

    4. KR

      Yeah.

    5. TF

      And I couldn't do it at all.

    6. KR

      Yeah.

    7. TF

      At not even one step-

    8. KR

      Yeah

    9. TF

      ... because it is a very much a nervous system practice.

    10. KR

      It's a nervous system practice.

    11. TF

      So I found this online. It's like a little home one.

    12. KR

      Yeah, that's cool.

    13. TF

      Do you have one like this?

    14. KR

      That's cool. I have played around with these. These, these are pretty sweet. So I have not used The smaller ones. I had one between trees. Same company, Gibbon. And just for people who've never played with this, if you're gonna try it, don't do, like, an hour thinking that you're gonna figure it out in one day. You actually, my f- belief is you need sleep cycles for your nervous system-

    15. TF

      Yes

    16. KR

      ... to try to integrate it. So you're better off doing a few minutes every day, and gradually you'll figure it out. But that's cool. Very portable.

    17. TF

      Yeah.

    18. KR

      So obviously a lot easier to set up and take down than a gigantic thing between two trees with ratchets and everything.

    19. TF

      Yeah, exactly. I just wanted to get one because, again, on the balance front, they, they'll have a little QR code there at the end that you scan, and they give you about 20 or 30 different exercises that you can do with it, like the toe taps where one foot is on and you just tap a toe on each side of the bar. And, like, you're right in ... There's this weird thing, and I noticed this in my kids, where they got those little hover boards for Christmas so they can just kind of zoom around, and they're seven and eight. And day one, like, eating shit [laughs] you know? Helmets, full gear. And day two, my youngest is just like, "Woo, shoo," like just flying all over the place.

    20. KR

      Totally figured it out.

    21. TF

      But they're, but the, it took a couple days of that, that kind of adaption-

    22. KR

      Yeah

    23. TF

      ... and that muscle memory to kind of kick in, which I think all these things do. But yeah, this has been awesome.

    24. KR

      Yeah. And for, for people who might wanna try slacklining, [laughs] don't get on a slackline really far off the ground, number one. But a lot of rock climbing gyms have slacklines set up. So you can potentially get someone to show you the basic ropes, pun intended, of walking on a slackline over there. And it's called Gibbon, pretty sure this is why it's called Gibbon, because if you see really good slackliners, they, they do this with their arms as they're walking across. And what does that look like? It looks like a gibbon, this monkey.

    25. TF

      Yeah.

    26. KR

      And you can s- you can see footage of gibbons walking across, like, rope on small suspension bridges. Pretty fascinating stuff.

    27. TF

      Hm.

    28. KR

      So try it out.

    29. TF

      Awesome.

  11. 32:36 – 34:34

    Bertolotti's Syndrome: My six-year back pain gets a name.

    1. KR

      And, you know, I'll, I'll, I'll throw something out there.

    2. TF

      Yeah, let's do it.

    3. KR

      Because it's related to rock climbing. Well, a couple things. [sighs] Since you brought it up, so for the last two days, you know, we've been hanging out a little bit, and you have not seen my little blow-up Pilates ball that I usually put behind my low back.

    4. TF

      Well, I just mentioned it a few minutes ago.

    5. KR

      I know.

    6. TF

      I know I do see it, yeah.

    7. KR

      No, but you haven't seen it.

    8. TF

      I know.

    9. KR

      So what's going on? Well, it seems like, and this is not going to apply to most people, and this is a work in progress, so it's not definitive. But I ended up meeting with a neurologist and surgeon in Austin.

    10. TF

      And you've injected baby seal stem cells [laughs] into your spine.

    11. KR

      No, no.

    12. TF

      It's gonna be some shit like that. Like it's [laughs]

    13. KR

      Well, no, it's, it's, it, it might apply to a very, very small fraction of the people who are actually-

    14. TF

      [laughs] Here it comes

    15. KR

      ... listening to this. He did imaging. He used to be in a clinic where they ran trials and studies related to something called Bertolotti's Syndrome. And Bertolotti's Syndrome is incredibly uncommon. Most specialists in his profession might see one or two cases in their entire careers.

    16. TF

      Hm.

    17. KR

      But he's seen hundreds. And he looked at my imaging and he said, "You may actually have Bertolotti's Syndrome," and he, he pointed out, they had very advanced imaging. It's the first time it came up. It corresponds perfectly to where I point to when people ask me when I have pain.

    18. TF

      Mm-hmm.

    19. KR

      Or where I have pain, excuse me. And it's, it's in effect where you have a transitional segment, so it's like a lumbar vertebra that's behaving like a sacral vertebra or vice versa. And let's just say it's, like, L5 and the, the transverse processes, I think it's transverse processes on both, try to form a pseudo joint.

    20. TF

      Hm.

    21. KR

      So they basically lay on bone and [laughs] other material to try to create what is then called a pseudo joint. And if you look at textbook cases of Bertolotti's, you're like, "Yeah, of course that's gonna hurt your low back."

    22. TF

      Hm.

  12. 34:34 – 40:10

    The nerve block test: everything wrong, zero pain.

    1. KR

      And as a way of testing the hypothesis, he said, "Well, let's, before we even consider any interventions, let's try to hone in on whether that is accurate or not as a diagnosis. The way we'll do that is there are some nerves that affect that area specifically. There's no, like, radiating effect or anything down the leg. Let's put in effectively a nerve block and then see what happens. Like, we'll inj- we'll put in a nerve block."

    2. TF

      What is a nerve block?

    3. KR

      Basically stops the area from transmitting pain signals to the brain.

    4. TF

      But, like, what, what does it mean, though? What, when you put in a nerve block?

    5. KR

      Well, you, you lay down, in my case, on your face. I hate when anyone is messing with my spine, man. It, it's, like, very ... I've had so many things done to me, and I'm usually cool as a cucumber, but when needles are, like, in or around my spine-

    6. TF

      Oh, ugh. Yeah

    7. KR

      ... I really get the fear sweats. I don't like it at all. But in this case, that was [laughs] required. So you get a, in this case, it was, I think it was lidocaine, small amount of lidocaine to numb the surface.

    8. TF

      Yeah, no shit.

    9. KR

      Then they're going through quite a bit of deep musculature. So they go in and then they're putting in, in, in this case, and obviously you need specialists for this who-

    10. TF

      It was a baby seal

    11. KR

      ... Prolocaine. [laughs] They have baby seal semen.

    12. TF

      [laughs]

    13. KR

      Um, no. It was Prolocaine and something called Kenalog. And but none, none of those specifics are the punchline. The punchline is he's, a- after he did the injection, he said, "Okay. This particular portion of the cocktail's gonna last 18 hours, and then you're gonna get probably two weeks of effect from the Kenalog," something like that, which is a cortisone shot, basically. And he said, "I want you to do all of the things that you think will most piss off your back."

    14. TF

      Hm.

    15. KR

      Like, all the things you've been avoiding, which for me are sitting on hard surfaces, sitting with a slightly flexed back, like if you're sitting on a bar stool and you're kind of like this.

    16. TF

      Hm.

    17. KR

      Any of those. Stretching in that position, sitting on the floor with the dogs. Certainly things like heavy deadlifts, squats. So I did all of that stuff for three days straight. Zero pain. And I'm like, "Holy shit." After having so many specialists from different disciplines say, like, "Yeah, I know you point to that, but that's not the spot. It's actually because there's referral pain from this, this, or this." And just having so many people dismiss how precisely I could point to where I felt the most pain, which, which was consistent over years. Mm-hmm. And for the first time, he's like, "If we look at the imaging, right here, it is exactly where you were- Wow ... pointing with your finger." So I'm, I'm cautiously optimistic. I mean, this is- Dude, that's amazing ... this is the first time in six years. Also, just, like, you have... There are different tools that work for different people. Sometimes it requires multiple tools. A lot of people have benefited from the work of John Sarno, but that school, for instance, in effect says, "None of the imaging really maps to symptoms well. It's all in your head. So- Mm ... do cognitive training and, uh, reconditioning to solve it, because that's- That's the guy that Howard Stern got his back problems fixed through, right? Like- It might be. A lot of people benefit from that space. Yeah. But it's also infuriating to be told, like, every type of back pain is in your head. I'm like, "Really? If I took a ball-peen hammer and smashed one of your- Right [laughs] ... vertebrae, that would be in your head?" Like, I guess technically- Technically it is [laughs] ... since the brain is governing pain, like, fine. Mm. But this is the first time with a very sim- relatively simple but precise intervention. I guess it's been about five days, and it's like I can do everything with no pain. So- Dude, that's amazing ... so what does that mean? Well- Could be the cortisol shot. That's the one thing that's like, hmm. Well, that's, that is going- But you probably had that before, right? Or no? No, I haven't. But, but here's the thing. So that, that's going to have- Anti-inflammatory ... a different... Yeah, anti-inflammatory. It's also gonna basically kind of, for lack of a better term, like puff up the pseudo joint in a way that sort of reverses the chronological [laughs] age or development of that in some ways from a symptom perspective. But the, the... This, this is where, uh, I'll offer people something they can potentially look into, obviously with the help of really, really, really good doctors. If that shot continues to deliver benefits and I can do all these things pain-free, which is the case right now, then there's something called radiofrequency ablation, RFA, which is used to, i- in this case, temporarily completely incapacitate those nerves. Hmm. So they go in, they apply radiofrequency ablation, and that should last for, like, a year to a year and a half, hopefully. And the hope in that case is, okay, with a year, year and a half... And I already spoke, you know, I've spoken to multiple people and they're like, "Yeah, it shouldn't... Even if you resume a lot of your activities and stair step into it that previously caused pain, you shouldn't structurally make that worse," right? Yeah. 'Cause that was a concern. And I think that's an enough, enough of a period of time where you could effectively reprogram your pain patterning, right? Because for years now, it's like if I sit on a hard surface, my brain is like code red, DEFCON 5. Yeah, yeah. Like, you are about to not be able to sleep for six to seven days. Yeah. And you're gonna have trouble walking, and sitting, and standing. So super exciting. Um- That's awesome.

  13. 40:10 – 42:27

    Abrahangs tendon protocol: 10 seconds on, 50 off.

    1. KR

      All right. So you mind if I continue my- Yeah ... TED Talk for a second? Let's do it. All right. So, uh, also [laughs] had long overdue surgery, I think I might have talked about this last time, but on my extensors, right? So the forearm extensors. So this would be considered, like, tennis elbow. Oh, God. Like 20-plus years overdue- Yeah ... from a sports injury. And I am back to rock climbing. I'm not great at rock climbing, but I love it. I just love rock climbing. Feeling really good. And if people have never seen something called [laughs] Abrahangs, so like Abraham, but A- Abrahangs, go on YouTube, find this Swedish rock climber named Emil Abrahamsson, so Abrahamsson, S-S-O-N. He is a monster. Very competent rock climber. Does, like, V13 problems and probably much more. Incredible explainer of things and dives into a lot of training. And he, along with the help of this scientist named Keith Baar, B-A-A-R, who I've actually had on the podcast, developed or tested this protocol for improving tendon strength, and it is the simplest, lowest impact thing you can imagine. Hmm. It's basically 10 minutes twice a day. And he does a bunch on a hang board, but let's keep it simple. Let's say you're hanging on, could be a pull-up bar, could be a door jamb, could be, you know, the, the underside of some stairs, whatever, and he's hanging with, like, 30 to 85% of his weight, so his feet are still on the floor. Mm-hmm. Does that for 10 seconds on, 50 seconds off, 10 seconds on, 50 seconds off, and you do it 10 times. That's 10 minutes. And then you do it again later in the day. And his before and after strength and endurance tests- Mm-hmm ... are mind-blowing. Yeah. This is already a guy who we could say is a high-level climber. Mm-hmm. And to see, [laughs] like, the before and after- Yeah ... is crazy. So you don't always have to kill yourself- Yeah ... to adapt- Yeah ... in really, really interesting ways. And that's something I've really, really benefited from, but the lower back has been a limiter, right? Hmm. For, like, the last few months, because hanging from a bar, if I don't engage the abs, it could cause some issues with the low back and spasming.

  14. 42:27 – 44:44

    The NUG: a pocket hangboard for travelers.

    1. KR

      So I bought this thing recommended by a friend of mine, Nick Norris, who's also been on the podcast, former Navy SEAL, called the NUG. And the NUG is... It's about the size of, like, a gigantic bar of soap. It's a piece of wood, and it has different depths of grips on it. It's, like, 25 millimeters, 20 millimeters, and you can move it around really easily. And basically, like, you could keep it in a jacket pocket And as long as you have a carabiner, like one of those things-

    2. TF

      Mm-hmm

    3. KR

      ... that kinda clicks on, y- you can do all sorts of exercises while you're traveling. And at home, I have basically a, a plate loading pin that you can load plates on.

    4. TF

      Like this?

    5. KR

      Yeah, exactly. So that you can basically do, like, a single-handed deadlift with, with the weight.

    6. TF

      And so this is the same as essentially doing the hanging board?

    7. KR

      It's, it's similar, right? You're gonna be... I'm looking for the same kinda loading. But what you can also do is take this thing that you can fit in your pocket and attach it to, like, a low cable machine. That's what I was doing in Santa Fe-

    8. TF

      Mm

    9. KR

      ... actually.

    10. TF

      Oh, that's cool.

    11. KR

      And just, like, get the weight off the ground, you know, the stack off of the resting position, and then I was doing 10 seconds on, 50 seconds off, 10 seconds on, 50 seconds off.

    12. TF

      And you only have one of these?

    13. KR

      Yeah, because I'll do one hand and then I'll do the other.

    14. TF

      Oh, amazing.

    15. KR

      So I'll be like 10 seconds, 10 seconds, 40 second rest. 10 seconds, 10 seconds, 40 second rest.

    16. TF

      Amazing.

    17. KR

      And I think a lot... Yeah, the, the website is Frictitious Climbing. Uh, it doesn't exactly roll off the tongue, but like friction, Frictitious Climbing. They have the Nug. They have a bunch of other items that you can use while traveling for this, which are really, really interesting. So that's another one that I've been traveling with. I'll let you go, and then-

    18. TF

      Yeah, this is awesome.

    19. KR

      Yeah. It's, it's just a fun little tool to play with. S- Do not overdo finger training. You do not want to tear a pulley or something in your fingers. So less is more. Less is more. Less is more. This is, I guess, something like 30 to 85% of body weight. Uh, and if, obviously, or maybe it's not obvious, if you're doing... That's with two hands. So if you're doing it with one hand, [laughs] it's gonna be, you know, 15 to 40%, let's just say.

    20. TF

      That's amazing. No, this is cool.

    21. KR

      Yeah.

    22. TF

      Thanks. I d- already just ordered by the time-

    23. KR

      Yeah

    24. TF

      ... you done talking about it. [laughs]

    25. KR

      Yeah, yeah. It's, it's fun to play with.

    26. TF

      Cool.

  15. 44:44 – 46:58

    Craig Mod's Japanese toothbrush and Toaster's cameo.

    1. KR

      What you got?

    2. TF

      Yeah, so I've got a couple things. One, I was hanging with Craig Mod in Japan, and you've had Craig on the show before.

    3. KR

      Yeah. Craig-

    4. TF

      Craig is-

    5. KR

      Amazing, amazing guy

    6. TF

      ... I don't think there's anybody that understands, like, Japan the way that Craig does. Like, in, in terms of the backcountry and just, like, the little artisans and all the stuff that he's into.

    7. KR

      Craig has walked, uh, probably fair to say, like, thousands of miles-

    8. TF

      Yeah

    9. KR

      ... of different trails and pilgrimage paths-

    10. TF

      Yeah

    11. KR

      ... in Japan. He's... It's very likely he has walked more of Japan on foot than any other person.

    12. TF

      Yeah. So he was out here visiting. He actually stayed in this house for a week when he was out here in LA. And I walked in, and he's got all his little toiletries, like, sitting out, you know?

    13. KR

      Yeah.

    14. TF

      And I'm always like... It, it's, like, sitting out. He puts it all in Japanese order, where it's like on a little, nice little cloth, and it's got, like, all this shit. Like, even the dress is-

    15. KR

      He even dresses like a Japanese person

    16. TF

      ... Yeah, I know. I know, [laughs] I know.

    17. KR

      So, I mean, he's lived there for 25 years-

    18. TF

      [laughs]

    19. KR

      ... so, like, that makes sense.

    20. TF

      But I saw his toothbrush, and I was like, "That is a dope-looking toothbrush."

    21. KR

      [laughs]

    22. TF

      And I got you one.

    23. KR

      Oh, wow. Look at this.

    24. TF

      So you can get these on Amazon.

    25. KR

      Okay.

    26. TF

      It's got a really wide head. He said it's his favorite Japanese toothbrush. It has some-

    27. KR

      It's, so, so for people who can't see it, it's like the toothbrush bristles are almost in a square, right?

    28. TF

      Yeah.

    29. KR

      I mean, it's very square-like as opposed to being more elongated.

    30. TF

      And so you get three of these for $11.50 on Amazon. And what does that say in Japanese?

  16. 46:58 – 50:43

    Kevin's $92 vintage fire jacket: Blue Heritage Japan.

    1. TF

      it. Thank you. Speaking of all things Japanese-

    2. KR

      Mm-hmm

    3. TF

      ... so I am hesitant to give this up. So if you want to get-

    4. KR

      [laughs]

    5. TF

      If you wanna get a-

    6. KR

      Oh, low in stock. Only one left.

    7. TF

      Well, hold, let me tell you why.

    8. KR

      [laughs]

    9. TF

      So first of all, check this out. Check out this jacket.

    10. KR

      Cool. All right. Oh, nice.

    11. TF

      Yeah, feel how heavy that is.

    12. KR

      It feels like a, almost like a... I know what this is. I know what this is.

    13. TF

      So this is, this is a fireman's jacket in Japan.

    14. KR

      Yeah.

    15. TF

      And this is a, a heavy-

    16. KR

      [laughs]

    17. TF

      ... like, dope fireman's jacket.

    18. KR

      [laughs]

    19. TF

      It's vintage from, like-

    20. KR

      Yeah, this would be hard, hard to rip

    21. TF

      ... like, the 1970s.

    22. KR

      Oh, wow.

    23. TF

      And so I found a store on Etsy.

    24. KR

      [laughs] How did you even think to look for this?

    25. TF

      Because I love this style of jacket.

    26. KR

      [laughs] Japanese fireman, vintage Japanese fireman jacket.

    27. TF

      I didn't type in fireman jacket. I just typed in, like, Japanese jacket on Etsy. And so this importer-

    28. KR

      Yeah

    29. TF

      ... they import, like, the coolest vintage Japanese-

    30. KR

      I'm gonna wear this

  17. 50:43 – 52:25

    Podcast picks: The Power Broker and STEM Talk.

    1. KR

      So I wanna recommend some podcasts for people, and these are two that I continue to revisit. One is this, is a miniseries by 99% Invisible, one of the OGs, Roman Mars. And he's got some co-hosts. It is a series on The Power Broker. So The Power Broker by Robert Caro won the Pulitzer Prize in 1975. It's a biography of Robert Moses, who basically shaped modern New York. And this book is considered the quintessential book to read if you want to understand state and local politics, especially power-wielding in New York.

    2. TF

      Hm.

    3. KR

      And it is, it's a legendary book. It's 1,200 pages. I've never made it through. I've never even really put a dent in it. And then what 99% Invisible does, they walk you through the whole book and kinda give you their highlights. They interview Robert Caro himself, who got to meet Robert Moses multiple times, and they have guest appearances by people like Conan O'Brien, who's a huge Robert Caro and Power Broker fan.

    4. TF

      Hm.

    5. KR

      It's a wonderful series.

    6. TF

      Awesome.

    7. KR

      And I think there are 12 parts. I had listened to it ages ago, but they only had three episodes out, and then I just petered out because I didn't wanna wait months for the next one to come out. Now they have the full 12. So that's one. And then the other one is a podcast called STEM Talk. And if I wanna find interesting scientists doing things that I think I might be able to apply to my life or the lives of loved ones, and certainly there's a lot of stuff that's out on the edges that is not yet ready for any clinical applications, STEM Talk is

  18. 52:25 – 53:46

    Alzheimer's: A plaque or mitochondrial problem?

    1. KR

      just incredible. And my latest discovery there is an inc- a really fascinating scientist named Dr. Francisco Gonzalez-Lima, who's at UT Austin. One of the many reasons I'm interested in his research is that he has a com- a very different view on neurodegenerative diseases like Alzheimer's.

    2. TF

      Hm.

    3. KR

      And thinks, as I do, that people underweight and researchers underweight just how critical or how you might think of Alzheimer's as a vascular disease-

    4. TF

      Mm-hmm

    5. KR

      ... and including mitochondrial dysfunction. And the more I dig into this, th- the less compelling I find kinda amyloid plaque, like amyloid beta plaque, amyloid beta plaque-

    6. TF

      Yeah

    7. KR

      ... for, for a, for a whole host of reasons.

    8. TF

      I mean, it's pretty widely accepted now that that is a byproduct of something gone wrong and not the cause of it, right?

    9. KR

      I do think a lot of doctors and scientists would view it as a byproduct. Nonetheless, a lot of the treatment options, like aducanumab infusions or otherwise, are focused on removing plaque.

    10. TF

      Right.

    11. KR

      But you can remove a lot of plaque-

    12. TF

      It doesn't do shit

    13. KR

      ... assuming it doesn't kill people-

    14. TF

      Yeah

    15. KR

      ... because there are risks-

    16. TF

      The side effects are huge

    17. KR

      ... with the MRI and stuff, and you may not see any-

    18. TF

      Right

    19. KR

      ... change in cognition whatsoever. But-

    20. TF

      What do you think of the Bredesen protocol?

    21. KR

      Dale Bredesen?

    22. TF

      Yeah.

    23. KR

      I ha- I, I don't know much about Dale, so you can illuminate me. Let's get to that in a second.

    24. TF

      Yeah, yeah, go ahead.

    25. KR

      But

  19. 53:46 – 54:58

    10 grams of ketones turns one-word answers into sentences.

    1. KR

      what I have seen, let's just say in the case of some of my relatives. I've got three relatives with Alzheimer's right now. One who's disintegrating very quickly, one who's in hospice, and another who's sort of in the ear- the early but rapidly advancing stages. And if I give... I gave one of them, actually the exact same ketone that I had before we sat down, only 10 grams, 'cause I didn't wanna risk them getting dizzy, which can be a byproduct, and falling. But I gave them 10 or 15 grams, and within 20 minutes, longer sentences, faster speech. This is someone who was giving, like, one-word, two-word responses.

    2. TF

      Mm.

    3. KR

      And that lasted for about an hour, hour and a half. So if plaques, even if we're talking about tau and so on-

    4. TF

      Mm-hmm

    5. KR

      ... if those were solely responsible, that shouldn't work.

    6. TF

      Mm-hmm.

    7. KR

      Right? But I don't wanna be dosing my family with ketones constantly for a lot of reasons. It's like, okay, what else can we do? And this Dr. Gonzalez-Lima has looked at low-dose methylene blue-

    8. TF

      Mm

    9. KR

      ... and also photobiomodulation using lasers or LEDs, like right on-

    10. TF

      Yeah

    11. KR

      ... in most cases, the right prefrontal cortex.

  20. 54:58 – 59:03

    Methylene blue on Amazon: 120 years of research, zero guardrails.

    1. TF

      By the way, do you know that they're selling methylene blue on freaking Amazon now?

    2. KR

      That's scary.

    3. TF

      I know. They didn't used to because they were scared to do it. Now there are supplement companies that are selling straight-up methylene blue on Amazon.

    4. KR

      That's scary. Yeah. Duh.

    5. TF

      Although the safety profile, like it's been used for a very long time.

    6. KR

      Yeah, it's got like 120 years of research. But if you overshoot the therapeutic window-

    7. TF

      Oh, yeah

    8. KR

      ... you can fuck yourself up.

    9. TF

      100%. Yes.

    10. KR

      So in this case it's low dose, ideally plus photobiomodulation, and you're hitting two aspects of the electron transport chain that should be synergistic for mitochondrial function and also glucose metabolism. So that's really got my attention right now.

    11. TF

      Dude, look at this on Amazon. Look at this guy drinking a big pitcher of it.

    12. KR

      Guy's drinking a, like a shaker bottle full of methylene blue.

    13. TF

      With a goldfish. Oh, no [laughs]

    14. KR

      [laughs] You know, methylene blue is what they used for fish tanks, right? To, to color the b- water blue.

    15. TF

      Is it?

    16. KR

      Yeah, they were using it in fish tanks.

    17. TF

      Well, if it's good enough for the fish tanks, I guess.

    18. KR

      Be careful.

    19. TF

      Yeah, look, look at, here it is. General disease, uh, prevention for fish.

    20. KR

      Oh, disease prevention. Well, you know.

    21. TF

      If it works for fish.

    22. KR

      Well, those pet stores figured it out.

    23. TF

      [laughs] Yeah, exactly.

    24. KR

      Be very careful, folks.

    25. TF

      Yes.

    26. KR

      If you overdo, this is true for a lot of things, you basically have a response curve where a hormetic dose, like a very small amount is good for you, kinda like iocane powder [laughs] in The Princess Bride, or it helps with immune function and so on.

    27. TF

      Right.

    28. KR

      If you take too much, it has the opposite effect. So you, you could, I believe, I don't, I don't think I'm getting this wrong, handicap your mitochondrial function by taking too much.

    29. TF

      Dude, look at this. 15 milligrams of methylene blue with 75 milligrams of vitamin C. NeuroPro. I'm not recommending this. This is just one on Amazon.

    30. KR

      It's all over Amazon.

  21. 59:03 – 1:02:06

    Bredesen Protocol, APOE genotyping, and a cognitive comeback.

    1. TF

      Yeah, so, so the, the Dale Bredesen protocol is, is pretty awesome. He wrote a book about six or seven years ago, maybe it's closer to 10 now.

    2. KR

      Ketone Animas, am I right?

    3. TF

      Exactly.

    4. KR

      [laughs]

    5. TF

      That's all, all it is. Uh-

    6. KR

      [laughs]

    7. TF

      Which you tried for the first time today.

    8. KR

      Oh, Jesus.

    9. TF

      Uh-

    10. KR

      Yeah.

    11. TF

      N- well, it wasn't exactly that, but yeah.

    12. KR

      [laughs]

    13. TF

      Um, so the, the one thing I like about, it's called The End of Alzheimer's is the name of his book, is that he's-

    14. KR

      Understood it.

    15. TF

      Yeah, exactly.

    16. KR

      [laughs]

    17. TF

      It n- it won't sell that many copies with that title. [laughs] But what he c- came up with is he said, "Okay, listen, the, the, what we're seeing in the brain is the byproduct of something going haywire. It's either blood-brain barrier breaking down, allowing bad shit in. It could be bacteria.

    18. KR

      Yeah.

    19. TF

      It could be like a whole slew of different things. It, it could be, like you said, an issue with blood flow and it could be, what did you call it? Vascular type, uh, issue.

    20. KR

      Yeah.

    21. TF

      And he thinks it's like three or four. He thinks it's either vascular, which sauna, other things like that help with. CocoaVia.

    22. KR

      Yeah.

    23. TF

      Like other ways to make sure that you have vascular health. Obviously the mitochondria thing is another one that he's huge on, and then he also thinks it's, it could be toxin related as well.

    24. KR

      Sure.

    25. TF

      Like, and, and talking about how to get those toxins out of your body, but his protocol is, uh, that very common sense. It's like-

    26. KR

      What is it?

    27. TF

      It is essentially a handful of supplements, which are all the ones you've basically talked about.

    28. KR

      Mm-hmm.

    29. TF

      Along with, it's like a lightweight keto, so just making sure you go into lightweight ketosis-

    30. KR

      Mm-hmm

  22. 1:02:06 – 1:04:31

    Photobiomodulation: $30k laser to the forehead.

    1. KR

      Yeah. Can I pause for a sec?

    2. TF

      Yeah, yeah.

    3. KR

      So that's part of the reason why the, the methylene blue and the photobiomodulation are so interesting. Because, for instance, there's a device that is actually worth investigating on some level. It's called the Cognito device. It's a headset. It was developed by scientists out of MIT, and it's 40 hertz, I believe, both visual and auditory stimulation. In rhesus monkeys, pretty recently in the last year, they showed a lot of plaque clearance enhanced by this, right? But that's still, if I'm understanding correctly, people fact-check this, but that's still predicated on the theory of disease for Alzheimer's, that by removing plaque you get clinical outcomes, right?

    4. TF

      Mm-hmm.

    5. KR

      The photobiomodulation ... Well, let me ... Before I get to that, as I understand it, this is an hour a day of wearing this device on your head.

    6. TF

      Mm-hmm.

    7. KR

      My mom's not gonna do that.

    8. TF

      Right.

    9. KR

      There's no fucking way.

    10. TF

      Right.

    11. KR

      Right? N- nor any of my relatives. However, the photobiomodulation, it's like eight to 10 minutes, right? Laser or LED. LED is a little harder to make architect-

    12. TF

      And do you have to go in to do that? Or d- can you get a device that does it at home?

    13. KR

      I'm gonna buy a device. And I'm not recommending people do that. You can really damage your eyes with lasers and so on. But right now, it's not like you can go to a clinic and be like, "Hey, I'd like to have this treatment." Just doesn't exist. So let me be the guinea pig [laughs] before anybody does anything. But you get this device and it's ... I'm sure it's gonna be very expensive, right? Some of these lasers, like, there's like $30,000. But eight minutes, eight to 10 minutes, and you s- you can see s- even after a single session, you can see multiple weeks of effect.

    14. TF

      Hmm.

    15. KR

      Crazy. So-

    16. TF

      And so it, it just sits, sits right on top of ... It g- uh, into the eye or on-

    17. KR

      No

    18. TF

      ... top of the-

    19. KR

      Well, y- there are devices that go through the eyes, but this one, what makes it so mystifying in a way for me, is that it's, it's actually pointed at the forehead as an infrared laser. It's so fascinating.

    20. TF

      Wow.

    21. KR

      And there's peer-reviewed published studies on this, which you can find. Anybody who looks up Gonzalez-Lima will, will find it. So it's exciting. It's super exciting. 'Cause there's certain things, like I know that my mitochondria are funky, right? And I, I know that through different types of endurance testing, different types of, obviously all sorts of stuff done through doctors and tests and blah, blah, blah, blah, blah. There's something funky with the mitochondria. And I'm like, "Okay. Well, let's try to get ahead of that."

  23. 1:04:31 – 1:11:38

    Urolithin A and the high price of mitochondrial upkeep.

    1. TF

      Yeah.

    2. KR

      And actually related to that, to invoke, I said she would come back. Rhonda Patrick also, you know, was texting with her at one point because I was listening to STEM Talk-

    3. TF

      Mm-hmm

    4. KR

      ... that podcast I mentioned, and I came across a scientist discussing something called Urolithin A.

    5. TF

      Of course, the Mitopure.

    6. KR

      Yeah, Mitopure. And two years ago, maybe it was two years ago, like she was pretty bearish on it, but there's a lot of new research, or I shouldn't say a lot, there's new research that's come out. And also met with a couple of biotech people in Boston who are very r- respected.

    7. TF

      Mm-hmm.

    8. KR

      I'm not gonna dox them 'cause I don't want to, but they basically did this like comprehensive analysis-

    9. TF

      Yeah

    10. KR

      ... and landed on three or four things, and one of them was Urolithin A.

    11. TF

      Right. I take 300 milligrams a day.

    12. KR

      300? How do you ... How did you choose 300 milligrams?

    13. TF

      Because that's what all of the studies are, are done on. Or no, sorry, 5- so 500 to 1,000.

    14. KR

      Yeah.

    15. TF

      I take 500 milligrams a day.

    16. KR

      Yeah.

    17. TF

      Clearly I need to be taking [laughs] much higher dose.

    18. KR

      [laughs] It's like-

    19. TF

      I've only been doing it ... You think I do it for three months to see some results? So bear with me, people. I only have this club, this 200 milligrams off. [laughs]

    20. KR

      The, the, what's, what's a little strange is that, that when you ... If you buy the bag, you can get this on Amazon, I'm not recommending you do that. Jury's still out. But I'm like, "Hey, I want to hit mitochondria from as many reasonably plausible mechanisms or angles as possible." You can get Mitopure. It's expensive AF.

    21. TF

      So-

    22. KR

      It is very expensive

    23. TF

      ... yeah, so I was gonna, I was gonna tell people that the one that people talk about the most in this world, that, that has done a lot of clinical studies around it, Urothinal- A, is this company called Timeline, who does, who does a, you know, they trademark the name of it, which is Mitopure. The problem is it's freaking expensive.

    24. KR

      It's very, very expensive.

    25. TF

      And I don't know, is there another company that's out there that has high quality? 'Cause I want ... I'm not gonna put shit into my body, right?

    26. KR

      Yeah.

    27. TF

      So the difference between ... But I would like to know, i- is there any company that has-

    28. KR

      Yeah. When you say expensive, it's like 60 count is $125, right?

    29. TF

      Right. And you're taking two a day.

    30. KR

      It's expensive, yeah.

  24. 1:11:38 – 1:14:29

    Recipe for disaster pants: espresso + creatine + MCT oil.

    1. KR

      deprivation.

    2. TF

      Holy shit. Good luck. [laughs]

    3. KR

      Yeah.

    4. TF

      Good luck making it to the toilet. [laughs]

    5. KR

      It's... [laughs] Yeah. Don't, don't, don't-

    6. TF

      The creatine jacks your stomach up, right?

    7. KR

      Don't combine... Actually, I'm fine with creatine. If I get-

    8. TF

      You told me at one point it was messing you up, though.

    9. KR

      Well, there was the story of me... What did I have? I had... I was in San Francisco. This is probably TMI, but whatever. We're all friends here, right? So I was, I was, I was [laughs] in San Francisco. I had my Volkswagen Golf that got broken into, like, three times for change. I was so annoyed. San Francisco for the win. [laughs] And in any case, I had to run to an international flight, and I was stressed out 'cause I was running behind. And I was like, "Well, just before I go, I'm gonna have double espresso-

    10. TF

      Oh

    11. KR

      ... 10 grams of creatine-

    12. TF

      [laughs]

    13. KR

      ... and then I had MCT oil.

    14. TF

      [laughs] Oh.

    15. KR

      And-

    16. TF

      Oh my God, dude

    17. KR

      ... a- and then I'm driving on my way to the airport, like, in a massive rush. I don't have time for anything.

    18. TF

      Yeah.

    19. KR

      And I lean to do a little squeaker and just-

    20. TF

      No

    21. KR

      ... full disaster pants.

    22. TF

      In an Uber?

    23. KR

      No, in my own car.

    24. TF

      Oh.

    25. KR

      I park in long-term parking and-

    26. TF

      You grab a new pair out of your thing, just wipe and go?

    27. KR

      I... Oh, God. All right. Can't believe I'm talking-

    28. TF

      [laughs]

    29. KR

      ... about this to millions of people. But basically took the underwear [laughs] and, like, some rags that I had.

    30. TF

      [laughs]

  25. 1:14:29 – 1:20:17

    Norwegian 4x4 training and lactate as a brain lever.

    1. KR

      And then there's the exercise, right? And so what kind of exercise? I did a podcast with Dr. Tommy Wood recently. Fascinating guy. People should listen to that episode. But 4x4 Norwegian high-intensity training-

    2. TF

      Mm-hmm

    3. KR

      ... which is like f- you're basically doing, I guess it would be considered zone four. You're really maxing out your heart rate.

    4. TF

      Mm-hmm.

    5. KR

      And you're doing four minutes on, three minutes off, four minutes on, three minutes off, four minutes on. You're repeating that four times.

    6. TF

      Mm-hmm.

    7. KR

      And it is very much puke-inducing. It's a lot of lactic acid.

    8. TF

      Yeah, yeah, yeah.

    9. KR

      The problem has always been, or one of the problems has always been, that if I'm traveling, stationary bikes in hotels are just terrible.

    10. TF

      Yeah, yeah, yeah.

    11. KR

      Like, they will destroy my knees. They're just t- they're just too inconsistent in terms of settings and stuff. So I was texting with Tommy. I don't think he'd mind me saying. I'll have to double-check with him. But I asked him, I said, "If..." In the conversation we had, I was like, "Well, what are the drivers here? Is it VO2 max?" 'Cause people talk about VO2 max, VO2 max, VO2 max. And he said, well, lactate actually seems to be a big driver. Like lactic acid, right?

    12. TF

      Driver of what?

    13. KR

      Driver of the cognitive changes, like the-

    14. TF

      Oh

    15. KR

      ... neuroanatomical and vascular changes. And it's like, okay, well, hold on a second. I was like, if that's the case, there are certain ways of weight training, like if you do 20-rep squats [laughs] in slow cadence, or any number of different things, like you are going to be brimming with lactic acid. Could that possibly achieve the same effect?

    16. TF

      You don't think it's klotho?

    17. KR

      Klotho's another part of it.

    18. TF

      'Cause klotho has been shown, like HIIT is what creates klotho in the humans.

    19. KR

      Well, klotho, klotho's another piece. I don't think it's the only piece. I think that... I mean, look, I can't wait for us to have proper injectable klotho or that lever to pull. But in the meantime, I guess the... Right now, today, right? What I'm saying is, like, high-intensity interval training when you're traveling is not always the easiest thing to do.

    20. TF

      Right, right, right.

    21. KR

      But, like for instance, when I go back to my hotel tonight-

    22. TF

      Yeah

    23. KR

      ... can I do like s- like a couple of sets of very high repetition leg presses and just basically have lactic acid pouring out my eyeballs? Yeah. I can do that.

    24. TF

      Yeah, yeah, yeah.

    25. KR

      And I can do it in, like, five minutes.

    26. TF

      Yeah, yeah.

    27. KR

      Right? It's very sh- And there are a many open questions about it, but that's the approach I'm taking. And what's really cool about the, the Norwegian 4x4 that Tommy describes, and I think I'm remembering this correctly, is that if you do it, I think it's three times a week for six months, you can observe the effects, the beneficial effects, for like five years afterwards.

    28. TF

      Wow. Holy shit.

    29. KR

      Isn't that fucking crazy?

    30. TF

      That's amazing.

  26. 1:20:17 – 1:26:21

    Blood flow restriction cuffs and schwantz ring koans.

    1. KR

      s- so second thing you can do, which I've been experimenting with, which Tommy Wood uses all the time, especially when traveling, is blood flow restriction cuffs.

    2. TF

      Yes.

    3. KR

      And so-

    4. TF

      I used to have some of those before my fire happened.

    5. KR

      Yes, I've got-

    6. TF

      I, I would blood flow... I got the automatic ones that would automatically keep the pressure too.

    7. KR

      Yeah, yeah. I mean, you're not gonna be... You don't have use like a hand pump. I've got the, I'm using the KAATSU.

    8. TF

      Yeah. My, my one's digital KAATSU.

    9. KR

      K-A-A-

    10. TF

      Yeah

    11. KR

      ... T-S-U C4. I'm using the C4 'cause I'm like, I don't want another app on my phone.

    12. TF

      Did you get the app? Oh, I got the app.

    13. KR

      I don't-

    14. TF

      That's nice.

    15. KR

      No. Like, look, if people want apps, they can. I'm kind of along the Bill Burr lines of like, I need to install a fucking app to use my toaster now? Like, please, shoot me.

    16. TF

      My Hummingbird feeder.

    17. KR

      Oh, yeah. We'll talk about that.

    18. TF

      Okay.

    19. KR

      Let me finish the blood flow [laughs] restriction. Jesus.

    20. TF

      [laughs] Okay.

    21. KR

      We're all over the place. All right. So the blood flow restriction, all it is, it's a cuff, it inflates, and it's [laughs] it causes a partial occlusion, right? It's cutting off circulation to your arms or your legs. And there's a lot of really good science on this, so you c- you can check it out. But what you can do when traveling, and I'm trying this right now... Tommy Wood, by the way, is a phenomenal athlete, endurance and strongman, in addition to being an incredible researcher. I don't know where they breed these people. Like Dominic Agostino-

    22. TF

      Yeah

    23. KR

      ... same thing, like 500-pound deadlift for 10 reps after a seven-day fast. Like, who are these people? Anyway, Tommy is, Tommy's a beast. When he's traveling, and he doesn't lose muscle when he's doing this, he'll use blood flow restriction and he'll bring bands.

    24. TF

      Oh, interesting.

    25. KR

      He'll just have a bunch of bands. And I gotta tell you-

    26. TF

      It doesn't take much, yeah

    27. KR

      ... like I li- I like to think of myself as reasonably strong. I'm not a world-class powerlifter, but like, I think like generally pretty strong guy.

    28. TF

      Yeah.

    29. KR

      I put on those cuffs today and I was like, I think I'll just bump it from light up to medium.

    30. TF

      Like 20 pounds?

  27. 1:26:21 – 1:29:12

    Hummingbirds named Sunset and squirrel obstacle courses.

    1. TF

      Hummingbirds.

    2. KR

      Hummingbirds.

    3. TF

      [laughs] Okay, so t- before we started the show, Tim's like, "You gotta mention the hummingbirds."

    4. KR

      Well, I looked at your-

    5. TF

      And I'm like, "Okay"

    6. KR

      ... your draft and I was like, "You gotta talk about your hummingbird thing. You're sending me watching these videos."

    7. TF

      Okay. Dude, they're so cool. Okay. So essentially for Christmas, I got my, my kids a hummingbird feeder with a digital camera built in, and the cool thing about it is it charges from the sunlight, and then also, so the camera just always stays on, and then also it detects what, in this case it's a hummingbird but, but they have them for normal birds as well, but it'll tell you the variety of hummingbird that landed.

    8. KR

      Oh, I did not.

    9. TF

      And then it uses AI, and then you can name them. And so we have one named-

    10. KR

      Tony. Tony's back.

    11. TF

      Yeah. [laughs] Exactly. And we have one named Sunset. Our girl's named him Sunset 'cause it has this beautiful red neck.

    12. KR

      Huh.

    13. TF

      And I'll get a text notification, "Sunset is drinking."

    14. KR

      Is this the one?

    15. TF

      I got him a feeder. That's the one.

    16. KR

      Bird Buddy.

    17. TF

      It's called Bird Buddy Smart Solar Pro Hummingbird Feeder. And it's fun, people.

    18. KR

      Yeah.

    19. TF

      'Cause you, these things are so beautiful and-

    20. KR

      The videos are amazing

    21. TF

      ... yeah, the videos are amazing, and then they play with each other, and you watch them h- hovering, and you get full audio so you, you see the little tiny tongues, like, sticking out.

    22. KR

      Huh.

    23. TF

      It's, it's just amazing.

    24. KR

      Yeah.

    25. TF

      It's really cool.

    26. KR

      The videos were, were quite cool.

    27. TF

      Then I got the one that is for just standard birds, which has bird feed, like, uh, that comes down.

    28. KR

      Yeah.

    29. TF

      And motherf- squirrels are taking it over.

    30. KR

      Oh, they're just, they're s- m- mercenaries

  28. 1:29:12 – 1:29:41

    Parting thoughts.

    1. KR

      Solid. Hummingbirds and cock rings. [laughs]

    2. TF

      Yeah. We covered it all this time, people.

    3. KR

      Brought to you [laughs]

    4. TF

      Yeah.

    5. KR

      This is the Random Show.

    6. TF

      Brother, good to see you.

    7. KR

      Yeah. Good to see you too, man.

    8. TF

      Glad you're-

    9. KR

      You too

    10. TF

      ... glad you're feeling better and-

    11. KR

      To be continued.

    12. TF

      To be continued.

    13. KR

      All right, folks. We'll put everything in the show notes, timdop blog/podcast. Uh, Random Show. It's gonna be one of those. Search for cock rings, it'll be the only result on Tim Dop blog.

    14. TF

      [laughs]

    15. KR

      And until next time-

    16. TF

      For now

    17. KR

      ... take care of yourselves, be nice, be a little kinder than is necessary to yourselves and to others.

Episode duration: 1:30:02

Install uListen for AI-powered chat & search across the full episode — Get Full Transcript

Transcript of episode 1dsTfXILUsM

Get more out of YouTube videos.

Read along on your phone, search it beside the video, or ask your favorite AI app what was said.

iOSAndroidClaudeChromeChatGPTComing soon