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Joe Lonsdale on AI, Defense, and American Optimism | Ep. 51

Joe Lonsdale is the Founder and Managing Partner at 8VC, an early-stage venture capital firm managing over $6 billion in capital. In 2003, he founded Palantir (NASDAQ:PLTR), a global software company known for its work supporting US and its allies’ defense and intelligence. Since then, he has founded over a dozen prominent companies, including Addepar, a wealth management platform helping investors manage over $7 trillion, and OpenGov, the leading cloud software provider for local governments which recently sold for $1.8 billion. Joe was an early investor in Anduril, Oculus (acq. FB), Guardant Health (NASDAQ:GH), Oscar (NYSE:OSCR), Illumio, Wish (NASDAQ:WISH), JoyTunes, Blend (NYSE:BLND), Flexport, Joby Aviation (NYSE:JOBY), Orca Bio, Qualia, Synthego, RelateIQ (acq. CRM), Yugabyte, among many others. We discussed what it takes to keep building after success, why AI is accelerating entire industries, and how it could reshape productivity, healthcare, defense, and the economy. Joe also shared his views on investing in hard problems, rebuilding trust in technology, and where America needs to adapt to win in the AI era. Timestamps: (0:00) Intro (0:32) Why Joe keeps building (3:53) AI being contrarian and right (5:39) What Palantir got right (6:53) Pulling forward innovation (9:32) AI vs social media (12:23) Making AI work for America (18:03) Department of War debate (21:16) Betting on defense (26:51) Robotics, bio, and energy (32:16) Investing in the AI era (35:38) Peptides opportunity (38:35) Texas vs California (40:12) Political correctness Links: https://x.com/JTLonsdale https://x.com/jaltma https://8vc.com/ https://uncappedpod.com/ friends@uncappedpod.com

Joe LonsdaleguestJack Altmanhost
May 27, 202643mWatch on YouTube ↗

Episode Details

EPISODE INFO

Released
May 27, 2026
Duration
43m
Channel
Uncapped with Jack Altman
Watch on YouTube
▶ Open ↗

EPISODE DESCRIPTION

Joe Lonsdale is the Founder and Managing Partner at 8VC, an early-stage venture capital firm managing over $6 billion in capital. In 2003, he founded Palantir (NASDAQ:PLTR), a global software company known for its work supporting US and its allies’ defense and intelligence. Since then, he has founded over a dozen prominent companies, including Addepar, a wealth management platform helping investors manage over $7 trillion, and OpenGov, the leading cloud software provider for local governments which recently sold for $1.8 billion. Joe was an early investor in Anduril, Oculus (acq. FB), Guardant Health (NASDAQ:GH), Oscar (NYSE:OSCR), Illumio, Wish (NASDAQ:WISH), JoyTunes, Blend (NYSE:BLND), Flexport, Joby Aviation (NYSE:JOBY), Orca Bio, Qualia, Synthego, RelateIQ (acq. CRM), Yugabyte, among many others. We discussed what it takes to keep building after success, why AI is accelerating entire industries, and how it could reshape productivity, healthcare, defense, and the economy. Joe also shared his views on investing in hard problems, rebuilding trust in technology, and where America needs to adapt to win in the AI era. Timestamps: (0:00) Intro (0:32) Why Joe keeps building (3:53) AI being contrarian and right (5:39) What Palantir got right (6:53) Pulling forward innovation (9:32) AI vs social media (12:23) Making AI work for America (18:03) Department of War debate (21:16) Betting on defense (26:51) Robotics, bio, and energy (32:16) Investing in the AI era (35:38) Peptides opportunity (38:35) Texas vs California (40:12) Political correctness Links: https://x.com/JTLonsdale https://x.com/jaltma https://8vc.com/ https://uncappedpod.com/ friends@uncappedpod.com

SPEAKERS

  • Joe Lonsdale

    guest

    Tech entrepreneur and venture capitalist; co-founder of Palantir and founder of 8VC.

  • Jack Altman

    host

    Host of "Uncapped" and investor/interviewer focused on technology and startups.

EPISODE SUMMARY

In this episode of Uncapped with Jack Altman, featuring Joe Lonsdale and Jack Altman, Joe Lonsdale on AI, Defense, and American Optimism | Ep. 51 explores joe Lonsdale on AI acceleration, defense tech, and policy reform Lonsdale argues AI is rapidly “pulling forward” innovation, compressing 2030s–2040s progress into the next few years and changing what company-building looks like.

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