Commure: The AI Operating System for Healthcare

Tanay Tandon is the co-founder and CEO of Athelas / Commure, the AI operating system for healthcare. Commure’s technology powers over 20 million appointments annually and processes more than $25 billion in claims volume, helping clinicians and health systems work faster, smarter, and spend more time on patient care. In this fireside with YC’s Ankit Gupta, Tanay shares how he built one of the most ambitious companies in healthcare, what AI means for doctors and patients, and why the next decade of medicine will be defined by software. Chapters: 00:00 – From Rejection Letters to YC Acceptance 02:30 – What Athelas and Commure Actually Do 05:33 – Building a Medical Device at 19 09:00 – Lessons from Clinical Trials and Early Healthcare Startups 16:39 – Pivoting from Hardware to Healthcare Software 21:24 – Fixing Physician Burnout with AI 27:14 – The Rise of Ambient Documentation 32:43 – Stripe for Healthcare: Rebuilding the Financial Layer 36:45 – Competing with Epic and Scaling Nationwide 45:41 – The Next Decade of Medicine

Tanay TandonguestAnkit Guptahost

Oct 29, 202549mWatch on YouTube ↗

EPISODE INFO

Released: October 29, 2025
Duration: 49m
Channel: YC Root Access
Watch on YouTube: ▶ Open ↗

EPISODE DESCRIPTION

Tanay Tandon is the co-founder and CEO of Athelas / Commure, the AI operating system for healthcare. Commure’s technology powers over 20 million appointments annually and processes more than $25 billion in claims volume, helping clinicians and health systems work faster, smarter, and spend more time on patient care. In this fireside with YC’s Ankit Gupta, Tanay shares how he built one of the most ambitious companies in healthcare, what AI means for doctors and patients, and why the next decade of medicine will be defined by software. Chapters: 00:00 – From Rejection Letters to YC Acceptance 02:30 – What Athelas and Commure Actually Do 05:33 – Building a Medical Device at 19 09:00 – Lessons from Clinical Trials and Early Healthcare Startups 16:39 – Pivoting from Hardware to Healthcare Software 21:24 – Fixing Physician Burnout with AI 27:14 – The Rise of Ambient Documentation 32:43 – Stripe for Healthcare: Rebuilding the Financial Layer 36:45 – Competing with Epic and Scaling Nationwide 45:41 – The Next Decade of Medicine

SPEAKERS

Tanay Tandon
guest
CEO of Athelas/Commure, building an AI operating system for healthcare workflows.
Ankit Gupta
host
Host of YC Root Access and interviewer for the episode.

EPISODE SUMMARY

In this episode of YC Root Access, featuring Tanay Tandon and Ankit Gupta, Commure: The AI Operating System for Healthcare explores commure and Athelas build AI platform automating healthcare operations nationwide Athelas Commure sells a bundled platform—ambient clinical documentation, revenue-cycle/payment automation, and patient engagement—used by everyone from solo practices to major hospital systems like HCA.

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