
DOGE vs USAID, Crypto Framework, Google's $75B AI Spend, US Sovereign Wealth Fund, GLP-1s
Jason Calacanis (host), Antonio Gracias (guest), Chamath Palihapitiya (host), David Sacks (host), Narrator, David Friedberg (host), Narrator, David Sacks (host), Narrator, Narrator
In this episode of All-In Podcast, featuring Jason Calacanis and Antonio Gracias, DOGE vs USAID, Crypto Framework, Google's $75B AI Spend, US Sovereign Wealth Fund, GLP-1s explores dOGE vs. USAID, Crypto Pivot, Google’s AI Bet, GLP-1 Revolution This All-In Podcast episode centers on the Trump administration’s new Department of Government Efficiency (DOGE), its aggressive audit of USAID and media funding, and the broader political realignment it may trigger. The besties and guest Antonio Gracias compare DOGE’s playbook to the Twitter/X turnaround and historic anti-waste efforts like the Truman Committee, framing it as zero-based budgeting for the federal government.
DOGE vs. USAID, Crypto Pivot, Google’s AI Bet, GLP-1 Revolution
This All-In Podcast episode centers on the Trump administration’s new Department of Government Efficiency (DOGE), its aggressive audit of USAID and media funding, and the broader political realignment it may trigger. The besties and guest Antonio Gracias compare DOGE’s playbook to the Twitter/X turnaround and historic anti-waste efforts like the Truman Committee, framing it as zero-based budgeting for the federal government.
David Sacks calls in from the White House to outline a bipartisan legislative roadmap for crypto (market structure and stablecoins), and to describe the administration’s AI reset after rescinding the Biden AI EO. The crew then debates Trump’s proposed U.S. sovereign wealth fund, whether government should act like a capitalist investor, and how to structure it to support industrial policy and debt reduction.
On the tech side, they dissect Google’s plan to spend $75B on AI-related capex, arguing that Google’s ROIC discipline and ad optimization upside likely justify the number despite market jitters. The show closes with a deep dive on new macro data for GLP‑1 weight-loss drugs, their surprisingly broad health benefits, and how to balance them against lifestyle interventions like diet, exercise, and strength training.
Key Takeaways
DOGE is applying a startup-style zero-based budget to government
Antonio Gracias and David Friedberg frame DOGE as a federal-scale zero-based budgeting exercise: instead of starting from last year’s spending and adding more, every line item is reset to zero and must be re‑justified. ...
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USAID’s media and NGO funding raises perceived corruption and ‘astroturfing’ risks
Data emerging from USAID shows sharp spending increases to outlets like Politico (~$8M/year under Biden vs. ...
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Crypto is shifting from regulatory hostility to a bipartisan legislative framework
Sacks outlines a new legislative push involving four key committees (House/Senate Banking and Agriculture) to pass two major bills: (1) a stablecoin bill first, then (2) a market structure bill (akin to an updated FIT 21) defining when a token is a security vs. ...
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A U.S. sovereign wealth fund could double as stealth industrial policy
Trump’s EO to explore a U. ...
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Google’s massive AI capex is likely rational given its ROIC track record
Investors punished Google for announcing $75B in 2025 capex, but Friedberg and Antonio argue the spend is probably disciplined given Google’s history as the most efficient infra operator. ...
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GLP‑1s appear to confer broad health benefits beyond weight loss—but trade-offs remain
Friedberg summarizes a massive VA database study (1. ...
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Health optimization is drowning in conflicting ‘protocols’; people need simpler, evidence-based baselines
Chamath notes the cognitive overload from overlapping health influencer protocols (Huberman, Gary Brecka, Bryan Johnson, etc. ...
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Notable Quotes
“What I'm afraid of now is we have a bureaucracy that is about to turn into a kleptocracy. I mean, a Latin American-style kleptocracy.”
— Antonio Gracias
“What they are are read-only auditors of the truth. And it's incredible the power that read-only access gives you.”
— Chamath Palihapitiya (on DOGE)
“The money is all going to them. New York Times getting paid, Politico getting paid, BBC getting paid… This is astroturf, not grassroots.”
— David Sacks
“I think the models are basically commodities. What matters is return on capital in data centers.”
— Antonio Gracias
“We really haven't been unlocking people's creativity over the last 15 years… We need to let these creative people cook, and I hope that happens.”
— Chamath Palihapitiya
Questions Answered in This Episode
You argue that DOGE is only a ‘read-only auditor of the truth.’ Concretely, what data fields are they pulling from Treasury and agency systems, and how do you prevent that access from drifting into de facto policymaking or targeting political enemies over time?
This All-In Podcast episode centers on the Trump administration’s new Department of Government Efficiency (DOGE), its aggressive audit of USAID and media funding, and the broader political realignment it may trigger. ...
Get the full analysis with uListen AI
On the media ‘payola’ point: can you walk through one or two specific examples—say Politico and the BBC—and show, step by step, how USAID money might have tangibly influenced editorial decisions or story placement rather than just funding generic services or subscriptions?
David Sacks calls in from the White House to outline a bipartisan legislative roadmap for crypto (market structure and stablecoins), and to describe the administration’s AI reset after rescinding the Biden AI EO. ...
Get the full analysis with uListen AI
If the U.S. creates a sovereign wealth fund seeded with forced TikTok equity or seized crypto, how do you stop a future administration from weaponizing that fund to punish disfavored industries or to subsidize politically connected firms under the banner of ‘industrial policy’?
On the tech side, they dissect Google’s plan to spend $75B on AI-related capex, arguing that Google’s ROIC discipline and ad optimization upside likely justify the number despite market jitters. ...
Get the full analysis with uListen AI
For a U.S.-based crypto founder building right now, what exact steps would you take in the next 6–12 months to maximize the odds of being on the right side of the coming market-structure and stablecoin legislation you described—entity structure, jurisdictional choices, and engagement with the new SEC task force?
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The VA GLP‑1 study you discussed shows impressive associations with reduced cardiac and organ failures, but it’s observational and in a diabetic population. How should a non-diabetic, overweight but otherwise healthy person rationally weigh that evidence against the known muscle/bone downsides and the alternative of aggressive diet and resistance training alone?
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Transcript Preview
I have four pieces of advice for people. Number one, get good sleep. Number two, exercise. Number three, diet. Number four, meditation. And if you want to do that, it's very simple. You get the Calm meditation app.
I have kids.
You get the Eight Sleep sleep. You get the FitBod for fitness.
All your investments are in- (laughs)
And then you get Nutrascents for your-
What a grifter. (laughs)
He's just talking about his investments. (laughs)
(laughs)
Those are the four things you focus on for people.
The four essentials.
You get a good Athena assistant. All of this is brought to you by my NGO, which is All In NGO. USAID gave us 18 million last year.
(laughs)
(laughs)
Guys, I forgot to tell you about it, but don't worry, it's in an offshore account for all of us. When we get back to Ethiopia and Vietnam, we have an All In castle built there, okay?
(laughs)
I'm going all in. Don't let your winners ride.
Rain Man, David Sacks.
I'm going all in.
And I said-
We open sourced it to the fans and they've just gone crazy with it.
Love US housing.
West Side Queen of Kinwah.
I'm going all in.
All right, everybody. Welcome back to the All In podcast, the number one MAGA finance, business, and personal optimization health. Yes, we are now larger in the health space than Huberman, Tim Ferriss, and, uh, Peter Attia combined. Yes, we've really started to grow the pod and, uh, if you want to, you can subscribe to the podcast on x.com, YouTube, Spotify, and all those other places. Especially if you want to have an incredibly positive world enlightening conversation with Ray Dalio, you can tune into Friedberg and Ray Dalio on the channel. Great conversation. It's gotten 300,000 or 400,000 views already on YouTube. How's the feedback been, Dave? Got so much great feedback on your Ray Dalio. Is it the end of the empire or are we coming back?
What's awesome is a lot of the recommendations he shared is becoming policy, it seems, for the Trump administration. Elon and Bessent and others in the administration have echoed trying to get government deficit below 3% of GDP.
Yeah.
That seems to be the economic magical number. And if you can do that, rates drop. I think that's resonated. It was great to have him publish that a couple weeks ago, talk with us about it. It's great.
Great bonus content from the team at All In. Today, we're super excited to have our friend, Antonio Gracias, joining the show. Antonio is the CEO of Valor Equity Partners and he's made some... yeah, he's made some solid investments. He was one of the first investors in Tesla, SpaceX, Athena, uh, tons of great... or he's the second investor in Athena after me.
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