How to Enhance Your Immune System | Dr. Roger Seheult

How to Enhance Your Immune System | Dr. Roger Seheult

Huberman LabFeb 24, 20253h 28m

Andrew Huberman (host), Dr. Roger Seheult (guest)

NEW START framework for immune and overall healthSunlight, red/infrared light, and mitochondrial functionSeasonality of flu/COVID and the role of latitude and lightHeat, hydrotherapy, cold exposure, and interferon/innate immunityNAC, zinc, eucalyptus, and other illness-supportive interventionsLong COVID mechanisms and mitochondrial repair strategiesLight hygiene: indoor lighting, dim nights, and circadian healthMold, terrain vs. germ theory, and pulmonary considerationsFlu vaccines, masks, handwashing, and hospital care navigationPsychological/spiritual factors like forgiveness, community, and trust

In this episode of Huberman Lab, featuring Andrew Huberman and Dr. Roger Seheult, How to Enhance Your Immune System | Dr. Roger Seheult explores sunlight, Heat, and NEW START: Genuine Immune Upgrades, Not Biohacks Andrew Huberman and pulmonologist/intensivist Dr. Roger Seheult detail evidence-based ways to prevent and recover from respiratory infections like colds, flu, COVID, and long COVID. They organize the discussion around the NEW START framework: Nutrition, Exercise, Water, Sunlight, Temperance, Air, Rest, and Trust, emphasizing how each pillar shapes immune and metabolic health.

Sunlight, Heat, and NEW START: Genuine Immune Upgrades, Not Biohacks

Andrew Huberman and pulmonologist/intensivist Dr. Roger Seheult detail evidence-based ways to prevent and recover from respiratory infections like colds, flu, COVID, and long COVID. They organize the discussion around the NEW START framework: Nutrition, Exercise, Water, Sunlight, Temperance, Air, Rest, and Trust, emphasizing how each pillar shapes immune and metabolic health.

A major focus is on sunlight and red/infrared light: how they penetrate deep into the body, support mitochondrial function, drive local melatonin production, and correlate with lower mortality, better metabolic markers, and reduced influenza risk. They contrast this with the harms of dim days, bright nights, and blue-heavy indoor lighting.

They also cover practical therapies: heat and hydrotherapy to enhance interferon and innate immunity, strategic cold exposure, NAC and zinc supplementation, eucalyptus/steam, and specific behavioral tools to speed illness recovery and support long COVID patients. Flu shots, masks, handwashing, and hospital care navigation are discussed in a nuanced, risk–benefit framework.

Throughout, Dr. Seheult weaves in clinical anecdotes, historical data on phototherapy and hydrotherapy, and emerging science on forest bathing, PFAS-free environments, and the powerful role of sleep, community, and spiritual ‘trust’ in shaping both mental and physical health outcomes.

Key Takeaways

Use NEW START as a practical immune-health checklist

Dr. ...

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Sunlight and infrared light are foundational for mitochondria and immunity

Only ~38% of solar energy is visible light; ~52% is infrared, which deeply penetrates skin and tissue (up to centimeters) and scatters through the body. ...

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Bright days and dark nights are non-negotiable metabolic and immune levers

Modern life has created ‘dark days and bright nights’: we spend ~93% of time indoors under blue-heavy, infrared-poor LEDs, behind low-E glass that blocks IR, and then are exposed to screens and overhead lighting at night. ...

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Heat and brief cold dramatically boost innate immunity via interferon

Raising core temperature is not just a symptom—it is a tool. ...

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NAC can significantly blunt flu symptoms and support redox balance

N-acetylcysteine (NAC) is a glutathione precursor and mucolytic used clinically for Tylenol overdose and some lung conditions. ...

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Long COVID often reflects lingering mitochondrial and redox dysfunction

Long COVID (symptoms ≥12 weeks) is heterogeneous, but emerging data show impaired beta-oxidation and mitochondrial metabolism in many patients. ...

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Your relationship to hospitals and clinicians can change the care you receive

In acute illness you cannot control bed availability or room assignments, but you can strongly influence care quality by demonstrating informed engagement. ...

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Notable Quotes

Maybe the lowest hanging fruit we can do right now, for literally no money, is simply to just work on getting more sun exposure in the wintertime.

Dr. Roger Seheult

We never get blue light or ultraviolet light ever without the presence of infrared light—unless it comes from an artificial source.

Dr. Roger Seheult

The engine in your house after age 40 loses about 70% of its energy output. Imagine what that would do if that were your mitochondria—and that’s basically what’s happening in the cell.

Dr. Roger Seheult

Every intervention in medicine has a benefit and every intervention has a risk, no matter what it is.

Dr. Roger Seheult

It’s not or, it’s and. Terrain and germ theory both matter. Whether you get infected depends on how good your immune system is and how virulent the burden of pathogen is.

Dr. Roger Seheult

Questions Answered in This Episode

In the NAC flu study you cited, were there any notable side effects or safety concerns at 600 mg twice daily, and would you modify that dose for people with liver or kidney impairment?

Andrew Huberman and pulmonologist/intensivist Dr. ...

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For long COVID patients showing clear signs of mitochondrial dysfunction, how would you prioritize interventions like time-restricted eating, graded exercise, red/infrared light, and pharmacologic options such as interferon or NAC in an actual stepwise protocol?

A major focus is on sunlight and red/infrared light: how they penetrate deep into the body, support mitochondrial function, drive local melatonin production, and correlate with lower mortality, better metabolic markers, and reduced influenza risk. ...

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You mentioned a biphasic response to red/infrared light where ‘more is not better.’ What intensity and duration thresholds do you consider safe for home devices so people don’t accidentally blunt or reverse the mitochondrial benefits?

They also cover practical therapies: heat and hydrotherapy to enhance interferon and innate immunity, strategic cold exposure, NAC and zinc supplementation, eucalyptus/steam, and specific behavioral tools to speed illness recovery and support long COVID patients. ...

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Given the strong seasonal mortality curves you described, if public health agencies fully accepted light and infrared exposure as causal factors, what concrete policy changes (e.g., building codes, hospital design, workday structure) would you want to see implemented first?

Throughout, Dr. ...

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How do you reconcile the traditional advice to ‘treat the fever’ with aspirin or acetaminophen in children and adults with the data you presented showing that modest fevers and deliberate heat exposure substantially amplify interferon and innate antiviral defenses?

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Transcript Preview

Andrew Huberman

Welcome to the Huberman Lab Podcast, where we discuss science and science-based tools for everyday life. I'm Andrew Huberman, and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine. My guest today is Dr. Roger Seheult. Dr. Roger Seheult is a board-certified medical doctor in pulmonology, which is the understanding and treatment of conditions that impact the respiratory system, such as colds, flus, and other viruses, mold infections, asthma, and more. Dr. Seheult is also board certified in sleep medicine. He does his clinical work in the intensive care unit at Loma Linda University, and he's actively involved in medical and public health education through his terrific online channel, called MedCram. Today we discuss how to avoid getting colds, flus, and other viruses, and how to treat them to minimize discomfort, accelerate healing, and avoid long-term consequences. During today's episode, we discuss long COVID as well as the use of sun and red light to stimulate mitochondrial, and therefore metabolic health across the entire brain and body. That opens up a broader discussion about phototherapy, which is the use of light to control health, and temperature and other levers for improving brain and bodily function. Dr. Seheult emphasizes that sun and red light therapy have a long and well-established medical history, and their mechanisms of action are known, and therefore it's not just biohacking as many people think. We also discussed the sometimes controversial topic of the flu shot, and if and when you should get one. Dr. Seheult, as you'll soon hear, is world class at making medical concepts and the actionable items related to health exceptionally clear. As a consequence, I'm certain that you'll truly appreciate the knowledge that he shares in your efforts to be and stay healthy at any age. In fact, by the end of today's episode, you'll be armed with the real knowledge on how to best get over nasty infections of the sinuses, lungs, and throat faster should you happen to get one, and even better, how to avoid them altogether. Before we begin, I'd like to emphasize that this podcast is separate from my teaching and research roles at Stanford. It is however part of my desire and effort to bring zero cost to consumer information about science and science-related tools to the general public. In keeping with that theme, this episode does include sponsors. And now for my discussion with Dr. Roger Seheult. Dr. Roger Seheult, welcome.

Dr. Roger Seheult

Thank you so much, Andrew, for having me.

Andrew Huberman

I discovered you because you were putting out and continue to put out incredible information about how to stay healthy amidst infectious diseases, airborne infectious diseases, skin contact-based infectious diseases, and on and on. And nobody likes to be sick. And you've provided me tremendously valuable information about how to avoid getting sick, and in many cases, how to accelerate the progression from sick to healthy again. It's been, uh, tremendously helpful for getting me back into life, as it were. Let's talk about some of the things that one can do to avoid getting sick when in the presence of airborne viruses, in particular, colds and flus, and other viruses, as it were. If you were to think about the, the major pillars of remaining healthy, especially when one is exposed to colds and flus from kids for, in your case, also in the, uh, intensive care unit where people are coming in specifically because they're sick, often with infections like colds and flus, or worse, you need to take specific precautions to avoid getting sick. What do you think of as the fundamental layer of keeping a healthy immune system to avoid getting sick? And then we'll talk about how to get over and move through being sick more quickly.

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