Science of Mindsets for Health & Performance | Dr. Alia Crum

Science of Mindsets for Health & Performance | Dr. Alia Crum

Huberman LabJan 24, 20221h 41m

Andrew Huberman (host), Alia Crum (guest)

Definition and function of mindsetsMindsets and physiology: food, hunger hormones, and metabolismExercise and activity mindsets, performance, and health outcomesStress mindsets: debilitating vs. enhancing and their consequencesPlacebo, nocebo, and belief effects in medicine and side effectsCultural and social origins of health-related mindsets (media, influencers, upbringing)Practical frameworks to recognize, shift, and teach adaptive mindsets

In this episode of Huberman Lab, featuring Andrew Huberman and Alia Crum, Science of Mindsets for Health & Performance | Dr. Alia Crum explores how Mindsets Rewire Stress, Food, Exercise And Medical Treatment Effects Dr. Andrew Huberman and Dr. Alia Crum explore how core beliefs—or mindsets—about stress, food, exercise, and medical treatments directly shape motivation, behavior, and even measurable physiology. Drawing on landmark studies, Crum shows that what we think about a milkshake, a work shift, or a medication can alter hormones like ghrelin and DHEA, blood pressure, immune markers, and performance under stress. They distinguish placebo/nocebo from broader “belief effects,” arguing mindsets act as a portal between conscious interpretations and subconscious bodily responses. The conversation concludes with practical frameworks for adopting more adaptive mindsets and a call to consciously design healthier cultural narratives around health and performance.

How Mindsets Rewire Stress, Food, Exercise And Medical Treatment Effects

Dr. Andrew Huberman and Dr. Alia Crum explore how core beliefs—or mindsets—about stress, food, exercise, and medical treatments directly shape motivation, behavior, and even measurable physiology. Drawing on landmark studies, Crum shows that what we think about a milkshake, a work shift, or a medication can alter hormones like ghrelin and DHEA, blood pressure, immune markers, and performance under stress. They distinguish placebo/nocebo from broader “belief effects,” arguing mindsets act as a portal between conscious interpretations and subconscious bodily responses. The conversation concludes with practical frameworks for adopting more adaptive mindsets and a call to consciously design healthier cultural narratives around health and performance.

Key Takeaways

Mindsets Are Core Assumptions That Steer Attention, Motivation, And Physiology

Crum defines mindsets as core beliefs about a domain (e. ...

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What You Believe About Food Changes Your Hormonal Response To Eating

In the milkshake study, participants drank the same ~300-calorie shake on two occasions but were told once that it was an indulgent 620-calorie shake and once that it was a light, sensible diet shake. ...

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Feeling You ‘Get Enough’ Exercise Can Improve Health Independently Of Activity Levels

In the hotel housekeepers study, women performing physically demanding cleaning work were objectively exceeding Surgeon General exercise guidelines but mostly believed they weren't exercising. ...

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Viewing Stress As Enhancing Changes How You Respond And Perform Under Pressure

Most people hold a ‘stress-is-debilitating’ mindset due to public health and cultural messaging, but the research literature shows stress responses can narrow focus, accelerate processing, and trigger physiological “toughening. ...

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Beliefs About Side Effects And Symptoms Can Worsen Or Improve Treatment Outcomes

Nocebo effects occur when negative expectations generate or amplify negative symptoms. ...

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Stress Can Be Leveraged, Not Just Managed—Using A Three-Step Framework

Crum proposes reframing stress from something to avoid or ‘cope with’ into a resource to be harnessed. ...

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We Can Consciously Audit And Reprogram Mindsets To Serve Us Better

Mindsets are shaped by upbringing, culture/media, influential others (e. ...

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Notable Quotes

Mindsets are core beliefs or assumptions that we have about a domain or category of things that orient us to a particular set of expectations, explanations, and goals.

Alia Crum

The total effect of anything you do or consume is a combined product of what you’re actually doing and what you think about what you’re doing.

Alia Crum

We only stress about things we care about. Stress is the other side of the coin of things we value.

Alia Crum

The question isn’t, ‘Is this mindset right or wrong?’ The question is, ‘Is it helpful or harmful?’

Alia Crum

We have done so little with the human resource—our own brains—relative to what’s possible.

Alia Crum

Questions Answered in This Episode

In the milkshake study, have you followed up to see whether mindset-induced changes in ghrelin translate into long-term differences in weight regulation or metabolic health, beyond the acute lab setting?

Dr. ...

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Your data show that simply believing you exercise less than others predicts higher mortality; how would you design a large-scale public health campaign that informs people about exercise needs without inadvertently making most of them feel ‘behind’ and thus at risk?

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In the peanut allergy trial, how did you balance honest disclosure of potential risks with framing side effects as signs of progress, and where do you think the ethical boundary lies for using mindset-based reframing in medicine?

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Given your findings on stress mindsets, what concrete steps would you recommend that schools, military training programs, or corporations take to systematically cultivate a ‘stress-is-enhancing’ mindset without minimizing very real burnout and trauma?

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Your analyses of influencers show that unhealthy foods are framed as exciting while healthy foods are framed as deprivation; if you were consulting for a major film studio or social media platform, what specific content guidelines or incentives would you implement to start rewiring cultural mindsets around healthy eating?

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Transcript Preview

Andrew Huberman

(uptempo music) Welcome to the Huberman Lab Podcast, where we discuss science and science-based tools for everyday life. I'm Andrew Huberman, and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine. Today, my guest is Dr. Alia Crum. Dr. Crum is a tenured professor of psychology at Stanford University, and the founder and director of the Stanford Mind & Body Lab. Her work focuses on mindsets, how what we think and what we believe shapes the way that our physiology, our biology reacts to things like what we eat, or stress, or exercise. Indeed, as you will soon learn from my discussion with Dr. Crum, what you believe about the nutritional content of your food changes the way that food impacts your brain and body to a remarkable degree, and the same is true for mindsets about exercise, and stress, and even medication. For instance, recent work from Dr. Crum's laboratory shows that what we believe about the side effect profiles of different drug treatments or different behavioral treatments has a profound impact on how quickly those treatments work, and the effectiveness of those treatments. I just want to mention one particular study that just came out from a graduate student in Dr. Crum's laboratory, Lauren Howe, H-O-W-E, showed that how kids react to a treatment for peanut allergies can be profoundly shaped by whether or not those kids were educated about the side effects of the treatment, such that if they learned that the side effects were a byproduct of a treatment that would help them, and they learned a little bit about why those side effects arose, and that the side effects might even help them en route to overcoming their peanut allergy, had an enormous impact on how quickly they moved through the treatment, and indeed how much they suffered, or in this case, did not suffer from those side effects. And that is but one example that you will learn about today as we discuss what mindsets are, the number of different mindsets that exist, and how we can adopt mindsets that make us more adaptive, more effective, allow us to suffer less, and to perform better in all aspects of life. I personally find the work of Dr. Alia Crum to be among the most important work being done in the fields of biology and psychology, and the interface of mind/body. Everything that she's done up until now and published, and indeed the work that she continues to do, has shaped everything within my daily routines, within my work routines, within my athletic routines, and we probably shouldn't be surprised by the fact that Dr. Crum works on all these things. She was not only an incredibly accomplished tenured research professor, she's also a clinical psychologist, and she was also a Division I athlete and ele- elite gymnast at one period in her life. So, she really walks the walk, uh, in terms of understanding what mindsets are and applying them in different aspects of life. I'm sure you're going to learn a ton from this conversation, as did I, and come away with many, many actionable items that you can apply in your own life. In fact, as we march into today's conversation, you might want to just put in the back of your mind the question, "What is my mindset about blank?" So for instance, ask yourself, what is my mindset about stress? What is my mindset about food? What is my mindset about exercise? What is my mindset about relationships of different kinds? Because in doing that, you'll be in a great position to extract the best of the information that Dr. Crum presents, and indeed to adapt those mindsets in the way that is going to be most beneficial for you. Before we begin, I'd like to emphasize that this podcast is separate from my teaching and research roles at Stanford. It is, however, part of my desire and effort to bring zero cost to consumer information about science and science-related tools to the general public. In keeping with that theme, I'd like to thank the sponsors of today's podcast. Our first sponsor is Thesis. Thesis makes custom nootropics that are ideal for the particular brain states that you want to be in. The term nootropic means smart drug, and it is not a term that I like, because there's no such thing as a universally useful smart drug. The reason for that is that our brain can be creative, we can be focused, we can be good at task switching, and each of those different things, creativity, focus, and task switching, involves different neurochemicals in different states of mind and body. So, the notion that there's one best nootropic is just not accurate. There's just no way that could possibly be. Thesis understands this, and for that reason, designs custom nootropics that are designed to bring your brain and body into the states that you want, and that are specifically designed to your neurochemistry. They use only the highest quality ingredients, many of which I've talked about before on the podcast. Things like DHA, ginkgo biloba, phosphatidylserine, Alpha GPC is one that I particularly like, and is in several of the formulations that are customized for me. However, ginkgo biloba, which has a lot of research to support it, and is well-tolerated by many people, doesn't work well for me. It actually gives me headaches, so it ... That one is not included in any of the custom formulations that Thesis has made particularly for me. Thesis has this tremendous asset, which is that they give you the ability to try several different blends over the course of a month and discover which nootropics work best for your unique brain chemistry and genetics. So, the formulas that work for me may not be the best ones for you, and vice versa. But in a short period of time, you can dial in the exact nootropic formulas for the states of mind and body that you want to be in. I've been using Thesis for close to six months now, and I can confidently say that their nootropics have been a total game-changer. I love the Motivation formula. I also like the Energy formula. I use those for different things, it turns out, but I love those, and I use their Logic formula and their Clarity formula that they've customized for me. In addition to their personalization, Thesis takes it a step further. They'll offer you a free consultation with a brain coach to help optimize your experience with the nootropics and dial in the best formulas for you. To get your own personalized nootropic starter kit, go online to takethesis.com/huberman, take their brief three-minute quiz, and Thesis will send you four different formulas to try in your first month. That's takethesis.com/huberman, and use the code "Huberman" at checkout to get 10% off your first box. Today's episode is also brought to us by ROKA. ROKA makes eyeglasses and sunglasses that are of the absolute highest quality. I've spent a lifetime working on the visual system, and I can tell you that our visual system has to contend with a huge number of different challenges, not the least of which is when we go from a very bright, sunny spot outside into the shade, our visual system has to adapt in order for us to continue to see clearly.Many sunglasses out there just don't allow that adaptation to occur in a seamless way. ROKA eyeglasses and sunglasses are designed with all of the biology of the visual system in mind, so that you always see things with crystal clarity, no matter what environment you're in. They also have a terrific aesthetic. They have many, many different styles to choose from, so their eyeglasses can be worn to dinner or out to lunch or to work. Their sunglasses can be worn essentially anywhere. They're very stylish and they were designed for performance. They won't slip off your face if you get sweaty. Indeed, you can wear them while running or while cycling. They're really terrific. They're really versatile. If you'd like to try ROKA glasses, go to ROKA, that's R-O-K-A, .com and enter the code Huberman to save 20% off your first order. Again, that's ROKA, R-O-K-A, .com, enter the code Huberman at checkout. Today's episode is also brought to us by InsideTracker. InsideTracker is a personalized nutrition platform that analyzes data from your blood and DNA to help you better meet your immediate and long-term health goals. Now, I've long been a believer in getting regular blood work done, for the simple reason that many of the things that impact your immediate and long-term health can only be assessed from a quality blood test. And nowadays, with the advent of modern DNA tests, you can also get a window into how your genes are impacting your health in the short and long term, and the various things that you should do in order to adjust your health in the right direction. Now, one of the major issues with a lot of blood tests and DNA tests out there, is you get numbers back and you learn whether or not your lipids or your hormones, et cetera, are within the proper range or not. But there aren't a lot of directives about what to do with that information. InsideTracker makes all of that very easy. They have a personalized dashboard that allows you to, of course, see the numbers that come back to you, and to make various changes in nutrition, various changes in exercise, various changes in all sorts of lifestyle factors that can bring those numbers into range. And so if you have a particular value for a particular metabolic factor or hormone or so forth, you click on that, and it will actually bring up the full menu of things that you can do in order to adjust that factor into the ranges that you like, all based on quality peer-reviewed research. If you'd like to try InsideTracker, you can visit insidetracker.com/huberman to get 25% off any of InsideTracker's plans. Just use the code Huberman at checkout. And now my conversation with Dr. Alia Crum. Well, great to have you here.

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