Diet & Nutrition for Mental Health | Dr. Chris Palmer

Diet & Nutrition for Mental Health | Dr. Chris Palmer

Huberman LabNov 21, 20223h 3m

Andrew Huberman (host), Chris Palmer (guest)

Personal history of mental illness and metabolic syndrome in Dr. PalmerKetogenic and low-carbohydrate diets as treatments for psychiatric disordersMitochondrial function, mitophagy, and mitochondrial biogenesis in brain healthHistorical and current use of ketogenic diets for epilepsyClinical case studies: depression, bipolar disorder, schizophrenia, alcohol use disorderDiet adherence, side effects, and interaction with psychiatric medicationsEmerging applications: obesity, Alzheimer’s disease, and GLP‑1 weight-loss drugs

In this episode of Huberman Lab, featuring Andrew Huberman and Chris Palmer, Diet & Nutrition for Mental Health | Dr. Chris Palmer explores ketogenic Metabolism: A New Frontier in Treating Serious Mental Illness Dr. Chris Palmer, a Harvard psychiatrist, argues that many mental illnesses are fundamentally metabolic and mitochondrial disorders, and that targeted nutrition—especially ketogenic and low-carbohydrate diets—can be powerful treatments alongside medication. Drawing on his own history of OCD, depression, and metabolic syndrome, he describes how an Atkins-style low-carb diet unexpectedly resolved not just his metabolic markers but also his mood, energy, and sleep.

Ketogenic Metabolism: A New Frontier in Treating Serious Mental Illness

Dr. Chris Palmer, a Harvard psychiatrist, argues that many mental illnesses are fundamentally metabolic and mitochondrial disorders, and that targeted nutrition—especially ketogenic and low-carbohydrate diets—can be powerful treatments alongside medication. Drawing on his own history of OCD, depression, and metabolic syndrome, he describes how an Atkins-style low-carb diet unexpectedly resolved not just his metabolic markers but also his mood, energy, and sleep.

He then details dramatic cases, including a man with schizoaffective disorder whose chronic hallucinations and delusions remitted after adopting a medically supervised ketogenic diet, allowing major functional recovery for the first time in years. Palmer connects these outcomes to a century of research on ketogenic diets for epilepsy, emphasizing that keto began as a neurological treatment, not a weight-loss fad.

The core mechanistic thesis is that ketogenic states promote mitophagy and mitochondrial biogenesis, improving cellular energy production, neurotransmitter balance, inflammation, hormone synthesis, and gene expression in ways that can reverse or mitigate psychiatric symptoms. While large randomized trials are still limited, early pilot data and extensive clinical experience across depression, bipolar disorder, schizophrenia, alcoholism, and Alzheimer’s disease point to nutrition as a crucial, underutilized lever in mental healthcare.

Key Takeaways

Mental disorders may often be rooted in metabolic and mitochondrial dysfunction, not just 'chemical imbalances'.

Palmer proposes that impaired mitochondrial function—affecting energy production, neurotransmitters, hormones, inflammation, and gene expression—is a unifying driver across depression, bipolar disorder, schizophrenia, anxiety, and even Alzheimer’s. ...

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Ketogenic diets can induce remission or major improvement in treatment-resistant psychiatric illness for some patients.

In a striking case, a 33‑year‑old man with schizoaffective disorder, daily hallucinations, and severe paranoia—unresponsive to 17 medications—lost 160 pounds and experienced remission of psychotic symptoms after starting a ketogenic diet. ...

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Degree and type of dietary change should be matched to diagnosis, metabolic status, and patient readiness.

Palmer rarely uses a one-size-fits-all approach. ...

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Mitochondria do far more than supply energy; improving their health can recalibrate multiple psychiatric-relevant systems.

Mitochondria help synthesize and release key neurotransmitters (serotonin, dopamine, glutamate, acetylcholine), regulate steroid hormones (cortisol, estrogen, testosterone, progesterone), control inflammatory responses, manage calcium signaling, and drive much of epigenetic gene expression (influencing ~60% of genes in some cells). ...

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Dietary interventions must be medically supervised when used as treatment for serious mental illness, especially alongside medications.

Changing brain metabolism can change medication dynamics. ...

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Alcohol, cannabis, and modern diets impair mitochondrial and brain metabolism, but metabolic interventions can partly reverse damage.

Chronic alcohol use deprives reward-system neurons of glucose-based energy while supplying acetate instead; NIH research (Nora Volkow’s group) shows that a ketogenic diet during detox reduced withdrawal symptoms, cravings, and neuroinflammation while improving brain metabolism. ...

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Obesity is likely a symptom of brain metabolic dysfunction, not just overeating; GLP‑1 drugs may help weight but miss the root cause.

Despite decades of 'eat less, move more' messaging, obesity rates continue to climb. ...

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Notable Quotes

Once you understand the science of mitochondria, you can actually connect all of the dots of the mental illness puzzle.

Dr. Chris Palmer

That man went on… he’s now lost 160 pounds and kept it off, and the voices and delusions that had tormented him for years essentially went away.

Dr. Chris Palmer

In many ways, using the ketogenic diet as a treatment for serious mental disorders is nothing new at all. We already use epilepsy drugs in tens of millions of psychiatric patients.

Dr. Chris Palmer

Fasting is not a healthy diet. Fasting is the process of no diet. The ketogenic diet was invented to mimic the fasting state so you could get the benefits without starving to death.

Dr. Chris Palmer

We don’t know what causes obesity. My strong belief is that mitochondria are the key to the obesity epidemic.

Dr. Chris Palmer

Questions Answered in This Episode

For a patient with long-standing bipolar disorder on multiple mood stabilizers, how would you sequence and structure a ketogenic intervention while safely tapering meds, and what early warning signs would tell you to slow down or reverse course?

Dr. ...

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You mentioned that some brain regions cannot use ketones and must have glucose; do you see any cognitive or mood side effects in patients who maintain deep ketosis for years, and how do you monitor for or mitigate those?

He then details dramatic cases, including a man with schizoaffective disorder whose chronic hallucinations and delusions remitted after adopting a medically supervised ketogenic diet, allowing major functional recovery for the first time in years. ...

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In the alcohol use disorder study where keto reduced cravings and withdrawal symptoms, what specific macronutrient ratios and ketone levels were targeted, and could a lower-intensity low-carb approach (without full ketosis) provide similar benefits with less relapse risk?

The core mechanistic thesis is that ketogenic states promote mitophagy and mitochondrial biogenesis, improving cellular energy production, neurotransmitter balance, inflammation, hormone synthesis, and gene expression in ways that can reverse or mitigate psychiatric symptoms. ...

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Given the observed sex differences and potential fertility impacts, what practical guidelines would you offer to premenopausal women considering keto primarily for mental health—especially if they are trying to conceive or have a history of menstrual irregularities?

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If obesity is primarily a symptom of brain mitochondrial dysfunction, what specific environmental or developmental exposures (e.g., in utero nutrition, microplastics, circadian disruption) do you suspect are most culpable, and how would you design studies to disentangle their relative contributions?

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Transcript Preview

Andrew Huberman

(instrumental music) Welcome to the Huberman Lab Podcast, where we discuss science, and science-based tools for everyday life. I'm Andrew Huberman, and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine. Today my guest is Dr. Chris Palmer. Dr. Chris Palmer is a medical doctor specializing in psychiatry at Harvard Medical School. He is the world expert in the relationship between metabolic disorders and psychiatric disorders. He treats a variety of different conditions, including psychosis, including schizophrenia, as well as attention deficit hyperactivity disorder, obsessive compulsive disorder, anxiety disorders, and depression, among others. He is best known for understanding the relationship between how metabolism and these various disorders of the mind interact. And indeed today, he describes not only his own fascinating journey into the field of psychiatry, but also his clinical and research experience using diet, that is, different forms of nutrition, in order to treat various psychiatric disorders. He describes some remarkable case studies of individuals and groups of people who have achieved tremendous relief from the types of psychiatric disorders that I just mentioned a few moments ago, as well as new and emerging themes as to how metabolism and the mind interact to control things like obesity. Indeed, he raises the hypothesis that perhaps obesity, in many cases, is the consequence of a brain dysfunction as opposed to a, the consequence of a metabolic dysfunction that then impacts the brain. During today's episode, he shares with us his overriding hypotheses about the critical roles that mitochondrial function and dysfunction play in mental health and mental illness, and how various particular types of diets, ranging from the ketogenic diet to modified ketogenic diet, and even just slight adjustments in carbohydrate intake, can be used in order to change mitochondrial function and bring relief for various psychiatric illnesses. He also highlights the essential and important theme that various diet interventions, including the ketogenic diet, were not first developed for sake of weight loss, but rather were developed as treatments for neurologic conditions such as epilepsy. Today, he shares with us how the foods that we eat, alone and in combination, and how fasting, both intermittent fasting and more lengthy fasts, can interact with the way that our brain functions to strongly control the way that we think, feel, and behave. What's wonderful is that Dr. Palmer not only explains the science and his clinical expertise, but also points to various actionable measures that people can take in order to improve their mental health. I'd like to mention that Dr. Palmer is also the author of a terrific new book. The title is Brain Energy: A Revolutionary Breakthrough in Understanding Mental Health and Improving Treatment for Anxiety, Depression, OCD, PTSD and More. I've read the book, and it is a terrific read. I came away from this book with a much evolved understanding of how the various psychiatric disorders that I just described, as well as ADHD, emerge in people, and it has completely revised my understanding about the possible origins of various psychiatric disorders and the best ways to treat them, including both with medications, but also with nutritional approaches. If you'd like to learn more about Dr. Palmer's work and the book, please go to chrispalmermd.com. We also provide links to the book and to his website in our show note captions. Before we begin, I'd like to emphasize that this podcast is separate from my teaching and research roles at Stanford. It is, however, part of my desire and effort to bring zero cost to consumer information about science and science-related tools for the general public. In keeping with that theme, I'd like to thank the sponsors of today's podcast. Our first sponsor is Thesis. Thesis makes custom nootropics, and as I've said many times before on this podcast, I am not a fan of the word "nootropics" because it means smart drugs, and frankly, there are no specific neural circuits in the brain or body for being, quote-unquote, "smart." Thesis understands this, and they've developed custom nootropics that are designed to bring your brain and body into the state that's ideal for what you need to accomplish. They use the highest quality ingredients, things like phosphatidylserine, Alpha-GPC, many ingredients that I've talked about before on this podcast and that I happen to use myself. I've been using Thesis for over a year now, and I can confidently say that their nootropics have been a game-changer. For me, I like their nootropic for clarity, I use that before cognitive work often, and I like their nootropic for energy, and I often use that before workouts, in particular, workouts that are especially intense. To get your own personalized nootropic starter kit, go online to takethesis.com/huberman, take their three-minute quiz, and Thesis will send you four different formulas to try in your first month. Again, that's takethesis.com/huberman and use the code "Huberman" at checkout to get 10% off your first box. Today's episode is also brought to us by Eight Sleep. Eight Sleep makes smart mattress covers with cooling, heating, and sleep tracking capacity. I've talked many times on this podcast about the critical relationship between sleep and body temperature. That is, in order to fall asleep and stay deeply asleep throughout the night, our body temperature needs to drop by about one to three degrees. And conversely, when we wake up in the morning, that is in large part because of our body heating up by one to three degrees. Now, people have different core body temperatures, and they tend to run colder or hotter throughout the night. Eight Sleep allows you to adjust the temperature of your sleeping environment so that you have the optimal temperature that gets you the best night's sleep. I started sleeping on an Eight Sleep mattress cover about eight months ago, and it has completely transformed my sleep. I sleep so much deeper, I wake up far less during the middle of the night, if at all, and I wake up feeling far better than I ever have, even after the same amount of sleep. If you wanna try Eight Sleep, you can go to eightsleep.com/huberman to save up to $400 off their Sleep Fit Holiday Bundle, which includes their new Pod 3 cover. Eight Sleep currently ships in the USA, Canada, United Kingdom, select countries in the EU, and Australia. Again, that's eightsleep.com/huberman. Today's episode is also brought to us by ROKA. ROKA makes eyeglasses and sunglasses that are of the absolute highest quality. The company was founded by two all-American swimmers from Stanford, and everything about ROKA eyeglasses and sunglasses were designed with performance in mind. I've spent a lifetime working on the biology of the visual system, and I can tell you that your visual system has to contend with an enormous number of challenges in order for you to see clearly, for instance when you move from a sunny area to a shady area and back again, whether or not you're looking at something up close or off into the distance. ROKA understands the biology of the visual system and has designed their eyeglasses and sunglasses accordingly so that you always see with perfect clarity. ROKA eyeglasses and sunglasses were initially designed for activities such as running and cycling, and indeed they are very lightweight. Most of the time I can't even remember that they're on my face they're so lightweight. But the important thing to know about ROKA eyeglasses and sunglasses is that while they can be used during sports activities, they also have a terrific aesthetic and they can be used just as well for wearing to work or out to dinner, et cetera. If you'd like to try ROKA eyeglasses and sunglasses, you can go to ROKA, that's roka.com, and enter the code "Huberman" to save 20% off on your first order. Again, that's ROKA, roka.com, and enter the code "Huberman" at checkout. And now for my discussion with Dr. Chris Palmer.Chris, Dr. Palmer, thank you for being here.

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