Dr. Kyle Gillett on Huberman Lab: Why lifestyle beats TRT

Sleep, diet, and exercise optimize hormones before any drug is needed; Gillett covers testosterone thresholds, TRT trade-offs, and DHEA for both sexes.

Andrew HubermanhostDr. Kyle Gillettguest

Dec 25, 202537mWatch on YouTube ↗

EPISODE INFO

Released: December 25, 2025
Duration: 37m
Channel: Huberman Lab
Watch on YouTube: ▶ Open ↗

EPISODE DESCRIPTION

In this Huberman Lab Essentials episode, my guest is Dr. Kyle Gillett, MD, a dual board-certified physician in family medicine and obesity medicine and an expert in optimizing hormone levels to improve overall health. We explain how to improve hormone levels across the lifespan in both men and women using behavioral, nutritional and exercise-based tools. We also discuss common clinical topics, including hormone testing, PCOS, hair loss, testosterone replacement therapy (TRT) and peptides, focusing on potential benefits, tradeoffs and risks. Episode show notes: https://go.hubermanlab.com/EkpDEyt Watch more Huberman Lab Essentials: https://youtube.com/playlist?list=PLPNW_gerXa4OGNy1yE-W9IX-tPu-tJa7S&si=a1_sA7rUT-fE0OM5 *Timestamps* 00:00:00 Kyle Gillett 00:00:36 Hormone Health; Women vs Men, Tool: Hormone Testing 00:02:35 Tool: Big 6 Lifestyle Pillars to Optimize Hormone Health 00:04:32 Diet, Individualization; Bloodwork & Frequency 00:05:35 Exercise, Zone 2 Cardio; Caloric Restriction 00:06:51 Intermittent Fasting, Growth Hormone, IGF-1 00:09:20 Hormones & Sleep, Growth Hormone, Menopause, Andropause, TRT 00:11:43 Testosterone & Women, SHGB 00:13:34 Dihydrotestosterone (DHT), Androgens; Turmeric & Black Pepper; Hair Loss 00:16:47 Polycystic Ovarian Syndrome (PCOS), Symptoms, Metformin, Inositol 00:20:13 Cannabis, Alcohol, Testosterone 00:21:47 Males & Testosterone, TRT, Prostate Cancer 00:23:04 Prolactin, Dopamine “Wave Pool”, Tool: Casein & Gluten 00:24:23 Social Relationships & Hormones, Tool: Planning for Crisis 00:26:22 Peptides, Growth Hormone & Risk; BPC 157, Sourcing & LPS 00:32:02 Melanotan, Uses & Risks 00:34:05 Spiritual Health, Interdisciplinary Health Integration 00:36:43 Caffeine & Hormones, Sleep; Acknowledgements #HubermanLab Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

SPEAKERS

Andrew Huberman
host
Dr. Kyle Gillett
guest

EPISODE SUMMARY

In this episode of Huberman Lab, featuring Andrew Huberman and Dr. Kyle Gillett, Dr. Kyle Gillett on Huberman Lab: Why lifestyle beats TRT explores science-Backed Strategies To Optimize Hormones, Health, Energy, And Relationships Andrew Huberman and Dr. Kyle Gillett discuss practical, science-based approaches to optimizing hormones for men and women across the lifespan, emphasizing lifestyle before drugs and peptides.

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