Essentials: Tools for Hormone Optimization in Males | Dr. Kyle Gillett

In this Huberman Lab Essentials episode, my guest is Kyle Gillett, MD, a dual board-certified physician in family medicine and obesity medicine, and an expert in hormone optimization. We discuss science-based tools for optimizing male hormones across the lifespan, including the role of bloodwork, nutrition, and exercise in supporting healthy hormone levels. We also discuss testosterone therapy, hair loss, prostate health, and supplements such as creatine, L-carnitine, Tongkat Ali, and Fadogia agrestis. Show notes: https://go.hubermanlab.com/pBONCAb Watch more Huberman Lab Essentials: https://youtube.com/playlist?list=PLPNW_gerXa4OGNy1yE-W9IX-tPu-tJa7S&si=a1_sA7rUT-fE0OM5 Timestamps 00:00:00 Kyle Gillett 00:00:20 Male Hormone Optimization, Testosterone, Tool: Blood Tests 00:02:17 Diet & Hormone Health, Diary, Vitamin D, Fiber 00:05:36 Caloric Restriction & Testosterone 00:06:44 Lifestyle Pillars: Stress, Life Purpose 00:07:56 Exercise & Hormone Health 00:08:59 Testosterone Replacement Therapy (TRT) & Young Adults 00:10:32 Supplements for Testosterone, Creatine & Hair Loss; Betaine, Doses 00:14:16 L-Carnitine, Forms, Dose, TMAO, Garlic & Berberine 00:17:29 Vitamin D, Boron 00:19:10 Tongkat Ali (Longjack); Fadogia Agrestis 00:23:56 Testosterone Therapy, Dose; Side Effects 00:28:32 Clomiphene, SERM & Testosterone 00:31:06 Alcohol, Aromatase & Testosterone 00:31:58 Prostate Health & Tadalafil, Nighttime Urination 00:33:59 Hair Loss, Caffeine, Finasteride, Dutasteride 00:36:02 Acknowledgements #hubermanlab #science #health Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

Andrew HubermanhostDr. Kyle Gillettguest

Jul 2, 202636mWatch on YouTube ↗

EPISODE INFO

Released: July 2, 2026
Duration: 36m
Channel: Huberman Lab
Watch on YouTube: ▶ Open ↗

EPISODE DESCRIPTION

In this Huberman Lab Essentials episode, my guest is Kyle Gillett, MD, a dual board-certified physician in family medicine and obesity medicine, and an expert in hormone optimization. We discuss science-based tools for optimizing male hormones across the lifespan, including the role of bloodwork, nutrition, and exercise in supporting healthy hormone levels. We also discuss testosterone therapy, hair loss, prostate health, and supplements such as creatine, L-carnitine, Tongkat Ali, and Fadogia agrestis. Show notes: https://go.hubermanlab.com/pBONCAb Watch more Huberman Lab Essentials: https://youtube.com/playlist?list=PLPNW_gerXa4OGNy1yE-W9IX-tPu-tJa7S&si=a1_sA7rUT-fE0OM5 Timestamps 00:00:00 Kyle Gillett 00:00:20 Male Hormone Optimization, Testosterone, Tool: Blood Tests 00:02:17 Diet & Hormone Health, Diary, Vitamin D, Fiber 00:05:36 Caloric Restriction & Testosterone 00:06:44 Lifestyle Pillars: Stress, Life Purpose 00:07:56 Exercise & Hormone Health 00:08:59 Testosterone Replacement Therapy (TRT) & Young Adults 00:10:32 Supplements for Testosterone, Creatine & Hair Loss; Betaine, Doses 00:14:16 L-Carnitine, Forms, Dose, TMAO, Garlic & Berberine 00:17:29 Vitamin D, Boron 00:19:10 Tongkat Ali (Longjack); Fadogia Agrestis 00:23:56 Testosterone Therapy, Dose; Side Effects 00:28:32 Clomiphene, SERM & Testosterone 00:31:06 Alcohol, Aromatase & Testosterone 00:31:58 Prostate Health & Tadalafil, Nighttime Urination 00:33:59 Hair Loss, Caffeine, Finasteride, Dutasteride 00:36:02 Acknowledgements #hubermanlab #science #health Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

SPEAKERS

Andrew Huberman
host
Professor of neurobiology and ophthalmology at Stanford School of Medicine and host of the Huberman Lab podcast.
Dr. Kyle Gillett
guest
Physician specializing in male hormone optimization and clinical management of therapies such as TRT, including lab interpretation and side-effect monitoring.

EPISODE SUMMARY

In this episode of Huberman Lab, featuring Andrew Huberman and Dr. Kyle Gillett, Essentials: Tools for Hormone Optimization in Males | Dr. Kyle Gillett explores practical male hormone optimization: tests, lifestyle, supplements, and therapies guidance Regular bloodwork (including total testosterone plus SHBG or free testosterone) is positioned as the foundation for monitoring hormone status and guiding decisions, often with ~6-month follow-ups.

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