Dr. Thaïs Aliabadi on Huberman Lab: Why PCOS goes undetected

Insulin resistance disrupts the brain-ovary axis to drive PCOS; AMH testing and Tyrer-Cuzick scoring give women early answers on fertility and cancer risk.

Dr. Thaïs AliabadiguestAndrew Hubermanhost

Nov 24, 20253h 7mWatch on YouTube ↗

EPISODE INFO

Released: November 24, 2025
Duration: 3h 7m
Channel: Huberman Lab
Watch on YouTube: ▶ Open ↗

EPISODE DESCRIPTION

My guest is Dr. Thaïs Aliabadi, MD, board-certified OB/GYN, surgeon and leading expert in women's health. We discuss polycystic ovary syndrome (PCOS) and endometriosis, two very common yet frequently undiagnosed causes of female infertility. Dr. Aliabadi explains the symptoms, underlying causes and evidence-based treatments for both conditions, including supplement and lifestyle interventions. We also discuss breast cancer risk and screening, pregnancy, perimenopause and menopause, and the hormone tests that women should request. This conversation offers empowering, potentially life-changing information for women of all ages to take control of their hormone, reproductive and overall health. Episode show notes: https://go.hubermanlab.com/mDpyoTs *Thank you to our sponsors* AGZ by AG1: https://drinkagz.com/huberman Lingo: https://hellolingo.com/huberman Our Place: https://fromourplace.com/huberman Joovv: https://joovv.com/huberman LMNT: https://drinklmnt.com/huberman Function: https://functionhealth.com/huberman *Follow Huberman Lab* Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab X: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://www.hubermanlab.com Newsletter: https://www.hubermanlab.com/newsletter *Dr. Thaïs Aliabadi* Medical website: https://www.draliabadi.com SheMD podcast: https://www.shemdpodcast.com/episodes SheMD website & resources: https://www.shemdpodcast.com The Women’s Health Blog: https://www.draliabadi.com/womens-health-blog Ovii Health: https://ovii.com Instagram: https://www.instagram.com/drthaisaliabadi/?hl=en YouTube: https://www.youtube.com/c/DrThaisAliabadi Facebook: https://www.facebook.com/ThaisAliabadiMd LinkedIn: https://www.linkedin.com/in/dr-thais-aliabadi-1232a392 *Timestamps* 00:00:00 Thaïs Aliabadi 00:02:56 Why Endometriosis & Polycystic Ovary Syndrome (PCOS) Go Undiagnosed 00:08:16 Infertility, Tool: Early Screening 00:10:54 Sponsors: Lingo & Our Place 00:14:07 Women’s Health Education Gap 00:15:24 PCOS Overview: Symptoms, Diagnosis, AMH, Disordered Eating 00:21:28 Irregular Periods, Teenage PCOS Diagnosis 00:24:36 Diagnosis, Pelvic Ultrasound; PCOS Naming 00:27:49 Thinning Hair & Acne; 4 PCOS Phenotypes; Mood & Treatment 00:35:54 Underlying Pillars of PCOS; HPA Axis, Androgens, Menstruation & Ovulation 00:40:30 Insulin Resistance & PCOS, Visceral Fat & Inflammation 00:46:30 Sponsors: AGZ by AG1 & Joovv 00:49:10 PCOS, Chronic Inflammation, Genetics & Lifestyle; Mood 00:52:31 PCOS, Fertility, Freezing Eggs, Tool: Egg Count & AMH Range By Age 00:58:34 Women’s Health Education, AI, Clinicians; Cataracts Analogy 01:01:20 Stress; PCOS Treatment, Birth Control, Insulin Resistance & Metformin 01:06:44 PCOS Risk Calculator, Supplements, Lifestyle Factors; GLP-1s 01:12:32 Berberine, Metformin; GLP-1s, Food Anxiety & Alcohol 01:19:13 PCOS Prescriptions & Fertility; PCOS Co-Occurrence with Endometriosis 01:21:56 Sponsor: LMNT 01:23:16 PCOS Treatment, Freezing Eggs, Egg Quality; Advocate For Your Health 01:32:02 PCOS Key Takeaways: Symptoms, Tests, Supplements & Lifestyle 01:36:03 Undiagnosed Endometriosis, Fertility 01:39:26 Endometriosis: Symptoms, Diagnosis, Painful Periods, Infertility 01:42:30 Male vs Female Health Issues, Undiagnosed Endometriosis 01:47:01 Inflammation, Ectopic Implants, Chronic Pelvic Pain; Adenomyosis 01:50:36 Egg Quality, Endometriosis, Tools: Egg Counts; Pelvic Ultrasound 01:54:29 Sponsor: Function 01:56:13 Pain & Health Testing, Tool: Endometriosis Symptoms, Screening & Tests 02:01:32 Treatment, Surgery, Different Types of Endometriosis 02:05:22 Endometriosis Causes, Inflammation; Incidence, PCOS 02:11:58 Obstetrics & Gynecology Separation, Surgery 02:16:00 Endometriosis Key Takeaways: Symptoms, Treatment & Diagnosis 02:17:04 Treatment, Estrogen & Progesterone, Birth Control, GnRH Antagonists 02:22:39 Endometriosis Stage & Pain, Endometriosis Types 02:23:49 Pregnancy; Postpartum Depression, Menopause; Frustration for Patients 02:29:55 Fibroids, Surgery, Uterine Septum, Tool: Pelvic Ultrasound 02:34:05 Tool: Assessing Your & Partner’s Fertility; Autoimmune Conditions 02:37:51 Breast Cancer, Tool: Lifetime Risk Calculator & Breast Imaging; Mastectomy 02:49:47 Endometriosis Tests, Autoimmune Disease; Brain Fog & Menopause; Inositol 02:53:06 Undiagnosed Infertility; PMDD Treatment; Fasting & Low-Carbohydrate Diets 02:57:21 Hair Loss & Perimenopause; Egg Quality; Endometriosis & Menopause 03:00:40 Increase Progesterone; Diet, Hormone & Menopause; Prolong Fertility 03:04:54 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter #HubermanLab #Health #HormoneHealth Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

SPEAKERS

Dr. Thaïs Aliabadi
guest
Andrew Huberman
host

EPISODE SUMMARY

In this episode of Huberman Lab, featuring Dr. Thaïs Aliabadi and Andrew Huberman, Dr. Thaïs Aliabadi on Huberman Lab: Why PCOS goes undetected explores ending Silent Suffering: PCOS, Endometriosis, Fertility And Breast Cancer Dr. Thaïs Aliabadi, a leading OB-GYN and surgeon, explains why PCOS and endometriosis—top causes of female infertility—are massively underdiagnosed and frequently dismissed as “normal” or “in your head.” She details how disruptions in brain–ovary signaling, insulin resistance, chronic inflammation, genetics, and lifestyle interact to create PCOS, and why classical fertility charts that only consider age are dangerously misleading.

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