Huberman LabHow Mitochondria Control Your Metabolism | Dr. Jared Rutter
Episode Details
EPISODE INFO
- Released
- September 7, 2026
- Duration
- 2h 3m
- Channel
- Huberman Lab
- Watch on YouTube
- ▶ Open ↗
EPISODE DESCRIPTION
Dr. Jared Rutter, PhD, Professor of Biochemistry at the University of Utah and Howard Hughes Medical Institute Investigator, is a leading expert on mitochondria and metabolism. He explains how mitochondria produce the energy for your cells to work but also how they regulate cell growth and replication and thereby contribute to health and disease. We also discuss how mitochondria are linked to aging, cancer, and other diseases. Our conversation explores your metabolism as the composite of trillions of individual cells and points to new ways to improve health, avoid, and treat diseases. Show notes: https://go.hubermanlab.com/VOYGC3w Pre-order Protocols: https://protocolsbook.com Thank you to our sponsors AG1: https://drinkag1.com/huberman Joovv: https://joovv.com/huberman BetterHelp: https://betterhelp.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman Huberman Lab Website: https://www.hubermanlab.com Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab X: https://x.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Jared Rutter Academic profile: https://medicine.utah.edu/faculty/jared-p-rutter HHMI: https://www.hhmi.org/scientists/jared-rutter Lab website: https://rutter.biochem.utah.edu Publications: https://rutter.biochem.utah.edu/publications BlueSky: https://bsky.app/profile/rutterlab.bsky.social X: https://x.com/rutterlab Timestamps 00:00:00 Jared Rutter 00:02:29 Metabolism, Cells; Aging 00:08:36 Mitochondria, Origin & Cell Complexity 00:13:07 Sponsors: Joovv & BetterHelp 00:15:16 Mitochondria Genome, Inheritance 00:18:18 Mitochondria & Spatial Distribution; Cell-Specific Metabolism 00:25:59 Nutrient Energy, Hormones, Fat Cells 00:31:13 Glucose, ATP Conversion, Pyruvate 00:36:41 Cell Choice: Energy or Growth, Cancer; Virus 00:46:02 Sponsors: AG1 & Eight Sleep 00:48:36 Microbiome, Role of Humans 00:51:44 Molecule Discovery Process, MPC1, MPC2 00:59:42 Cell Resource Sensing, Fasting, Glucagon, Fat Cells; Neurons, Heart 01:07:03 Cell Resource Allocation, MPC, Heart Failure; Disease 01:11:46 Sponsor: Function 01:13:24 Cell Size vs Fuel Balance, Cell Identity & Disease 01:20:43 MPC Discovery, Genetics, Model Systems 01:24:29 Lactate, Oxygen, Exercise; Energy Prioritization Hierarchy 01:31:32 Cancer, Mutations, Metabolism Changes & Warburg Effect 01:36:18 Cancer Challenges & Therapies 01:43:00 Therapy Combinations, Unique Cancer Mutations & Metabolism 01:48:31 Technology to Visualize Metabolism; Disease, Metabolism & Scents 01:56:34 Excess Energy & Mitochondria, Reactive Oxygen Species 02:01:12 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter #hubermanlab Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer
SPEAKERS
Dr. Jared Rutter
guestProfessor of biochemistry at the University of Utah and an investigator with the Howard Hughes Medical Institute, specializing in mitochondrial biology and metabolism.
Andrew Huberman
hostProfessor of neurobiology and ophthalmology at Stanford School of Medicine and host of the Huberman Lab Podcast.
EPISODE SUMMARY
In this episode of Huberman Lab, featuring Dr. Jared Rutter and Andrew Huberman, How Mitochondria Control Your Metabolism | Dr. Jared Rutter explores mitochondria steer cellular fuel choices that shape health, aging, and disease Metabolism is described as the summed output of many distinct cellular metabolic programs, coordinated by nutrient availability and hormones rather than a single unified “metabolic rate.”
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