Dr. Rhonda Patrick on Huberman Lab: Why gut LPS harms health

Through gut permeability: LPS from processed meals enters blood and binds LDL; foam cells form and fasting triggers a metabolic switch that limits the cascade.

Dr. Rhonda PatrickguestAndrew Hubermanhost

Mar 23, 20263h 31mWatch on YouTube ↗

EPISODE INFO

Released: March 23, 2026
Duration: 3h 31m
Channel: Huberman Lab
Watch on YouTube: ▶ Open ↗

EPISODE DESCRIPTION

Dr. Rhonda Patrick, PhD, is a biomedical scientist and public science educator. She shares the exercise, nutrition, supplementation and lifestyle practices linked to better health and lower disease risk including specific cardio and resistance training routines, when and why to do intermittent fasting, ways to lower visceral fat, omega-3 sourcing, creatine for brain and muscle and peptides such as BPC-157. It’s broad and thorough coverage of how to build a total health program tailored to your goals and individual biology. Show notes: https://go.hubermanlab.com/h6uw5eR Thank you to our sponsors AG1: https://drinkag1.com/huberman Our Place: https://fromourplace.com/huberman Lingo: https://hellolingo.com/huberman LMNT: https://drinklmnt.com/huberman Function: https://functionhealth.com/huberman Mateina: https://drinkmateina.com/huberman Huberman Lab Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab X: https://x.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://www.hubermanlab.com Newsletter: https://www.hubermanlab.com/newsletter Dr. Rhonda Patrick Website: https://www.foundmyfitness.com Newsletter: https://www.foundmyfitness.com/newsletter Podcast episodes: https://www.foundmyfitness.com/episodes Google scholar: https://scholar.google.com/citations?user=iXt3ow0AAAAJ YouTube: https://www.youtube.com/user/FoundMyFitness Instagram: https://www.instagram.com/foundmyfitness X: https://x.com/foundmyfitness Threads: https://www.threads.com/@foundmyfitness Facebook: https://www.facebook.com/foundmyfitness Timestamps 00:00:00 Rhonda Patrick 00:02:40 Competition, Jumping Rope, Rope Flow 00:06:49 Rhonda's Exercise Routine, Cardiovascular & Resistance Training 00:12:30 Cognitive & Physical Benefits of Exercise, Serotonin & Impulse Control 00:14:40 Sponsors: Our Place & Lingo 00:17:03 Phones While Training? 00:18:45 Rhonda's Strength Training, Low-Reps, Modifications, Mental Resilience 00:27:00 Daily Protein Intake, Intermittent Fasting, Processed Carbohydrates 00:33:32 Lipopolysaccharide (LPS); Gut Permeability, Gluten; Cardiovascular Health 00:42:58 Sponsor: AG1 00:44:21 Tight Junctions, Gut, Neuroinflammation 00:47:26 L-glutamine, Immune System, Cancer Risk 00:54:55 N-acetylcysteine (NAC), Vitamin E; Antioxidant Balance, Reductive Stress 01:00:08 Starch, Tool: Bedtime Fast & Cardiovascular Health 01:03:36 Cortisol, Intermittent Fasting Benefits 01:08:09 Cortisol, Train Fasted?; Hormones, Visceral Fat 01:13:35 Visceral Fat, Perimenopause/Menopause, Insulin Resistance in Brain & Body 01:21:13 Sponsor: LMNT 01:22:33 Cortisol & Sleep 01:25:42 Intermittent Fasting, Metabolic Switch, Ketones, Muscle Loss? 01:36:47 Tools: Logic-Based Habits; Daily Metabolic Switch; Exercise, Autophagy 01:45:06 Exercise After Poor Sleep?; Training Breaks 01:52:47 Tool: "Exercise Snacks"; Sedentary Lifestyle & Cardiorespiratory Fitness 02:03:31 Sponsor: Function 02:05:16 Creatine, Dose, Resistance Training, Cognitive Function 02:17:43 Biology; Creatine; Supplement Safety 02:25:18 Omega-3s, Inflammation, Cancer Risk, Vitamin D; Trans Fat 02:36:52 Magnesium Threonate vs Bisglycinate, Sleep, Cognitive Benefit; Vitamin D 02:45:46 Supplement Types, Multivitamin, Coenzyme Q10, Urolithin A, Sulforaphane 02:55:10 Microplastics 02:57:26 Sponsor: Mateina 02:58:28 BPC-157, NMN, NR, Tool: Evaluating Supplements, Safety, Sources 03:06:28 L-Carnitine, Alpha-GPC, Nicotine, GABA & Ketogenic Diet 03:15:20 Nattokinase; Microplastics, Water Bottles; Seed Oils 03:22:21 Sauna, Creatine for Kids?, Bananas, Tool: Evaluating Studies 03:28:37 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter #HubermanLab #Health #Science Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

SPEAKERS

Dr. Rhonda Patrick
guest
Biomedical scientist and public health educator focused on nutrition, exercise, and longevity science.
Andrew Huberman
host
Professor of neurobiology and ophthalmology at Stanford School of Medicine and host of the Huberman Lab Podcast.

EPISODE SUMMARY

In this episode of Huberman Lab, featuring Dr. Rhonda Patrick and Andrew Huberman, Dr. Rhonda Patrick on Huberman Lab: Why gut LPS harms health explores rhonda Patrick’s integrated protocols for exercise, fasting, supplements, and inflammation reduction Patrick emphasizes vigorous exercise plus resistance training as non-negotiables, highlighting that even brief “exercise snacks” totaling ~9 minutes/day correlate with large mortality risk reductions.

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