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Manolis Kellis: Biology of Disease | Lex Fridman Podcast #133

Manolis Kellis is a computational biologist at MIT. Please support this podcast by checking out our sponsors: - SEMrush: https://www.semrush.com/partner/lex/ to get a free month of Guru - Pessimists Archive: https://pessimists.co/ - Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get $200 off - BetterHelp: https://betterhelp.com/lex to get 10% off EPISODE LINKS: Manolis Website: http://web.mit.edu/manoli/ Manolis Twitter: https://twitter.com/manoliskellis Manolis YouTube: https://www.youtube.com/channel/UCkKlJ5LHrE3C7fgbnPA5DGA Manolis Wikipedia: https://en.wikipedia.org/wiki/Manolis_Kellis PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ Full episodes playlist: https://www.youtube.com/playlist?list=PLrAXtmErZgOdP_8GztsuKi9nrraNbKKp4 Clips playlist: https://www.youtube.com/playlist?list=PLrAXtmErZgOeciFP3CBCIEElOJeitOr41 OUTLINE: 0:00 - Introduction 2:49 - Molecular basis for human disease 26:48 - Deadliest diseases 32:31 - Genetic component of diseases 41:22 - Genetic understanding of disease 57:09 - Unified theory of human disease 1:03:10 - Genome circuitry 1:28:13 - CRISPR 1:39:50 - Mitochondria 1:47:54 - Future of biology research 2:17:30 - The genetic circuitry of disease CONNECT: - Subscribe to this YouTube channel - Twitter: https://twitter.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/LexFridmanPage - Instagram: https://www.instagram.com/lexfridman - Medium: https://medium.com/@lexfridman - Support on Patreon: https://www.patreon.com/lexfridman

Lex FridmanhostManolis Kellisguest
Oct 25, 20202h 34mWatch on YouTube ↗

CHAPTERS

  1. 0:00 – 2:49

    Introduction

  2. 2:49 – 26:48

    Molecular basis for human disease

  3. 26:48 – 32:31

    Deadliest diseases

  4. 32:31 – 41:22

    Genetic component of diseases

  5. 41:22 – 57:09

    Genetic understanding of disease

  6. 57:09 – 1:03:10

    Unified theory of human disease

  7. 1:03:10 – 1:28:13

    Genome circuitry

  8. 1:28:13 – 1:39:50

    CRISPR

  9. 1:39:50 – 1:47:54

    Mitochondria

  10. 1:47:54 – 2:17:30

    Future of biology research

  11. 2:17:30 – 2:34:57

    The genetic circuitry of disease

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