No Priors Ep. 138 | The Best of 2025 (So Far) with Sarah Guo and Elad Gil

ℹ️ EPISODE INFO

Released

October 31, 2025

Duration

18m

Channel

No Priors

Watch on YouTube

▶ Open ↗

📝 EPISODE DESCRIPTION

2025 has thus far been a year of great leaps and advances in AI technology. And Sarah and Elad have spoken with some of the most enterprising founders and scientific minds in the field of AI today. So we’re revisiting a few of our favorite conversations on No Priors so far in 2025 – Winston Weinberg (Harvey), Dr. Fei-Fei Li (World Labs), Brendan Foody (Mercor), Dan Hendrycks (Center for AI Safety), Noubar Afeyan (Flagship Pioneering), Brandon McKinzie and Eric Mitchell (OpenAI o3), Isa Fulford (OpenAI), Arvind Jain (Glen), and Dr. Shiv Rao (Abridge). Sign up for new podcasts every week. Email feedback to show@no-priors.com Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil Chapters: 00:00 – Episode Introduction 0:21 – Winston Weinberg on Leaning into New Capabilities 02:01 – Dr. Fei-Fei Li on Spatial Intelligence 04:13 – Brendan Foody on AI Disruption in the Workforce 06:10 – Dan Hendrycks on the Geopolitics of Superintelligence 08:06 – Noubar Afeyan on Entrepreneurship 10:38 – Brandon McKinzie and Eric Mitchell on Reasoning Models 12:41 – Isa Fulford on Training Deep Research 13:49 – Arvind Jain on Innovating Enterprise Search 16:21 – Dr. Shiv Rao on AI’s Human Impact 18:58 – Conclusion

🎤 SPEAKERS

• Sarah Guo

  host

• Winston Weinberg

  guest

• Fei-Fei Li

  guest

• Brendan Foody

  guest

• Elad Gil

  host

• Dan Hendrycks

  guest

• Noubar Afeyan

  guest

• Brandon McKinzie

  guest

• Eric Mitchell

  guest

• Isa Fulford

  guest

• Guest (founder describing building a search product)

  guest

🧾 EPISODE SUMMARY

In this episode of No Priors, featuring Sarah Guo and Winston Weinberg, No Priors Ep. 138 | The Best of 2025 (So Far) with Sarah Guo and Elad Gil explores aI’s Hinge Moment: Work, Wealth, Safety, and Human Impact in 2025 This highlight episode of No Priors showcases pivotal 2025 conversations about how AI is reshaping industries, work, and global dynamics. Founders and researchers from Harvey, OpenAI, Glean, Abridge, and others describe discovering hidden opportunities as models quietly became good enough to transform “bad” markets like legal advice and enterprise search. Guests explore frontier capabilities such as spatial and visual reasoning, tool-using models, and AI-assisted research, alongside the labor displacement and geopolitical risks of approaching superintelligence. The episode closes on the deeply human side of AI, with healthcare AI enabling doctors to reclaim time, purpose, and connection with their families.

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