
100K subscribers·166 episodes
Biohub: The Future of Biology is Open-Source with Mark Zuckerberg, Priscilla Chan, and Alex Rives
The Rise of the Full-Stack Builder and Hyper-Leveraged Generalist with Microsoft CEO Satya Nadella
Building an AI Guardian for Enterprise with Onyx Security CEO Maxim Bar Kogan
The Story Behind Cerebras’ $63 Billion IPO with Founder and CEO Andrew Feldman
Pax Silica: Inside the Trump Administration’s Tech Strategy with Jacob Helberg
Amex Global Business Travel: The World’s First AI Take Private with Long Lake CEO Alexander Taubman
Baseten CEO Tuhin Srivastava on Custom Models, and Building the Inference Cloud
SAP: Bringing the ‘Operating System’ of a Company into the AI Era with CTO Philipp Herzig
Scaling Global Organizations in the Age of AI with ServiceNow Chairman and CEO Bill McDermott
How AI Agents Will Transform the Financial System with Circle Co-Founder and CEO Jeremy Allaire
AI for Atoms: How Periodic Labs is Revolutionizing Materials Engineering with Co-Founder Liam Fedus
Skill Issue: Andrej Karpathy on Code Agents, AutoResearch, and the Loopy Era of AI
From Note-Taking App to AI Workspace: The Simon Last Interview
Why SaaS isn’t dying—AI shifts bottlenecks, defenses, and scale fast
Rivian’s vertically integrated AI stack for autonomy and mass-market EVs
Roblox’s AI roadmap: Holodeck realism, NPCs, and creator leverage
Reversible cryopreservation roadmap: from transplant organs to human hibernation
MongoDB’s CJ Desai on platforms, AI shifts, and durable moats
Pentagon’s AI push: applied deployment, autonomous systems, industrial-base rebuilding ...
Jensen Huang argues AI’s next wave is grounded, embodied, diverse
AI’s 2026 Outlook: Agents, Robotics, New Labs, and Real-World Impact
ElevenLabs Bets Big On Voice As The Future Interface
Harvey’s AI Transforms Legal Workflows, Not Law Firms Themselves
Sunday Robotics Builds Cheap, Safe Home Robots With Massive Real-World Data
AI agents, biotech data, and rethinking how we develop new drugs
Snowflake CEO on Reinventing Data Cloud for Enterprise AI Future
AI’s Hinge Moment: Work, Wealth, Safety, and Human Impact in 2025
Warp CEO Zach Lloyd Explores AI Coding, Consciousness, And Developer Futures
Base Power Builds Distributed Battery Grid To Cut Global Energy Costs
From IQ to EQ: Building Human-Centric AI That Truly Collaborates
Nikesh Arora on AI’s Disruption of Search, Security, and Workflows
AI-Powered Alpha School Reinvents Education With Two-Hour Academic Days
Decagon’s AI Concierge Is Quietly Reinventing Enterprise Customer Conversations Globally
Jared Kushner on AI, global investing, and transforming Middle East ties
AI-Powered OpenEvidence Becomes Doctors’ Operating System For Clinical Decisions
Superintelligence, Supply Chains, and Nuclear: Rebuilding American Economic Power
Andrew Ng on Agentic AI, Rapid Engineering, and Founder Mindsets
AI Chips, Open Source Models, And Data Centers Reshaping Global Power
Cloudflare CEO on AI, content economics, and reshaping the internet’s future
White House AI Advisor Outlines America’s Strategy To Win Global Race
Bootstrapped Data Giant SurgeAI Redefines Quality Human Input For AI
ReflectionAI Bets on RL to Build Code-Comprehension Superintelligence
Parker Conrad on brutal founding, platform bets, and AI reality
AI-designed antibodies promise biotech revolution with CHAI 2.0 breakthrough
AlphaEvolve: Google DeepMind’s AI Agent That Discovers New Algorithms
Applied Intuition quietly builds vehicle intelligence powering autonomy’s real future
Anthropic’s Ben Mann on Claude 4, agents, safety, and MCP’s future
Fei-Fei Li on spatial intelligence, world models, and fearless AI
AI Markets Crystallize As Founders Face Consolidation And New Frontiers
Glean’s Arvind Jain on Reinventing Enterprise Search with AI Agents
Duolingo CEO: Motivation, Gamification, And AI Are Rewiring Learning
OpenAI’s O3: Tool-Using Reasoning Model Redefines Deep, Steerable AI
Inside OpenAI Deep Research: Building a Broadly Capable Research Agent
AI-Powered Mineral Exploration Reshapes Global Supply of Copper and Lithium
AI Evals, Labor Displacement, and Building a Global Talent Marketplace
AI Image Breakthroughs, Macro Jitters, and the Maturing Model Ecosystem
AI-powered medical notes relieve burnout and reshape healthcare’s front line
Chelsea Finn on building general-purpose robots through data and hierarchy
GitHub CEO Envisions AI Agents As Everyday Teammates For Developers
AI, Geopolitics, and Nuclear Parallels: Dan Hendrycks’ Safety Playbook
Flagship’s Noubar Afeyan on Emergent Innovation, AI, and Polyintelligence
Tahoe 100 launches virtual cell era, redefining AI-driven drug discovery
Kyle Vogt Bets Big On Home Robots After Self‑Driving Lessons
Harvey’s Winston Weinberg on AI Reshaping Law, Workflows, And Careers
DeepSeek, OpenAI Stargate, and 2025: AI Frontier Tightens and Widens
Rick Caruso Blasts LA Leadership, Outlines Faster, Smarter Wildfire Rebuild
Fixing Wildfire Disasters: Policy Failures, Tech Solutions, And Market Incentives
Decagon’s Transparent AI Agents Redefine Enterprise Customer Support at Scale
Modal’s Erik Bernhardsson Rethinks Cloud Infrastructure For Modern AI Workloads
AI’s 2024 Frontiers: Data Centers, Exocortex, Agents, World Models, AGI
Immigrant founder reimagines customer success and software in AI era
Diamond-cooled AI servers promise cooler chips, faster compute, safer grids
Bolt.new turns ideas into full-stack apps, redefining software creation
Cohere CEO Aidan Gomez on Enterprise AI, Reasoning, and Non-AGI Futures
DeepMind’s AlphaProof Pushes AI Toward Rigorous Mathematical Reasoning Frontier
Jensen Huang on AI factories, hyperscale GPUs, and software’s future
Regulated prediction markets reshape risk, forecasting, and election betting in America
Waymo’s Co-CEO Explains Cracking Full Autonomy And Scaling Robo‑taxis
AI’s Next Wave: Consumer Tools, Human-AI Relationships, and Job Disruption
Braintrust CEO Explains Enterprise AI Evals, Data, Teams, and Tooling
Lina Khan on AI, antitrust, and keeping markets truly open
Rippling’s Talent Signal Uses AI To Grade Employee Work, Not Vibes
Bret Taylor Maps The Future Of AI Agents For Business
AI Titans Debate LLM Consolidation, Chips, Risk, And Model Futures
Andrej Karpathy on self-driving, humanoid robots, transformers, and education’s future
Magic.dev’s Erik Steinberger on AGI, coding coworkers, and safety
AWS CEO Matt Garman on Cloud’s Past, AI Future, Startup Edge
Foundry’s Jared Davis Reimagines AI Cloud, GPU Economics, And Scaling Laws
Ramp Co-Founders Build Self-Driving Money And AI-First Productivity Platform
Brex CEO Pedro Franceschi on AI, continuous finance, and focus
Google DeepMind’s Oriol Vinyals on Gemini, AGI, and Infinite Context
Airtable’s CEO on Democratizing Enterprise AI With No-Code Platforms
AI Capex, Market Myths, and New Opportunities in Services and Buyouts
Mid-2024 AI: From Fintech and Design to Robots and AGI
Cartesia Bets on State Space Models for Real-Time Voice AI
HeyGen’s AI Avatars Aim To Replace Cameras And Personalize Video
Zapier’s Mike Knoop Challenges LLM Dominance With New AGI Prize
Voyage CEO Explains Why RAG Beats Long Context For Enterprise AI
Garry Tan on YC, AI startup surge, and rebuilding San Francisco
Scale AI’s Alexandr Wang on data abundance, evals, and AGI’s path
Suno’s CEO on Democratizing Music Creation With AI-Generated Songs
AI’s Next Frontiers: Local Models, Long Context, Energy Limits, Music
Cognition’s Devin Reimagines Software Engineering With Autonomous AI Teammates
OpenAI’s Sora: Building a World-Simulating Video Engine for AGI
Playground AI Bets Big On Pixels, Editing, And Open-Source Models
AI Market Fragments: Open Models, Agents, Prosumer Apps Redefine Value Capture
Brett Adcock bets on humanoid robots as universal labor platform
LangChain CEO on building reliable AI agents, memory, and UX
Baseten CEO Explains Fast AI Inference, Infrastructure, And Enterprise Adoption
Figma’s Dylan Field on AI, Adobe breakup, and design’s future
AI Models, Chips, and Agents: Google, Nvidia, and Enterprise Disruption
AMD CTO Reveals Strategy Powering Next-Generation AI Chips and Computing
Pinecone CEO Explains Vector Databases, RAG, And Scalable AI Memory
Notion CEO Ivan Zhao on AI, bundling, and rethinking knowledge work
Stripe’s Data Chief on Generative AI, Fintech Infrastructure, and Education
Shopify VP Glen Coates on AI Copilots, Commerce Data, and Scale
Covariant’s Peter Chen Builds Data-Driven Foundation Models For Real-World Robots
Sourcegraph CTO Beyang Liu on AI’s Real Impact on Coding Workflows
AI’s Transformative Year: Governance, Labor, Safety, and Open Innovation Debated
Reid Hoffman champions optimistic, human-centric AI amid doomer backlash
Former Square CEO Alyssa Henry on AI, Cloud, and Commerce’s Future
Salesforce AI CEO Clara Shih on Data, Copilots, and Enterprise Adoption
OpenAI shake-up, AI governance, and the rise of video diffusion
Imbue Envisions Reliable Reasoning Agents To Transform Everyday Computer Use
Mistral CEO Arthur Mensch Champions Efficient, Open-Source Frontier AI Models
Ilya Sutskever on scaling, safety, and the road to superintelligence
AI Supercharges Cybersecurity: Material Security’s Ryan Noon On Defense
Inside Google Cloud’s Generative AI Strategy: Models, Trust, and Scale
HubSpot’s Brian Halligan on Inbound, AI, Culture, and Climate Reinvention
How Fine-Tuning, RAG, and Open Source Will 10X AI’s Impact
Programming Living Cells: AI, Synthetic Biology, and Future Biosecurity Infrastructure
Replit’s Amjad Masad on AI Coders, Bounties, and Open-Source Futures
Transformers, NEAR, and AI Agents: Building a Verified, Decentralized Web3 Future
Cerebras CEO on Beating GPU Bottlenecks With Wafer-Scale AI Supercomputers
Vercel CEO on AI-Native Web Apps, Frontend Future, and Security
Transformer pioneer builds 'biological software' to reprogram life with RNA
Sal Khan Envisions AI Tutors Transforming Education, Equity, And Learning
Sal Khan Envisions AI Tutors Transforming Global Education and Equity
GPU Crunch, AI Agents, And Startup Survival In Early AI Era
Lukas Biewald on building ML tooling, data, and the LLM shift
Palantir CTO on AIP, Ontologies, and AI’s Operational Future
Devi Parikh on generative video, multimodal AI, and creative control
Frank Slootman on urgency, data clouds, and AI’s real frontier
Instacart’s CEO on AI-Native Commerce, Leadership, and Curing Chronic Illness
Datadog CEO on AI, observability, security, and disciplined hypergrowth strategy
AI’s New Era: Misconceptions, Regulation Risks, And Startup Openings Explored
AI-Driven Defense: Anduril’s Bid To Reinvent Modern Military Capability
Microsoft CTO Kevin Scott on AI Platforms, Partnerships, and Purpose
Hugging Face’s Clem Delangue on Open-Source AI, Community, and Infrastructure
Daphne Koller on Reinventing Drug Discovery With Machine Learning and Biology
Google’s Med-PaLM 2 Aims to Safely Transform Healthcare With AI
Mustafa Suleyman on Personal AI, Governance, and the Coming Wave
Zipline’s Radical Drone Logistics: From Rock Climbing To Saving Lives
Google’s Kelvin Guu on Retrieval, Modularity, Memory, and Future AI
Stability AI’s Emad Mostaque Bets On Open Models Powering Humanity’s Future
Runway ML Fuses Art and AI To Reinvent Creative Video Tools
AI’s Open-Source Surge, Regulation Risks, and Where Value Emerges Next
Databricks CTO on democratizing data, open LLMs, and AI’s future
Neeva’s Sridhar Ramaswamy on Reinventing Search With AI Answers
Percy Liang on Foundation Models, Open Research, and AI’s Future Impact
Perplexity Founders Reimagine Search As Trustworthy Conversational Answer Engine
From Poker Bots To Diplomacy: Noam Brown Redefines AI Reasoning Benchmarks
Jensen Huang Reveals NVIDIA’s Long Game Building the AI Era