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No Priors Ep. 89 | With NVIDIA CEO Jensen Huang

In this week’s episode of No Priors, Sarah and Elad sit down with Jensen Huang, CEO of NVIDIA, for the second time to reflect on the company’s extraordinary growth over the past year. Jensen discusses AI’s takeover of datacenters and NVIDIA’s rapid development of x.AI’s supercluster. The conversation also covers Nvidia’s decade-long infrastructure bets, software longevity, and innovations like NVLink. Jensen shares his views on the future of embodied AI, digital employees, and how AI is transforming scientific discovery. Sign up for new podcasts every week. Email feedback to show@no-priors.com Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @Nvidia Show Notes: 0:00 Introduction 1:22 NVIDIA's 10-year bets 2:28 Outpacing Moore’s Law 3:42 Data centers and NVLink 7:16 Infrastructure flexibility for large-scale training and inference 10:40 Building and optimizing data centers 13:30 Maintaining software and architecture compatibility 15:00 X.AI’s supercluster 18:55 Challenges of super scaling data centers 20:39 AI’s role in chip design 22:23 NVIDIA's market cap surge and company evolution 27:03 Embodied AI 28:33 AI employees 31:25 Impact of AI on science and engineering 35:40 Jensen’s personal use of AI tools

Sarah GuohostJensen HuangguestElad Gilhost
Nov 6, 202436mWatch on YouTube ↗

At a glance

WHAT IT’S REALLY ABOUT

Jensen Huang on AI factories, hyperscale GPUs, and software’s future

  1. NVIDIA CEO Jensen Huang discusses how accelerated computing and full‑stack co-design are reinventing the entire computing paradigm, enabling performance and cost improvements that outpace Moore’s Law at data center scale. He explains NVIDIA’s strategy of treating the data center as the unit of compute, vertically integrating and optimizing whole “AI factories,” then disaggregating them so they can plug into any cloud. Huang highlights frontier model training, inference scaling, and the emergence of AI agents across disciplines—from chip design to enterprise SaaS—as key forces reshaping industry and science. He also argues that generative AI is becoming foundational across all scientific fields, making it unlikely that any future breakthrough will occur without it.

IDEAS WORTH REMEMBERING

5 ideas

Computing is shifting from CPU-centric to GPU-accelerated, full-stack systems.

Huang argues that the entire stack—from algorithms and numerical formats to networking fabrics—must be co-designed around GPUs, enabling parallelization from a single chip to multi-data-center clusters.

Performance and cost are improving faster than Moore’s Law at data center scale.

By co-designing hardware, software, and algorithms (e.g., moving from FP64 to FP8 and beyond) and treating the network as a compute fabric, NVIDIA aims to double or triple effective performance and energy efficiency annually for large-scale systems.

The new unit of computing is the data center, not the chip or server.

NVIDIA designs, simulates, and optimizes entire data centers as integrated "AI factories," then disaggregates them into components so cloud providers can adopt the architecture while developers get a broadly consistent CUDA-based platform.

Infrastructure for training becomes highly valuable inference capacity later.

Huang notes that clusters built for training frontier models are repurposed for inference and distillation into smaller models, preserving ROI and creating a spectrum from giant to tiny specialized models (e.g., “tiny language models”).

AI is already a critical engineer inside NVIDIA, especially in chip design.

NVIDIA used AI to design chips like Hopper, allowing exploration of vastly larger design spaces and cross-module optimizations that human teams lack the time or combinatorial capacity to perform.

WORDS WORTH SAVING

5 quotes

We don’t build computers anymore. We build factories.

Jensen Huang

The new unit of computing is the data center.

Jensen Huang

If you’re serious about software, then you’re going to build your whole computer.

Jensen Huang

Software is how humans encode knowledge. We encode it in a very different way now. That’s going to affect everything.

Jensen Huang

There’s not going to be one breakthrough in science where generative AI isn’t at the foundation of it.

Jensen Huang

Reinventing computing through GPUs, accelerated computing, and full-stack co-designData center–scale architecture and NVIDIA’s concept of AI factoriesTraining vs. inference, model size spectrum, and infrastructure reuseHyper-scaling clusters (e.g., x.ai) and treating data centers as productsAI-assisted chip design and internal use of AI engineersEmbodied AI and robotics, including self-driving and humanoid robotsGenerative AI’s impact on science, engineering, and enterprise software platforms

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