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Simple Exercises That Can Repair Tendons — Dr. Keith Baar

Dr. Keith Baar is a Professor at the University of California, Davis in the Department of Physiology and Membrane Biology. During his Ph.D. studies, his research revealed that mechanical strain on muscle fibers activates the mammalian target of rapamycin (mTOR) signaling pathway, a crucial regulator of muscular hypertrophy. Subsequently, he studied the molecular dynamics of skeletal muscle adaptation to endurance training under the guidance of Dr. John Holloszy, a legend in the field of exercise physiology, considered the father of modern exercise biochemistry. Building on all of this experience, he conducted research into tendon health and the potential for engineering ligaments, which could have implications for treatment and recovery from injuries. This episode is brought to you by: Cresset prestigious family office for CEOs, founders, and entrepreneurs: https://cressetcapital.com/tim (book a call today) AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D (and 5 free AG1 travel packs) with your first subscription purchase.) Shopify global commerce platform, providing tools to start, grow, market, and manage a retail business: https://shopify.com/tim (one-dollar-per-month trial period) * Links to everything discussed: https://tim.blog/2025/02/26/dr-keith-baar/ Tim Ferriss is one of Fast Company’s “Most Innovative Business People” and an early-stage tech investor/advisor in Uber, Facebook, Twitter, Shopify, Duolingo, Alibaba, and 50+ other companies. He is also the author of five #1 New York Times and Wall Street Journal bestsellers: The 4-Hour Workweek, The 4-Hour Body, The 4-Hour Chef, Tools of Titans and Tribe of Mentors. The Observer and other media have named him “the Oprah of audio” due to the influence of his podcast, The Tim Ferriss Show, which has exceeded 900 million downloads and been selected for “Best of Apple Podcasts” three years running. Sign up for "5-Bullet Friday" (Tim's free weekly email newsletter): https://go.tim.blog/5-bullet-friday-yt/ Follow the Tim Ferriss Podcast: https://tim.blog/podcast/ Visit the Tim Ferriss Blog: https://tim.blog/ Follow Tim Ferriss on Twitter: https://twitter.com/tferriss/ Follow Tim Ferriss on Instagram: https://www.instagram.com/timferriss/ Like Tim Ferriss on Facebook: https://www.facebook.com/TimFerriss/ [00:00] Start [01:14] How I discovered Keith's work through a tweet about tennis elbow and rock climbing. [02:01] Emil Abrahamsson's hangboard training protocol. [03:29] The fundamental principles of strength training and connective tissue adaptation. [04:46] mTOR complex 1 and its role in muscle growth. [06:12] Engineered ligaments and the discovery of minimal effective doses for tendon adaptation. [07:59] The refractory period between optimal tendon loading sessions. [10:58] Rapamycin's effects on muscle hypertrophy. [13:10] Protocols for tennis elbow rehabilitation. [14:48] Why isometrics work better than eccentrics for tendon healing. [16:32] Stress shielding and how load distribution affects tendon healing. [23:28] The misconception about eccentric loading for tendon injuries and why velocity matters. [24:22] Ideal duration for isometric holds (10-30 seconds) based on injury status. [27:14] My elbow issues and current rehab approach. [29:22] Overcoming vs. yielding isometrics and optimal loading strategies. [40:43] Dr. Barr's movement prescription for my tennis elbow. [45:51] Loading timing post-surgery and RICE protocol criticism. [50:33] Achilles tendon rehabilitation after surgery. [53:54] Critique of orthopedic suturing techniques and recommendation for resorbable sutures. [57:43] Multiple position isometrics for tennis elbow rehabilitation. [01:01:12] Collagen synthesis, supplementation, and vitamin C timing. [01:06:44] Critique of BPC-157 and other injectable peptides for tendon healing. [01:12:09] Evaluation of orthobiologics' (PRP, prolotherapy, stem cells) effectiveness. [01:15:23] JAK-STAT inhibitor drugs and their effects on tendon growth. [01:19:15] Drugs that increase risk of tendon ruptures (fluoroquinolones, AT-1 receptor drugs). [01:23:03] How estrogen affects tendon stiffness and injury risk in women. [01:26:19] Testosterone's opposite effects on tendon compared to estrogen. [01:29:00] Protein intake recommendations and timing. [01:33:47] Ketogenic diet effects on mitochondrial biogenesis and longevity. [01:35:35] Comparison of ketogenic diet, low protein diet, and rapamycin for longevity. [01:40:56] Inflammation's role in adaptation and when to reduce it. [01:44:49] Timing of ice baths relative to training for optimal recovery. [01:46:01] Parting thoughts.

Dr. Keith BaarguestTim Ferrisshost
Feb 27, 20251h 47mWatch on YouTube ↗

At a glance

WHAT IT’S REALLY ABOUT

Why brief isometrics can rebuild tendons faster than eccentrics

  1. Dr. Keith Baar explains that tendon/ligament adaptation has a short signaling window (about 10 minutes) and benefits from being repeated after a 6–8 hour refractory period, which helps explain rapid grip gains seen in climbers using brief isometric “hang” protocols.
  2. He argues that isometrics can be superior to eccentrics for tendon rehabilitation because holding at zero velocity helps redistribute load across the tendon, while the classic eccentric benefits often came from slow tempo (reduced velocity) rather than the eccentric phase itself.
  3. He critiques standard immobilization practices (including boots and prolonged rest) as “stress shielding” that can promote scarring, and describes using early, low-jerk isometric loading—done with minimal pain—as a way to improve recovery after injuries and even post-surgery.
  4. He outlines practical rehab concepts such as overcoming vs. yielding isometrics, using multiple joint positions for tennis elbow/rotator cuff-type problems, and keeping pain very low (with “ice pick” point pain as a stop signal).
  5. Beyond rehab, he discusses nutrition and longevity trade-offs, including how ketogenic diets, low-protein diets, and low-dose rapamycin all aim to reduce mTOR activity, plus the role of mitochondria/mitophagy and the limitations of ketogenic diets for speed-focused athletes.

IDEAS WORTH REMEMBERING

5 ideas

Tendons and other connective tissues appear to max out their adaptive signal in about 10 minutes of optimized loading.

He described a “minimal effective dose” where connective tissue cells respond strongly for only a short window, after which additional work becomes mostly wear and tear rather than additional adaptive signaling.

An approximate 6–8 hour refractory period separates optimal tendon-loading sessions.

He said the key is spacing tendon-loading bouts so the tissue can respond again, and that his group found a similar timing pattern to what other researchers observed in bone.

Isometrics can outperform eccentrics for tendon healing because velocity (and load distribution), not “eccentric-ness,” is the core variable.

He argued isometrics help distribute load more evenly across healthy and weak regions by allowing strong regions to fatigue/relax, reducing “stress shielding” of weaker areas; he also said the success of eccentric rehab was largely a velocity/tempo effect, not something magical about eccentrics themselves.

Minimizing jerk—by ramping force slowly into and out of holds—helps reduce wear while still providing tendon signal.

He described “jerk” (rate of change of acceleration) as a major driver of tendon injury and said overcoming isometrics allow a slow force ramp-up and ramp-down to reduce jerk compared to yielding isometrics or dynamic work.

Early, carefully controlled loading can accelerate recovery compared with delayed loading or immobilization.

He criticized immobilization (boots, prolonged rest) as mechanical “stress shielding” that can promote scarring, and cited data and anecdotes supporting very early, low-jerk loading (with medical oversight) after injury/surgery to speed return.

WORDS WORTH SAVING

5 quotes

If I've told you that the thing that's gonna cause that tissue to get a scar is that you take off the tension, what I've just done is I've made the problem worse.

— Dr. Keith Baar

If I took you and you said you had cancer, you would not want a treatment that was developed 4,500 years ago. You would hope that something new has been developed in the last 4,500 years. That is where we are for our orthopedic situations.

— Dr. Keith Baar

The tendons stop getting the signal to adapt at ten minutes. Everything on top of that was just wear and tear that could, you know, slightly cause problems.

— Dr. Keith Baar

Jerk is the thing that's going to induce injury. Jerk is that rate of change of acceleration.

— Dr. Keith Baar

We get into this whole thing, this is like this macho business with lifting weights is a, oh, no pain, no gain. There's no reality to that, okay?

— Dr. Keith Baar

Minimal effective dose for tendon adaptationRefractory period between loading sessionsIsometrics vs. eccentrics and velocity/tempoStress shielding, scarring, and immobilization critiqueOvercoming vs. yielding isometricsCollagen supplementation and vitamin C timingOrthobiologics/peptides skepticism (BPC-157, PRP) and needling effects

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