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BigDeal by Codie Sanchez

Ozempic Expert: They’re Lying To You About Getting Fat | Dr. Tyna Moore

My new book Own Or Be Owned is out now! I wrote Own or Be Owned to answer one question: How do you make more money, less miserably?

Dr. Tyna MooreguestCodie Sanchezhost

Mar 26, 20251h 22mWatch on YouTube

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CHAPTERS

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Chapter summaries

Dr. Tyna's Background and Walking the Talk
Codie introduces Dr. Tyna, a naturopathic doctor trained both ways, and asks whether doctors should practice what they preach. Tyna describes her own past of chain-smoking, drinking and poor eating, and the moment with her young daughter that pushed her to change.
- •Tyna chain-smoked from age 14 to 24 and ate what she calls a macaroni-and-cheesetarian diet
- •Lying on the couch with a migraine while her toddler asked her to play was her turning point
- •Her mentor taught her in the '90s to lift weights, cut white foods and focus on protein
- •She watched her mother's metabolic health go sideways in menopause
- •She cites stats that about 94% of US adults have cardiometabolic compromise
Calories, Insulin Resistance and the Balance of Metabolic Pathways
Responding to a joke about dieting humans versus dogs, Tyna says it's both calories and insulin resistance. She describes AMPK and mTOR as counterbalancing pathways and argues for a buffet of approaches.
- •Calories-in/calories-out and insulin-resistance camps are both partly right
- •AMPK is revved by things like high-dose GLP-1 and can become catabolic when too high
- •mTOR is driven by strength training and protein and can contribute to cancer when pathologically high
- •The goal is balance across pathways, not one extreme
Food Pyramids, Carnivore and Protein Targets
Codie asks about the inverted low-carb food pyramid. Tyna says it's too simplistic, that people can over-carnivore into insulin resistance, and that aging women become more insulin resistant, with real food and enough protein as the baseline.
- •Eat real food, get a variety of colors and aim for roughly a gram of protein per pound of body weight
- •Tyna says she carnivored herself into insulin resistance
- •Loss of estrogen and muscle with age increases insulin resistance
- •Unexplained 15 to 20 pound gains in midlife are a sign she goes by, even with normal labs
- •Her long-standing advice is eat more meat and lift weights
Sleep, Sarcopenia and Dialing Back Intensity as Women Age
Tyna discusses sleep, the Gen X thin culture, and sarcopenia, then explains why women in menopause should moderate intensity and favor strength training. Codie shares her own experience with high-stress and intense workouts.
- •Sarcopenia is muscle wasting, and cachexia is its inflammation-driven sister
- •Women entering menopause often do better with strength training than Orange Theory or CrossFit
- •Strength training can be modulated through rest, load, reps and tempo
- •Stacy Sims' short sprint intervals with long rests are one way to include intensity
- •Too much intensity raises cortisol, which is catabolic and causes puffiness
How to Know Whether a Workout Is Right for You
Codie asks how a woman can tell if her workout suits her. Tyna says you should leave feeling better, explains hormesis and recovery, and tells women they can do less.
- •You should feel invigorated after training and better the next day, not hit by a truck
- •A midsection that blows up can signal too much intensity and fasting combined with stress
- •Hormesis means strategic stress followed by rest and refeeding
- •Gentle movement like walking, yoga or swimming supports recovery
- •Sometimes a glass of wine or stopping a workout early supports homeostasis
Body Fat, Hormones, Metabolism and Why Deadlifts
Tyna says women look better with a little fat in midlife and that fat stores serve as an estrogen depot. She then addresses whether metabolism slows with age and explains her love of deadlifts as a central-nervous-system reset.
- •Fat cells make estrone after ovarian function declines, so extreme leanness may not help longevity
- •Data reportedly shows metabolism isn't slowing, but hormonal shifts, lower stress tolerance and muscle loss change outcomes
- •Lifting is non-negotiable for aging well, as it's about not breaking a hip
- •Heavy deadlifts hit the nervous system in a way light lifting doesn't
- •Tyna lifts, sleeps and then decides on big choices
Who You Surround Yourself With
Codie asks about the science of social circles. Tyna covers contagious microbiomes, mirror neurons and her own decisions to leave friends behind, while Codie adds data on productivity, money and divorce being contagious.
- •A friend's eagles-and-turkeys line stayed with Tyna and shaped her choice of circle
- •Microbiomes are described as contagious, and one family's microbiome shifted after one member took antibiotics
- •Codie cites productivity rising about 15% near a high performer and falling about 30% near an underperformer
- •Tyna quit smoking at 24 and told her friends she could no longer hang out
- •Circles get tighter with age and relationships should be reciprocal
Jealousy, Friendship and Seasons of Life
Starting from a study about friends urging you to cut your hair, the conversation turns to women's competitiveness and jealousy. Codie and Tyna share honest stories of envy toward friends and discuss looking for expanders and seasons of rest and push.
- •Tyna read an abstract suggesting friends who urge you to cut your hair see you as mating competition
- •Tyna thinks women's resource guarding is evolutionary
- •Codie called her friend Vanessa to admit her initial jealousy
- •Tyna and a friend discovered they envied each other's lives
- •Look for expanders and thank them, and accept seasons of rest and grind
The Fertility Crisis and IVF
Codie asks whether it's harder for women to get pregnant. Tyna says fertility rates are in trouble and links it to metabolic dysfunction, toxins, thyroid and progesterone issues, and the IVF-heavy approach doctors take.
- •Tyna thinks we may be going extinct as a species, citing falling fertility in both women and men
- •She names metabolic dysfunction as the overarching factor, including in children
- •Codie says most of her friends 30 to 41 have needed IVF
- •Tyna says repeated IVF hormonal load can further harm metabolic health
- •Doctors default to their own hammer, which she says is profitable for IVF
GLP-1s as Peptides: Benefits, Backlash and Deplatforming
Codie asks whether GLP-1s are good or bad. Tyna explains they are peptides with broad anti-inflammatory and regenerative benefits, describes the backlash she faced, the messages from patients, and her deplatforming from Instagram.
- •GLP-1s are peptides, and Tyna says data shows effects beyond appetite, on metabolic pathways, brain, pain and immunity
- •She faced fierce pushback from both mainstream and functional medicine communities
- •She says she is not a Big Pharma shill and that lifestyle comes first
- •Tyna says she was deplatformed from Instagram around the time Eli Lilly released vials and sent cease-and-desist letters
- •She sees potential for addiction and other conditions
Compounding Pharmacies, Microdosing and Pen Dosing
Codie probes why the drug companies oppose compounding. Tyna explains 503A and 503B compounding, shortages, personalized dosing in vials, and a paper on a pen-click microdosing method.
- •Brand-name pens come prefilled, while compounded vials allow personalized doses
- •Compounders could fill shortages under 503B, and lawsuits followed once shortages ended
- •Tyna says 503A has less oversight
- •Starting doses can be too high, and people shouldn't vomit for a month
- •A Journal of Diabetes paper showed a pen-click method for microdosing in type 2 diabetes
Standard of Care, Long-Term Drug Use and GLP-1 Management
Codie asks whether people get stuck on GLP-1s for life. Tyna contrasts allopathic standard of care with naturopathic best practices, discusses cycling peptides and drugs, and warns about high doses with no lifestyle change leading to muscle loss.
- •MDs follow the standard of care for legal reasons, while NDs work under best practices
- •Tyna cycles peptides and some drugs, and says Prozac was never studied long term
- •She believes a disease of obesity exists but not every obese person has it
- •She says no one should start a GLP-1 without lifting and hitting protein
- •High doses with no lifestyle change risk wasting lean tissue and permanent dependence
Why Doctors Fall Short and Patient Resistance
Codie wonders why doctors skip lifestyle advice. Tyna says doctors are time-pressed, unhealthy themselves and working in a corrupt system, and that patients often resist her advice. Codie shares her brother's health struggles and Tyna offers gut-support suggestions.
- •Tyna says she received no kickbacks and that doctors are time-constrained, citing a neurologist who said seven minutes was the profitability limit
- •Many doctors are unhealthy themselves and under heavy stress
- •Even cash-paying patients got angry when she told them to lift and eat better
- •Tyna shut down her practice because of how draining this was
- •For Codie's brother she suggested digestive enzymes, ox bile and HCL
Supporting Someone Who Isn't Ready: Gym, Plate and Modeling
Codie asks how to get someone to prioritize health once they have no choice. Tyna says it often takes pain or vanity, that the gym begets other healthy habits, and that the best you can do for resistant loved ones is model it.
- •Pain and vanity usually push people to hit a wall
- •Committing to the gym three days a week leads to better eating, hydration and sleep
- •The answer starts in the gym and on your plate, but people want sexy solutions like GLP-1s
- •Decision fatigue makes good choices hard at the end of the day
- •The only thing you can do for resistant family is model it
Optimizing as a High Performer, Where to Find Tyna, and Closing Letter
For high performers, Tyna says to handle hormones early, learn peptides, nutrition and fitness, and manage stress. She shares where to find her work and reads a letter to her younger self.
- •Get hormones handled before you think you need to, with a hormone-literate practitioner
- •Become peptide literate and learn how to navigate nutrition and the gym
- •Stress erodes all efforts, so ages 45 to 50 call for getting serious
- •Libido and sleep are markers of good health
- •Her letter tells her younger self not to stress or starve so much and to seek joy

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