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Jacob Kimmel on Dwarkesh Patel: Why Evolution Ignored Aging

Why the high ancestral hazard rate cut longevity's gradient signal; editing TRIM5alpha shows epigenetic reprogramming can outpace evolution.

Jacob KimmelguestDwarkesh Patelhost
Aug 21, 20251h 45mWatch on YouTube ↗

CHAPTERS

  1. 0:00 – 12:48

    Three reasons evolution didn't optimize for longevity

  2. 12:48 – 26:08

    Why didn't humans evolve their own antibiotics?

  3. 26:08 – 45:24

    De-aging cells via epigenetic reprogramming

  4. 45:24 – 1:07:03

    Viral vectors and other delivery mechanisms

  5. 1:07:03 – 1:10:13

    Synthetic transcription factors

  6. 1:10:13 – 1:32:13

    Can virtual cells break Eroom's Law?

  7. 1:32:13 – 1:45:20

    Economic models for pharma

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