Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan Williams

_In loving memory of Nolan Williams (1982-2025):_ ⁠⁠https://stan.md/3Qle2zp⁠⁠ In this Huberman Lab Essentials episode, my guest is Dr. Nolan Williams, MD, a triple board-certified psychiatrist and neurologist. We discuss cutting-edge treatments for depression and post-traumatic stress disorder (PTSD), including transcranial magnetic stimulation, neuromodulation, and psychedelic-assisted therapies. We also discuss the neurobiology and therapeutic potential of specific psychedelic compounds, including psilocybin, MDMA, ibogaine, and ayahuasca. Show notes: https://go.hubermanlab.com/KWwu7p6 Huberman Lab Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab X: https://x.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://www.hubermanlab.com Newsletter: https://www.hubermanlab.com/newsletter Timestamps 00:00:00 Nolan Williams 00:00:26 Depression 00:02:51 Heart & Mind Connection, Transcranial Magnetic Stimulation (TMS) 00:05:21 TMS for Depression 00:07:52 SSRIs & Chemical imbalance, TMS, Psychedelics 00:13:51 Psilocybin, MDMA, Trauma 00:16:48 MDMA Clinical Trials & PTSD; Psilocybin & Depression 00:18:46 Psilocybin, Brain Connectivity & Depression 00:21:07 Ibogaine, Empathy; Psychedelic Breakthrough & Risk 00:27:44 Ayahuasca, Behavior Change, Prisoners 00:31:54 Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT) 00:35:56 Acknowledgements #hubermanlab #science Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

Andrew HubermanhostDr. Nolan Williamsguest

Jun 4, 202636mWatch on YouTube ↗

EPISODE INFO

Released: June 4, 2026
Duration: 36m
Channel: Huberman Lab
Watch on YouTube: ▶ Open ↗

EPISODE DESCRIPTION

_In loving memory of Nolan Williams (1982-2025):_ ⁠⁠https://stan.md/3Qle2zp⁠⁠ In this Huberman Lab Essentials episode, my guest is Dr. Nolan Williams, MD, a triple board-certified psychiatrist and neurologist. We discuss cutting-edge treatments for depression and post-traumatic stress disorder (PTSD), including transcranial magnetic stimulation, neuromodulation, and psychedelic-assisted therapies. We also discuss the neurobiology and therapeutic potential of specific psychedelic compounds, including psilocybin, MDMA, ibogaine, and ayahuasca. Show notes: https://go.hubermanlab.com/KWwu7p6 Huberman Lab Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab X: https://x.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://www.hubermanlab.com Newsletter: https://www.hubermanlab.com/newsletter Timestamps 00:00:00 Nolan Williams 00:00:26 Depression 00:02:51 Heart & Mind Connection, Transcranial Magnetic Stimulation (TMS) 00:05:21 TMS for Depression 00:07:52 SSRIs & Chemical imbalance, TMS, Psychedelics 00:13:51 Psilocybin, MDMA, Trauma 00:16:48 MDMA Clinical Trials & PTSD; Psilocybin & Depression 00:18:46 Psilocybin, Brain Connectivity & Depression 00:21:07 Ibogaine, Empathy; Psychedelic Breakthrough & Risk 00:27:44 Ayahuasca, Behavior Change, Prisoners 00:31:54 Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT) 00:35:56 Acknowledgements #hubermanlab #science Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

SPEAKERS

Andrew Huberman
host
Professor of neurobiology and ophthalmology at Stanford School of Medicine and host of the Huberman Lab podcast.
Dr. Nolan Williams
guest
Stanford-trained psychiatrist and neurologist specializing in depression treatments, psychedelics research, and neurostimulation/TMS (SAINT/SNT).

EPISODE SUMMARY

In this episode of Huberman Lab, featuring Andrew Huberman and Dr. Nolan Williams, Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan Williams explores depression treatments: circuits, TMS, and psychedelics reshape brain connectivity safely Depression is framed as a leading global disability and a risk factor that worsens other illnesses, including coronary artery disease, highlighting the need for fast-acting, acute-care treatments.

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