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How Smell, Taste & Pheromone-Like Chemicals Control You

This episode I explain how we sense chemicals by way of smell, taste and pheromones. How things smell and taste and bodily chemicals of others have a profound effect on how we feel, what we do and our hormones. I explain the 3 types of responses to smell, the 5 types of tastes, the possible existence of sixth taste sense. I explain how smell and taste reflect brain health and can be used to assess and even promote brain regeneration. Both basic science and protocols are described including how to make sour things taste sweet and how to develop a heightened sense of smell and taste. Thank you to our sponsors: ROKA - https://www.roka.com - code: huberman InsideTracker - https://www.insidetracker.com/huberman Athletic Greens - https://www.athleticgreens.com/huberman Our Patreon page: https://www.patreon.com/andrewhuberman Supplements from Thorne: http://www.thorne.com/u/huberman Social: Instagram - https://www.instagram.com/hubermanlab Twitter - https://twitter.com/hubermanlab Facebook - https://www.facebook.com/hubermanlab Website: https://hubermanlab.com Links: 1. What Is Color? By Arielle & Joann Eckstut https://www.amazon.com/What-Color-Questions-Answers-Science/dp/1419734512 2. The smell of tears lowers testosterone DOI: 10.1126/science.1198331 3. Inhaling (sniffing) improves non olfactory attention & cognition: https://pubmed.ncbi.nlm.nih.gov/31089297/ 4. Smelling Salts & Improved Athletic Performance https://pubmed.ncbi.nlm.nih.gov/28922211/ 5. Taste Receptors Are Expressed By Ovaries & Testes doi:10.1093/molehr/gat009 Timestamps: 00:00:00 Introduction 00:06:02 Sensing Chemicals: Smell, Taste & Chemicals That People Make To Control Each Other 00:09:10 Vision Protocols Recap (Brief) & Correction 00:12:20 Color Vision: Excellent Resource: What is Color? (The Book) 00:13:54 How We Sense Chemicals: Enter Our Nose, Mouth, Eyes, Skin 00:17:28 The Chemicals From Other People’s Tears Lower Testosterone & Libido 00:21:16 SMELL: Sniffing, A Piece of Your Brain In Your Nose, 3 Responses To Smells 00:24:40 Smells & Memory: Why They Are So Powerfully Associated 00:26:40 Pheromone Effects: Spontaneous Miscarriage, Males & Timing Female Puberty 00:28:56 Sniffing Creates Alertness & If Done Properly Can Help You Focus & Learn Better 00:34:00 Protocol 1: Sniffing (Nothing) 10-15X Enhances Your Ability to Smell & Taste 00:35:50 Smelling Salts, Ammonia & Adrenaline 00:38:25 How You Can Become A Human Scent Hound, Detecting Cancer, & Tasting Better 00:43:45 Smell As A Readout Of Brain Health & Longevity; Regaining Lost Sense Of Smell 00:48:30 Dopamine, Sense Of Smell, New Neurons & New Relationships 00:50:20 Why Brain Injury Causes Loss Of Smell; Using Smell To Gauge & Speed Recovery 00:53:33 Using Smell To Immediately Becoming Physically Stronger 00:54:40 Smelling In Our Dreams, Active Sniffing In Sleep, Sniffing As a Sign Of Consciousness 00:57:35 Mint Scents Create Alertness By Activating Broad Wake-Up Pathways 00:59:48 Protocol 2 Pleasant Or Putrid: The Microwave Popcorn Test, Cilantro, Asparagus, Musk 01:03:00 Skunks, Costello, All Quiet On The Western Front 01:04:32 TASTE: Sweet, Salty, Bitter, Umami, Sour; Your Tongue, Gustatory Nerve, NST, Cortex 01:08:45 Energy, Electrolytes, Poisons, Gagging, Amino Acid & Fatty Acid Sensing, Fermentation 01:13:48 Our 6th Sense of Taste: FAT Sensing 01:15:05 Gut-Brain: Your Mouth As An Extension Of Your Gut; Burned Mouth & Regeneration 01:19:30 Protocol 3: Learn To Be A Super-Taster By Top-Down Behavioral Plasticity 01:22:20 The Umami-Sweet Distinction: Tigers Versus Pandas 01:25:05 Eating More Plants Versus Eating More Meat, Cravings & Desire 01:27:15 Food That Makes You Feel Good Or Bad: Taste Receptors On Our Testes Or Ovaries 01:30:05 Biological Basis For The Sensuality of Umami and Sweet Foods 01:32:28 Appetitive & Aversive Sensing: Touching Certain Surfaces, Tasting Certain Foods 01:33:35 Amino Acids Are Key To Life, The Maillard Reaction, Smell-Taste Merge, Food Texture 01:39:00 How Processed Food Make You Crave More Processed Foods 01:39:44 Protocol 4: Invert Your Sense of Sweet & Sour: Miracle Fruit; Swapping Bitter & Sweet 01:43:03 Pheromones, Desire To Continue Mating: Coolidge Effect Occurs In Males & Females 01:46:40 Do Women Influence Each Others Menstrual Cycles? 01:49:19 Recognizing the Smell Of Your Romantic Partner 01:50:30 Differences In Odor Detection Ability, Effects Of Hormones 01:53:00 We Rub The Chemicals Of Others On Our Eyes and Skin, Bunting Behavior 01:56:40 Summary Please note that The Huberman Lab Podcast is distinct from Dr. Huberman's teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Photo Credit: Mike Blabac - https://www.blabacphoto.com

Andrew Hubermanhost
Jun 20, 20211h 59mWatch on YouTube ↗

At a glance

WHAT IT’S REALLY ABOUT

How Smell and Taste Quietly Rewire Your Brain, Hormones, Behavior Daily

  1. Andrew Huberman explains how smell, taste, and pheromone‑like chemicals shape our brain states, hormones, and behaviors, often outside conscious awareness. He details the neurobiology of olfaction and taste, including how inhalation itself heightens alertness, learning, and memory. The episode outlines how chemical cues from food and other people influence attraction, appetite, metabolic health, and even reproductive biology. Huberman also offers practical tools to improve smell and taste sensitivity, support recovery after brain injury, and leverage these systems to enhance cognition and decision‑making around food and relationships.

IDEAS WORTH REMEMBERING

5 ideas

Nasal inhalation and sniffing directly increase brain alertness and learning capacity.

Research from Noam Sobel and others shows that inhalation (especially through the nose) transiently raises cortical arousal and improves attention and memory, independent of what you’re smelling. Exhalation is associated with a slight dip in arousal. Restricting breathing to the nose during learning tasks improves performance versus mouth or mixed breathing. Practically, prioritizing nasal breathing—and taking a few deliberate nasal inhales before focused work—can measurably enhance focus and retention.

You can train and rapidly improve your sense of smell and taste with simple sniffing protocols.

Olfactory neurons are unusually plastic and replenish every 3–4 weeks, making the smell system highly trainable. Doing 10–15 deliberate nasal sniffs of ‘nothing’ and then smelling a food or object increases the richness and sensitivity of smell perception, likely by both waking up arousal systems and priming olfactory receptors. Repeating this regularly can long‑term enhance discrimination of odors and, via smell–taste coupling, make eating more satisfying while sharpening your palate.

Loss or change of smell is a meaningful signal of brain and nervous system health.

Olfactory neurons project through the cribriform plate and are often sheared off in concussions and other head trauma, making smell loss common after TBI. Recovery of smell tracks, in part, recovery of neural integrity and neurogenesis from the subventricular zone. Similarly, early smell deficits can correlate with neurodegenerative conditions and were a key early sign in COVID‑19. Structured olfactory training (frequent deliberate smelling, nasal breathing) and behaviors that support dopamine and blood flow can aid recovery of olfaction.

Taste is a safety and nutrient-detection system first, pleasure system second.

The five core tastes—sweet, salty, bitter, sour, umami—and a likely sixth (fat) each serve specific survival functions: sweet signals rapid energy, salty signals electrolytes, bitter warns of poisons and connects directly to gag reflex circuits, sour warns of spoilage/fermentation, and umami flags amino acids/protein. These receptors are intermingled across the tongue (not in distinct “zones” as textbooks once claimed) and relay via the gustatory nerve to insular cortex, where we construct our taste perceptions.

Gut and brain circuitry can be hijacked by processed foods to drive overconsumption.

Neurons in the gut sense sugars, fats, and amino acids and send signals via the vagus nerve to release dopamine in the brain, independent of conscious taste. Food manufacturers exploit this by designing textures and ingredient combinations (e.g., specific sugar–fat–salt ratios, Maillard browning flavors) that strongly activate gut–brain reward circuits and oral texture pleasure, making it “impossible to eat just one” even when the food doesn’t taste particularly good. Recognizing this helps explain persistent cravings and can motivate shifting toward less engineered foods.

WORDS WORTH SAVING

5 quotes

Inhaling itself wakes up the brain. It’s not about what you’re smelling, it’s the act of inhalation.

Andrew Huberman

Just the tiniest bit of training and attention in the olfactory system can radically change your relationship to food.

Andrew Huberman

Chemical sensing is among the most primitive senses we have, but it’s still controlling huge aspects of our biology today.

Andrew Huberman

Processed foods may make you eat more of them not because they taste good, but because they feel good in your gut and drive dopamine.

Andrew Huberman

You are actively seeking out and evaluating other people’s chemistry from the time you’re born until the time you die.

Andrew Huberman

Neurobiology of smell (olfaction) and inhalation-driven brain arousalTaste receptors, gut–brain signaling, and food craving mechanismsGenetic differences in odor perception and individual taste worldsNeurogenesis and smell: olfaction as a marker and tool in brain healthHuman pheromone‑like effects: tears, sweat, menstrual cycle interactionsProcessed foods, dopamine, and manipulation of our reward circuitryChemical sensing beyond the tongue: gut, respiratory tract, gonads

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