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Episode Details
EPISODE INFO
- Released
- January 29, 2019
- Duration
- 2h 21m
- Channel
- The Joe Rogan Experience
- Watch on YouTube
- ▶ Open ↗
EPISODE DESCRIPTION
David Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. https://genetics.med.harvard.edu/sinclair/people/sinclair.php
SPEAKERS
Joe Rogan
hostDavid Sinclair
guest
EPISODE SUMMARY
In this episode of The Joe Rogan Experience, featuring Joe Rogan and David Sinclair, Joe Rogan Experience #1234 - David Sinclair explores Harvard longevity scientist reveals real-world strategies to slow aging Joe Rogan interviews Harvard geneticist David Sinclair about emerging science that treats aging as a disease-like process that can be slowed and potentially reversed. Sinclair explains how pathways like sirtuins, AMPK, and mTOR respond to stressors such as fasting, exercise, heat, and cold—and how certain molecules (like NMN, resveratrol, and metformin) can pharmacologically tap into those systems. They cover Sinclair’s personal regimen, the ethics and economics of longevity drugs, and how epigenetic damage—not just DNA mutations—may underlie aging. The conversation ranges from diet, exercise, and blood testing to CRISPR, designer babies, Lyme disease diagnostics, and future therapies that may restore vision and rejuvenate tissues.
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