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Lewis Howes"This Is Why You FEEL LOST & UNHAPPY In Life" - Fix This TODAY! | Andrew Huberman
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130 min read · 25,600 words- 0:00 – 12:19
How the Body and Mind Are Connected
- AHDr. Andrew Huberman
The old narrative 10 years ago was that if you're feeling depressed, just smile. Well, if that worked-
- SPSpeaker
[laughs] Right
- AHDr. Andrew Huberman
... we would have a lot less depression than we see out there.
- SPSpeaker
Right. I think you gotta have a dream. The School of Greatness. Really? [laughs] Please welcome Lewis Howes. Welcome back, everyone, to The School of Greatness Podcast. I'm super excited about our guest today, Andrew Huberman in the house. Good to see you, my friend.
- AHDr. Andrew Huberman
Hey, great to be here. Thanks.
- SPSpeaker
Very excited. You are a neuroscientist, professor of neurobiology and ophthalmology, which is the hardest word to say, at Stanford. Uh, you run a lab, Huberman Lab, which is primarily studying brain states such as fear, courage, anxiety, calm, and how we can better move in and out of certain things. My first question, I've been super excited about this interview happening because I'm fascinated by how we think, how we feel, our emotions, how everything is connected in our body and our brains, and I'm curious, how much does the body control the mind and the mind control the body? Are they very connected, or is the mind in complete control?
- AHDr. Andrew Huberman
That's a great question. The short answer is the body has a huge and profound influence on our mind. And the reason is that we often talk about the brain, and we think the brain, the brain, the brain. The brain is important, but the brain and the spinal cord, which is, makes up what we call the central nervous system, are extensively connected with the body, and the body is extensively connected with the brain and spinal cord.
- SPSpeaker
So the spinal cord is connected to the brain-
- AHDr. Andrew Huberman
That's right
- SPSpeaker
... in the back. It comes up the neck-
- AHDr. Andrew Huberman
That's right
- SPSpeaker
... and it's, the actual nerves are connected inside of your brain.
- AHDr. Andrew Huberman
That's right.
- SPSpeaker
And go all the way down to lower back?
- AHDr. Andrew Huberman
Yeah. Yeah, so basically we are a big tube, uh, or our nervous system is a big tube. So your brain obviously is the thing that's shaped like, more or less like this, and then the spinal cord extends off the back, and all that is housed in skull except for two pieces of the brain, uh, which are the eyes, which are the, actually two pieces of the brain that are outside the skull.
- SPSpeaker
The eyes are a part of the brain.
- AHDr. Andrew Huberman
They are absolutely a part of the brain. They are central nervous system. So it's eyes, brain, and spinal cord make up-
- SPSpeaker
They're all connected.
- AHDr. Andrew Huberman
They're all connected.
- SPSpeaker
So if, if you took that out of the body, let's say-
- AHDr. Andrew Huberman
Yeah
- SPSpeaker
... they would all be connected in some way.
- AHDr. Andrew Huberman
That's right. They're contiguous, as we say. They're just one unit.
- SPSpeaker
They're one piece.
- AHDr. Andrew Huberman
That's right. And when, sometimes I get challenged, people say, "The eyes aren't part of the brain." Well, then that means that the spinal cord is part of the brain, too, and I, I wanna be really clear. This is not semantics. There is a genetic program that ensures that early in development during the first trimester when we were all in our mothers' bellies, the retinas, the neural retinas and eyes were deliberately pushed out of the skull. And the reason you have those eyes outside your skull is so that you can evaluate things at a great distance from you, right? Because otherwise everything would have to be in contact with you. Other animals do this mainly using smell. We are very visually driven. So a lot of our genome is devoted to vision and understanding what's going on at a distance from us, and that's afforded us a huge evolutionary advantage.
- SPSpeaker
To survive.
- AHDr. Andrew Huberman
To survive because the, the more that I can anticipate events at a distance, the more that I could coordinate with my environment like daytime and nighttime, but also when objects are coming at me or things I wanna chase and kill or, um, you know, you think about mating behavior and hunter-gatherer behavior, all of that, evaluating faces and face, facial expressions without actually having to come into contact with people afforded a huge evolutionary advantage. But I wanna make sure that I answer your question thoroughly.
- SPSpeaker
Mm-hmm.
- AHDr. Andrew Huberman
The nervous system includes the brain, which we now know includes the eyes as well, the spinal cord, and then what's called the peripheral nervous system, all the connections with the body. And every organ in our body, our heart, our diaphragm, our lungs, our spleen, our liver, all of it is, is, as we say, innervated. It receives-
- SPSpeaker
Connected
- 12:19 – 19:41
Depression, Baselines and Taking Responsibility
- SPSpeaker
With, with, with feelings, I wanna talk about feelings and emotions for a second. Can a person make it so they never get depressed, they never react to, um, their perception, their, people's actions towards them, where they never get to a state of, "Ah, I don't feel good. I'm feeling more depressed. I'm in a, a dark place now. I'm stuck in this place." Is there a way that we could ever defend ourselves against negative stressors and negative emotions, or are we just, are they, do we need them as well to have contrast in life?
- AHDr. Andrew Huberman
Yeah. Well, there's sort of two views on this. Um, I'll reveal mine after I, um, sort of r- uh, explain the two views. One is that s- these states, uh, I guess I'm, I'm automatically calling things like depression a state of mind-
- SPSpeaker
State of body. Is it-
- AHDr. Andrew Huberman
So when I say a state of mind, I mean brain and body
- SPSpeaker
'Cause your body is really feeling, it's like the brain is connected to the body.
- AHDr. Andrew Huberman
Right
- SPSpeaker
And so if you're saying internally a thought of like, "I'm depressed, I don't feel good," or, "I'm sad," or, "I'm lonely," or, "I'm not good enough," the body's gonna react. Is that what I'm understanding?
- AHDr. Andrew Huberman
Absolutely
- SPSpeaker
Like, the body's going to manifest what the mind is telling you.
- AHDr. Andrew Huberman
Absolutely
- SPSpeaker
The thought, the idea. You're gonna be like, "I'm sad. I'm not good enough," and you're gonna shrink.
- AHDr. Andrew Huberman
Right
- SPSpeaker
Is that right?
- AHDr. Andrew Huberman
That's right. I mean, there are really two forms of depression. Um, and sometimes they're intermixed, but one is anxiety associated depression, and you, you, if you've ever experienced it or for anyone that's experienced it, they feel agitation in their body, and their mind races, but in their body. So the body is recruited. There are also depressive states that people feel very fatigued and exhausted. It's, and overwhelmed, and they also experience that in their body. The, the idea of getting out of bed in the morning is hard, um, motivating to exercise, doing the sorts of things that we know are powerful for pushing back on depression.
- SPSpeaker
Mm-hmm
- AHDr. Andrew Huberman
So the body is recruited. I think most people would say that depressive states are bad when they bring down the baseline on life. I, just to, as a brief aside, anytime there's a question about mental health or addiction or trauma or anything, o- one could look at it and make up some argument of, "Well, evolutionarily this makes sense. We all get depressed." Right? But we have to be fair to the person experiencing it, of course, and have sensitivity that some behaviors will keep the baseline of our life steady, meaning job, relationships, et cetera, will continue as they are. Other activities will tend to improve the baseline on our life, job activities, relationship, et cetera, will, will improve. And then there's some things like heroin, which does very quickly, we can predict that very quickly the baseline on life is gonna creep down regardless of who that person is. Right?
- SPSpeaker
Mm-hmm.
- AHDr. Andrew Huberman
So people say, "Can you get addicted to water?" Well, maybe, but I have to drink a lot of water before the baseline on my life starts to go down.
- SPSpeaker
Oh, sure. It feels uncomfortable.
- AHDr. Andrew Huberman
That's right
- SPSpeaker
You're just like, "Man, I'm so bloated all the time." [laughs]
- AHDr. Andrew Huberman
Exactly. So we tend to throw around things like addiction and depression a little loosely. So-
- SPSpeaker
Yeah
- AHDr. Andrew Huberman
... I, I think that it's fair to say that depression is wired into us as a possible state that we can all fall into, but that it's very important, in my opinion, that humans have tools to remove themselves from that state-
- SPSpeaker
Mm-hmm
- AHDr. Andrew Huberman
... of course, to avoid, you know, tragedies like suicide, but also because when the baseline on someone's life s- goes down far enough, they find it increasingly hard to do the sorts of things that are gonna get them out of depression. So you or I could say-
- SPSpeaker
So they stay in that state of depression-
- AHDr. Andrew Huberman
That's right
- SPSpeaker
... because, "Ah, it's too hard to go work out. It's too hard to change my habit-
- AHDr. Andrew Huberman
Right
- 19:41 – 22:00
Why You Can't Think Your Way Out of an Emotional State
- AHDr. Andrew Huberman
Right. It's, right. So a specific tool.
- SPSpeaker
Go outside for a walk.
- AHDr. Andrew Huberman
A specific tool.
- SPSpeaker
Yeah.
- AHDr. Andrew Huberman
Right? And when it comes to depression and emotions, I mean, the... It's very hard to talk oneself out of an emotional state. It's just very challenging.
- SPSpeaker
Very hard.
- AHDr. Andrew Huberman
That's right. [laughs]
- SPSpeaker
It's like when I talk to my girlfriend and she's just, like, she's not happy about something, and she gets on a tangent, I'm like, there's nothing I can say to calm her down. There's nothing I can say to s- to someone who's emotional-
- AHDr. Andrew Huberman
Mm-hmm
- SPSpeaker
... about an idea in the moment-
- AHDr. Andrew Huberman
Mm-hmm
- SPSpeaker
... until I'm like, "Okay, let's talk later."
- AHDr. Andrew Huberman
Mm-hmm.
- SPSpeaker
Otherwise, me trying to tell them to relax, no, that's not what you're thinking-
- AHDr. Andrew Huberman
It's counterproductive
- SPSpeaker
... that's not what... You know, "It's not the truth, that's not what you're thinking," or whatever, it's counterproductive, right?
- AHDr. Andrew Huberman
Yeah.
- SPSpeaker
Makes them [laughs] more emotional.
- AHDr. Andrew Huberman
Well, that's because these states, like these emotional states-
- SPSpeaker
Ah
- AHDr. Andrew Huberman
... of mind, they, they recruit the whole nervous system. So we are actually-
- SPSpeaker
Wow
- AHDr. Andrew Huberman
... a different host-
- SPSpeaker
Your whole body is out of control.
- AHDr. Andrew Huberman
Your mind, your body. L- like, for instance, if you're angry, upset, or stressed, your pupils dilate. This is subconscious.
- SPSpeaker
[laughs]
- AHDr. Andrew Huberman
As a consequence, as a consequence of that, you view the world in paner- in a, kinda like portrait mode, not panoramic, excuse me. Portrait mode on your phone, where the thing that's upsetting you is in sharper focus and everything else is blurry. So you actually see the world differently. In addition to that, the timing, uh, the, your perception of time, excuse me, is now faster, so that things outside you seem to be moving more slowly in comparison to how you feel inside. You've experienced this if you were ever in line at the airport or something and it's taking a long time and you're about to miss your flight, seems like the person in front of you is moving very slowly.
- SPSpeaker
They're taking forever, yeah.
- AHDr. Andrew Huberman
Yeah, but time is time. It's, you know, it's moving at the same rate regardless. When you're very calm, or let's say you're, you're fatigued. Let's say you're exhausted. You didn't sleep well the night before. Things in front of you are gonna seem like they're moving really fast. They're saying, "Take off your shoes," putting them on the conveyor belt, and it's kind of overwhelming.
- SPSpeaker
Like, "Slow down, here."
- 22:00 – 27:33
Breathing Tools: The Physiological Sigh
- AHDr. Andrew Huberman
So there are two ways that you can shift your brain state quickly. You mentioned one already, which is respiration or breathing. And the reason is there's a direct connection from the brain to an organ in our body called the diaphragm, which is skeletal muscle. The diaphragm is designed to move the lungs up and down, bring in more oxygen, expel more oxygen, and it's unlike other organs, like the heart or the spleen or the liver, because it's actually made up of what's called striated muscle, just like a bicep, tricep, or quadricep. It can be voluntarily controlled. You can't voluntarily control your heart directly right now. Like, you can't say, "Speed up," and speed it up.
- SPSpeaker
Or slow down.
- AHDr. Andrew Huberman
Or slow it down.
- SPSpeaker
But you can slow down your breathing-
- AHDr. Andrew Huberman
You can d-
- SPSpeaker
... and you can slow down the way you think about things, I'm assuming. Or sl- or change your thought to something else to help you be more relaxed.
- AHDr. Andrew Huberman
That's right. So one of the reasons why breathing is such a powerful tool for shifting one's state is that, A, it's always available for voluntary control. It's just right there. You can d- I can decide right now to do three inhales. [inhales] Or I can just go back to breathing reflexively. I can just do that at any moment. So the, the neural archit- you know, real estate which is in the brainstem that controls breathing is in a unique position because it's at the kind of boundary between conscious control and unconscious control. I can't do that for my digestion. I can't do that for-
- SPSpeaker
Wow
- AHDr. Andrew Huberman
... most e- most everything that happens internally. The other thing is that breathing controls our level of alertness very dramatically. So the faster you breathe, generally, the more alert you are. The slower you breathe, the more calm you're gonna be.
- SPSpeaker
The faster you breathe meaning shorter, quick breaths, or [quick inhales]
- AHDr. Andrew Huberman
Either way. So, um, so we're just to take a brief, um, adventure through the, the neuroscience of breathing and how it relates to brain states and, and there's some fun tools in here, so forgive me for this tangent. But you have two brain areas that are responsible for breathing. One is called, for the aficionados, the prebotzinger complex. It was discovered by Jack Feldman at UCLA. It's named after a bottle of wine, so now you w- people won't forget it.
- SPSpeaker
[laughs]
- AHDr. Andrew Huberman
And it controls rhythmic breathing. So inhale, exhale, inhale, exhale. It's just rhythmic breathing. There's another brain area that controls breathing, which is near what's called the parafacial nucleus, which involves breathing any time there are double inhales or double exhales or triple inhales. And you say, "Well, why would you have this second brain area for breathing?" Well, it turns out when you're speaking- Or crying or coughing, you need to coordinate your breathing with your speaking, and that means sometimes you need to take multiple inhales or multiple exhales, and this is all happening very, very fast, so you don't notice. But there's a very important discovery that was made a few years ago by Jack's lab and by a guy named Mark Krasnow at Stanford, who discovered there's a set of neurons in your brain stem, my brain stem, everybody's brain stem, and every animal, every mammal's brain stem. It's a very small number of neurons that controls a specific pattern of breathing, which are called physiological sighs. So these are not just sighs where you go [exhales] and exhale. These are sighs that involve doing two inhales and then an extended exhale.
- SPSpeaker
We all do this.
- AHDr. Andrew Huberman
You do this during sleep, anytime carbon dioxide levels in your bloodstream get too high, in order to get more oxygen into your system. People also do this if they've been crying or sobbing. They'll do this [inhales] and then they'll exhale. So what's happening with these physiological sighs and why is this powerful? So your lungs are two big bags of air, but they actually are made up of a ton of little sacks of air called the alveoli of the lungs.
- SPSpeaker
Hmm.
- AHDr. Andrew Huberman
When we are exercising or when we are sleeping or anytime we're doing anything, these l- these little sacks of air eventually start to collapse. And what happens is carbon dioxide builds up in our system and we experience that as stress. We actually feel the impulse to breathe because carbon dioxide levels get too high. There are neurons that sense carbon dioxide. And then, without realizing it, you do a double inhale and then exhale. Typically, the inhales are done through the nose and the exhale is done through the mouth. So it looks like [inhales and exhales] . And why the second inhale? Well, if you've ever, um, tried to blow up a balloon for a kid at a kid's party or you're just blowing up a balloon, you sometimes blow into that empty balloon, it doesn't work-
- SPSpeaker
It doesn't go anywhere. Stop
- AHDr. Andrew Huberman
... so what do you do? You do two in... You do two. You go [blows air] and then it pops open. So these double inhales pop open the alveoli of the lungs.
- SPSpeaker
Huh.
- AHDr. Andrew Huberman
They don't explode them, but they pop them open, which pulls carbon dioxide out of the bloodstream, brings oxygen, and then you offload carbon dioxide.
- SPSpeaker
[laughs]
- AHDr. Andrew Huberman
So if you watch a dog right before it takes a nap or something, it often will do these. Now, what's cool about these physiological sighs is, from work in our lab and w- that's still ongoing, I just want to say it's still ongoing, but work in other labs as well, f- double inhales followed by an extended exhale are the fastest way that I'm aware of to bring the mind and the body into a more relaxed-
- SPSpeaker
No way
- AHDr. Andrew Huberman
... state.
- SPSpeaker
Really?
- AHDr. Andrew Huberman
Yeah. It, it only-
- SPSpeaker
The fastest way
- AHDr. Andrew Huberman
... the fastest way.
- SPSpeaker
If I'm stressed, I'm overwhelmed, just do a [inhales] three or two?
- 27:33 – 37:33
Stress, Adrenaline, Cortisol and the Immune System
- AHDr. Andrew Huberman
But I think for anyone that experiences anxiety from time to time, which is everybody, knowing that you can consciously take control over these neurons that control the ratio of carbon dioxide and oxygen in your lungs, et cetera, even if you don't remember any of that, it's just two inhales through the nose [inhales] . What you're trying to do is maximally inflate those little sacks in your lungs [inhales] and then exhale long through the mouth, 'cause you're blowing off carbon dioxide.
- SPSpeaker
I heard you do a... Does it matter the cadence? 'Cause you did a long, deep breath and then a shorter-
- AHDr. Andrew Huberman
Not so much.
- SPSpeaker
That's just your style.
- AHDr. Andrew Huberman
Yeah, you're just trying to fill those lo- those as big as you can. [exhales] So the advice that we hear of take a deep breath-
- SPSpeaker
Yeah
- AHDr. Andrew Huberman
... or just exhale is sort of right, but it doesn't capture-
- SPSpeaker
Huh
- AHDr. Andrew Huberman
... the, the, this neural circuit. So a lot of what my lab is focused on, 'cause there's so many great labs and people doing great stuff in the breathwork community, Patrick McKeown, Brian Mackenzie, there, there are all these incredible people doing this work, Wim Hof-
- SPSpeaker
Yeah
- AHDr. Andrew Huberman
... but my lab's been mainly focused on what is the neural machinery that controls these brain body states? And the reason these physiological sighs work is partially 'cause you offload carbon dioxide, you re-inflate the lungs, so when the body has oxygen, it's happy. When it ha- doesn't have oxygen, it gets stressed. But the other reason is the most direct and fastest connection between the brain and body for controlling your state of mind is what's called the phrenic nerve, P-H-R-E-N-I-C. The phrenic nerve connects these neurons that I'm referring to in these two brain centers that control breathing with the diaphragm.
- SPSpeaker
Huh.
- AHDr. Andrew Huberman
A lot of people get excited about the vagus nerve, and I'm not out to punish the vagus nerve or the vaganistas.
- SPSpeaker
[laughs]
- AHDr. Andrew Huberman
But the truth is the vagus nerve is a very slow system for calming the brain and body. It's called the rest and digest pathway.
- SPSpeaker
Mm-hmm.
- AHDr. Andrew Huberman
People are engaging their vagus all the time when they eat a big meal. When the stomach is distended, it sends a signal to the brain that, "Oh, I have enough food. It's time to rest-
- SPSpeaker
Relax
- AHDr. Andrew Huberman
... and digest." But eating, first of all, if you're only using food as a way to control your stress-
- SPSpeaker
That's not a good habit [laughs]
- AHDr. Andrew Huberman
... it's not a good habit. And-
- SPSpeaker
And you'll, you'll be depressed once-
- AHDr. Andrew Huberman
That's right. People have l- learned long ago, thousands of years ago, that the best way to suppress a cortisol response is with carbohydrates, because it blunts cortisol. But this is why people eat carbohydrate-rich foods when they're stressed.
- SPSpeaker
And when cortisol is spiked, what happens?
- AHDr. Andrew Huberman
So every morning when you wake up, there's a cortisol spike. That's a good cortisol spike.
- SPSpeaker
That's a rest spike, right?
- AHDr. Andrew Huberman
That's-
- SPSpeaker
It's like a-
- AHDr. Andrew Huberman
It's a good one. It's the one that wakes you up out of sleep and you want that early in the day.
- SPSpeaker
So you're not just, like, groggy all day, right?
- 37:33 – 43:12
Stress Inoculation and the Power of Narrative
- AHDr. Andrew Huberman
What they tend to do and what cold showers and ice baths and things like that do is they raise the ceiling on your stress threshold. And what I mean by that is throughout the day and throughout the year, we're confronted with different things. Right now we're confronted with a lot of things.
- SPSpeaker
Yeah. [laughs]
- AHDr. Andrew Huberman
2020 is the year of being confronted with stress of various kinds. The mind plays an important role in interpreting whether or not it's overwhelming or tolerable. So intense breathing like Tummo breathing or ice baths or cold showers or intense exercise like, you know, high-intensity interval training type stuff teaches the mind to be comfortable in these higher stress states where, in other words, it teaches people to be comfortable when they have a lot of adrenaline in their body.
- SPSpeaker
Mm.
- AHDr. Andrew Huberman
This is a, this is basically stress inoculation. But stress inoculation is not about not getting stressed. It's actually about divorcing the mind-body relationship a bit so that you're calm in the mind when your body is very amplified.
- SPSpeaker
Under stress.
- AHDr. Andrew Huberman
Yeah. So if you've ever done Tummo-type breathing or you've done a cold shower-
- SPSpeaker
Mm-hmm
- AHDr. Andrew Huberman
... the goal is to get the adrenaline release, but then-
- SPSpeaker
And then calm your mind
- AHDr. Andrew Huberman
... and then calm your mind.
- SPSpeaker
And stay in the ice, not like, "Ah, I'm exha-
- AHDr. Andrew Huberman
Right
- SPSpeaker
... I'm freezing," but more like, "No, I can handle this."
- AHDr. Andrew Huberman
That's right. That's right.
- SPSpeaker
And, and have power over your thoughts and your mind so that you can have more control of your body.
- AHDr. Andrew Huberman
That's right.
- SPSpeaker
Obviously you're gonna feel cold.
- AHDr. Andrew Huberman
Right.
- SPSpeaker
But if you can... But the, I mean, does the mind have 100% power over what the body feels?
- AHDr. Andrew Huberman
No.
- SPSpeaker
Okay.
- AHDr. Andrew Huberman
But it doesn't mean that it doesn't have a significant c- control over it. But if-
- SPSpeaker
Say I f- say I feel cold.
- AHDr. Andrew Huberman
Yeah.
- SPSpeaker
In the ice, right?
- AHDr. Andrew Huberman
Right.
- SPSpeaker
I'm in ice. It's 30 degrees.
- AHDr. Andrew Huberman
Right.
- SPSpeaker
Can I control my mind to say, "You know what? This is actually a hot tub," and you feel warm, and you're feeling hot right now? Or is it too much physiological ba- barriers to break through that?
- 43:12 – 52:48
Dopamine, Effort and Growth Mindset
- AHDr. Andrew Huberman
But most of our dopamine release is not from achieving goals. It's actually released when we are en route to our goals, when we're in pursuit of our goals and we think we're on the right path.
- SPSpeaker
This is why a lot of people get depressed after they achieve a big goal-
- AHDr. Andrew Huberman
That's right
- SPSpeaker
... because they feel like, "I'm supposed to feel something greater. I felt this thing for two minutes, and now that's it?"
- AHDr. Andrew Huberman
That's right. High achievers know to attach dopamine to the effort process.
- SPSpeaker
To the pursuit, the day-to-day tasks, the, the growth, the lessons, the losses, like everything, right?
- AHDr. Andrew Huberman
Well, and it can be to some wins along the way.
- SPSpeaker
Yeah.
- AHDr. Andrew Huberman
But growth mindset, which is the academic discovery and laboratory discovery of my colleague Carol Dweck at Stanford, is the hallmark of growth mindset is, is really two things. One is, "I'm not where I wanna be now, but I, but I will... I'm capable of getting there eventually." The other is to attach a sense of reward to the effort process itself. In fact-
- SPSpeaker
Don't reward the result. Reward the effort
- AHDr. Andrew Huberman
That's right. And if you look at true high performers, people that are consistently good at what they do, they don't peak and go through the po- postpartum depression and crash and come back and their life is a cycle of ups and downs, but really people who are on that upward trajectory consistently, those people attach dopamine to the effort process. And actually, Carol's, uh, one of her original studies on the discovery of growth mindset was these kids that loved doing math problems that they knew they couldn't get right. So it's like the people who love puzzles, but in this case, they knew they couldn't get it right, but they loved doing it. And it, incidentally or not so incidentally, these kids are fantastic at math when there is a right answer because they're, they feel some sense of reward from the effort process.
- SPSpeaker
Yeah.
- AHDr. Andrew Huberman
Now, the cool thing about dopamine is that it's very subjectively controlled. We can all learn to secrete dopamine in our brain in response to things that are in a purely subjective way. And-
- SPSpeaker
Our interpretation
- AHDr. Andrew Huberman
... our interpretation and, but it has to be attached to reality. So, you know, one should never confuse-
- SPSpeaker
What is real
- AHDr. Andrew Huberman
... right. So no, so if you're ef- if you're thinking about the effort you're expending. So let's say somebody right now is financially back on their heels and they're setting up a new business, for instance, and it's hard. If they can take a few moments or, or minutes each day to reflect on the fact that the effort process is allowing them to climb out of their hole potentially, that it's giving them an opportunity, that it's somehow po- they are on the right path, or they're, or if they're not in movement along that path or at least oriented on the right path, they're not lying in bed all day, back on their heels.
- SPSpeaker
They're taking a step forward
- AHDr. Andrew Huberman
They're taking a step. If they can reward that process internally, two things happen. First of all, the brain circuits that are associated with building subjective rewards and dopamine get stronger, so you get better at that process. And second, and most importantly, dopamine has an amazing ability to buffer adrenaline and buffer epinephrine. And what I mean by that is there was a study that was published in the journal Cell, excellent journal, Cell Press journal, a couple years ago showing that with repeated bouts of effort, we use and we release more and more epinephrine. It's kind of adrenaline, but in the brain.
- SPSpeaker
With more effort, we release-
- AHDr. Andrew Huberman
Every time. Every time you put in effort. So every time you ma- let, for this, let's keep it in, if I were to keep it in the business context, every time you make to write that email, every time you, let's say it's a, a person who's a craftsman or a craftswoman, every time you're working in the, in the shop and doing that, every bit of effort, you're taking a little bit of money out of this epinephrine account. You're spending epinephrine. At some point, those levels of epinephrine get high enough that you c- you feel like quitting. It feels exhausting.
- SPSpeaker
[laughs]
- AHDr. Andrew Huberman
And this was done in a beautiful study actually where, um, they control the visual environments and they have the subjects ex- exert effort. And they can control the visual environment, so sometimes the effort of, of taking steps and moving forward, this is actually kind of pushing forward in a kind of swimming motion, um, would give them the sensation that they were actually making progress, and other times it was an exercise in futility where they would just keep the, the visual world stationary and they would expend effort, and they didn't think they were going anywhere.
- SPSpeaker
Right. Oh.
- AHDr. Andrew Huberman
Epinephrine's climbing, climbing, climbing, and eventually they quit. Now, dopamine is able to push back on that epinephrine and give you, anyone, the, the feeling that you could continue and maybe even the feeling that you want to continue. And you've seen this actually, like football's a good example. Two teams play, say the Super Bowl. Both teams are max effort the entire time.
- SPSpeaker
Yeah.
- AHDr. Andrew Huberman
Max effort. The team that wins suddenly in a moment has the energy to jump all over the place, party for days.
- SPSpeaker
[laughs]
- AHDr. Andrew Huberman
They can talk. I mean, they, they, they have the energy.
- SPSpeaker
They're exhausted right before then.
- 52:48 – 1:06:08
Rewarding the Hard Part and Staying Forward
- AHDr. Andrew Huberman
Okay. So we've all heard the sayings, you know, how do you... You know, a journey of a thousand miles starts with a single step. Or how do you eat an elephant? One bite at a time.
- SPSpeaker
Mm.
- AHDr. Andrew Huberman
Or, you know, all, there are all these sayings and, and it, you know, goes back to the Bible and earlier.
- SPSpeaker
Yeah.
- AHDr. Andrew Huberman
Right? I mean, this is not new. These are not new sayings, but they're showing up in different forms. What's lost in those short descriptions, however, is that every step is not equivalent. If it were just that a journey of a thousand miles starts with a single step, everyone would pursue their goals.
- SPSpeaker
[laughs]
- AHDr. Andrew Huberman
Everyone would push back against adversity. Everyone... I mean, you can read the inspirational stories a- as many times as one needs, and I do think inspirational stories are a very high value. In fact, I think they're vicarious dopamine. I think they give us the sense that we could, which then orients-
- SPSpeaker
Hope
- AHDr. Andrew Huberman
... hope, which then orients us to the world again.
- SPSpeaker
To start. Yeah.
- AHDr. Andrew Huberman
That's-
- SPSpeaker
So it's po- maybe it's possible for me.
- AHDr. Andrew Huberman
That's right. So let's say, um, let's take the example of somebody who's, um-
- SPSpeaker
But just to finish that, that story of it's not about just taking a single step and one step at a time. Is it because there's adversities every 10 steps you go, and so it's harder and harder?
- AHDr. Andrew Huberman
Yeah.
- SPSpeaker
So it's not just one-
- AHDr. Andrew Huberman
Well, it's just very non-linear.
- SPSpeaker
Yeah, yeah.
- AHDr. Andrew Huberman
You know, it's, it's some days go... You know, I know this from my scientific career. It's, you know, some days it's easy, some days it's hard. It's all over the place.
- SPSpeaker
Mm-hmm.
- AHDr. Andrew Huberman
Right? So I think the thing to remember is that dopamine is this incredibly powerful molecule that allows us to buffer the effort process. It allows us to be in effort longer, and it allows us to actually eventually enjoy the process of effort.
- SPSpeaker
And not think about the reward, but just say, "Oh, I'm enjoying the process."
- AHDr. Andrew Huberman
Right. Well, you just described the first step. The first step in learning to attach dopamine to the effort process, which is the key- ... operation in order to succeed is to be very careful about how much you focus on the end goal. Keeping the goal in mind is important for, like, a proper orientation. You have to know the ultimate destination. But if at any point we were to evaluate our progress relative to that end goal, or if we don't know what the end goal is, there's a huge gap there.
- SPSpeaker
Right
- AHDr. Andrew Huberman
And it can feel overwhelming.
- SPSpeaker
And depressing, and I'm not good enough.
- AHDr. Andrew Huberman
That's right.
- SPSpeaker
I should just give up. What am I doing this for?
- AHDr. Andrew Huberman
That's right. You know-
- SPSpeaker
And those thoughts will affect us
- 1:06:08 – 1:16:47
Neuroplasticity, Learning and Play
- SPSpeaker
Reflexive, same thing as reactive, or what's reflective?
- AHDr. Andrew Huberman
Yeah, so, um, there are two modes of brain operations.
- SPSpeaker
Mm-hmm.
- AHDr. Andrew Huberman
So now this is, um, getting a little nitty-gritty, but one is deliberate, where we're in v- thinking duration, path, and outcome. What should I do? What, you know, how long should I do it, and what's the outcome?
- SPSpeaker
Deliberate.
- AHDr. Andrew Huberman
Yeah.
- SPSpeaker
Intentional.
- AHDr. Andrew Huberman
And it feels like work. This is what people need to understand.
- SPSpeaker
[laughs]
- AHDr. Andrew Huberman
The deliberate thought, deliberate action, writing the book, doing the workout you don't wanna do, whatever it is, having the conversation, it's supposed to feel hard.
- SPSpeaker
Hard.
- AHDr. Andrew Huberman
It's supposed to feel hard. But you should subjectively reward it so that you get better at, at doing that.
- SPSpeaker
Ah.
- AHDr. Andrew Huberman
So it's supposed to feel hard, because it's associated with this release of these neurochemicals that create this agitation. The mental strain you feel when you're learning something is the trigger for neuroplasticity for your brain to change. It's-
- SPSpeaker
Say that again. The mental strain you feel while doing something is the what?
- AHDr. Andrew Huberman
Is the trigger for neuroplasticity.
- SPSpeaker
Which neuroplasticity allows you to expand your mind to do more things.
- AHDr. Andrew Huberman
That's right. So neuroplasticity is a process of taking something where there's duration, path, and outcome, where I'm working hard, I'm thinking hard. Maybe it's a hard conversation, maybe it's a business plan, maybe it's a scientific career. And the goal of neuroplasticity is to make things reflexive so you don't have to think about them, right?
- SPSpeaker
For instance, I just started taking Spanish class one-on-one, and it's extremely hard.
- AHDr. Andrew Huberman
Right.
- SPSpeaker
It makes me wanna say, "Why am I doing this?"
- AHDr. Andrew Huberman
Right.
- SPSpeaker
This is gonna take me years-
- AHDr. Andrew Huberman
Mm-hmm
- SPSpeaker
... until I'm conversational. Who knows how long till I'm fluent. You know, if it's this hard as, at like this stage, man, is it ever gonna get easier? I have those moments-
- AHDr. Andrew Huberman
Mm-hmm
- SPSpeaker
... every time I'm doing class.
- AHDr. Andrew Huberman
Mm-hmm.
- SPSpeaker
I'm like, "This sucks."
- AHDr. Andrew Huberman
Right.
- 1:16:47 – 1:22:42
Serotonin, Rest and Yoga Nidra
- AHDr. Andrew Huberman
And it's so powerful because unless that dop- uh, that, excuse me, that serotonin box is checked off periodically, we cannot lean back into the dopamine outward pursuit process for very long.
- SPSpeaker
So we need serotonin-
- AHDr. Andrew Huberman
Absolutely
- SPSpeaker
... to feel more, what? Complete? Whole?
- AHDr. Andrew Huberman
Safe.
- SPSpeaker
Safe.
- AHDr. Andrew Huberman
Once you feel... This is where people, you know, I think that the go-getters get it wrong [laughs]
- SPSpeaker
Mm.
- AHDr. Andrew Huberman
No pun intended, where getting after it and being hard-driving is really important. But, you know, we've all seen examples of this. I've seen a number of these in Silicon Valley, friends that did very well in tech get to the point where they reach that finish line, and then they don't have a whole lot or a whole lot of people to share that with, and they end up very isolated and depressed. And then they go through this whole cycle-
- SPSpeaker
Yeah
- AHDr. Andrew Huberman
... of trying to find themselves. And, um, you need to balance serotonin and dopamine, maybe across the day, maybe across the week. You know, I think in religious practices, um, all religions really, there's a kind of Sabbath, there's a rest period, you know, for many, many or I think all of them. Um, that makes sense because there needs to be a renewal. Whether or not people have a religious practice or not, there needs to be a renewal or-
- SPSpeaker
A recovery
- AHDr. Andrew Huberman
... a recovery to recover the immune system. You can't drive the immune system all week, all week, all week. You need to recover it.
- SPSpeaker
This is why I love sports analogies, because there's, uh, a preseason, there's a season, there's a postseason where you're really in high stress and emotion, and then there's a postseason.
- AHDr. Andrew Huberman
Yeah.
- SPSpeaker
There's an off-season-
- AHDr. Andrew Huberman
Right
- SPSpeaker
... for a reason. You can't be in season- 10 years-
- AHDr. Andrew Huberman
Yeah
- SPSpeaker
... you know, in a row.
- AHDr. Andrew Huberman
Yeah.
- SPSpeaker
You've got to find time to relax and have a bye week. It's like if you don't-
- AHDr. Andrew Huberman
Mm-hmm
- SPSpeaker
... have a bye week, you're probably gonna get injured eventually.
- AHDr. Andrew Huberman
Mm-hmm.
- SPSpeaker
So it's just like trying to create that in your own life. Do you do that for yourself as well? Do you have-
- AHDr. Andrew Huberman
Definitely. I've got things I do each day, and then I've got things I do on a weekly basis. I'm less good about the annual vacation.
- SPSpeaker
[laughs]
- AHDr. Andrew Huberman
I've never done it.
- SPSpeaker
So are-
- 1:22:42 – 1:31:52
Behaviors First, Then Supplements and Drugs, Plus Gratitude
- AHDr. Andrew Huberman
For some people, you know, a drink is fine. I'm, I'm focused on behavioral tools.
- SPSpeaker
Mm-hmm.
- AHDr. Andrew Huberman
You know, supplements and drugs have their place and, you know, some, there are clinically depressed people that need a boost in dopamine or need a boost in serotonin. And I'm, I think even though drugs like Prozac get a bad rap, th- those drugs have also saved millions of lives. There's just an appropriate dose and context, and some people shouldn't take them, right?
- SPSpeaker
Well, people also, what I'm hearing you say is you can, should take them when you need them, when you're unable to physically create those habits for yourself and routines for yourself. But then once you take it, you're always gonna need it until you can learn how to behaviorally change your actions.
- AHDr. Andrew Huberman
That's right.
- SPSpeaker
Right?
- AHDr. Andrew Huberman
It's like the obese person that finally, you know, if they really can't move, right? You know, maybe they do need to do some sort of surgical procedure.
- SPSpeaker
Like the gastric, yeah.
- AHDr. Andrew Huberman
Or they need to, or they need to do something that... But then once they start exercising, you, you, o- I believe you always wanna go behaviors, focus on behaviors first. Get the behaviors dialed in. Everything we've talked about today is free.
- SPSpeaker
Yeah.
- AHDr. Andrew Huberman
Everything we've talked about is, is self-directed, so it's behaviors. Then I think it, I think diet and, is very important for nutrition. I think supplementation definitely has its place. I think we are past the, the ridiculous idea of the '80s and '90s, like, "Oh, can't you get everything from what you eat?"
- SPSpeaker
Right.
- AHDr. Andrew Huberman
No one can even agree on what we're supposed to eat.
- SPSpeaker
Right.
- AHDr. Andrew Huberman
Every scientist I know who's serious about their mind and body takes supplements.
- SPSpeaker
Yeah.
- AHDr. Andrew Huberman
I don't have a supplement company, I'm gonna be very clear about this, but they all have their regime for them.
- SPSpeaker
Mm-hmm.
- AHDr. Andrew Huberman
And I think we're seeing a tide change now where supplements are no longer being thought of as this, like, niche thing that only bodybuilders and, like, people who are selling snake oil are about. There is a lot of snake oil out there, but there are also some supplements that are powerful for the sorts of things that we're talking about-
- SPSpeaker
Mm-hmm
- AHDr. Andrew Huberman
... for sleep and all the others. We can talk about them if you like. But I think it's, um, behaviors, nutrition, supplements, and then there is a place for prescription drugs. There are people that are clinically depressed and suicidal and need help, and they need to talk to a board-certified MD and get ahold of, in some cases, the opinion of whether or not they should take these drugs. Doesn't mean they should take them forever, but, you know, we tend to jump to drugs, and that's why I think a lot-
- SPSpeaker
Yeah
- AHDr. Andrew Huberman
... of those drugs have, they, they won't change your behaviors. You still need to change your behaviors.
- SPSpeaker
That's the easy way out to start is taking the drugs-
- AHDr. Andrew Huberman
Right
- SPSpeaker
... but what you should be doing is the behavioral, nutrition, supplements. If you do those three things first, you should start to feel better.
- AHDr. Andrew Huberman
Oh, absolutely.
- SPSpeaker
Yeah.
- AHDr. Andrew Huberman
Sunlight in the morning, the things we've talked about. I-
- SPSpeaker
Breathing, relaxing, yeah, all these things.
- 1:31:52 – 1:44:38
Accelerated Learning, Nootropics and the Will to Live
- AHDr. Andrew Huberman
I am pretty confident saying that it's not gonna shorten your life.
- SPSpeaker
Mm-hmm.
- AHDr. Andrew Huberman
Remember that the dopamine system... And so dopamine and acetylcholine are the primary triggers for adult neuroplasticity. We know this because if you s- there are experiments, um, done by a guy named Mike Merzenich at UCSF, that if you stimulate the areas of the brain that release dopamine and acetylcholine, you can rapidly induce plasticity, like one trial learning.
- SPSpeaker
Oh.
- AHDr. Andrew Huberman
Like Spanish today.
- SPSpeaker
Right.
- AHDr. Andrew Huberman
Like fluent in Spanish today.
- SPSpeaker
Wow.
- AHDr. Andrew Huberman
Which is kinda scary. This is actually the basis of companies that are thinking about-
- SPSpeaker
Hmm
- AHDr. Andrew Huberman
... inserting wires into the brain and stimulating.
- SPSpeaker
Wait, I could be, I could be fluent in Spanish today?
- AHDr. Andrew Huberman
In theory, if you stimulate enough acetylcholine and dopamine release while-
- SPSpeaker
[laughs]
- AHDr. Andrew Huberman
... experiencing enough Spanish, you'd probably have to speak that Spanish. You'd probably have to read it.
- SPSpeaker
Wow. You could re- remember it and connect it.
- AHDr. Andrew Huberman
Yeah. It's, it's possible.
- SPSpeaker
It's like Matrix.
- AHDr. Andrew Huberman
It's possible.
- SPSpeaker
Like, "I know kung fu."
- AHDr. Andrew Huberman
Yeah. We're not quite there yet, but it's possible. It's been done in, in other forms of learning in other studies.
- SPSpeaker
Really?
- AHDr. Andrew Huberman
Yeah. Well, well-
- SPSpeaker
What's it called?
- AHDr. Andrew Huberman
Well, if you release the... Well, you'd have to actually have an electrode down in your head. I don't know that you wanna drill a hole in your skull.
- SPSpeaker
You'd put something in your head-
- AHDr. Andrew Huberman
You'd have to drill into your skull
- SPSpeaker
... and put enough dopamine in your-
- AHDr. Andrew Huberman
You would s- remember, the dopamine comes from the neurons that are in there, so you'd be stimulating the dopamine neurons, the acetylcholine neurons, and you'd be r- probably reading a Spanish script. There are, I, I will say there are-
- SPSpeaker
Shut up. [laughs]
- 1:44:38 – 1:53:04
Fear, Fun and Learning Spanish
- SPSpeaker
How does someone like you, I don't wanna stereotype a scientist and a professor, but how does someone like you have fun?
- AHDr. Andrew Huberman
[laughs]
- SPSpeaker
When most scientists are more like lab rats that are just-
- AHDr. Andrew Huberman
Yeah
- SPSpeaker
... like focused on the research and the work and getting it done, how do you incorporate play and fun in your life?
- AHDr. Andrew Huberman
Well, I love doing science, 'cause to me, being a brain explorer is, like, the coolest thing.
- SPSpeaker
It is fun. Yeah.
- AHDr. Andrew Huberman
I mean, when I was a little kid, I wanted to be an astronaut.
- SPSpeaker
Oh.
- AHDr. Andrew Huberman
And then I didn't pursue that path. And but for me, the next best thing is to be a brain explorer-
- SPSpeaker
Wow
- AHDr. Andrew Huberman
... and, you know, dig around in the brain and try and understand the brain. And um, but I enjoy, let's see, I, I mean, I'm a little bit of a sicko in the sense that I love music.
- SPSpeaker
[laughs]
- AHDr. Andrew Huberman
I love food.
- SPSpeaker
Yeah.
- AHDr. Andrew Huberman
I love to eat, I love to train, I love friendship.
- SPSpeaker
Yeah.
- AHDr. Andrew Huberman
I, I'm at this point now, and I wasn't always like this. I've definitely experienced depression. I've been there. I, I'm at the point now where maybe it's the gratitude practice, maybe it's the fact that I've been trying to get enough sleep, and I sometimes do, but I'm, I just feel so happy to be in relation to all these opportunities. And the fact that people care about neuroscience and they wanna learn, and that there's a place for me in this world to teach it-
- SPSpeaker
Mm
- AHDr. Andrew Huberman
... you know, is just kind of like an endless source of joy. I love movies, music, friendship, training, food.
- SPSpeaker
Your dog.
- AHDr. Andrew Huberman
My dog.
- SPSpeaker
Yeah, yeah, yeah.
- AHDr. Andrew Huberman
Um, goodness, uh, art. I, you know, I, I think I've found enough things in the world that I love, that, um, you know, I feel like I have like five time, five lifetimes worth of-
- SPSpeaker
Sure
- AHDr. Andrew Huberman
... things to, to pursue.
- SPSpeaker
What about fears? Do you have a lot of fears? And how much does fear play into, um, the body and mind connection?
- AHDr. Andrew Huberman
Well, the f- fear is huge in the body-mind connection because it can shut us down. I mean, fear can really take us to the point of, you know, from a place of feeling really great to just, it can, like, crump us all at once. And I mean, the, the things that, um... Well, I have several fears. One is, you know, I have this weird, um, history in science where my undergraduate advisor, my graduate advisor, and my postdoc advisor are all dead. They all died young. So it was like, it was suicide-
- SPSpeaker
Oh, man
- AHDr. Andrew Huberman
... cancer, cancer. It was really rough, 'cause I was close with all of them. And so I have one major fear, which is dying without getting the information that I-
- 1:53:04 – 1:59:44
Three Truths, Where to Follow, and Defining Greatness
- SPSpeaker
We'll, we'll, we'll do more and talk about fear and how to overcome fear and all these different things. But this has been fascinating, and I wanna ask you a couple final questions, Andrew. One is, um, called the three truths. So imagine it's your last day on earth, and, uh, you've, you've actually accomplished all of your s- you've gotten all your work out there in the world that you wanted to create.
- AHDr. Andrew Huberman
Okay.
- SPSpeaker
Your books, your lab results, all the research you got to do, 99% of it, right?
- AHDr. Andrew Huberman
Okay.
- SPSpeaker
You're always gonna wanna do more.
- AHDr. Andrew Huberman
Uh-huh.
- SPSpeaker
But you got to do as much as you could.
- AHDr. Andrew Huberman
Okay. Yeah.
- SPSpeaker
You have books out there, lectures, everything is out in the world that you wanted to do, but it's your last day and you've gotta, for whatever reason, you've gotta take all of your work with you. So this podcast is gone, your books, your results, everything.
- AHDr. Andrew Huberman
Oh, wow.
- SPSpeaker
So it's all gone, with you to the next place.
- AHDr. Andrew Huberman
Okay.
- SPSpeaker
Wherever you go.
- AHDr. Andrew Huberman
Uh-huh.
- SPSpeaker
But you got a pen and a piece of paper, and you get to write down three things you know to be true about your entire life and the lessons you've learned that you would share with the world. And this is all we have to remember you by or your lessons. I call it the three truths.
- AHDr. Andrew Huberman
Okay.
- SPSpeaker
So what would you say are your three truths?
- AHDr. Andrew Huberman
Okay. Well, the first one I'm gonna poach from the Oracle.
- SPSpeaker
Mm-hmm.
- AHDr. Andrew Huberman
Which is know thyself.
- SPSpeaker
Mm-hmm.
- AHDr. Andrew Huberman
I do believe that through whatever exploration, whether or not it's therapy, meditation, religious, uh, exercise, all of the above, I think people should, um, explore what they're, you know, sort of how they're showing up in the world.
- SPSpeaker
Yeah.
- AHDr. Andrew Huberman
And then obviously based on today's discussion, I believe that we can make changes around that, but know thyself. Wish I had said it, but the Oracle.
- SPSpeaker
[laughs]
- AHDr. Andrew Huberman
Someone beat me to the punch. The second one is, um, it's rather Freudian, but, um, I do think there's a core set of operations about the way we work, um, that are important, is you can imagine three boxes, it's like a three box diagram, and in the first one it would say wish, then there's an arrow next to it, it would say anxiety, and then there would be an arrow, and then the last one would say defense. Typically, we have a wish It creates some anxiety in us, and then we get into some reflexive defensive behavior. For some people, that's addiction. For some people, that's, you know, rabid ambition to the point of neglecting things, whatever the defense is. And I think our job is to intervene between anxiety and defense.
- SPSpeaker
Mm-hmm.
- AHDr. Andrew Huberman
Or at least come up with defenses that serve humanity-
- SPSpeaker
Sure
- AHDr. Andrew Huberman
... so that we're giving as opposed to destroying.
Episode duration: 1:59:44
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Transcript of episode A1KSvTboNgA