David Sinclair: Extending the Human Lifespan Beyond 100 Years | Lex Fridman Podcast #189

ℹ️ EPISODE INFO

Released

June 7, 2021

Duration

1h 41m

Channel

Lex Fridman Podcast

Watch on YouTube

▶ Open ↗

📝 EPISODE DESCRIPTION

David Sinclair is a geneticist at Harvard and author of Lifespan. Please support this podcast by checking out our sponsors:

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EPISODE LINKS: David's Twitter: https://twitter.com/davidasinclair David's Website: https://lifespanbook.com PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ Full episodes playlist: https://www.youtube.com/playlist?list=PLrAXtmErZgOdP_8GztsuKi9nrraNbKKp4 Clips playlist: https://www.youtube.com/playlist?list=PLrAXtmErZgOeciFP3CBCIEElOJeitOr41 OUTLINE: 0:00 - Introduction 1:34 - Staying young at heart 5:30 - Bringing people back to life 11:05 - Wearables and tracking health data 20:18 - How to solve aging 30:22 - Why do we age? 35:50 - Genetic reset switch that reverses aging 38:20 - AI in biology 40:52 - Health data 48:58 - Fasting 56:29 - Diet 1:04:40 - Exercise 1:10:01 - Sleep 1:18:29 - Data 1:24:00 - Extending lifespan 1:26:42 - Immortality 1:32:28 - Denial of death 1:35:45 - Meaning of life without death SOCIAL:

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• Support on Patreon: https://www.patreon.com/lexfridman

🎤 SPEAKERS

• Lex Fridman

  host

• David Sinclair

  guest

🧾 EPISODE SUMMARY

In this episode of Lex Fridman Podcast, featuring Lex Fridman and David Sinclair, David Sinclair: Extending the Human Lifespan Beyond 100 Years | Lex Fridman Podcast #189 explores david Sinclair and Lex Fridman Reimagine Aging As an Engineering Problem Lex Fridman and Harvard geneticist David Sinclair explore aging as an information problem in biology that might be slowed, reset, or even partially reversed. Sinclair explains his theory that aging stems from loss and corruption of epigenetic information—"scratches on a CD"—and describes experiments in mice that can both accelerate and reverse signs of aging using genetic reprogramming. They discuss current and near‑term tools for extending healthspan: wearables, continuous monitoring, blood and DNA-based clocks, personalized AI-driven recommendations, as well as lifestyle levers like fasting, diet, exercise, sleep, and stress management. The conversation also dives into philosophical and societal implications of long lives, digital immortality, brain uploading, and whether death is necessary for meaning.

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