#112 – Ned David, Ph.D.: How cellular senescence influences aging, and what we can do about it

ℹ️ EPISODE INFO

Released

July 8, 2020

Duration

2h 15m

Channel

Peter Attia MD

Watch on YouTube

▶ Open ↗

📝 EPISODE DESCRIPTION

Sign up to receive Peter's email newsletter: https://bit.ly/4c602k2 Original release date: 6/1/20 Ned David is the co-founder of Unity Biotechnology, a company developing senolytic medicines—molecules that target and destroy senescent cells in the human body. In this episode, Ned explains the science of cellular senescence and how it impacts the aging process. Ned discusses how senolytics may delay, prevent, treat, or even reverse age-related diseases, including cancer, cardiovascular disease, and neurodegenerative disease. As a serial entrepreneur, Ned also provides advice on how to transform a simple idea into the creation of a company. We discuss: -Defining longevity and the principles of aging [2:50]; -The control knobs of aging and how we can turn them [15:10]; -Role of cellular senescence in aging and cancer [27:00]; -History of senescence in scientific study [40:30]; -The cellular senescence paradox [46:00]; -Developing medicines that target cellular senescence [52:15]; -Ned’s lessons on risk analysis in business [1:05:15]; -The search for a molecule that could eliminate senescent cells [1:15:15]; -Senescent cell elimination example in osteoarthritic knees [1:30:30]; -Extending lifespan by removing senescent cells [1:45:00]; -Senolytic molecule example in macular degeneration reversal [1:52:30]; -The future of senescent cell targeting [1:58:30]; -The role of cellular senescence and metabolic syndrome [2:01:30]; -The role of cellular senescence and brain health [2:03:30] -How building the company Kythera prepared Ned for his grander project of creating Unity Biotechnology [2:05:45]; -Advice for someone considering an entrepreneurial career path versus an academic career path [2:08:50]; and -More. Show notes page: https://peterattiamd.com/neddavid/ -------- About: The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 30 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more. Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life). Learn more: https://peterattiamd.com Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter Connect with Peter on: Facebook: http://bit.ly/PeterAttiaMDFB Twitter: http://bit.ly/PeterAttiaMDTW Instagram: http://bit.ly/PeterAttiaMDIG Subscribe to The Drive: Apple Podcast: http://bit.ly/TheDriveApplePodcasts Overcast: http://bit.ly/TheDriveOvercast Spotify: http://bit.ly/TheDriveSpotify Google Podcasts: http://bit.ly/TheDriveGoogle

🎤 SPEAKERS

• Peter Attia

  host

  Physician and host of The Drive podcast focused on longevity and health.

• Ned David

  guest

  Biotechnology executive and Ph.D. focused on cellular senescence and senolytic therapeutics (Unity Biotechnology).

🧾 EPISODE SUMMARY

In this episode of Peter Attia MD, featuring Peter Attia and Ned David, #112 – Ned David, Ph.D.: How cellular senescence influences aging, and what we can do about it explores cellular senescence as a druggable aging mechanism: science, strategy, early results Ned David frames longevity as reducing the “indignities” of aging—mobility loss, degenerative disease, and cognitive decline—by using biology to change how aging manifests in people.

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