220 ‒ Ketamine: Benefits, risks, and promising therapeutic potential | Celia Morgan, Ph.D.

ℹ️ EPISODE INFO

Released

August 29, 2022

Duration

1h 42m

Channel

Peter Attia MD

Watch on YouTube

▶ Open ↗

📝 EPISODE DESCRIPTION

Watch the full episode and view show notes here: https://bit.ly/3Pwj05T Become a member to receive exclusive content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Celia Morgan is a Professor of Psychopharmacology at the University of Exeter who has authored numerous publications on the potential therapeutic uses of ketamine in mental healthcare. In this episode, Celia dives deep into the neurobiology of ketamine, how it affects users, and how it differs from other, more classical psychedelics (LSD, MDMA, PCP, and psilocybin). She explains the potential promise of ketamine as a treatment for recalcitrant depression and addiction, and she details the results from her clinical trials in these areas. She discusses the importance of using ketamine in combination with psychotherapy to maximize its benefits, the potential risks associated with ketamine use, and advice for those interested in the therapeutic use of ketamine. We discuss: 0:00:00 - Intro 0:00:08 - Celia’s training and interest in ketamine 0:01:58 - The history of ketamine, medical uses, and use as a party drug 0:07:48 - Neurobiology and pharmacology of ketamine 0:19:30 - Ketamine regulation and abuse, and how it compares with psychedelics and other molecules 0:35:38 - Ketamine as a therapeutic for depression [30:45]; 0:56:43 - The brain under the influence of ketamine and theoretical mechanisms for its anti-depressive effects 1:07:56 - Risks and concerns with overusing ketamine, and what an intermittent or maintenance dose might look for a patient 1:16:39 - Treating addiction with ketamine: Celia’s studies of alcohol dependance 1:35:49 - Advice for people considering the therapeutic use of ketamine -------- About: The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 45 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more. Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life). Learn more: https://peterattiamd.com Connect with Peter on: Facebook: http://bit.ly/PeterAttiaMDFB Twitter: http://bit.ly/PeterAttiaMDTW Instagram: http://bit.ly/PeterAttiaMDIG Subscribe to The Drive: Apple Podcast: http://bit.ly/TheDriveApplePodcasts Overcast: http://bit.ly/TheDriveOvercast Spotify: http://bit.ly/TheDriveSpotify Google Podcasts: http://bit.ly/TheDriveGoogle Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures and the companies I invest in or advise, please visit my website where I keep an up-to-date and active list of such companies.

🎤 SPEAKERS

• Peter Attia

  host

  Physician and host of The Drive podcast focusing on medicine, longevity, and health.

• Celia Morgan

  guest

  Psychology and pharmacology researcher (Ph.D., University College London) specializing in ketamine’s effects and therapeutic applications.

🧾 EPISODE SUMMARY

In this episode of Peter Attia MD, featuring Peter Attia and Celia Morgan, 220 ‒ Ketamine: Benefits, risks, and promising therapeutic potential | Celia Morgan, Ph.D. explores ketamine’s NMDA-driven dissociation, rapid antidepressant effects, and clinical risks Celia Morgan describes ketamine’s origins as an NMDA-receptor-acting dissociative anesthetic developed as a replacement for PCP, and explains why it remains widely used due to relative physiologic safety (notably limited respiratory depression).

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